High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | PMC:PMC11006707 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research
High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | PMC:PMC11006707 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research
High LINC00626 expression promotes esophagogastric junction adenocarcinoma metastasis: the mediating role of the JAK1/STAT3/KHSRP axis
CONCLUSION: High LINC00626 expression promotes esophageal-gastric junction adenocarcinoma metastasis by activating the JAK1/STAT3/KHSRP signal axis.PMID:38597446 | PMC:PMC11006707 | DOI:10.12122/j.issn.1673-4254.2024.03.16 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: F Zhang L Fan X Kang H Wei L Li Source Type: research
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
British Journal of Cancer, Published online: 10 April 2024; doi:10.1038/s41416-024-02683-xSPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Chen Wang Yutong Li Linhong Wang Yu Han Xiaohui Gao Tiandong Li Man Liu Liping Dai Renle Du Source Type: research
Esophageal Dysphagia in Adults
This article underscores the role of detailed patient history and physical examinations, including prompt endoscopic evaluation, for accurate differentiation between esophageal and oropharyngeal dysphagia. The authors discuss the heightened importance of early intervention in certain patient groups, such as elderly individuals and patients with head and neck cancer, to mitigate the risk of malnutrition and infection. The authors delve into etiologic factors highlighting the complexity of clinical presentations and the significance of tailored management strategies. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 10, 2024 Category: ENT & OMF Authors: Miller Richmond, Elliana Kirsh DeVore, Phillip C. Song Source Type: research
DNMT1-mediated epigenetic suppression of FBXO32 expression promoting cyclin dependent kinase 9 (CDK9) survival and esophageal cancer cell growth
. (Source: Cell Cycle)
Source: Cell Cycle - April 10, 2024 Category: Cytology Authors: Xian-Qiang SongBin-Bin ChenYong-Mei JinChang-Yong Wanga Department of Radiotherapy, Qinhuai Medical District, General Hospital of Eastern Theater Command, Nanjing, PR Chinab Departments of Laboratory Medicine, Qinhuai Medical District, General Hospital of Source Type: research
Neoadjuvant therapy for non-small cell lung cancer and esophageal cancer
Am J Cancer Res. 2024 Mar 15;14(3):1258-1277. doi: 10.62347/TCEC1867. eCollection 2024.ABSTRACTAs the major malignant tumors in the chest, non-small cell lung cancer (NSCLC) and esophageal cancer (EC) bring huge health burden to human beings worldwide. Currently, surgery is still the mainstay for comprehensive treatment for NSCLC and EC, but the prognosis is still poor as the results of cancer recurrence and distant metastasis. Neoadjuvant therapy refers to a single or combined treatment before surgery, aiming to improve the therapeutic effects of the traditional therapies. Unfortunately, the clinical outcomes and effects ...
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Yunlong He Yaqi Zhao Muhammad Luqman Akhtar Yu Li Mingyan E Huan Nie Source Type: research
Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair
CONCLUSIONS: Our results identify SMAD3 as a promising therapeutic target for future combination strategies for the treatment of patients with EAC.PMID:38592373 | DOI:10.1158/1078-0432.CCR-24-0027 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 9, 2024 Category: Cancer & Oncology Authors: Farah Ballout Heng Lu Nadeem Bhat Lei Chen Dunfa Peng Zheng Chen Steven Chen Xiaodian Sun Silvia Giordano Simona Corso Alexander Zaika Oliver McDonald Alan S Livingstone Wael El-Rifai Source Type: research
Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study
CONCLUSION: CXI is associated with disease progression, worse postoperative mortality, and overall survival, and could improve prognostication and decision-making in patients with locally advanced oesophagogastric cancer.PMID:38593042 | DOI:10.1093/bjs/znae098 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 9, 2024 Category: Surgery Authors: Leo R Brown Georgina G Thomson Ellen Gardner Siobhan Chien Josh McGovern Ross D Dolan Stephen T McSorley Matthew J Forshaw Donald C McMillan Stephen J Wigmore Andrew B Crumley Richard J E Skipworth Source Type: research
Identification of subgroups of patients with oesophageal cancer based on exercise intensity during prehabilitation
CONCLUSIONS: This cluster analysis identified three subgroups with distinct patterns in exercise intensity during prehabilitation. Participants who were physically fit were able to train at high intensity. Fatigued participants trained at lower intensity but showed the greatest improvement. A small group of participants, despite being physically active, had a low training capacity and could be considered frail.PMID:38591988 | DOI:10.1080/09638288.2024.2337106 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - April 9, 2024 Category: Rehabilitation Authors: Elja A E Reijneveld Mitchel Griekspoor Jaap J Dronkers Ad Kerst Jelle P Ruurda Cindy Veenhof Source Type: research
Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair
CONCLUSIONS: Our results identify SMAD3 as a promising therapeutic target for future combination strategies for the treatment of patients with EAC.PMID:38592373 | DOI:10.1158/1078-0432.CCR-24-0027 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 9, 2024 Category: Cancer & Oncology Authors: Farah Ballout Heng Lu Nadeem Bhat Lei Chen Dunfa Peng Zheng Chen Steven Chen Xiaodian Sun Silvia Giordano Simona Corso Alexander Zaika Oliver McDonald Alan S Livingstone Wael El-Rifai Source Type: research
Identification of subgroups of patients with oesophageal cancer based on exercise intensity during prehabilitation
CONCLUSIONS: This cluster analysis identified three subgroups with distinct patterns in exercise intensity during prehabilitation. Participants who were physically fit were able to train at high intensity. Fatigued participants trained at lower intensity but showed the greatest improvement. A small group of participants, despite being physically active, had a low training capacity and could be considered frail.PMID:38591988 | DOI:10.1080/09638288.2024.2337106 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - April 9, 2024 Category: Rehabilitation Authors: Elja A E Reijneveld Mitchel Griekspoor Jaap J Dronkers Ad Kerst Jelle P Ruurda Cindy Veenhof Source Type: research
Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study
CONCLUSION: CXI is associated with disease progression, worse postoperative mortality, and overall survival, and could improve prognostication and decision-making in patients with locally advanced oesophagogastric cancer.PMID:38593042 | PMC:PMC11003541 | DOI:10.1093/bjs/znae098 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 9, 2024 Category: Surgery Authors: Leo R Brown Georgina G Thomson Ellen Gardner Siobhan Chien Josh McGovern Ross D Dolan Stephen T McSorley Matthew J Forshaw Donald C McMillan Stephen J Wigmore Andrew B Crumley Richard J E Skipworth Source Type: research
Endoscopic submucosal dissection (ESD) outcomes in T1B esophageal cancer: a retrospective study
ConclusionESD is safe with high en-bloc and R0 resection rates in T1b EC. Recurrence rates are low but patients need close monitoring. Larger-scale studies are needed to determine the long-term clinical efficacy of ESD in T1b EC.Graphical abstract (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 9, 2024 Category: Surgery Source Type: research
A novel technique to remove migrated esophageal stent under fluoroscopy
ConclusionFluoroscopy-guided “Loop method” for MES removal is an effective and safe alternative technique. (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 9, 2024 Category: Radiology Source Type: research
