Soluble IL-2R α correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis
AbstractBackgroundPrevious studies showed that soluble IL-2R α is an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis. However, data regarding adult patients with brucellosis were unknown. The aim of study was to explore the potential role of serum sIL-2Rα evaluating treatment responses in adult patients with brucellosis, and T cell immune status was also examined.MethodsDuring January 2016 –April 2017, 30 patients with acute brucellosis from the Third People’s Hospital of Linfen in Shanxi Province and Beijing Di Tan Hospital, a...
Source: Infectious Diseases of Poverty - July 13, 2020 Category: Infectious Diseases Source Type: research

Personalizing symptom monitoring and contact tracing efforts through a COVID-19 web-app
ConclusionsA COVID-19 Symptom Monitoring and Contact Tracking web-app has been developed to facilitate contact tracing efforts through public engagement. This app serves an additional purpose of providing information about COVID-19 from reliable resources. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 13, 2020 Category: Infectious Diseases Source Type: research

Universities as catalysts of social innovation in health systems in low-and middle-income countries: a multi-country case study
ConclusionsThis case study shows the opportunity that reside within LMIC universities to act as eco-system enablers of SI in healthcare delivery in order to fill the evidence gap on SI and enhance cross-sectoral participation in support of achieving UHC. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 11, 2020 Category: Infectious Diseases Source Type: research

High multiple mutations of Plasmodium falciparum -resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria
ConclusionsThere was increased prevalence indhfr triple haplotype mutations when compared with previous reports in the same environment but aligned with high prevalence in other locations in Nigeria and other countries in Africa. Also, high prevalence ofdhfr anddhps mutant alleles occurred in the study areas in Lagos, Nigeria five to eight years after the introduction of artemisinin combination therapy underscores the need for continuous monitoring. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 11, 2020 Category: Infectious Diseases Source Type: research

How Shenzhen, China avoided widespread community transmission: a potential model for successful prevention and control of COVID-19
AbstractShenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia. The city has extensive ties to Hubei Province, the first reported  epicenter of the coronavirus disease 2019 (COVID-19) outbreak in the world. Initial predictions suggested Shenzhen would experience a high number of COVID-19 cases. These predictions have not materialized. As of 31 March 2020 Shenzhen had only 451 confirmed cases of COVID-19. Contact tracing has shown that no cases were the result of community transmission within the city. While Shenzhen did not implement a citywide lockdo...
Source: Infectious Diseases of Poverty - July 10, 2020 Category: Infectious Diseases Source Type: research

Transmissibility of COVID-19 in 11 major cities in China and its association with temperature and humidity in Beijing, Shanghai, Guangzhou, and Chengdu
ConclusionsThe transmissibility of COVID-19 was strong and importance should be attached to the intervention of its transmission especially in Wuhan. According to the correlation betweenR0 and weather, the spread of disease will be suppressed as the weather warms. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 10, 2020 Category: Infectious Diseases Source Type: research

Strategies supporting the prevention and control of neglected tropical diseases during and beyond the COVID-19 pandemic
AbstractEmerging and re-emerging zoonotic diseases represent a public health challenge of international concern. They include a large group of neglected tropical diseases (NTDs), many of which are of zoonotic nature. Coronavirus disease 2019 (COVID-19), another emerging zoonotic disease, has just increased the stakes exponentially. Most NTDs are subject to the impact of some of the very same human-related activities triggering other emerging and re-emerging diseases, including COVID-19, severe acute respiratory syndrome (SARS), bird flu and swine flu. It is conceivable that COVID-19 will exacerbate the NTDs, as it will div...
Source: Infectious Diseases of Poverty - July 10, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics of different subtypes and risk factors for the severity of illness in patients with COVID-19 in Zhejiang, China
AbstractBackgroundThe outbreak of coronavirus disease 2019 (COVID-19) is now becoming an enormous threat to public health. The clinical spectrum of COVID-19 is extensive, of which critical cases are with rapid disease progression and high mortality. The aim of our study is to summarize the characteristics of different subtypes and explore risk factors of illness severity for early identification and prompt treatment.MethodsIn this retrospective study, we collected data of patients confirmed COVID-19 in Zhejiang Province from 17 January to 12 February 2020. According to the definition of clinical classification, we divided ...
Source: Infectious Diseases of Poverty - July 8, 2020 Category: Infectious Diseases Source Type: research

