Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 12, 2021 Category: Biomedical Science Source Type: research

Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters
Cardiovascular disease is the leading cause of deaths in nonalcoholic steatohepatitis (NASH) patients. Mouse models, while widely used for drug development, do not fully replicate human NASH nor integrate the associated cardiac dysfunction, i.e. heart failure with preserved ejection fraction (HFpEF). To overcome these limitations, we established a nutritional hamster model developing both NASH and HFpEF. We then evaluated the effects of the dual peroxisome proliferator activated receptor alpha/delta agonist elafibranor developed for the treatment of NASH patients. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2021 Category: Biomedical Science Authors: Fran çois Briand, Julie Maupoint, Emmanuel Brousseau, Natalia Breyner, Mélanie Bouchet, Clément Costard, Thierry Leste-Lasserre, Mathieu Petitjean, Li Chen, Audrey Chabrat, Virgile Richard, Rémy Burcelin, Caroline Dubroca, Thierry Sulpice Source Type: research

Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?
Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver dysfunctions and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma. Mitochondria are highly dynamic organelles involved in multiple metabolic/bioenergetic pathways in the liver. Emerging evidence outlined that hepatic mitochondria adapt in number and functionality in response to external cues, as high caloric intake and obesity, by modulating mitochondrial biogenesis, and maladaptive mitochondrial response has been described from the early stages of NAFLD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2021 Category: Biomedical Science Authors: Miriam Longo, Marica Meroni, Erika Paolini, Chiara Macchi, Paola Dongiovanni Source Type: research

PPAR α/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation
The preservation of body proteins is essential to guarantee their functions in organisms. Therefore, the utilization of amino acids as energy substrates is regulated by a precise fine-tuned mechanism. Recent evidence suggests that the transcription factors peroxisome proliferator-activated receptor alpha (PPAR α) and hepatocyte nuclear factor 4 alpha (HNF4α) are involved in this regulatory mechanism. Thus, the aim of this study was to determine how these transcription factors interact to regulate the expression of amino acid catabolism genes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 7, 2021 Category: Biomedical Science Authors: Sandra Tob ón-Cornejo, Ariana Vargas-Castillo, Alekxa Leyva-Martínez, Victor Ortíz, Lilia G. Noriega, Laura A. Velázquez-Villegas, Gabriela Aleman, Janette Furosawa, Nimbe Torres, Armando R. Tovar Source Type: research

Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring
Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabolic alterations in GDM mothers later in life, but also protects 6-week-old male offspring from adverse effects of maternal diet. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 6, 2021 Category: Biomedical Science Authors: Jelena Stevanovi ć Silva, Jorge Beleza, Pedro Coxito, Susana Pereira, Hugo Rocha, Tiago Bordeira Gaspar, Fátima Gärtner, Rossana Correia, Maria João Martins, Tiago Guimarães, Sandra Martins, Paulo Oliveira, António Ascensão, José Magalhães Source Type: research

Lipoprotein (a) and Coronary Artery Calcification: Prospective study assessing interactions with other risk factors
Elevated plasma lipoprotein (a) [Lp(a)] and coronary artery calcification (CAC) are established cardiovascular risk factors that correlate with each other. We hypothesized that other cardiovascular risk factors could affect their relationship. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 6, 2021 Category: Biomedical Science Authors: Kwok Leung Ong, Robyn L. McClelland, Matthew A. Allison, Mary Cushman, Parveen K. Garg, Michael Y. Tsai, Kerry-Anne Rye, Fatiha Tabet Source Type: research

Excess body weight is an independent risk factor for severe forms of COVID-19
Few studies distinguished the independent role of overweight/obesity or their associated-comorbidities in the evolution towards severe forms of COVID-19. Obesity as a unifying risk factor for severe COVID-19 is an emerging hypothesis. The aim of this study was to evaluate whether excessive body weight per se, was a risk factor for developing a severe form of COVID-19. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 5, 2021 Category: Biomedical Science Authors: L éa Pietri, Roch Giorgi, Audrey Bégu, Manon Lojou, Marie Koubi, Raphael Cauchois, Rachel Grangeot, Noémie Dubois, Gilles Kaplanski, René Valéro, Sophie Béliard Source Type: research

Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: the role of hydrogen sulfide
Protein malnutrition in childhood predisposes individuals to vascular and pancreatic endocrine dysfunction, thus increasing the risk of diabetes and hypertension. Because taurine may reduce cardiometabolic risk, we hypothesized that taurine treatment has a beneficial effect on the pancreatic vasculature during protein restriction.Methods and Results.Weaned mice were fed a normal or a low-protein diet and were treated with or without taurine for 3  months. The lieno-pancreatic artery (LPA) from low-protein diet-treated mice exhibited impaired endothelium-dependent relaxation to acetylcholine that was associated with decre...
Source: Metabolism - Clinical and Experimental - January 5, 2021 Category: Biomedical Science Authors: Daniele M. Guizoni, Israelle N. Freitas, Jamaira A. Victorio, Isabela R. Possebom, Thiago R. Araujo, Everardo M. Carneiro, Ana P. Davel Source Type: research

METTL3 is required for maintaining β-cell function
N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β-cell-specific deletion of Mettl3 induces β-cell failure and hyperglycemia, which is likely due to decreased m6A modification and r educed expression of insulin secretion-related genes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 5, 2021 Category: Biomedical Science Authors: Xinzhi Li, Yuze Jiang, Xu Sun, Yongsen Wu, Zheng Chen Tags: Brief Report Source Type: research

LKB1 up-regulation inhibits hypothalamic inflammation and attenuates diet-induced obesity in mice
Diet-induced obesity (DIO) is associated with chronic, low-grade inflammation in the hypothalamus. The inflammatory pathway of the hypothalamus is activated during obesity, and inhibition of activation of the inflammatory pathway can partially reverse obesity. Therefore, exploring new targets for inhibiting hypothalamic inflammation will provide new ideas for the prevention and treatment of obesity. Liver kinase B1 (LKB1), a serine/threonine kinase, is a tumor suppressor and metabolic regulator. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 21, 2020 Category: Biomedical Science Authors: Zhaoxia Wu, Pengjiao Xi, Yan Zhang, Haomin Wang, Jie Xue, Xuguo Sun, Derun Tian Source Type: research

Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNF α-induced death: an analysis at the single-cell level
We examined the cytokine profiles of hypoxic visceral ASCs (hypox-visASCs) from subjects with different metabolic risk, the interactions between cytokines as well as the impact of TNF α-induced death in the behavior of surviving hypoxic subcutaneous ASCs (hypox-subASCs) both at bulk population and single-cell level.Materials/Methods. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 14, 2020 Category: Biomedical Science Authors: Wilfredo Oliva-Olivera, Daniel Castellano-Castillo, Ferdinand von Meyenn, Fernando Cardona, Tapio Lonnberg, Francisco J. Tinahones Source Type: research

Serum Uric Acid is Associated with Increased Risk of Posttransplantation Diabetes in Kidney Transplant Recipients: A Prospective Cohort Study
Serum uric acid (SUA) is associated with fasting glucose in healthy subjects, and prospective epidemological studies have shown that elevated SUA is associated with increased risk of type 2 diabetes. Whether SUA is independently associated with higher risk of posttransplantation diabetes mellitus (PTDM) in kidney transplant recipients (KTR) remains unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 11, 2020 Category: Biomedical Science Authors: Camilo G. Sotomayor, Sara Sokooti Oskooei, Nicol ás I. Bustos, Ilja M. Nolte, António W. Gomes-Neto, Marcia Erazo, Juan G. Gormaz, Stefan P. Berger, Gerjan J. Navis, Ramón Rodrigo, Robin P.F. Dullaart, Stephan J.L. Bakker Source Type: research

Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse
GDI1 gene encodes for αGDI, a protein controlling the cycling of small GTPases, reputed to orchestrate vesicle trafficking. Mutations in human GDI1 are responsible for intellectual disability (ID). In mice with ablated Gdi1, a model of ID, impaired working and associative short-term memory was recorded. This cognitive p henotype worsens if the deletion of αGDI expression is restricted to neurons. However, whether astrocytes, key homeostasis providing neuroglial cells, supporting neurons via aerobic glycolysis, contribute to this cognitive impairment is unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 9, 2020 Category: Biomedical Science Authors: Patrizia D ’Adamo, Anemari Horvat, Antonia Gurgone, Maria Lidia Mignogna, Veronica Bianchi, Michela Masetti, Maddalena Ripamonti, Stefano Taverna, Jelena Velebit, Maja Malnar, Marko Muhič, Katja Fink, Angela Bachi, Umberto Restuccia, Sara Belloli, Rosa Source Type: research

