Activation of TRPV1 channel antagonizes diabetic nephropathy through inhibiting endoplasmic reticulum-mitochondria contact in podocytes
The impairment of podocyte protein filtration function caused by excessive mitochondrial calcium intake is a critical feature of diabetic nephropathy (DN). Ca2+ channel transient receptor potential cation channel subfamily V member 1 (TRPV1) has been reported to protect against ischemia-reperfusion induced acute renal injury, but there is no report about its role in DN. Here, we report that dietary capsaicin potently inhibits and reverses chronic renal structural and functional damages in db/db or streptozotocin (STZ)-induced diabetic mice in a TRPV1-dependent manner. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 13, 2020 Category: Biomedical Science Authors: Xiao Wei, Xing Wei, ZongShi Lu, Li Li, YingRu Hu, Fang Sun, YanLi Jiang, Huan Ma, HongTing Zheng, GangYi Yang, DaoYan Liu, Peng Gao, ZhiMing Zhu Source Type: research

Established and emerging factors affecting the progression of nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease affecting approximately 25% of the global population. Although a majority of NAFLD patients will never experience liver-related symptoms it is estimated that 5 –10% will develop cirrhosis-related complications with risk of death or need for liver transplantation. NAFLD is closely associated with cardiovascular disease and components of the metabolic syndrome. However, NAFLD is not uncommon in lean individuals and may in these subjects represent a differe nt entity with separate pathophysiological mechanisms involved implying a ...
Source: Metabolism - Clinical and Experimental - February 13, 2020 Category: Biomedical Science Authors: Stergios Kechagias, Patrik Nasr, Julia Blomdahl, Mattias Ekstedt Source Type: research

Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the relationship between insulin sensitivity and cardiovascular risk (RISC) study cohort
Uncertainty still exists on the earliest beta-cell defects at the bases of the type 2 diabetes. We assume that this depends on the inaccurate distinction between fasting and post-load glucose homeostasis and aim at providing a description of major beta-cell functions across the full physiologic spectrum of each condition. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 13, 2020 Category: Biomedical Science Authors: Alessandro Mengozzi, Domenico Tric ò, Lorenzo Nesti, John Petrie, Kurt Højlund, Asimina Mitrakou, Michael Krebs, Andrea Mari, Andrea Natali, RISC investigators Source Type: research

Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans
Abnormal glucagon concentrations are a feature of prediabetes but it is uncertain if α-cell dysfunction contributes to a longitudinal decline in β-cell function. We therefore sought to determine if a decline in β-cell function is associated with a higher nadir glucagon in the postprandial period or with higher fasting glucagon. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 8, 2020 Category: Biomedical Science Authors: Jon D. Adams, Chiara Dalla Man, Marcello C. Laurenti, M. Daniela Hurtado Andrade, Claudio Cobelli, Robert A. Rizza, Kent R. Bailey, Adrian Vella Tags: Brief Report Source Type: research

IDH1-dependent α-KG regulates brown fat differentiation and function by modulating histone methylation
Brown adipocytes play important roles in the regulation of energy homeostasis by uncoupling protein 1-mediated non-shivering thermogenesis. Recent studies suggest that brown adipocytes as novel therapeutic targets for combating obesity and associated diseases, such as type II diabetes. However, the molecular mechanisms underlying brown adipocyte differentiation and function are not fully understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 5, 2020 Category: Biomedical Science Authors: Hyun Sup Kang, Jae Ho Lee, Kyoung-Jin Oh, Eun Woo Lee, Baek Soo Han, Kun-Young Park, Jae Myoung Suh, Jeong-Ki Min, Seung-Wook Chi, Sang Chul Lee, Kwang-Hee Bae, Won Kon Kim Source Type: research