Evaluating the implementation of rapid diagnostic tests in a malaria elimination setting
ConclusionsThe comprehensive package of RDT implementation in this study is promising in scaling up RDT use and improving access to care among malaria patients, especially in malaria elimination settings. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 8, 2020 Category: Infectious Diseases Source Type: research

Transmission patterns of COVID-19 in the mainland of China and the efficacy of different control strategies: a data- and model-driven study
ConclusionsThe quarantine measures adopted by the Chinese government since January 23, 2020 were necessary and effective. Postponing the relaxation of isolation, early diagnosis, patient isolation, broad close-contact tracing, and strict monitoring of infected persons could effectively control the COVID-19 epidemic. April 1, 2020 would be a reasonable date to lift quarantine in Hubei and Wuhan. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 6, 2020 Category: Infectious Diseases Source Type: research

Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China
ConclusionsThe severity of COVID-19 might be influenced by immune system state and underlying diseases in cancer patients. And the treatment of SARS-CoV-2 infection in cancer patients is challenged by the immunosuppressive state of these patients under chemotherapy or surgery. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 2, 2020 Category: Infectious Diseases Source Type: research

Health-education to prevent COVID-19 in schoolchildren: a call to action
ConclusionAn entertainment education intervention for schoolchildren systematically implemented in schools would be highly effective and fill this need. With such measures in place there would be greater confidence around the opening of schools. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 1, 2020 Category: Infectious Diseases Source Type: research

Epidemiologically characteristics of human brucellosis and antimicrobial susceptibility pattern of Brucella melitensis in Hinggan League of the Inner Mongolia Autonomous Region, China
In this study, the epidemiological characteristics of human brucellosis were analyzed, and the genotypic profile and antimicrobial susceptibilities ofBrucella melitensis strains isolated from humans in Hinggan League were investigated.MethodsThe epidemic characteristics were described using case number, constituent ratio, and rate. The 418 human blood samples were collected and tested by bacteriology, and suspect colonies were isolated and identified by conventional biotyping assays, the VITEK 2.0 microbial identification system, and AMOS (Brucella abortus,B. melitensis,B. ovis, andB. suis)-PCR. Subsequently, all strains w...
Source: Infectious Diseases of Poverty - June 29, 2020 Category: Infectious Diseases Source Type: research

Association between obesity and clinical prognosis in patients infected with SARS-CoV-2
In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2.MethodsThis is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People ’s Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2)  ≤ 300 mmHg. We ...
Source: Infectious Diseases of Poverty - June 29, 2020 Category: Infectious Diseases Source Type: research

Treatment of coronavirus disease 2019 in Shandong, China: a cost and affordability analysis
ConclusionsOur data demonstrate that clinical management of COVID-19 patients incurs a great financial burden to national health insurance. The cost for drug acquisition is the major contributor to the medical cost, whereas the risk factors for higher cost are pre-existing diseases and severity of COVID-19. Improvement of insurance coverage will need to address the barriers of rural patients to avoid the occurrence of catastrophic health expenditure. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 29, 2020 Category: Infectious Diseases Source Type: research

A close look at the biology of SARS-CoV-2, and the potential influence of weather conditions and seasons on COVID-19 case spread
ConclusionThis report highlights the potential influence of weather conditions, seasons and non-climatological factors on the geographical spread of cases of COVID-19 across the globe. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 26, 2020 Category: Infectious Diseases Source Type: research

COVID-19 seeding time and doubling time model: an early epidemic risk assessment tool
ConclusionsOur main finding is that the ST/DT Model can be used to produce meaningful assessments of the risk of escalation in country/territory-level COVID-19 epidemics using only case reporting data. Our model can help support timely, decisive action at the national level as leaders and other decision makers face of the serious public health threat that is COVID-19. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 23, 2020 Category: Infectious Diseases Source Type: research

