Viruses, Vol. 16, Pages 653: Delving into the Aftermath of a Disease-Associated Near-Extinction Event: A Five-Year Study of a Serpentovirus (Nidovirus) in a Critically Endangered Turtle Population
ll
Lee Skerratt
Bellinger River virus (BRV) is a serpentovirus (nidovirus) that was likely responsible for the catastrophic mortality of the Australian freshwater turtle Myuchelys georgesi in February 2015. From November 2015 to November 2020, swabs were collected from turtles during repeated river surveys to estimate the prevalence of BRV RNA, identify risk factors associated with BRV infection, and refine sample collection. BRV RNA prevalence at first capture was significantly higher in M. georgesi (10.8%) than in a coexisting turtle, Emydura macquarii (1.0%). For M. georgesi, various risk factors were identified d...
Source: Viruses - April 22, 2024 Category: Virology Authors: Kate Parrish Peter Kirkland Paul Horwood Bruce Chessman Shane Ruming Gerry McGilvray Karrie Rose Jane Hall Lee Skerratt Tags: Article Source Type: research
Viruses, Vol. 16, Pages 649: Characterizing Infections in Two Epidemic Waves of SARS-CoV-2 Omicron Variants: A Cohort Study in Guangzhou, China
Conclusions: The rapid large-scale infections of the Omicron variants have quickly established herd immunity among the population in mainland China. In the future of the COVID-19 epidemic, a lower infection rate but a longer duration can be expected. Given the large population size and ongoing diversified herd immunity, it remains crucial to closely monitor the molecular epidemiology of SARS-CoV-2 for the emergence of new variants of concern in this region. Additionally, the timely evaluation of the immune status across different age groups is essential for informing future vaccination strategies and intervention policies. (Source: Viruses)
Source: Viruses - April 22, 2024 Category: Virology Authors: Lin Qu Chunyan Xie Ming Qiu Lina Yi Zhe Liu Lirong Zou Pei Hu Huimin Jiang Huimin Lian Mingda Yang Haiyi Yang Huiling Zeng Huimin Chen Jianguo Zhao Jianpeng Xiao Jianfeng He Ying Yang Liang Chen Baisheng Li Jiufeng Sun Jing Lu Tags: Article Source Type: research
Peripheral Nerve Stimulation in Postoperative Analgesia: A Narrative Review
AbstractPurpose of ReviewRecent research has shown the effectiveness of peripheral nerve stimulators (PNS) in managing chronic pain conditions. Ongoing studies aim to explore its potential application in treating acute postoperative pain states. The purpose of this systematic review is to assess the role of PNS in providing relief for postoperative pain.Recent FindingsClinical studies investigating the use of peripheral nerve stimulators (PNS) for analgesia following various surgeries, such as total knee arthroplasty, anterior cruciate ligament repair, ankle arthroplasty, rotator cuff repair, hallux valgus correction, and ...
Source: Current Pain and Headache Reports - April 20, 2024 Category: Neurology Source Type: research
Outcomes of Total Hip Arthroplasty Performed for HIV-Associated Osteonecrosis in China: A Retrospective Cohort Study
CONCLUSION: THA is safe and effective in Chinese AIDS patients with ONFH. However, optimal treatment has limited efficacy in AIDS patients undergoing THA for ONFH. The reconsideration and evaluation of the predictive value of CD4+ T lymphocytes for postoperative complications in joint replacement procedures is warranted.PMID:38638043 | DOI:10.2174/011570162X302889240408033958 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Kangpeng Li Rui Ma Rugang Zhao Qiang Zhang Source Type: research
Viruses, Vol. 16, Pages 636: U-CAN-seq: A Universal Competition Assay by Nanopore Sequencing
erris
Mark T. Heise
RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary fitness of novel viral variants relative to well-studied genotypes of epidemic viruses. Competition assays are an effective and rigorous system with which to assess the relative fitness of viral genotypes. However, it is challenging to quickly and cheaply distinguish and quantify fitness differences between very similar viral genotypes. Here, we describe a protocol for using reverse tr...
Source: Viruses - April 19, 2024 Category: Virology Authors: Jennifer Diaz John Sears Che-Kang Chang Jane Burdick Isabella Law Wes Sanders Colton Linnertz Paul Sylvester Nathaniel Moorman Martin T. Ferris Mark T. Heise Tags: Article Source Type: research
Tobacco price elasticity by socioeconomic characteristics in Ecuador
This article aims to estimate the price and income elasticity of cigarettes for different population groups in Ecuador. The National Survey of Urban and Rural Household I ncome and Expenditures (ENIGHUR) 2011–2012 was used, which has information on household cigarette consumption and its sociodemographic characteristics. Deaton’s Almost Ideal Demand System, which decouples the effect of quality on the price of the good, was applied. The elasticities were calculat ed for several groups: urban/rural, income levels (tertiles), education level, sex and age ranges of the household head, and frequency of cigarette purchases ...
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Ana Cristina Mena Source Type: research
Impact of an ICU bed capacity optimisation method on the average length of stay and average cost of hospitalisation following implementation of Chinas open policy with respect to COVID-19: a difference-in-differences analysis based on information management system data from a tertiary hospital in southwest China
Conclusions
This study corroborates a significant positive impact of ICU bed optimisation in mitigating the shortage of medical resources following an epidemic outbreak. The findings hold theoretical and practical implications for identifying effective emergency coordination strategies in managing hospital bed resources during sudden public health emergency events. These insights contribute to the advancement of resource management practices and the promotion of experiences in dealing with public health emergencies. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Zheng, Q., Zeng, Z., Tang, X., Ma, L. Tags: Open access, Health economics Source Type: research
Social, behavioral and environmental determinants of vector-borne diseases: A narrative review of evidence and implications for integrated control approaches
J Vector Borne Dis. 2024 Apr 18. doi: 10.4103/JVBD.JVBD_34_24. Online ahead of print.ABSTRACTVector-borne diseases exert immense health burdens worldwide. Malaria alone causes over 200 million cases and 600,000 deaths annually. Transmission involves complex drivers requiring examination beyond entomological factors. A systematic literature search across databases identified relevant studies on vector-borne disease determinants published in the last two decades, with priority given to rigorous designs like longitudinal analyses, reviews, and meta-analyses from diverse epidemic regions, allowing narrative synthesis of key de...