The role of serum adipokine levels in preeclampsia: a systematic review
Preeclampsia represents a major pregnancy complication, associated with high rates of perinatal morbidity. The aim of this systematic review is to accumulate current literature evidence in order to examine the pattern of serum adipokine levels among preeclamptic women and asses their potential efficacy in the prediction of the disease. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 3, 2020 Category: Biomedical Science Authors: Georgios Daskalakis, Ioannis Bellos, Melina Nikolakea, Vasilios Pergialiotis, Angeliki Papapanagiotou, Dimitrios Loutradis Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 1, 2020 Category: Biomedical Science Source Type: research

Complications, morbidity and mortality of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized public health problem, affecting up to a quarter of the world's adult population. The burden of NAFLD is influenced by the epidemics of obesity and type 2 diabetes mellitus (T2DM) and the prevalence of these conditions is not expected to decrease in the forthcoming decades. Consequently, the burden of NAFLD-related liver complications (non-alcoholic steatohepatitis [NASH], cirrhosis and hepatocellular carcinoma) and the need for life-saving liver transplantation are also expected to increase further in the near future. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 29, 2020 Category: Biomedical Science Authors: Alessandro Mantovani, Eleonora Scorletti, Antonella Mosca, Anna Alisi, Christopher D. Byrne, Giovanni Targher Tags: Invited Review Source Type: research

Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans
Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex specific. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 29, 2020 Category: Biomedical Science Authors: So-Young Kwak, InHyeok Chung, Joon Kang, Nikolaos Perakakis, Eun Hye Yoo, Juhee Lee, Hun Taek Jung, Bo-Ram Mun, Won-Seok Choi, Oh. Yoen Kim, Seolsong Kim, Eun-Kyoung Kim, Hannah Oh, Christos S. Mantzoros, Ji Hyung Chung, Hyeon Soo Kim, Min-Jeong Shin Source Type: research

Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion
Redirecting glucose from skeletal muscle and adipose tissue, likely benefits the tumor ’s energy demand to support tumor growth, as cancer patients with type 2 diabetes have 30% increased mortality rates. The aim of this study was to elucidate tissue-specific contributions and molecular mechanisms underlying cancer-induced metabolic perturbations. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 24, 2020 Category: Biomedical Science Authors: Xiuqing Han, Steffen H. Raun, Michala Carlsson, Kim A. Sj øberg, Carlos Henriquez-Olguín, Mona Ali, Annemarie Lundsgaard, Andreas M. Fritzen, Lisbeth L.V. Møller, Zhen Li, Jinwen Li, Thomas E. Jensen, Bente Kiens, Lykke Sylow Source Type: research

Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males
Brown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R) within the central nervous system activates BAT in mice. Moreover, in patients with type 2 diabetes, GLP-1R agonism lowers body weight and improves glucose and lipid levels, possibly involving BAT activation. Interestingly, people from South Asian descent are prone to develop cardiometabolic disease. We studied the effect of GLP-1R agonism on BAT in humans, specifically in South Asians and Europids without obesity or type 2 diabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 23, 2020 Category: Biomedical Science Authors: Laura G.M. Janssen, Kimberly J. Nahon, Katrien F.M. Brack é, Dennis van den Broek, Renée Smit, Aashley S.D. Sardjoe Mishre, Lisa L. Koorneef, Borja Martinez-Tellez, Jedrzej Burakiewicz, Hermien E. Kan, Floris H.P. van Velden, Lenka M. Pereira Arias-Boud Source Type: research

Normalization of metabolic flux data during clamp studies in humans
There is no consensus in the field regarding the optimal method for the expression of metabolic flux data, such as glucose disposal rates during hyperinsulinemic-euglycemic clamp experiments. Several normalization methods are in use today, but their impact on study outcomes is rarely discussed. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 23, 2020 Category: Biomedical Science Authors: Kasper W. ter Horst, Mireille J. Serlie Source Type: research

