CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Evaluation of different body temperature measurement methods for patients in the intraoperative period
CONCLUSION: the data from the current study do not recommend using infrared temporal thermometers as a strategy for measuring the body temperature of patients undergoing anesthetic-surgical procedures. Central cutaneous thermometers and esophageal/nasopharyngeal thermometers are equivalent for detecting intraoperative hypothermia.PMID:38655937 | DOI:10.1590/1518-8345.6873.4143 (Source: Revista Latino-Americana de Enfermagem)
Source: Revista Latino-Americana de Enfermagem - April 24, 2024 Category: Nursing Authors: Ariane Souza do Nascimento Cassiane de Santana Lemos Fernanda Baratojo Biachi Fernanda Ribeiro Silva de Lyra Juliana Rizzo Gnatta Vanessa de Brito Poveda Source Type: research
Identification of Key lncRNAs Associated with Immune Infiltration and Prognosis in Gastric Cancer
In this study, we systematically analyzed lncRNA and miRNA transcriptomic profiles of GC based on bioinformatics methods and experimental validation. An lncRNA-miRNA interaction network related to GC was constructed, and the nine crucial lncRNAs were identified. These 9 lncRNAs were found to be associated with the prognosis of GC patients by Cox proportional hazards regression analysis. Among them, the expression of lncRNA SNHG14 can affect the survival of GC patients as a potential prognostic marker. Moreover, it was shown that SNHG14 was involved in immune-related pathways and significantly correlated with immune cell in...
Source: Biochemical Genetics - April 24, 2024 Category: Genetics & Stem Cells Authors: Wen Jin Jianchao Jia Yangming Si Jianli Liu Hanshuang Li Hao Zhu Zhouying Wu Yongchun Zuo Lan Yu Source Type: research
Extensive pulmonary hyalinizing granuloma- an unexpected manifestation during esophageal cancer treatment
Asian J Surg. 2024 Apr 23:S1015-9584(24)00745-0. doi: 10.1016/j.asjsur.2024.04.086. Online ahead of print.NO ABSTRACTPMID:38658278 | DOI:10.1016/j.asjsur.2024.04.086 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 24, 2024 Category: Surgery Authors: Sen-Ei Shai Chen-I Chang Yi-Ling Lai Chi-Wei Hsieh Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
CONCLUSION: The novel protein PDE5A-500aa encoded by circPDE5A can act as an inhibitor of the PI3K/AKT signaling pathway to inhibit the progression of ESCC by promoting USP14-mediated de-ubiquitination of PIK3IP1 and may serve as a potential target for the development of therapeutic agents.PMID:38658954 | DOI:10.1186/s13046-024-03054-3 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Kai Lei Ruihao Liang Jialu Liang Nan Lu Jing Huang Ke Xu Binghua Tan Kexi Wang Yicheng Liang Wenjian Wang Huayue Lin Minghui Wang Source Type: research
Evaluation of different body temperature measurement methods for patients in the intraoperative period
CONCLUSION: the data from the current study do not recommend using infrared temporal thermometers as a strategy for measuring the body temperature of patients undergoing anesthetic-surgical procedures. Central cutaneous thermometers and esophageal/nasopharyngeal thermometers are equivalent for detecting intraoperative hypothermia.PMID:38655937 | DOI:10.1590/1518-8345.6873.4143 (Source: Revista Latino-Americana de Enfermagem)
Source: Revista Latino-Americana de Enfermagem - April 24, 2024 Category: Nursing Authors: Ariane Souza do Nascimento Cassiane de Santana Lemos Fernanda Baratojo Biachi Fernanda Ribeiro Silva de Lyra Juliana Rizzo Gnatta Vanessa de Brito Poveda Source Type: research
Extensive pulmonary hyalinizing granuloma- an unexpected manifestation during esophageal cancer treatment
Asian J Surg. 2024 Apr 23:S1015-9584(24)00745-0. doi: 10.1016/j.asjsur.2024.04.086. Online ahead of print.NO ABSTRACTPMID:38658278 | DOI:10.1016/j.asjsur.2024.04.086 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 24, 2024 Category: Surgery Authors: Sen-Ei Shai Chen-I Chang Yi-Ling Lai Chi-Wei Hsieh Source Type: research
Identification of Key lncRNAs Associated with Immune Infiltration and Prognosis in Gastric Cancer
In this study, we systematically analyzed lncRNA and miRNA transcriptomic profiles of GC based on bioinformatics methods and experimental validation. An lncRNA-miRNA interaction network related to GC was constructed, and the nine crucial lncRNAs were identified. These 9 lncRNAs were found to be associated with the prognosis of GC patients by Cox proportional hazards regression analysis. Among them, the expression of lncRNA SNHG14 can affect the survival of GC patients as a potential prognostic marker. Moreover, it was shown that SNHG14 was involved in immune-related pathways and significantly correlated with immune cell in...
Source: Biochemical Genetics - April 24, 2024 Category: Genetics & Stem Cells Authors: Wen Jin Jianchao Jia Yangming Si Jianli Liu Hanshuang Li Hao Zhu Zhouying Wu Yongchun Zuo Lan Yu Source Type: research