CER-001 ameliorates lipid profile and kidney disease in a mouse model of Familial LCAT Deficiency
This study was designed to investigate whether the absence of LCAT affects the catabolic fate of CER-001, and to evaluate the effects of CER-001 on kidney disease associated with LCAT deficiency. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 9, 2020 Category: Biomedical Science Authors: Alice Ossoli, Arianna Strazzella, Daniela Rottoli, Cristina Zanchi, Monica Locatelli, Carlamaria Zoja, Sara Simonelli, Fabrizio Veglia, Ronald Barbaras, Cyrille Tupin, Jean-Louis Dasseux, Laura Calabresi Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 8, 2020 Category: Biomedical Science Source Type: research

Reply to Vitamin D deficiency in COVID-19: mixing up cause and consequence
Conflict of interest: None. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 7, 2020 Category: Biomedical Science Authors: M. Chakhtoura, G. El Hajj Fuleihan Source Type: research

Advances in biological therapies for dyslipidemias and atherosclerosis
This article focuses on the latest developments, clinical potential and current challenges of monoclonal antibodies, vaccines and genome/transcriptome modification strategies, including antisense oligonucleotides, genome/base editing and gene therapy. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 5, 2020 Category: Biomedical Science Authors: Eftaxia-Konstantina Valanti, Katerina Dalakoura-Karagkouni, Gerasimos Siasos, Dimitris Kardassis, Aristides G. Eliopoulos, Despina Sanoudou Source Type: research

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction
Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, master elements and final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple metabolic cues to regulate reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), the fundamental cellular sensor that becomes activated in conditions of energy deficit, has been recently shown to participate in the control of Kiss1 neurons, essential gatekeepers of the reproductive axis, by driving an inhibitory valence in situa...
Source: Metabolism - Clinical and Experimental - December 3, 2020 Category: Biomedical Science Authors: D. Franssen, A. Barroso, F. Ruiz-Pino, M.J. V ázquez, D. García-Galiano, J.M. Castellano, R. Onieva, M. Ruiz-Cruz, M. Poutanen, F. Gaytán, C. Diéguez, L. Pinilla, M. Lopez, J. Roa, M. Tena-Sempere Source Type: research

Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis
Lipolysis is essential for the supply of nutrients during fasting, the control of body weight, and remodeling of white adipose tissues and thermogenesis. In the obese state, lipolysis activity and the expression of adipose triglyceride lipase (ATGL), a rate-limiting enzyme, is suppressed. However, the mechanism underlying the regulation of ATGL remains largely unknown. We previously reported that a high-fat diet obviously increases protein levels of the prolyl isomerase, Pin1, in epididymal white adipose tissue (epiWAT) of mice and that Pin1 KO mice are resistant to developing obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 3, 2020 Category: Biomedical Science Authors: Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano Source Type: research

Direct impact of gonadotropins on glucose uptake and storage in preovulatory granulosa cells: Implications in the pathogenesis of polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is often associated with higher levels of LH, and arrested ovarian follicular growth. The direct impact of high LH on FSH mediated metabolic responses in PCOS patients is not clearly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 2, 2020 Category: Biomedical Science Authors: Nidhi Chahal, Anjali Geethadevi, Surleen Kaur, Ruchi Lakra, Anjali Nagendra, T.G. Shrivastav, Francesco De Pascali, Eric Reiter, Pascale Cr épieux, M. Gouri Devi, Neena Malhotra, K. Muralidhar, Rita Singh Tags: Basic Science Source Type: research

Direct impact of gonadotropins on glucose uptake and storage
Polycystic ovary syndrome (PCOS) is often associated with higher levels of LH, and arrested ovarian follicular growth. The direct impact of high LH on FSH mediated metabolic responses in PCOS patients is not clearly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 2, 2020 Category: Biomedical Science Authors: Nidhi Chahal, Anjali Geethadevi, Surleen Kaur, Ruchi Lakra, Anjali Nagendra, T.G. Shrivastav, Francesco De Pascali, Eric Reiter, Pascale Cr épieux, M. Gouri Devi, Neena Malhotra, K. Muralidhar, Rita Singh Source Type: research

Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression
Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls. However, it remains unclear whether or not specific BAs are associated with the clinically relevant transition from nonalcoholic fatty liver (i.e. simple steatosis) to non-alcoholic steatohepatitis (NASH), or enhanced progression of hepatic fibrosis, or genetic determinants of NAFLD/NASH. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 1, 2020 Category: Biomedical Science Authors: Nisreen Nimer, Ibrahim Choucair, Zeneng Wang, Ina Nemet, Lin Li, Janet Gukasyan, Taylor L. Weeks, Naim Alkhouri, Nizar Zein, W.H. Wilson Tang, Michael A. Fischbach, J. Mark Brown, Hooman Allayee, Srinivasan Dasarathy, Valentin Gogonea, Stanley L. Hazen Source Type: research

The effect of the magnitude of weight loss on non-alcoholic fatty liver disease: a systematic review and meta-analysis
Trials show that weight loss interventions improve biomarkers of non-alcoholic fatty liver disease (NAFLD), but it is unclear if a dose-response relationship exists. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 28, 2020 Category: Biomedical Science Authors: Dimitrios A. Koutoukidis, Constantinos Koshiaris, John A. Henry, Michaela Noreik, Elizabeth Morris, Indrani Manoharan, Kate Tudor, Emma Bodenham, Anna Dunnigan, Susan A. Jebb, Paul Aveyard Source Type: research

CT-derived abdominal adiposity: distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China
Although abdominal adiposity is associated with an altered cardiometabolic risk profile, the specific contribution of abdominal adipose tissue distribution remains not fully understood. Computed tomography (CT) is a well-established and precise method to measure abdominal adipose tissue distribution. The present study investigated abdominal adiposity assessed by CT in a large-scale Chinese population. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2020 Category: Biomedical Science Authors: Qiang Zeng, Ling Wang, Shengyong Dong, Xiaojuan Zha, Limei Ran, Yongli Li, Shuang Chen, Jianbo Gao, Shaolin Li, Yong Lu, Yuqin Zhang, Xigang Xiao, Yuehua Li, Xiao Ma, Xiangyang Gong, Wei Chen, Yingying Yang, Xia Du, Bairu Chen, Yinru Lv, Yan Wu, Guobin Ho Tags: Brief Report Source Type: research

The nutrient sensing pathways FoxO1/3 and mTOR in the heart are coordinately regulated by central leptin through PPAR β/δ. Implications in cardiac remodeling
Cardiovascular disease in obese individuals with type 2 diabetes is often associated with hyperleptinemia and leptin resistance, while other studies support that leptin has cardioprotective effects. Besides, the role of leptin in regulating cardiac atrophy or hypertrophy remains to be clearly defined. In fact, in rats with normal leptin sensitivity, the molecular underpinnings of the effects of central leptin regulating cardiac structural pathways remain poorly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 26, 2020 Category: Biomedical Science Authors: Blanca Rubio, Cristina Mora, Cristina Pintado, Lorena Mazuecos, Alejandro Fern ández, Virginia López, Antonio Andrés, Nilda Gallardo Source Type: research

Effects of bariatric surgery on lipid-lipoprotein profile
Most patients with severe obesity will present some lipid-lipoprotein abnormalities. The atherogenic dyslipidemia associated with severe obesity is characterized by elevated fasting and postprandial triglyceride levels, low high-density lipoprotein cholesterol concentrations, and increased proportion of small and dense low-density lipoproteins. Bariatric surgery has been proven safe and successful in terms of long-term weight loss and improvement in obesity co-existing metabolic conditions including lipid-lipoprotein abnormalities. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Marie-Eve Pich é, Isabelle Tardif, Audrey Auclair, Paul Poirier Tags: Review Source Type: research

Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester
This study sought to evaluate the maximal ketone body utilization capacity and its determinants in controls and in patients with moderate HF and reduced ejection fraction (HFrEF). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Luca Monzo, Kamil Sedlacek, Katarina Hromanikova, Lucie Tomanova, Barry A. Borlaug, Antonin Jabor, Josef Kautzner, Vojtech Melenovsky Tags: Clinical Science Source Type: research

Bariatric surgery and lipid profile
Declaration of interest: None. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Marie-Eve Pich é, Isabelle Tardif, Audrey Auclair, Paul Poirier Source Type: research

