Impact of an ICU bed capacity optimisation method on the average length of stay and average cost of hospitalisation following implementation of Chinas open policy with respect to COVID-19: a difference-in-differences analysis based on information management system data from a tertiary hospital in southwest China
Conclusions
This study corroborates a significant positive impact of ICU bed optimisation in mitigating the shortage of medical resources following an epidemic outbreak. The findings hold theoretical and practical implications for identifying effective emergency coordination strategies in managing hospital bed resources during sudden public health emergency events. These insights contribute to the advancement of resource management practices and the promotion of experiences in dealing with public health emergencies. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Zheng, Q., Zeng, Z., Tang, X., Ma, L. Tags: Open access, Health economics Source Type: research
Social, behavioral and environmental determinants of vector-borne diseases: A narrative review of evidence and implications for integrated control approaches
J Vector Borne Dis. 2024 Apr 18. doi: 10.4103/JVBD.JVBD_34_24. Online ahead of print.ABSTRACTVector-borne diseases exert immense health burdens worldwide. Malaria alone causes over 200 million cases and 600,000 deaths annually. Transmission involves complex drivers requiring examination beyond entomological factors. A systematic literature search across databases identified relevant studies on vector-borne disease determinants published in the last two decades, with priority given to rigorous designs like longitudinal analyses, reviews, and meta-analyses from diverse epidemic regions, allowing narrative synthesis of key de...
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ahmad Y Alqassim Source Type: research
Heat-Related Emergency Department Visits - United States, May-September 2023
MMWR Morb Mortal Wkly Rep. 2024 Apr 18;73(15):324-329. doi: 10.15585/mmwr.mm7315a1.ABSTRACTUnprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced record-breaking high temperatures in 2023, with populations exposed to extremely high temperatures for prolonged periods. CDC examined emergency department (ED) visits associated with heat-related illness (HRI) from the National Syndromic Surveillance Program and compared daily HRI ED visi...
Source: MMWR Morb Mortal Wkl... - April 18, 2024 Category: Epidemiology Authors: Ambarish Vaidyanathan Abigail Gates Claudia Brown Emily Prezzato Aaron Bernstein Source Type: research
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
Bioorg Chem. 2024 Apr 16;147:107380. doi: 10.1016/j.bioorg.2024.107380. Online ahead of print.ABSTRACTThe COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (Mpro) stands as an essential enzyme in the maturation process of SARS-CoV-2, playing an irreplaceable role in regulating viral RNA replication and transcription. It has emerged as an ideal target for developing antiviral agents against SARS-CoV-2 due to ...
Source: Bioorganic Chemistry - April 18, 2024 Category: Chemistry Authors: Ya-Qi Xiao Jiao Long Shuang-Shuang Zhang Yuan-Yuan Zhu Shuang-Xi Gu Source Type: research
Une combinaison tr ès rare de thrombose veineuse et artérielle chez un patient atteint du COVID 19
Ann Cardiol Angeiol (Paris). 2024 Apr 17;73(3):101744. doi: 10.1016/j.ancard.2024.101744. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This epidemic has caused serious socio-economic problems worldwide, with a very high mortality rate. Several articles have been published in the literature showing the consequences of this disease on the human body. Among the most serious complications are venous and arterial thrombosis, which are rarely observed together in the same patient. In this article, we report an exceptional case of a patient with COVID-19 with the combination of i...
Source: Annales de Cardiologie et d'Angeiologie - April 18, 2024 Category: Cardiology Authors: Hicham El Malki Yassine Morjane Adam Belarbi Mohammed Taha Berkane El Mehdi Moutaouekkil Source Type: research
Une combinaison tr ès rare de thrombose veineuse et artérielle chez un patient atteint du COVID 19
Ann Cardiol Angeiol (Paris). 2024 Apr 17;73(3):101744. doi: 10.1016/j.ancard.2024.101744. Online ahead of print.ABSTRACTCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This epidemic has caused serious socio-economic problems worldwide, with a very high mortality rate. Several articles have been published in the literature showing the consequences of this disease on the human body. Among the most serious complications are venous and arterial thrombosis, which are rarely observed together in the same patient. In this article, we report an exceptional case of a patient with COVID-19 with the combination of i...
Source: Annales de Cardiologie et d'Angeiologie - April 18, 2024 Category: Cardiology Authors: Hicham El Malki Yassine Morjane Adam Belarbi Mohammed Taha Berkane El Mehdi Moutaouekkil Source Type: research
Social, behavioral and environmental determinants of vector-borne diseases: A narrative review of evidence and implications for integrated control approaches
J Vector Borne Dis. 2024 Apr 18. doi: 10.4103/JVBD.JVBD_34_24. Online ahead of print.ABSTRACTVector-borne diseases exert immense health burdens worldwide. Malaria alone causes over 200 million cases and 600,000 deaths annually. Transmission involves complex drivers requiring examination beyond entomological factors. A systematic literature search across databases identified relevant studies on vector-borne disease determinants published in the last two decades, with priority given to rigorous designs like longitudinal analyses, reviews, and meta-analyses from diverse epidemic regions, allowing narrative synthesis of key de...
