Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives
Clin Microbiol Rev. 2024 Apr 30:e0015222. doi: 10.1128/cmr.00152-22. Online ahead of print.ABSTRACTSUMMARYThe human immunodeficiency virus (HIV) epidemic remains a formidable global health concern, with 39 million people living with the virus and 1.3 million new infections reported in 2022. Despite anti-retroviral therapy's effectiveness in pre-exposure prophylaxis, its global adoption is limited. Broadly neutralizing antibodies (bNAbs) offer an alternative strategy for HIV prevention through passive immunization. Historically, passive immunization has been efficacious in the treatment of various diseases ranging from onco...
Source: Clinical Microbiology Reviews - April 30, 2024 Category: Microbiology Authors: Sharana Mahomed Source Type: research
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Res. 2024 Apr 27:105897. doi: 10.1016/j.antiviral.2024.105897. Online ahead of print.ABSTRACTHuman respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infections are still lacking. Here, we identified two Keggin-type polyoxometalates (POMs), [TiW11CoO40]8- (TiW11Co) and [Ti2PW10O40]7- (Ti2PW10), endowed with broad-spectrum activity against enveloped and non-enveloped human respiratory viruses, i.e., coronavirus (HCoV-OC43), rhinovirus (HRV-...
Source: Antiviral Research - April 30, 2024 Category: Virology Authors: Irene Arduino Rachele Francese Andrea Civra Elisa Feyles Monica Argenziano Marco Volante Roberta Cavalli Ali M Mougharbel Ulrich Kortz Manuela Donalisio David Lembo Source Type: research
Advancements in the management of obesity: a review of current evidence and emerging therapies
This study aimed to provide a narrative overview of the past, currently available, and future treatment options that offer therapeutic and preventive advantages for obesity management.AREAS COVERED: Historically, rimonabant, and lorcaserin, were approved and used for managing non-syndromic obesity. Currently, orlistat, naltrexone/bupropion, glucagon-like peptide-1 receptor agonist (GLP-1 RA), and a few promising therapeutic agents are under investigation, including retatrutide, cagrilintide and orforglipron, which show promising weight reduction effects. We have developed a search string of the Medical Subject Headings (Me...
Source: Expert Review of Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Mohammed Altigani Abdalla Ahmed Emmanuel Ssemmondo Charlotte Mark-Wagstaff Thozhukat Sathyapalan Source Type: research
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Res. 2024 Apr 27:105897. doi: 10.1016/j.antiviral.2024.105897. Online ahead of print.ABSTRACTHuman respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infections are still lacking. Here, we identified two Keggin-type polyoxometalates (POMs), [TiW11CoO40]8- (TiW11Co) and [Ti2PW10O40]7- (Ti2PW10), endowed with broad-spectrum activity against enveloped and non-enveloped human respiratory viruses, i.e., coronavirus (HCoV-OC43), rhinovirus (HRV-...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Irene Arduino Rachele Francese Andrea Civra Elisa Feyles Monica Argenziano Marco Volante Roberta Cavalli Ali M Mougharbel Ulrich Kortz Manuela Donalisio David Lembo Source Type: research
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Antiviral Res. 2024 Apr 27:105897. doi: 10.1016/j.antiviral.2024.105897. Online ahead of print.ABSTRACTHuman respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infections are still lacking. Here, we identified two Keggin-type polyoxometalates (POMs), [TiW11CoO40]8- (TiW11Co) and [Ti2PW10O40]7- (Ti2PW10), endowed with broad-spectrum activity against enveloped and non-enveloped human respiratory viruses, i.e., coronavirus (HCoV-OC43), rhinovirus (HRV-...
Source: Antiviral Research - April 30, 2024 Category: Virology Authors: Irene Arduino Rachele Francese Andrea Civra Elisa Feyles Monica Argenziano Marco Volante Roberta Cavalli Ali M Mougharbel Ulrich Kortz Manuela Donalisio David Lembo Source Type: research
GSE263865 Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice
Contributors : Lucia Cilenti ; Jacopo Di Gregorio ; Rohit Mahar ; Camilla T Ambivero ; Muthu Periasamy ; Matthew E Merritt ; Antonis S ZervosSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is a growing epidemic affecting billions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have a profound role in diet-induced obesity and the associated metabolic changes, but the molecular mechanisms linking mitochondria to obesity remain poorly understood. Our studies have identif...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Clinical and epidemiological characteristics of 96 pediatric human metapneumovirus infections in Henan, China after COVID-19 pandemic: a retrospective analysis
In the aftermath of the COVID-19 pandemic, there has been a surge in human metapneumovirus (HMPV) transmission, surpassing pre-epidemic levels. We aim to elucidate the clinical and epidemiological characterist... (Source: Virology Journal)
Source: Virology Journal - April 30, 2024 Category: Virology Authors: Wangquan Ji, Yu Chen, Shujie Han, Bowen Dai, Kang Li, Shuang Li, Zijie Li, Shouhang Chen, Yaodong Zhang, Xiaolong Zhang, Xiaolong Li, Qingmei Wang, Jiaying Zheng, Chenyu Wang, Qiujing Liang, Shujuan Han & hellip; Tags: Research Source Type: research
Cholera and diarrheal diseases in Cuamba District, Niassa Province, Mozambique: Systematic healthcare facility-based surveillance strengthening, characteristics of suspected cholera and diarrheal patients, and incidence of diarrheal diseases
Conclusion/SignificanceEfforts were made to strengthen the systematic surveillance of suspected cholera with standardised patient screening, enrolment, and diagnostics. The first basic microbiology laboratory in Niassa Province established in Cuamba District under the MOCA project needs to be integrated into the national network of laboratories for sustainability. No reports of laboratory confirmed cholera cases from the surveillance catchment area may be highly related to the pre-emptive oral cholera vaccine (OCV) mass vaccination campaign conducted in 2018 and the use of drugs by local populations prior to visiting the s...