Mean and visit-to-visit variability of glycemia and left ventricular diastolic dysfunction: a longitudinal analysis of 3,025 adults with serial echocardiography
We aimed to determine the mean glucose thresholds to increase the risk of left ventricular diastolic dysfunction (LVDD) and whether visit-to-visit variability of fasting plasma glucose (FPG) and glycated hemoglobin (A1C) could independently increase the risk in a cohort with serial echocardiography. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Jiyeon Ahn, Janghyun Koh, Darae Kim, Gyuri Kim, Kyu Yeon Hur, Sang Won Seo, Kyunga Kim, Jae Hyeon Kim, Jeong Hoon Yang, Sang-Man Jin Source Type: research

Ketone body metabolism in failing heart
This study sought to evaluate the maximal ketone body utilization capacity and its determinants in controls and in patients with moderate HF and reduced ejection fraction (HFrEF).Methods and Results. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Luca Monzo, Kamil Sedlacek, Katarina Hromanikova, Lucie Tomanova, Barry A. Borlaug, Antonin Jabor, Josef Kautzner, Vojtech Melenovsky Source Type: research

Functions of amyloid precursor protein in metabolic diseases
Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely expressed in the central nervous system and peripheral tissues in the liver and pancreas, adipose tissue, and myotubes. APP can be cleaved by proteases in two different ways to produce a variety of short peptides, each with different physiological properties and functions. APP peptides generated by non-amyloidogenic processing can positively influence metabolism, while the peptides produced by amyloidogenic processing have the opposite effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 25, 2020 Category: Biomedical Science Authors: Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu Source Type: research

Moderate alcohol consumption is associated with advanced fibrosis in non-alcoholic fatty liver disease and shows a synergistic effect with type 2 diabetes mellitus
This study aimed to evaluate if moderate alcohol consumption assessed with different methods, including the biological marker phosphatidylethanol (PEth), is associated with advanced fibrosis in NAFLD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 24, 2020 Category: Biomedical Science Authors: Julia Blomdahl, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias Tags: Brief Report Source Type: research

visceral fat is associated to the severity of COVID-19
Excess visceral fat (VF) or high body mass index (BMI) are risk factors for severe COVID-19. The receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is expressed at higher levels in the VF than in the subcutaneous fat (SCF) of obese patients. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 24, 2020 Category: Biomedical Science Authors: Guillaume Favre, Kevin Legueult, Christian Pradier, Charles Raffaelli, Carole Ichai, Antonio Iannelli, Alban Redheuil, Olivier Lucidarme, Vincent Esnault Tags: Brief Report Source Type: research

Epicardial adipose tissue is associated with extent of pneumonia and adverse outcomes in patients with COVID-19
AimWe sought to examine the association of epicardial adipose tissue (EAT) quantified on chest computed tomography (CT) with the extent of pneumonia and adverse outcomes in patients with coronavirus disease 2019 (COVID-19). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 19, 2020 Category: Biomedical Science Authors: Kajetan Grodecki, Andrew Lin, Aryabod Razipour, Sebastien Cadet, Priscilla A. McElhinney, Cato Chan, Barry D. Pressman, Peter Julien, Pal Maurovich-Horvat, Nicola Gaibazzi, Udit Thakur, Elisabetta Mancini, Cecilia Agalbato, Robert Men è, Gianfranco Parat Source Type: research

Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity
Deficiency in the leptin-leptin receptor (LEPR) axis leads to severe, and potentially treatable, obesity in humans. To guide clinical decision-making, the functional relevance of variants in the LEPR gene needs to be carefully investigated.Cases and methods.We characterized the functional impact of LEPR variants identified in two cases with severe early-onset obesity (1: compound heterozygous for the novel variant p.Tyr411del and p.Trp664Arg; 2: heterozygous for p.Arg612His) by investigating leptin-mediated signaling, leptin binding, receptor expression on cell surfaces, and receptor dimerization and activation for either ...
Source: Metabolism - Clinical and Experimental - November 19, 2020 Category: Biomedical Science Authors: Franziska Voigtmann, Philipp Wolf, Kathrin Landgraf, Robert Stein, J ürgen Kratzsch, Samuel Schmitz, Rami Abou Jamra, Matthias Blüher, Jens Meiler, Annette G. Beck-Sickinger, Wieland Kiess, Antje Körner Source Type: research