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ahmad Y Alqassim Source Type: research
Heat-Related Emergency Department Visits - United States, May-September 2023
MMWR Morb Mortal Wkly Rep. 2024 Apr 18;73(15):324-329. doi: 10.15585/mmwr.mm7315a1.ABSTRACTUnprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced record-breaking high temperatures in 2023, with populations exposed to extremely high temperatures for prolonged periods. CDC examined emergency department (ED) visits associated with heat-related illness (HRI) from the National Syndromic Surveillance Program and compared daily HRI ED visi...
Source: MMWR Morb Mortal Wkl... - April 18, 2024 Category: Epidemiology Authors: Ambarish Vaidyanathan Abigail Gates Claudia Brown Emily Prezzato Aaron Bernstein Source Type: research
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
Bioorg Chem. 2024 Apr 16;147:107380. doi: 10.1016/j.bioorg.2024.107380. Online ahead of print.ABSTRACTThe COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm for research & development of effective anti-coronavirus drugs, which are crucial for the patients and urgently needed for the current epidemic and future crisis. The main protease (Mpro) stands as an essential enzyme in the maturation process of SARS-CoV-2, playing an irreplaceable role in regulating viral RNA replication and transcription. It has emerged as an ideal target for developing antiviral agents against SARS-CoV-2 due to ...
Source: Bioorganic Chemistry - April 18, 2024 Category: Chemistry Authors: Ya-Qi Xiao Jiao Long Shuang-Shuang Zhang Yuan-Yuan Zhu Shuang-Xi Gu Source Type: research
Sexually Transmitted Infections in the Emergency Department
As the United States faces a worsening epidemic of sexually transmitted infections (STIs), emergency departments (EDs) play a critical role in identifying and treating these infections. The growing health inequities in the distribution and disproportionate impact of STIs add to the urgency of providing high-quality sexual health care through the ED. Changes in population health are reflected in the new Centers for Disease Control recommendations on screening, diagnostic testing, and treatment of STIs. This review covers common, as well as and less common or emerging STIs, and discusses the state-of-the-art guidance on test...
Source: Emergency Medicine Clinics of North America - April 18, 2024 Category: Emergency Medicine Authors: Rachel E. Solnick, Laura Hernando L ópez, Patricia Mae Martinez, Jason E. Zucker Source Type: research
O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36
Nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH), constitute a burgeoning worldwide epidemic with no FDA-approved pharmacotherapies. The multifunctional immunometabolic receptor, fatty acid translocase CD36 (CD36), plays an important role in the progression of hepatic steatosis. O-GlcNAcylation is a crucial posttranslational modification that mediates the distribution and function of CD36, but its involvement in NAFLD remains poorly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 18, 2024 Category: Biomedical Science Authors: Hanlong Zhu, Tianming Zhao, Si Zhao, Suzhen Yang, Kang Jiang, Shupei Li, Ying Kang, Zhuoxin Yang, Jiajia Shen, Si Shen, Hui Tao, Ji Xuan, Miaofang Yang, Bing Xu, Fangyu Wang, Mingzuo Jiang Source Type: research
Association of same-sex criminalisation laws and national HIV policies with HIV testing in African MSM: an ecological single-level and multilevel cross-sectional study of sub-Saharan African countries
Conclusions
This study suggests elimination of discriminatory laws and policies might be important for increasing HIV status awareness of MSM, an important first step in epidemic control. Additionally, we highlight heterogeneity between South Africa and other SSA countries, which has implications for studying SSA countries as a homogeneous group. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Kalu, N., Ross, M. W., Taegtmeyer, M., Lamontagne, E., Howell, S., Neuman, M. Tags: Open access Original research Source Type: research
Impact of national commissioning of pre-exposure prophylaxis (PrEP) on equity of access in England: a PrEP-to-need ratio investigation
Conclusions
Despite the overall increase in PrEP use, substantial PrEP Impact trial inequities widened postcommissioning in England, particularly across gender, ethnicity and region of residence. This study emphasises the need to guide HIV combination prevention based on equity metrics relative to the HIV epidemic. The PnR could support the optimisation of combination prevention to achieve zero new HIV infections in England by 2030. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Coukan, F., Sullivan, A., Mitchell, H., Jaffer, S., Williams, A., Saunders, J., Atchison, C., Ward, H. Tags: Open access, Editor's choice, COVID-19 Original research Source Type: research
Can laboratory HIV and infectious syphilis data inform future pre-exposure prophylaxis use in women in Ontario, Canada?
Conclusion
Although it is clinically appropriate to recommend HIV PrEP to women with syphilis, Ontario surveillance data suggest that the population-level impact of this strategy on the HIV epidemic in Ontario would have been modest during this 11-year period. Future studies should explore additional ways of prioritising women for PrEP. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Sadeghi, Y., Nelson, P., Sullivan, A., Allen, V., Hasso, M., Liu, J., Tran, V., Tan, D. H. S. Tags: Open access Short reports Source Type: research
A trial of implementation facilitation to increase timely admission to methadone treatment
During the ongoing opioid epidemic, some Opioid Treatment Programs (OTPs) are unable to admit program applicants in a timely fashion. Interim methadone (IM) treatment (without routine counseling) is an effective approach to overcome this challenge when counseling capacity is inadequate to permit admissions within 14 days of request. It requires both federal and state approval and has been rarely utilized since its incorporation into the federal OTP regulations in 1993. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - April 18, 2024 Category: Addiction Authors: J. Gryczynski, S.G. Mitchell, M. Whitter, D. Fuller, M.M. Mitchell, E.J. Edelman, R.P. Schwartz Source Type: research
