Addressing the Youth Mental Health Epidemic
(Source: Academic Psychiatry)
Source: Academic Psychiatry - April 17, 2024 Category: Psychiatry Source Type: research
MODELS: a six-step framework for developing an infectious disease model
AbstractSince the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.Graphical Abstract (Source: Infectiou...
Source: Infectious Diseases of Poverty - April 17, 2024 Category: Infectious Diseases Source Type: research
Seizures in febrile children with SARS-CoV-2 infection: clinical features, short-term follow-up
This study ... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 17, 2024 Category: Pediatrics Authors: Jipeng Jiang, Zhengsong Shen and Jie Cao Tags: Research Source Type: research
Quantifying the impact of hospital catchment area definitions on hospital admissions forecasts: COVID-19 in England, September 2020 –April 2021
Defining healthcare facility catchment areas is a key step in predicting future healthcare demand in epidemic settings. Forecasts of hospitalisations can be informed by leading indicators measured at the commu... (Source: BMC Medicine)
Source: BMC Medicine - April 17, 2024 Category: Internal Medicine Authors: Sophie Meakin and Sebastian Funk Tags: Research article Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
Opioid use disorder in pediatric populations: considerations for perioperative pain management and precision opioid analgesia
Expert Rev Clin Pharmacol. 2024 Apr 16. doi: 10.1080/17512433.2024.2343915. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder.AREAS COVERED: Enhanced recovery after surgery (ERAS) protocols, are often inadequate in treating a child's severe surgical pain. Research suggests that 'older' and longer-acting opioids such as methad...
Source: Pharmacological Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Yun Han Chen Anastasios Xenitidis Paul Hoffman Leslie Matthews Swathi G Padmanabhan Lakshmi Aravindan Ruth Ressler Inesh Sivam Sahana Sivam Chase F Gillispie Senthilkumar Sadhasivam Source Type: research
Opioid use disorder in pediatric populations: considerations for perioperative pain management and precision opioid analgesia
Expert Rev Clin Pharmacol. 2024 Apr 16. doi: 10.1080/17512433.2024.2343915. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder.AREAS COVERED: Enhanced recovery after surgery (ERAS) protocols, are often inadequate in treating a child's severe surgical pain. Research suggests that 'older' and longer-acting opioids such as methad...
Source: Expert Review of Clinical Pharmacology - April 16, 2024 Category: Drugs & Pharmacology Authors: Yun Han Chen Anastasios Xenitidis Paul Hoffman Leslie Matthews Swathi G Padmanabhan Lakshmi Aravindan Ruth Ressler Inesh Sivam Sahana Sivam Chase F Gillispie Senthilkumar Sadhasivam Source Type: research
Indirect interaction between an endemic and an invading pathogen: A case study of Plasmodium and Usutu virus dynamics in a shared bird host population
Theor Popul Biol. 2024 Apr 14:S0040-5809(24)00035-2. doi: 10.1016/j.tpb.2024.04.002. Online ahead of print.ABSTRACTInfectious disease agents can influence each other's dynamics in shared host populations. We consider such influence for two mosquito-borne infections where one pathogen is endemic at the time that a second pathogen invades. We regard a setting where the vector has a bias towards biting host individuals infected with the endemic pathogen and where there is a cost to co-infected hosts. As a motivating case study, we regard Plasmodium spp., that cause avian malaria, as the endemic pathogen, and Usutu virus (USUV...
Source: Theoretical Population Biology - April 16, 2024 Category: Biology Authors: Afonso Dimas Martins Mick Roberts Quirine Ten Bosch Hans Heesterbeek Source Type: research
Quantification of the burden of chronic kidney disease in Latin America: an invisible epidemicQuantifica ção da carga da doença renal crônica na América Latina: uma epidemia invisível
CONCLUSIONS: Chronic kidney disease is an invisible epidemic that places an excessive burden in terms of mortality and DALYs on Latin American countries. It is essential to join forces to tackle the disease in the region, and promote local actions that address the particularities of each country.PMID:38623527 | PMC:PMC11018258 | DOI:10.26633/RPSP.2024.41 (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 16, 2024 Category: International Medicine & Public Health Authors: Fernando Ulises Rosas-Valdez Andrea Fernanda Aguirre-V ázquez Marcela Agudelo-Botero Source Type: research
Synthesis of Rupestonic Acid L-Ephedrine Derivatives with Preliminary In vitro Anti-influenza Viral Activity
CONCLUSION: The rupestonic acid L-ephedrine ester (A) and rupestonic acid L-ephedrine complex (B) were synthesized and characterized using 1H NMR and 13C NMR. Moreover, their purity was determined by HPLC. Both compounds A and B exhibited more potent activities against the strains of A/PR/8/34 (H1N1) and A/FM/1/47 (H1N1) than rupestonic acid. Compound A can be regarded as a very promising lead compound for the development of anti-influenza inhibitors. Based on these results, more rupestonic acid derivatives will be designed and synthesized in the future for the development of anti-influenza inhibitors.PMID:38623973 | DOI:1...