Metabolic flexibility is impaired in women who are pregnant and overweight/obese and related to insulin resistance and inflammation.
Context.Maternal obesity is a significant public health concern that contributes to unfavorable outcomes such as inflammation and insulin resistance. Women with obesity may have impaired metabolic flexibility (i.e. an inability to adjust substrate metabolism according to fuel availability). Impaired metabolic flexibility during pregnancy may mediate poor pregnancy outcomes in women with obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2020 Category: Biomedical Science Authors: Rachel A. Tinius, Maire M. Blankenship, Karen E. Furgal, W. Todd Cade, Kevin J. Pearson, Naomi S. Rowland, Regis C. Pearson, Donald L. Hoover, Jill M. Maples Source Type: research

Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway
Insulin deficiency in type 2 diabetes mellitus (DM) involves a decline in both pancreatic β-cell mass and function. Enhancing β-cell preservation represents an important therapeutic strategy to treat type 2 DM. Far-infrared (FIR) radiation has been found to induce promyelocytic leukemia zinc finger protein (PLZF) activation to protect the vascular endothelium in diabetic mice. The infl uence of FIR on β-cell preservation is unknown. Our previous study reveals that the biologically effective wavelength of FIR is 8–10 μm. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2020 Category: Biomedical Science Authors: Yung-Ho Hsu, Yen-Cheng Chen, Yu-Wei Chen, Tzu-Hsuan Chiu, Yung-Ting Kuo, Cheng-Hsien Chen Source Type: research

Obeticholic acid for the treatment of nonalcoholic steatohepatitis: expectations and concerns
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2020 Category: Biomedical Science Authors: Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros Source Type: research

Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin α8-mediated activation of RhoA signaling pathway
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases that may progress to liver fibrosis or cancer. The present study aimed to investigate the role of microRNA-125b-5p (miR-125b-5p) in NAFLD and to further explore underlying molecular mechanisms. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 8, 2020 Category: Biomedical Science Authors: Qingxian Cai, Fengjuan Chen, Fen Xu, Ke Wang, Ka Zhang, Guojun Li, Jun Chen, Hong Deng, Qing He Source Type: research

Time Trends and Predictors of Hypovitaminosis D Across the Life Course: 2009 –2016
We investigated prevalence, determinants, seasonal changes, and time trends in hypovitaminosis D. We derived a desirable serum 25-hydroxy-vitamin D (25OHD) level in adults/elderly by evaluating the 25OHD-parathyroid hormone (PTH) exponential relationship. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 7, 2020 Category: Biomedical Science Authors: Randa K. Saad, Vanessa C. Akiki, Maya Rahme, Sara Ajjour, Mariam Assad, Ghada A. El-Hajj Fuleihan Source Type: research

High-density lipoprotein cholesterol efflux capacity and cardiovascular risk in autoimmune and non-autoimmune diseases
Functional assessment of cholesterol efflux capacity (CEC) to high-density lipoprotein (HDL) is an emerging tool for evaluating morbidity and mortality associated with cardiovascular disease (CVD). By promoting macrophage reverse cholesterol transport (RCT), HDL-mediated CEC is believed to play an important role in atherosclerotic lesion progression in the vessel wall. Furthermore, recent evidence indicates that the typical inverse associations between various forms of CEC and CV events may be strongly modulated by environmental systemic factors and traditional CV risk factors, in addition to autoimmune diseases. (Source: ...
Source: Metabolism - Clinical and Experimental - January 7, 2020 Category: Biomedical Science Authors: Anouar Hafiane, Elda Favari, Stella S. Daskalopoulou, Nicolas Vuilleumier, Miguel A. Frias Source Type: research

Time for a paradigm shift in treating type 1 diabetes mellitus: coupling inflammation to islet Regeneration
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that targets the destruction of islet beta-cells resulting in insulin deficiency, hyperglycemia and death if untreated. Despite advances in medical devices and longer-acting insulin, there is still no robust therapy to substitute and protect beta-cells that are lost in T1DM. Attempts to refrain from the autoimmune attack have failed to achieve glycemic control in patients highlighting the necessity for a paradigm shift in T1DM treatment. Paradoxically, beta-cells are present in T1DM patients indicating a disturbed equilibrium between the immune attack and beta-cell r...
Source: Metabolism - Clinical and Experimental - January 2, 2020 Category: Biomedical Science Authors: Nadia Cobo Vuilleumier, Benoit R. Gauthier Source Type: research

