Multi-omic analysis of Esophageal Adenocarcinoma uncovers candidate therapeutic targets and cancer-selective post-transcriptional regulation

CONCLUSIONS: By quantitative proteomic analysis we have identified GPA33 as an EAC-selective biomarker. Integrated analysis of proteome, transcriptome, and genome in EAC has revealed several genes with tumor-selective, post-transcriptional regulation of protein expression which may be an exploitable vulnerability.PMID:38604503 | DOI:10.1016/j.mcpro.2024.100764

Source: Molecular and Cellular Proteomics : MCP - April 11, 2024 Category: Molecular Biology Authors: J Robert O'Neill Marcos Y ébenes Mayordomo Goran Mitulovi ć Sofian Al Shboul Georges Bedran Jakub Faktor Lenka Hernychova Lukas Uhrik Maria Gomez-Herranz Miko łaj Kocikowski Vicki Save Bo řivoj Vojtěšek Mark Arends OCCAMS consortium Ted Hupp Javier Source Type: research