Spatial distribution of people diagnosed with tuberculosis through routine and active case finding: a community-based study in Kampala, Uganda
AbstractBackgroundRoutine tuberculosis (TB) notifications are geographically heterogeneous, but their utility in predicting the location of undiagnosed TB cases is unclear. We aimed to identify small-scale geographic areas with high TB notification rates based on routinely collected data and to evaluate whether these areas have a correspondingly high rate of undiagnosed prevalent TB.MethodsWe used routinely collected data to identify geographic areas with high TB notification rates and evaluated the extent to which these areas correlated with the location of undiagnosed cases during a subsequent community-wide active case ...
Source: Infectious Diseases of Poverty - June 22, 2020 Category: Infectious Diseases Source Type: research

Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART: a long-term observation in treatment-na ïve patients
AbstractBackgroundIt is not completely clear whether a very high pre-therapy viral load ( ≥ 500 000 copies/ml) can impair the virological response. The aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of regimen.MethodsA retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009, and from May 2013 to December 2015. Untreated HIV infected adults between 18 and 65  years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based regimen. A...
Source: Infectious Diseases of Poverty - June 22, 2020 Category: Infectious Diseases Source Type: research

Evaluation of serum-based real-time PCR to detect Schistosoma mansoni infection before and after treatment
ConclusionsThe data presented here show that the serum-based real-time PCR exhibits excellent diagnostic accuracy, in contrast to the use of urine as sample material forS. mansoni DNA detection. However, as circulating DNA does not necessarily reflect the persistence of living worms in schistosomiasis, this method is less well suited to verify the success of treatment with praziquantel. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 22, 2020 Category: Infectious Diseases Source Type: research

Asymptomatic and Pre-Symptomatic COVID-19 in China
(Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 22, 2020 Category: Infectious Diseases Source Type: research

Critical medical ecology and SARS-COV-2 in the urban environment: a pragmatic, dynamic approach to explaining and planning for research and practice
ConclusionsIn the end, SARS-CoV-2 is acting upon dynamic social human beings, entangled within structures and relationships that include but extend far beyond their cells, and in fact beyond their own individual behavior. As a comprehensive way of thinking, the Critical Medical Ecology model helps identify these elements and dynamics in the context of ecological processes that create, shape, and sustain people in their multidimensional, intersecting environments. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 19, 2020 Category: Infectious Diseases Source Type: research

A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management
ConclusionsThis report suggested that, in the early phase of COVID-19 pneumonia, routine screening could miss patients who were virus carriers. Highlighting travel history is of paramount importance for the early detection and isolation of severe acute respiratory syndrome coronavirus 2 cases. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 19, 2020 Category: Infectious Diseases Source Type: research

Estimating the daily trend in the size of the COVID-19 infected population in Wuhan
ConclusionsIn the early stage of COVID-19 outbreak, the testing capacity of Wuhan was insufficient. Clinical diagnosis could be a good complement to the method of confirmation at that time. The reporting rate is very close to 100% now and there are very few cases since 17 March 2020, which might suggest that Wuhan is able to accommodate all patients and the epidemic has been controlled. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 18, 2020 Category: Infectious Diseases Source Type: research

Mozambique ’s response to cyclone Idai: how collaboration and surveillance with water, sanitation and hygiene (WASH) interventions were used to control a cholera epidemic
We describe emergency measures taken by the Government of Mozambique, in collaboration with multilateral partners, to establish a real-time disease surveillance system, implement interventions recommended by a Water, Sanitation and Hygiene (WASH) taskforce and rapidly scale up a massive community vaccination program to control a cholera epidemic. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 16, 2020 Category: Infectious Diseases Source Type: research

Evaluation of morbidity in Schistosoma mansoni -positive primary and secondary school children after four years of mass drug administration of praziquantel in western Kenya
ConclusionsWe did not detect differences in morbidity markers measured in a population of those infected or re-infected after multiple MDA. This could have been due to their relative insensitivity or a failure of MDA to prevent morbidity among those who remain infected. High malaria transmission in this area and/or a lack of suitable methods to measure the more subtle functional morbidities caused by schistosomiasis could be a factor. Further research is needed to identify and develop well-defined, easily quantifiableS. mansoni morbidity markers for this age group. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 15, 2020 Category: Infectious Diseases Source Type: research