In memoriam: The life and times of Theodore B. Van Itallie (1919 –2019)
Theodore “Ted” Van Itallie (shown above), an intellectual giant and pioneer in the field of nutrition, metabolism, obesity, and cognitive function research, professor emeritus, Columbia University College of Physicians and Surgeons, former editor-in chief of the journals Metabolism and the American Journ al of Nutrition, and a former director of medicine at St. Luke's Hospital Center in New York City (1957–75), died at his home in Old Lyme, CT on September 14th 2019 at the age of 99 years. A special memorial service was held for him at Saint Ann's Episcopal Church in Old Lyme on November 8th 201 9, the ...
Source: Metabolism - Clinical and Experimental - December 27, 2019 Category: Biomedical Science Authors: Ernst J. Schaefer, Anne B. Pierson, F. Xavier Pi Sunyer, Christos S. Mantzoros, Sami Hashim Source Type: research

The combination of Linagliptin, Metformin and Lifestyle Modification to prevent Type 2 Diabetes (PRELLIM). A randomized clinical trial
Prediabetes is a highly prevalent health problem with a high risk of complications and progression to type 2 diabetes (T2D). The goals of this study were to evaluate the effect of the combination of lingaliptin + metformin + lifestyle on glucose tolerance, pancreatic β-cell function and T2D incidence in patients with prediabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 27, 2019 Category: Biomedical Science Authors: Rodolfo Guardado-Mendoza, Sara Stephania Salazar-L ópez, Mildred Fátima de la Luz Álvarez-Canales, Diana Farfán Vázquez, Yoscelina Estrella Martínez-López, Lilia M. Jiménez-Ceja, Erick L. Suárez-Pérez, Fabiola Angulo-Romero, Maria Lola Evia-Visc Source Type: research

High-resolution metabolomics study revealing L-homocysteine Sulfinic acid, Cysteic acid, and Carnitine as novel biomarkers for high acute myocardial infarction risk
Identifying changes in serum metabolites before the occurrence of acute myocardial infarction (AMI) is an important approach for finding novel biomarkers of AMI. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 21, 2019 Category: Biomedical Science Authors: Adnan Khan, Yoonjeong Choi, Joung Hwan Back, Sunmi Lee, Sun Ha Jee, Youngja H. Park Source Type: research

Management of X-linked hypophosphatemia in adults
X-linked hypophosphatemia (XLH) is caused by mutations in the PHEX gene which result in Fibroblast Growth Factor-23 (FGF23) excess and phosphate wasting. Clinically, XLH children present with rickets, bone deformities and short stature. In adulthood, patients may still be symptomatic with bone and joint pain, osteomalacia-related fractures or pseudofractures, precocious osteoarthrosis, entesopathy, muscle weakness and severe dental anomalies. Besides these musculoskeletal and dental manifestations, adult XLH patients are also prone to secondary and tertiary hyperparathyroidism, cardiovascular and metabolic disorders. (Sour...
Source: Metabolism - Clinical and Experimental - December 18, 2019 Category: Biomedical Science Authors: Anne-Lise Lecoq, Maria Luisa Brandi, Agn ès Linglart, Peter Kamenický Source Type: research

Reversibility of cerebral blood flow in patients with Cushing's disease after surgery treatment
Cushing's disease (CD) patients have metabolic abnormalities in the brain caused by excessive exposure to endogenous cortisol. However, the reversibility of brain metabolism of CD patients after treatment remains largely unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 18, 2019 Category: Biomedical Science Authors: Hewei Cheng, Lu Gao, Bo Hou, Feng Feng, Xiaopeng Guo, Zihao Wang, Ming Feng, Bing Xing, Yong Fan Source Type: research

Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor
Angiotensin-(1-7) [Ang-(1-7)], a component of the renin angiotensin system, is a vasodilator that exerts its effects primarily through the Mas receptor. The discovery of the Mas receptor in white adipose tissue (WAT) suggests an additional role for this peptide. The aim of the present study was to assess whether Ang-(1-7) can induce the expression of thermogenic genes in white adipose tissue and increase mitochondrial respiration in adipocytes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 13, 2019 Category: Biomedical Science Authors: Ariana Vargas-Castillo, Sandra Tobon-Cornejo, Leonardo Del Valle-Mondragon, Ivan Torre-Villalvazo, Alejandro Schcolnik-Cabrera, Martha Guevara-Cruz, Edgar Pichardo-Ontiveros, Rebeca Fuentes-Romero, Michael Bader, Natalia Alenina, Antonio Vidal-Puig, Enriq Source Type: research

Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis
Hepatic ER stress is a risk factor of insulin resistance and type 2 diabetes. X-box binding protein 1 spliced (XBP1s), a transcription factor, plays a key role in ameliorating insulin resistance and maintaining glucose homeostasis. Unfortunately, the short half-life of the protein dampens its clinical application, and the specific site of lysine residue that could be ubiquitinated and involved in the degradation of XBP1s remains elusive. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 11, 2019 Category: Biomedical Science Authors: Honglin Sun, Gang Wei, He Liu, Danrui Xiao, Jianbo Huang, Junxi Lu, Ji Miao, Junli Liu, Suzhen Chen Source Type: research

Perinatal programming of metabolic diseases: the role of glucocorticoids
The worldwide increase in metabolic diseases has urged the scientific community to improve our understanding about the mechanisms underlying its cause and effects. A well supported area of studies had related maternal stress with early programming to the later metabolic diseases. Mechanisms upon origins of metabolic disturbances are not yet fully understood, even though stressful factors rising glucocorticoids have been put out as pivotal trigger by programming metabolic diseases as long-term consequence. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 11, 2019 Category: Biomedical Science Authors: J úlia Cristina Facchi, Thalyne Aparecida Leite de Lima, Lucas Ryba de Oliveira, Hercules de Oliveira Costermani, Ginislene Dias de Souza Miranda, Júlio Cezar de Oliveira Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 8, 2019 Category: Biomedical Science Source Type: research

Differential indication for SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with established atherosclerotic heart disease or at risk for congestive heart failure
SGLT-2 inhibitors and most GLP-1 receptor agonists demonstrated cardiovascular superiority and reduction of cardiovascular and overall mortality. These results stand as a turning point in the management of diabetes, shifting the focus from controlling glucose levels to mastering the extra-glycemic effects of these new drugs. This narrative review will discuss recent CVOT with focus on SGLT-2 inhibitors and GLP-1 receptor agonists to distinguish relevant patients' characteristics as potential predictors for therapeutic efficacy. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 7, 2019 Category: Biomedical Science Authors: Francesco Giorgino, Irene Caruso, Julia Moellmann, Michael Lehrke Source Type: research

Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents
Skeletal muscle atrophy is characterized by muscle wasting with partial or complete functional loss. Skeletal muscle atrophy severely affects the quality of life and currently, there is no available therapy except for spinal muscular atrophy. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 5, 2019 Category: Biomedical Science Authors: Anagha Ashok Gurjar, Sapana Kushwaha, Sourav Chattopadhyay, Nabanita Das, Subhashis Pal, Shyamsundar Pal China, Harish Kumar, Arun Kumar Trivedi, Rajdeep Guha, Naibedya Chattopadhyay, Sabyasachi Sanyal Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 30, 2019 Category: Biomedical Science Source Type: research

Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women
Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on energy substrate utilisation are unknown. The aim of this study was to investigate the impact of 4-weeks IPE supplementation, in combination with a moderate intensity exercise training programme, on whole body fat oxidation and on plasma GLP-1 and PYY. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 29, 2019 Category: Biomedical Science Authors: Dalia Malkova, Thelma Polyviou, Eleni Rizou, Konstantinos Gerasimidis, Edward S. Chambers, Tom Preston, Catriona M. Tedford, Gary Frost, Douglas J. Morrison Tags: Brief Report Source Type: research

