24. Divalent Vaccination to Protect Against the Cardiopulmonary and Antinociceptive Effects of Fentanyl, Oxycodone, and Their Mixture in Male Rats

The opioid overdose epidemic continues to worsen despite the availability of reversal agents. Although much work has been done developing vaccines targeting individual drugs, targeting multiple drugs may provide greater clinical utility given the prevalence of polydrug use. Thus, the current studies evaluated the cardiopulmonary and antinociceptive effects of fentanyl, oxycodone, and a fentanyl+oxycodone mixture in rats vaccinated with a novel divalent vaccine targeting both drugs.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research