Misdiagnosis of a multi-organ involvement hematogenous disseminated tuberculosis as metastasis: a case report and literature review
ConclusionsIn the past, most TB misdiagnosis cases involved in single organ and were finally confirmed through invasive examination. This case enriched clinical experiences in the diagnosis of atypical HDTB. We encouraged clinicians to establish a dynamic thinking for diagnosis and treatment and emphasized the value of biopsy and18F-FDG-PET in distinguishing TB and cancer. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 9, 2020 Category: Infectious Diseases Source Type: research

Rising challenge of multidrug-resistant tuberculosis in China: a predictive study using Markov modeling
ConclusionsMDR-TB, especially untreated MDR-TB, would rise rapidly under China ’s current MDR-TB control strategies. Interventions designed to promote effective detection and treatment of MDR-TB are imperative in the fights against MDR-TB epidemics. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 8, 2020 Category: Infectious Diseases Source Type: research

Effect of household water treatment with chlorine on diarrhea among children under the age of five years in rural areas of Dire Dawa, eastern Ethiopia: a cluster randomized controlled trial
ConclusionsIn rural areas where diarrhea is the second leading cause of morbidity, water chlorination at the household level using liquid bleach considerably reduced episodes of diarrhea among children under the age of 5 years. Therefore, chlorinating drinking water at the household level may be a valuable interim solution for reducing the incidence of diarrheal diseases until potable water is made accessible to the majority of the population in Dire Dawa Administration and other Ethiopian communities.Trial registrationPACTR,PACTR201807815961394. Registered 16 July 2018, www.pactr.org (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 8, 2020 Category: Infectious Diseases Source Type: research

Surveillance-based evidence: elimination of schistosomiasis as a public health problem in the Peoples ’ Republic of China
AbstractBackgroundA steady progress on schistosomiasis control in the Peoples ’ Republic of China (P.R. China) was achieved and broadened into the twelve-year medium and long term national plan (MLNP) which marled the implementation of an integrated control strategy across all endemic areas in P.R. China in 2004. To understand the endemic trends of schistosomiasis to assess the effectiveness of an integrated strategy, we conducted an analysis of schistosomiasis surveillance data spanned from 2005 to 2015.MethodsThe schistosomiasis sentinel surveillance data from sentinel sites were collected and analyzed from 2005 to...
Source: Infectious Diseases of Poverty - June 6, 2020 Category: Infectious Diseases Source Type: research

Impact of a community-based intervention on Aedes aegypti and its spatial distribution in Ouagadougou, Burkina Faso
ConclusionsThe contribution of spatial methods for assessing community-based intervention are relevant for monitoring at local levels as a complement to epidemiological analyses conducted within neighbourhoods. They are useful, therefore, not only for assessment but also for establishing interventions.  This study shows that spatial analyses also have their place in population health intervention research. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 5, 2020 Category: Infectious Diseases Source Type: research

Factors associated with mobile phone ownership and potential use for rabies vaccination campaigns in southern Malawi
ConclusionsThe study showed a majority of those surveyed have the use of a mobile phone and most mobile phone owners indicated they would like to receive SMS messages about future rabies vaccination campaigns. This study provides insight into the feasibility of distributing information about rabies vaccination campaigns using mobile phones in Malawi. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 5, 2020 Category: Infectious Diseases Source Type: research

Human rabies in China: evidence-based suggestions for improved case detection and data gathering
ConclusionsSerum or blood samples collected in the last 3 days of a patient ’s life can be used to measure viral RNA, which means that serum samples, as well as saliva and CSF, can be used to detect viral RNA for anti-mortem diagnosis of rabies. Because of our findings, we have modified our “National Surveillance Project for Human Rabies”, by adding the collection and testing of serum samples from the end of the survival period. This will improve our national surveillance and laboratory diagnosis of human rabies. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 1, 2020 Category: Infectious Diseases Source Type: research

