Epitranscriptomic challenges and promises in metabolic diseases
The in-depth investigations of the genome and epigenome have enabled important discoveries shedding light to the pathogenesis of metabolic diseases and the identification of potential therapeutic targets [1 –4]. Beyond the study of the DNA sequence and the regulatory processes modulating gene expression such as DNA methylation, histone modifications, chromatin remodeling and more, extends the rapidly expanding field of epitranscriptomics. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 17, 2022 Category: Biomedical Science Authors: Despina Sanoudou, Kalliopi K. Gkouskou, Aristides G. Eliopoulos, Christos S. Mantzoros Tags: Review Source Type: research

Cardiorespiratory fitness, genetic susceptibility, inflammation and risk of incident type 2 diabetes: A population-based longitudinal study
To examine whether the association between cardiorespiratory fitness (CRF) and type 2 diabetes (T2D) is modified by genetic susceptibility and inflammation. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 16, 2022 Category: Biomedical Science Authors: Chenjie Xu, Yabing Hou, Keyi Si, Zhi Cao Source Type: research

Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy
Diabetic nephropathy (DN) is a serious complication of diabetes and a common cause of end stage renal failure. Insulin-like growth factor (IGF)-signaling has been implicated in DN, but is mechanistically poorly understood. Here, we assessed the activity of the metalloproteinase PAPP-A, an activator of IGF activity, and its possible interaction with the endogenous PAPP-A inhibitors stanniocalcin (STC)-1 and -2 in the mammalian kidney under normal and hyperglycemic conditions. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 16, 2022 Category: Biomedical Science Authors: Malene R. Jepsen, Jakob A. Østergaard, Cheryl A. Conover, Lise Wogensen, Henrik Birn, Søren P. Krag, Robert A. Fenton, Claus Oxvig Source Type: research

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on
The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especially as it interacts with the COVID pandemic to create a twin pandemic, to increase morbidity and mortality. Obesity is a complex disease which has reached pandemic dimensions. The worldwide prevalence of obesity has nearly tripled since 1975, mainly due to the adoption of a progressively more sedentary lifestyle and the consumption of less healthy diets. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 14, 2022 Category: Biomedical Science Authors: Chrysoula Boutari, Christos S. Mantzoros Source Type: research

Increased plasma fatty acid clearance, not fatty acid concentration, is associated with muscle insulin resistance in people with obesity
Although it is well-accepted that increased plasma free fatty acid (FFA) concentration causes lipid overload and muscle insulin resistance in people with obesity, plasma FFA concentration poorly predicts insulin-resistant glucose metabolism. It has been proposed that hyperinsulinemia in people with obesity sufficiently inhibits adipose tissue triglyceride lipolysis to prevent FFA-induced insulin resistance. However, we hypothesized enhanced FFA clearance in people with obesity, compared with lean people, prevents a marked increase in plasma FFA even when FFA appearance is high. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 13, 2022 Category: Biomedical Science Authors: Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer Source Type: research

Glycerol's contribution to lactate production outside of a glucose intermediate in fasting humans
Glycerol is a well-recognized substrate for new glucose production via gluconeogenesis in the liver. However, its carbon contribution to the glycolytic intermediate lactate is not known in humans. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 10, 2022 Category: Biomedical Science Authors: Ankit Shah, Yujue Wang, Xiaoyang Su, Fredric E. Wondisford Source Type: research

Effects of statins on specialized pro-resolving mediators: An additional pathway leading to resolution of inflammation
Statins are a class of cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Anti-inflammatory and antioxidant properties, as well as improvement of endothelial function and plaque stabilization have also been proposed as parts of the pleiotropic effects of statins. Specialized pro-resolving mediators (SPMs) are endogenous lipid-derived molecules originating from ω-6 and ω-3 polyunsaturated fatty acids, such as arachidonic, docosahexaenoic and eicosapentaenoic acid that trigger and modulate the resolution of inflammation. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 5, 2022 Category: Biomedical Science Authors: Shabnam Radbakhsh, Niki Katsiki, Raul D. Santos, Dimitri P. Mikhailidis, Christos S. Mantzoros, Amirhossein Sahebkar Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 2, 2022 Category: Biomedical Science Source Type: research