Adiponectin and leptin in the diagnosis and therapy of NAFLD
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and the most prevalent cause of abnormal liver enzymes in the western world [1]. It is defined as the accumulation of excessive fat in the liver in the absence of alcohol abuse or other causes of hepatic steatosis [2]. Subcategories of NAFLD include simple fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) as well as more advanced cases of fibrosis, cirrhosis and liver failure. Simple fatty liver, also called nonalcoholic fatty liver (NAFL), is a form of NAFLD in which excess fat is stored in the liver but little or no inflammation ...
Source: Metabolism - Clinical and Experimental - November 27, 2019 Category: Biomedical Science Authors: Chrysoula Boutari, Christos S. Mantzoros Tags: Editorial Source Type: research

The rollercoaster history of using physiological and pharmacological properties of incretin hormones to develop diabetes medications with a convincing benefit-risk relationship
Incretin-based glucose-lowering medications (glucagon-like peptide-1 receptor agonists, GLP-1 RAs, and inhibitors of dipeptidyl peptidase-4, DPP-4 I) are now established drug classes, widely used because of their ability to substantially reduce high plasma glucose concentrations and levels of glycated hemoglobin without themselves causing hypoglycemic episodes, doing so without prompting body weight gain (DPP-4-I) or even with a chance to meaningfully reduce adipose tissue mass (GLP-1 RA) [1, 2]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2019 Category: Biomedical Science Authors: Michael A. Nauck Source Type: research

Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term High Fat Diet in humans
Our previous work demonstrated that a short-term high fat diet (HFD) increased fasting serum endotoxin, and altered postprandial excursions of serum endotoxin, and led to metabolic and transcriptional responses in skeletal muscle in young, healthy male humans. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2019 Category: Biomedical Science Authors: Suzanne M. Bowser, Ryan P. McMillan, Nabil E. Boutagy, Michael D. Tarpey, Andrew T. Smithson, Kristin L. Osterberg, Andrew P. Neilson, Brenda M. Davy, Kevin P. Davy, Matthew W. Hulver Source Type: research

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes
Bile acids (BAs) are signaling molecules controlling lipid and glucose metabolism. Since BA alterations are associated with obesity and insulin resistance, plasma BAs have been considered candidates to predict type 2 diabetes (T2D) risk. We aimed to determine (1) the association of BAs with glucose homeostasis parameters and (2) their predictive association with the risk of conversion from prediabetes to new-onset diabetes (NOD) in a prospective cohort study. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2019 Category: Biomedical Science Authors: Oscar Ch ávez-Talavera, Matthieu Wargny, Matthieu Pichelin, Amandine Descat, Emmanuelle Vallez, Mostafa Kouach, Edith Bigot-Corbel, Marielle Joliveau, Jean-Francois Goossens, Cédric Le May, Samy Hadjadj, Rémy Hanf, Anne Tailleux, Bart Staels, Bertrand Source Type: research

The Adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice
Glucocorticoids (GCs) are highly effective anti-inflammatory and immunosuppressive drugs. However, prolonged GC therapy may cause numerous adverse effects leading to diabetes and obesity, as well as bone disorders such as osteoporosis in adults and growth retardation in children and adolescents. Prevention and care of the GC-induced adverse effects remain challenging. We have previously demonstrated the efficacy of a treatment with a non-peptidic agonist of adiponectin receptors, AdipoRon, to reverse behaviour disorders and fat mass gain induced by long-term GC treatment. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 26, 2019 Category: Biomedical Science Authors: Sarah Nicolas, Nathalie Rochet, Nadine Gautier, Jo ëlle Chabry, Didier Pisani Source Type: research

Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise
Exogenous carbohydrate oxidation is lower during steady-state aerobic exercise in native lowlanders sojourning at high altitude (HA) compared to sea level (SL). However, the underlying mechanism contributing to reduction in exogenous carbohydrate oxidation during steady-state aerobic exercise performed at HA have not been explored. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 26, 2019 Category: Biomedical Science Authors: Lee M. Margolis, Marques A. Wilson, Claire C. Whitney, Christopher T. Carrigan, Nancy E. Murphy, Patrick N. Radcliffe, Jess A. Gwin, David D. Church, Robert R. Wolfe, Arny A. Ferrando, Andrew J. Young, Stefan M. Pasiakos Source Type: research

Central Sfrp5 regulates hepatic glucose flux and VLDL- triglyceride secretion
Secreted frizzled-related protein 5 (Sfrp5) has been shown to be associated with energy homeostasis and insulin resistance in mouse models of obesity and diabetes. However, its central role in glucose and lipid metabolism is unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 23, 2019 Category: Biomedical Science Authors: Yang Li, Mingyuan Tian, Mengliu Yang, Gangyi Yang, Jianrong Chen, Han Wang, Dongfang Liu, Hongyan Wang, Wuquan Deng, Zhiming Zhu, Hongting Zheng, Ling Li Source Type: research

Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors
Metabolic complications are highly prevalent in cancer survivors treated with irradiation but the underlying mechanisms remain unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 22, 2019 Category: Biomedical Science Authors: Nadia Amorim, Anthony Kee, Adelle C.F. Coster, Christine Lucas, Sarah Bould, Sara Daniel, Jacquelyn M. Weir, Natalie A. Mellett, Jayne Barbour, Peter J. Meikle, Richard J. Cohn, Nigel Turner, Edna C. Hardeman, David Simar Source Type: research

Low levels of total and high-molecular-weight adiponectin may predict non-alcoholic fatty liver in Korean adults
While weight gain is known as a predictor of non-alcoholic fatty liver disease (NAFLD) incidence, it remains controversial whether adipokine levels predict the development of NAFLD. We aimed to investigate the relationship of total adiponectin, high-molecular-weight (HMW) adiponectin, and leptin with the development and improvement of non-alcoholic fatty liver (NAFL) independent of sex and weight change over a maximum of 8.5  years. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 22, 2019 Category: Biomedical Science Authors: Young-Sang Kim, Soo-Hyun Lee, Seung Geon Park, Bo Youn Won, Hyejin Chun, Doo-Yeoun Cho, Moon-Jong Kim, Ji Eun Lee, Ji-Hee Haam, Kunhee Han Source Type: research

Curcumin analog CUR5 –8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity
Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat storage in the liver and it is strongly linked with metabolic syndrome including obesity, insulin resistance, dyslipidemia and hypertension. Curcumin5 –8 (CUR5–8) is a synthetic derivative of naturally active curcumin (CUR) that has anti-oxidative and anti-inflammatory properties. In the present study, we investigated the effects of CUR5–8, a novel CUR analog, on hepatic steatosis in mice with high-fat diet (HFD)-induced obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 20, 2019 Category: Biomedical Science Authors: Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Ho Bum Woo, Chan Mug Ahn, Choon Hee Chung Source Type: research

The homeobox factor Irx3 maintains adipogenic identity
Inhibition of Irx3 and Irx5 has been shown to reduce body weight and white adipose tissue (WAT) mass through cell-autonomous and sympathetic-induced increases in adipocyte beiging and thermogenesis in mice and humans. However, the underlying mechanisms of the Irx control over beiging are still largely unknown, as illustrated by recent reports showing divergent effects of Irx3 on adipocyte metabolism and function. Here, we investigated the role of Irx3 in controlling beige preadipocyte function and differentiation. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 18, 2019 Category: Biomedical Science Authors: Jan-Inge Bjune, Laurence Dyer, Gro V. R øsland, Karl Johan Tronstad, Pål R. Njølstad, Jørn V. Sagen, Simon N. Dankel, Gunnar Mellgren Source Type: research

LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue
In this study, we aim to investigate the role of lysine specific demethylase (LSD1), a histone demethylase and important regulator of thermogenesis, in mediating gut microbial metabolite butyrate regulation of thermogenesis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 14, 2019 Category: Biomedical Science Authors: Dan Wang, Chu-Dan Liu, Hong-Fei Li, Meng-Li Tian, Jia-Qiang Pan, Gang Shu, Qing-Yan Jiang, Yu-Long Yin, Lin Zhang Source Type: research

Effects of preeclampsia and eclampsia on maternal metabolic and biochemical outcomes in later life: a systematic review and meta-analysis
To evaluate the association between preeclampsia (PE) and eclampsia (E) on subsequent metabolic and biochemical outcomes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 14, 2019 Category: Biomedical Science Authors: Vanesa Alonso-Ventura, Yangzhou Li, Vinay Pasupuleti, Yuani M. Roman, Adrian V. Hernandez, Faustino R. P érez-López Source Type: research

Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy
Transforming growth factor (TGF)- β/Smad3 signaling is highly activated in kidneys of patients with type 2 diabetic nephropathy (T2DN), however, the precise role of Smad3 in the pathogenesis of diabetic nephropathy remains unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 14, 2019 Category: Biomedical Science Authors: Bi-Hua Xu, Jingyi Sheng, Yong-Ke You, Xiao-Ru Huang, Ronald C.W. Ma, Qingwen Wang, Hui-Yao Lan Source Type: research

Hepatic exosome-derived miR-130a-3p attenuates glucose tolerance via suppressing PHLPP2 gene in adipocyte
Glucose and lipid metabolism disorder is a major risk factor for type II diabetes and cardiovascular diseases. Evidence has indicated that the interplay between the liver and adipose tissue is crucial in maintaining energy homeostasis. Recently, the interaction between two distant endocrine organs mainly focuses on the regulation of hormones and receptors. However, as a novel carrier in the inter-tissue communication, exosome plays a role in liver-fat crosstalk, but its effects on glucose and lipid metabolisms are still unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 10, 2019 Category: Biomedical Science Authors: Jiahan Wu, Tao Dong, Ting Chen, Jiajie Sun, Junyi Luo, Jiajian He, Limin Wei, Bin Zeng, Haojie Zhang, Weite Li, Jie Liu, Xingping Chen, Mei Su, Yuechun Ni, Qingyan Jiang, Yongliang Zhang, Qianyun Xi Source Type: research

Metabolism Updates: New directions, techniques, and exciting research that is broadening the horizons
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 9, 2019 Category: Biomedical Science Authors: Chrysoula Boutari, Eirini Bouzoni, Aditya Joshi, Konstantinos Stefanakis, Olivia M. Farr, Christos S. Mantzoros Source Type: research

Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function
In this study, AMPK's pivotal role in SFN-mediated prevention against T2D-induced cardiomyopath y was tested using global deletion of AMPKα2 gene (AMPKα2-KO) mice.Methods and Results.T2D was established by feeding 3-month high-fat diet (HFD) to induce insulin resistance, followed by an intraperitoneal injection of streptozotocin (STZ) to induce mild hyperglycemia in both AMPKα2-KO and wild- type (WT) mice. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 8, 2019 Category: Biomedical Science Authors: Yike Sun, Shanshan Zhou, Hua Guo, Jian Zhang, Tianjiao Ma, Yang Zheng, Zhiguo Zhang, Lu Cai Source Type: research

Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: a proof of concept study
This study aimed to train models for the non-invasive diagnosis of NASH and liver fibrosis based on measurements of lipids, glycans and biochemical parameters in peripheral blood and with the use of different machine learning methods. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 8, 2019 Category: Biomedical Science Authors: Nikolaos Perakakis, Stergios A. Polyzos, Alireza Yazdani, Aleix Sala-Vila, Jannis Kountouras, Athanasios D. Anastasilakis, Christos S. Mantzoros Source Type: research