Local adaptive evolution of two distinct clades of Beijing and T families of Mycobacterium tuberculosis in Chongqing: a Bayesian population structure and phylogenetic study
ConclusionsBSP2 and TSL6 clades might originate from BSP4 and TSL5, respectively, by their local adaptive evolution in Chongqing. Our study suggests MIRU-VNTR be combined with other robust markers for a more comprehensive genotyping approach, especially for families of clades with the same MIRU-VNTR pattern. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - June 1, 2020 Category: Infectious Diseases Source Type: research

Psychological status and behavior changes of the public during the COVID-19 epidemic in China
ConclusionsWe need to pay more attention to public psychological stress, especially among young people, as they are likely to experience anxiety, depression, and psychological abnormalities. Different psychological interventions could be formulated according to the psychological characteristics of different gender and age groups. The majority of respondents followed specific behaviors required by the authorities, but it will take time to observe the effects of these behaviors on the epidemic. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 29, 2020 Category: Infectious Diseases Source Type: research

Multidrug-resistant tuberculosis transmission among middle school students in Zhejiang Province, China
ConclusionsDiscovery delay for an index patient played a primary role in MDR-TB transmission inside the school. To immediately detect TB, morning examinations in schools should be performed. TB trackers and case managers should work closely with public health workers and physicians in cases of TB outbreaks or transmissions involving students. Moreover, individuals who are in close contact with MDR-TB patients should undergo careful clinical follow-up for at least two  years. Implementing a joint examination strategy to ensure early detection, diagnosis, and treatment of MDR-TB transmission is recommended. (Source: Inf...
Source: Infectious Diseases of Poverty - May 27, 2020 Category: Infectious Diseases Source Type: research

Tuberculosis infection prevention and control: why we need a whole systems approach
We present an on-going project entitledUmoya omuhle ( “good air”), conducted in two provinces of South Africa, that adopts an interdisciplinary, ‘whole systems’ approach to problem analysis and intervention development for reducing nosocomial transmission ofMycobacterium tuberculosis (Mtb) through improved IPC. We suggest that TB IPC represents a complex intervention that is delivered within a dynamic context shaped by policy guidelines, health facility space, infrastructure, organisation of care, and management culture. Methods drawn from epidemiology, anthropology, and health policy and systems re...
Source: Infectious Diseases of Poverty - May 25, 2020 Category: Infectious Diseases Source Type: research

Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China, 2017
ConclusionsOverall, the PDR prevalence was moderate, with a particularly high prevalence in areas with severe HIV epidemics. These results indicate the importance of continuous PDR monitoring in patients initiating antiretroviral therapy. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 24, 2020 Category: Infectious Diseases Source Type: research

Disability progression among leprosy patients released from treatment: a survival analysis
ConclusionsPeople released from treatment as cured of leprosy are susceptible to worsening of the PD, especially those who have had complications during multi-drug therapy treatment. This indicates that leprosy patients should be periodically monitored, even after the successful completion of multidrug therapy. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 24, 2020 Category: Infectious Diseases Source Type: research

Brucellosis in China: history, progress and challenge
AbstractBrucellosis is a neglected zoonosis. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. Over the past two decades, improvements have been made to better understand the various aspects of human and animal brucellosis. Meanwhile, especially in the developing world, immense challenges that remain in controlling and eradicating brucellosis are novel diagnostics tools and efficacious vaccines. Here, we will focus on the remarkable issues on epidemiological survey, as well as the priority and challenge of brucellosis in...
Source: Infectious Diseases of Poverty - May 24, 2020 Category: Infectious Diseases Source Type: research

The China tuberculosis clinical trials consortium network: a model for international TB clinical trials capacity building
ConclusionsThe CTCTC, with mature management structure and sustainable development model, which are distilled five key lessons for other developing countries or investigators of interest. They are the respectively using assessment-based approach to design tailored training package, understanding the availability of clinical researchers, providing solutions to maintain sustainability, understanding local regulatory environments and working with an international organization with local on-site team, respectively. Although, the experiences and capacity of China ’s TB hospitals in conducting clinical research vary. Consi...
Source: Infectious Diseases of Poverty - May 15, 2020 Category: Infectious Diseases Source Type: research