Vascular smooth muscle cell c-Fos is critical for foam cell formation and atherosclerosis
Hyperlipidemia-induced vascular smooth muscle cell (VSMC)-derived foam cell formation is considered a crucial event in the development of atherosclerosis. Since c-Fos emerges as a key modulator of lipid metabolism, we investigated whether c-Fos plays a role in hyperlipidemia-induced VSMC-derived foam cell formation and atherosclerosis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - May 2, 2022 Category: Biomedical Science Authors: Guolin Miao, Xi Zhao, Siu-Lung Chan, Lijun Zhang, Yaohua Li, Yuke Zhang, Lijun Zhang, Beibei Wang Source Type: research

Metabolic obesity phenotypes: a friend or foe of digestive polyps? —An observational study based on National Inpatient Database
Obesity is associated with an increased risk of digestive polyps, whereas all obesity are not created equally. The role of metabolic states in occurrence risks of polyps among individuals with varying degrees of obesity remains unknown. Our study aimed to evaluate the association between metabolic obesity phenotypes and the occurrence of digestive polyps. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 12, 2022 Category: Biomedical Science Authors: Yiping Cheng, Junming Han, Qihang Li, Yingzhou Shi, Fang Zhong, Yafei Wu, Zhixiang Wang, Zhongshang Yuan, Xiude Fan, Jiajun Zhao Source Type: research

Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway
In this study, the role of Sch B-induced autophagy in lipid-lowering activities of Sch B was examined and the underlying mechanisms were elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 7, 2022 Category: Biomedical Science Authors: Li-Shan Yan, Shuo-Feng Zhang, Gan Luo, Brian Chi-Yan Cheng, Chao Zhang, Yi-Wei Wang, Xin-Yu Qiu, Xiao-Hong Zhou, Qing-Gao Wang, Xue-Lan Song, Si-Yuan Pan, Yi Zhang Source Type: research

Effects of ileal glucose infusion on enteropancreatic hormone secretion in humans: relationship to glucose absorption
The distal small intestine plays an important role in regulating the secretion of entero-pancreatic hormones that are critical to the control of glucose metabolism and appetite, but the quantitative contribution of a specific segment to these effects is unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 5, 2022 Category: Biomedical Science Authors: Xiang Zhang, Zhiqiang Cheng, Shuohui Dong, Christopher Rayner, Tongzhi Wu, Mingwei Zhong, Guangyong Zhang, Kexin Wang, Sanyuan Hu Source Type: research

Prandial hepatic glucose production during hypoglycemia is altered after gastric bypass surgery and sleeve gastrectomy
Roux-en Y gastric bypass surgery (GB) and sleeve gastrectomy (SG) alter prandial glucose metabolism, producing lower nadir glucose values and predisposing susceptible individuals to prandial hypoglycemia. The glycemic phenotype of GB or SG is associated with prandial hyperinsulinemia and hyperglucagonemia along with an increased influx of ingested glucose. Following insulin-induced hypoglycemia, glucagon is the most important stimulus for hepatic glucose production (HGP). It is unclear whether prandial hyperglucagonemia after GB or SG changes HGP under hyperinsulinemic hypoglycemia conditions. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 4, 2022 Category: Biomedical Science Authors: Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo Source Type: research

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients
Lipids are involved in the interaction between viral infection and the host metabolic and immunological responses. Several studies comparing the lipidome of COVID-19-positive hospitalized patients vs. healthy subjects have already been reported. It is largely unknown, however, whether these differences are specific to this disease. The present study compared the lipidomic signature of hospitalized COVID-19-positive patients with that of healthy subjects, as well as with COVID-19-negative patients hospitalized for other infectious/inflammatory diseases. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 2, 2022 Category: Biomedical Science Authors: Helena Casta ñé, Simona Iftimie, Gerard Baiges-Gaya, Elisabet Rodríguez-Tomàs, Andrea Jiménez-Franco, Ana Felisa López-Azcona, Pedro Garrido, Antoni Castro, Jordi Camps, Jorge Joven Source Type: research

Preadmission use of antidiabetic medications and mortality among patients with COVID-19 having type 2 diabetes: A meta-analysis
Diabetes is an independent predictor of poor outcomes in patients with COVID-19. We compared the effects of the preadmission use of antidiabetic medications on the in-hospital mortality of patients with COVID-19 having type 2 diabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 31, 2022 Category: Biomedical Science Authors: Nam Nhat Nguyen, Dung Si Ho, Hung Song Nguyen, Dang Khanh Ngan Ho, Hung-Yuan Li, Chia-Yuan Lin, Hsiao-Yean Chiu, Yang-Ching Chen Source Type: research