Source: Current Pharmaceutical Design - April 16, 2024 Category: Drugs & Pharmacology Authors: Jianping Yong Canzhong Lu Source Type: research
Opioid use disorder in pediatric populations: considerations for perioperative pain management and precision opioid analgesia
Expert Rev Clin Pharmacol. 2024 Apr 16. doi: 10.1080/17512433.2024.2343915. Online ahead of print.ABSTRACTINTRODUCTION: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder.AREAS COVERED: Enhanced recovery after surgery (ERAS) protocols, are often inadequate in treating a child's severe surgical pain. Research suggests that 'older' and longer-acting opioids such as methad...
Source: Pharmacological Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Yun Han Chen Anastasios Xenitidis Paul Hoffman Leslie Matthews Swathi G Padmanabhan Lakshmi Aravindan Ruth Ressler Inesh Sivam Sahana Sivam Chase F Gillispie Senthilkumar Sadhasivam Source Type: research
Indirect interaction between an endemic and an invading pathogen: A case study of Plasmodium and Usutu virus dynamics in a shared bird host population
Theor Popul Biol. 2024 Apr 14:S0040-5809(24)00035-2. doi: 10.1016/j.tpb.2024.04.002. Online ahead of print.ABSTRACTInfectious disease agents can influence each other's dynamics in shared host populations. We consider such influence for two mosquito-borne infections where one pathogen is endemic at the time that a second pathogen invades. We regard a setting where the vector has a bias towards biting host individuals infected with the endemic pathogen and where there is a cost to co-infected hosts. As a motivating case study, we regard Plasmodium spp., that cause avian malaria, as the endemic pathogen, and Usutu virus (USUV...
Source: Theoretical Population Biology - April 16, 2024 Category: Biology Authors: Afonso Dimas Martins Mick Roberts Quirine Ten Bosch Hans Heesterbeek Source Type: research
Quantification of the burden of chronic kidney disease in Latin America: an invisible epidemicQuantifica ção da carga da doença renal crônica na América Latina: uma epidemia invisível
CONCLUSIONS: Chronic kidney disease is an invisible epidemic that places an excessive burden in terms of mortality and DALYs on Latin American countries. It is essential to join forces to tackle the disease in the region, and promote local actions that address the particularities of each country.PMID:38623527 | PMC:PMC11018258 | DOI:10.26633/RPSP.2024.41 (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 16, 2024 Category: International Medicine & Public Health Authors: Fernando Ulises Rosas-Valdez Andrea Fernanda Aguirre-V ázquez Marcela Agudelo-Botero Source Type: research
Indirect interaction between an endemic and an invading pathogen: A case study of Plasmodium and Usutu virus dynamics in a shared bird host population
Theor Popul Biol. 2024 Apr 16;157:118-128. doi: 10.1016/j.tpb.2024.04.002. Online ahead of print.ABSTRACTInfectious disease agents can influence each other's dynamics in shared host populations. We consider such influence for two mosquito-borne infections where one pathogen is endemic at the time that a second pathogen invades. We regard a setting where the vector has a bias towards biting host individuals infected with the endemic pathogen and where there is a cost to co-infected hosts. As a motivating case study, we regard Plasmodium spp., that cause avian malaria, as the endemic pathogen, and Usutu virus (USUV) as the i...
Source: Theoretical Population Biology - April 16, 2024 Category: Biology Authors: Afonso Dimas Martins Mick Roberts Quirine Ten Bosch Hans Heesterbeek Source Type: research
Quantification of the burden of chronic kidney disease in Latin America: an invisible epidemicQuantifica ção da carga da doença renal crônica na América Latina: uma epidemia invisível
CONCLUSIONS: Chronic kidney disease is an invisible epidemic that places an excessive burden in terms of mortality and DALYs on Latin American countries. It is essential to join forces to tackle the disease in the region, and promote local actions that address the particularities of each country.PMID:38623527 | PMC:PMC11018258 | DOI:10.26633/RPSP.2024.41 (Source: Pan American Journal of Public Health)
Source: Pan American Journal of Public Health - April 16, 2024 Category: International Medicine & Public Health Authors: Fernando Ulises Rosas-Valdez Andrea Fernanda Aguirre-V ázquez Marcela Agudelo-Botero Source Type: research