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil
ConclusionTogether, this study provided evidences that serum biomarkers increase along the age continuum and may have potential implications for establishing clinical management protocols and therapeutic intervention in Chagas disease patients. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 11, 2020 Category: Infectious Diseases Source Type: research

IL-6 and INF- γ levels in patients with brucellosis in severe epidemic region, Xinjiang, China
AbstractBackgroundThe incidence of brucellosis, which is caused by theBrucella species of bacteria, is rapidly rising worldwide; however, few studies have investigated the immune response to this pathogen and clinical biochemical features. In this paper, we examined the levels of various cytokines and inflammatory factors as well as clinical course characteristics in patients with brucellosis, in order to provide evidence for the diagnosis, assessment, and prognosis of this infectious disease.MethodsA total of 191 brucellosis inpatients (50 acute cases and 141 chronic cases), as well as 60 healthy control subjects, were in...
Source: Infectious Diseases of Poverty - May 7, 2020 Category: Infectious Diseases Source Type: research

Estimated need for anthelminthic medicines to control soil-transmitted helminthiases in school-aged children, 2020 –2030
ConclusionsThe number of anthelmintic medicines needed to achieve elimination of morbidity due to STH in school-aged children will decline during 2020 –2030. The decline will be substantial if a number of “upper-middle income” countries in which STH are endemic procure, as expected, anthelminthic medicines independently. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 7, 2020 Category: Infectious Diseases Source Type: research

Determinants of delayed diagnosis and treatment of tuberculosis in Cambodia: a mixed-methods study
ConclusionsTB diagnostic delay was substantial. Increasing public awareness about TB and consciousness regarding stigma, engaging the private healthcare providers, and tailoring approaches targeting the rural areas could further improve early detection of TB and narrowing the gap of missing cases in Cambodia. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 7, 2020 Category: Infectious Diseases Source Type: research

Improvement cues of lesion absorption using the adjuvant therapy of traditional Chinese medicine Qinbudan tablet for retreatment pulmonary tuberculosis with standard anti-tuberculosis regimen
ConclusionsNo significant improvement in culture conversion was observed for retreatment PTB with traditional Chinese medicine plus standard anti-TB regimen. However, QBDT as an adjunct therapy significantly promoted lesion absorption, thereby reducing lung injury due toMycobacterium tuberculosis infection.Trial registrationThis trial is registered at ClinicalTrials.gov,NCT02313610. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - May 7, 2020 Category: Infectious Diseases Source Type: research

Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population
ConclusionsThis study indicated thatMBL2 polymorphisms, haplotypes, and diplotypes were associated with TB susceptibility in the Han Chinese population. Additionally, larger sample size studies are needed to further confirm these findings in the future. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 29, 2020 Category: Infectious Diseases Source Type: research

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues
ConclusionsOur data indicate that SARS-CoV-2 may infect other tissues aside from the lungs and infect persons with different sexes, ages, and races equally. The different host immune responses to SARS-CoV-2 infection may partially explain why males and females, young and old persons infected with this virus have markedly distinct disease severity. This study provides new insights into the role of ACE2 in the SARS-CoV-2 pandemic. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 28, 2020 Category: Infectious Diseases Source Type: research

Preparedness for Chagas disease spreading worldwide
AbstractChagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns. However, current treatment and vector control are highly challenged by drug and insecticide resistance. Chemotherapy and vector control have been proved to be effective attempts to minimize the disease burden. Continued efforts are necessary to keep adapting the surveillance-response systems to the dynamic health systems. More attention and investments are needed to improve appropriate strategy and technology in different settings. This may be accomplished by creating effective risk...
Source: Infectious Diseases of Poverty - April 27, 2020 Category: Infectious Diseases Source Type: research

Protecting the gains of malaria elimination in China
(Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - April 24, 2020 Category: Infectious Diseases Source Type: research