Source: PLoS Neglected Tropical Diseases - April 30, 2024 Category: Tropical Medicine Authors: Cynthia Sem á Baltazar Source Type: research
Detection of DENV-1, DENV-3, and DENV-4 Serotypes in Aedes aegypti and Aedes albopictus, and Epidemic Risk in the Departments of Oueme and Plateau, South-Eastern Benin
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - April 30, 2024 Category: Infectious Diseases Authors: Germain Gil Padonou Alphonse Keller Konkon David Mahouton Zoungb édji Albert Sourou Salako Arthur Sovi Olivier Oussou Aboubakar Sidick Juv énal Ahouandjinou Linda Towakinou Razaki Oss é Lamine Baba-Moussa Martin Codjo Akogb éto Source Type: research
Delineating the evolutionary pathway to multidrug-resistant outbreaks of a Mycobacterium tuberculosis L4.1.2.1/Haarlem sublineage
Multidrug-resistant tuberculosis (MDR-TB) is caused by TB bacteria that are resistant to at least isoniazid and rifampicin, the two most potent TB drugs. This form of TB infection remains a major public health concern globally, which has been exacerbated by the HIV epidemic. The recent advent of the COVID-19 pandemic has further severely complicated the situation, by disrupting healthcare systems. Indeed, the burden of MDR-TB increased by 3% between 2020 and 2021, with 450 000 new cases of rifampicin-resistant TB in 2021, thus hampering the global TB control efforts [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 30, 2024 Category: Infectious Diseases Authors: Naira Dekhil, Helmi Mardassi Source Type: research
Clinical, molecular, and drug resistance epidemiology of HIV in Jordan, 2019-2021: a national study
This study aimed to address this gap to inform HIV prevention and control. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 30, 2024 Category: Infectious Diseases Authors: Faris G. Bakri, Heyam H. Mukattash, Hiam Esmeiran, Glenna Schluck, Casey K. Storme, Erica Broach, Tsedal Mebrahtu, Mohammad Alhawarat, Anais Valencia-Ruiz, Oussama M'Hamdi, Jennifer A. Malia, Zebiba Hassen, Mah'd M.S. Shafei, Ala Y. Alkhatib, Mahmoud Gazo Source Type: research
24. Divalent Vaccination to Protect Against the Cardiopulmonary and Antinociceptive Effects of Fentanyl, Oxycodone, and Their Mixture in Male Rats
The opioid overdose epidemic continues to worsen despite the availability of reversal agents. Although much work has been done developing vaccines targeting individual drugs, targeting multiple drugs may provide greater clinical utility given the prevalence of polydrug use. Thus, the current studies evaluated the cardiopulmonary and antinociceptive effects of fentanyl, oxycodone, and a fentanyl+oxycodone mixture in rats vaccinated with a novel divalent vaccine targeting both drugs. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Robert Seaman, Davide Tronconi, Caroline Kim, Bryan Hannon, Courtney Marecki, Marco Pravetoni Source Type: research
Financing for pandemic preparedness and response measures: a systematic scoping review
CONCLUSION: Our review identified three important gaps: a formal definition of pandemic preparedness and response, impeding the accurate quantification of the financing shortfall; research on the extent to which financing for pandemic preparedness and response has been targeted at the most vulnerable households; and an analysis of specific financial instruments and an evaluation of the feasibility of their implementation.PMID:38680465 | PMC:PMC11046164 | DOI:10.2471/BLT.23.290207 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - April 29, 2024 Category: International Medicine & Public Health Authors: Roberto Duran-Fernandez Daniel Bernal-Serrano Jose Alberto Garcia-Huitron Raymond Hutubessy Source Type: research
Responding to and managing multijurisdictional outbreaks of COVID-19 in Canadian industrial worksite/work camp settings
Can J Public Health. 2024 Apr 29. doi: 10.17269/s41997-024-00887-5. Online ahead of print.ABSTRACTSETTING: Early in the COVID-19 pandemic, the Public Health Agency of Canada (PHAC) and provincial/territorial (P/T) public health identified the need for a coordinated response to complex multijurisdictional COVID-19 outbreaks. The first large multijurisdictional industrial worksite COVID-19 outbreak highlighted the risk of transmission within these congregate work settings, the risk of transmission to the broader community(ies), and the need to develop setting-specific outbreak response frameworks.INTERVENTION: PHAC assembled...
Source: Canadian Journal of Public Health - April 29, 2024 Category: International Medicine & Public Health Authors: Erin McGill Anna Bellos Andrea Nwosu Adrian Zetner Andrea Tyler Natalie Knox Kristyn Franklin Kaitlin Patterson Source Type: research
An mRNA technology transfer programme and economic sustainability in health care
Bull World Health Organ. 2024 May 1;102(5):344-351. doi: 10.2471/BLT.24.291388. Epub 2024 Mar 27.ABSTRACTThe World Health Organization (WHO) set up the messenger ribonucleic acid (mRNA) technology transfer programme in June 2021 with a development hub in South Africa and 15 partner vaccine producers in middle-income countries. The goal was to support the sustainable development of and access to life-saving vaccines for people in these countries as a means to enhance epidemic preparedness and global public health. This initiative aims to build resilience and strengthen local vaccine research, and development and manufacturi...
Source: Bulletin of the World Health Organization - April 29, 2024 Category: International Medicine & Public Health Authors: Devika Dutt Mariana Mazzucato Els Torreele Source Type: research