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ahmad Y Alqassim Source Type: research
Shifting spatial, temporal and demographic patterns of dengue incidence and associated meteorological factors in Jazan Region of Saudi Arabia from 2015-2020
CONCLUSION: Enhanced surveillance, outbreak forecasting, targeted control activities, and integrated prevention policies grounded in continuous evidence assessment can effectively address endemic dengue transmission in Jazan. This study provides key insights to optimize data-driven decision-making for dengue control in Saudi Arabia.PMID:38634364 | DOI:10.4103/JVBD.JVBD_15_24 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ahmad Y Alqassim Mohammed Badedi Mohammed A Muaddi Abdullah A Alharbi Mohammad A Jareebi Anwar M Makeen Maged El-Setouhy Osama B Albasheer Abdullah Sabai Ahmed Sahly Source Type: research
Heat-Related Emergency Department Visits - United States, May-September 2023
MMWR Morb Mortal Wkly Rep. 2024 Apr 18;73(15):324-329. doi: 10.15585/mmwr.mm7315a1.ABSTRACTUnprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced record-breaking high temperatures in 2023, with populations exposed to extremely high temperatures for prolonged periods. CDC examined emergency department (ED) visits associated with heat-related illness (HRI) from the National Syndromic Surveillance Program and compared daily HRI ED visi...
Source: MMWR Morb Mortal Wkl... - April 18, 2024 Category: Epidemiology Authors: Ambarish Vaidyanathan Abigail Gates Claudia Brown Emily Prezzato Aaron Bernstein Source Type: research
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
Bioorg Chem. 2024 Apr 16;147:107380. doi: 10.1016/j.bioorg.2024.107380. Online ahead of print.ABSTRACTThe COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (Mpro) stands as an essential enzyme in the maturation process of SARS-CoV-2, playing an irreplaceable role in regulating viral RNA replication and transcription. It has emerged as an ideal target for developing antiviral agents against SARS-CoV-2 due to ...
Source: Bioorganic Chemistry - April 18, 2024 Category: Chemistry Authors: Ya-Qi Xiao Jiao Long Shuang-Shuang Zhang Yuan-Yuan Zhu Shuang-Xi Gu Source Type: research
Une combinaison tr ès rare de thrombose veineuse et artérielle chez un patient atteint du COVID 19
Ann Cardiol Angeiol (Paris). 2024 Apr 17;73(3):101744. doi: 10.1016/j.ancard.2024.101744. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This epidemic has caused serious socio-economic problems worldwide, with a very high mortality rate. Several articles have been published in the literature showing the consequences of this disease on the human body. Among the most serious complications are venous and arterial thrombosis, which are rarely observed together in the same patient. In this article, we report an exceptional case of a patient with COVID-19 with the combination of i...
Source: Annales de Cardiologie et d'Angeiologie - April 18, 2024 Category: Cardiology Authors: Hicham El Malki Yassine Morjane Adam Belarbi Mohammed Taha Berkane El Mehdi Moutaouekkil Source Type: research
Sexually Transmitted Infections in the Emergency Department
As the United States faces a worsening epidemic of sexually transmitted infections (STIs), emergency departments (EDs) play a critical role in identifying and treating these infections. The growing health inequities in the distribution and disproportionate impact of STIs add to the urgency of providing high-quality sexual health care through the ED. Changes in population health are reflected in the new Centers for Disease Control recommendations on screening, diagnostic testing, and treatment of STIs. This review covers common, as well as and less common or emerging STIs, and discusses the state-of-the-art guidance on test...
Source: Emergency Medicine Clinics of North America - April 18, 2024 Category: Emergency Medicine Authors: Rachel E. Solnick, Laura Hernando L ópez, Patricia Mae Martinez, Jason E. Zucker Source Type: research
O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36
Nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH), constitute a burgeoning worldwide epidemic with no FDA-approved pharmacotherapies. The multifunctional immunometabolic receptor, fatty acid translocase CD36 (CD36), plays an important role in the progression of hepatic steatosis. O-GlcNAcylation is a crucial posttranslational modification that mediates the distribution and function of CD36, but its involvement in NAFLD remains poorly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 18, 2024 Category: Biomedical Science Authors: Hanlong Zhu, Tianming Zhao, Si Zhao, Suzhen Yang, Kang Jiang, Shupei Li, Ying Kang, Zhuoxin Yang, Jiajia Shen, Si Shen, Hui Tao, Ji Xuan, Miaofang Yang, Bing Xu, Fangyu Wang, Mingzuo Jiang Source Type: research
Association of same-sex criminalisation laws and national HIV policies with HIV testing in African MSM: an ecological single-level and multilevel cross-sectional study of sub-Saharan African countries
Conclusions
This study suggests elimination of discriminatory laws and policies might be important for increasing HIV status awareness of MSM, an important first step in epidemic control. Additionally, we highlight heterogeneity between South Africa and other SSA countries, which has implications for studying SSA countries as a homogeneous group. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Kalu, N., Ross, M. W., Taegtmeyer, M., Lamontagne, E., Howell, S., Neuman, M. Tags: Open access Original research Source Type: research