Letter to the Editor: Obesity, diabetes, non-alcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease are proinflammatory hypercoagulable states associated with severe disease and thrombosis in Covid-19
Obesity [1,2], diabetes [3,4], non-alcoholic fatty liver disease (NAFLD) [5] and metabolic dysfunction associated fatty liver disease (MAFLD) [6,7] are associated with severe Disease in Covid-19. High incidence (25 –70%) of deep vein thrombosis (DVT) had been reported in patients with severe COVID-19, particularly among those admitted to the intensive care units [8–10]. Obesity (BMI ≥30), Padua score > 4 and D-dimer>1.0 ( μg/ml) were associated with DVT in COVID-19 patients in multivariant analysis [9,10]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 18, 2020 Category: Biomedical Science Authors: Dong Ji, Mingjie Zhang, Enqiang Qin, Lunqing Zhang, Jing Xu, Yudong Wang, Gregory Cheng, Feng Wang, George Lau Tags: Correspondence Source Type: research

Roles for fibroblast growth Factor-23 and α-Klotho in acute kidney injury
Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23 —α-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions beyond bone-mineral metabolism. However, although dysregulation of fibroblast growth factor-23—α-Klotho has been observed in acute kidney injury, the role of fibroblast growth factor-23—α-Klot ho in the pathophysiology of acute kidney injury remains largely unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 18, 2020 Category: Biomedical Science Authors: Pan-Pan Hu, Jing-Fu Bao, Aiqing Li Source Type: research

Obesity, Diabetes, Non-alcoholic Fatty Liver Disease and Metabolic Dysfunction Associated Fatty Liver Disease are Proinflammatory Hypercoagulable States associated with Severe Disease and Thrombosis in Covid-19
(See Table 1.) (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 18, 2020 Category: Biomedical Science Authors: Dong Ji, Mingjie Zhang, Enqiang Qin, Lunqing Zhang, Jing Xu, Yudong Wang, Gregory Cheng, Feng Wang, George Lau Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 17, 2020 Category: Biomedical Science Source Type: research

Letter to the editor: vitamin D deficiency in COVID-19: mixing up cause and consequence
Recently, Chakhtoura et al. discussed the possible role of vitamin D supplements in Coronavirus disease 2019 (COVID-19) in this journal [1]. COVID-19 is characterized by a systemic inflammatory response [2]. Based on anti-inflammatory and anti-microbial properties of vitamin D metabolites, protective effects of vitamin D supplementation in COVID-19 are suggested. This hypothesis is supported by some [3], but not all [4] cohort and case-control studies describing low 25-hydroxyvitamin D (25(OH)D) levels (i.e. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 17, 2020 Category: Biomedical Science Authors: Joost Smolders, Jody van den Ouweland, Christopher Geven, Peter Pickkers, Mathijs Kox Source Type: research

MAFLD and risk of CKD
Background/aims.Whereas nonalcoholic fatty liver disease (NAFLD) is a multisystem disease, the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and extra-hepatic diseases is not known. The aim of this cross-sectional study was to compare the prevalence of chronic kidney disease (CKD) in patients with either MAFLD or NAFLD, and then to examine the association between the presence and severity of MAFLD and CKD and abnormal albuminuria. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 16, 2020 Category: Biomedical Science Authors: Dan-Qin Sun, Yan Jin, Ting-Yao Wang, Kenneth I. Zheng, Rafael S. Rios, Hao-Yang Zhang, Giovanni Targher, Christopher D. Byrne, Wei-Jie Yuan, Ming-Hua Zheng Source Type: research

The chronic effect of cortisol on orchestrating cerebral blood flow and brain functional connectivity: evidence from Cushing's disease
Cortisol has long been considered to play a crucial role in the pathogenesis of stress-related disorders. Cushing ’s disease (CD) provides an excellent “hyperexpression model” to investigate the chronic effects of cortisol on brain physiology and cognition. Previous studies have shown that cortisol is associated with neurophysiological alterations in animal models, which has also been examined by neural a ctivity and cerebral blood flow (CBF) in human studies. However, the manner in which cortisol affects the coupling between brain activity and metabolic demand remains largely unknown. (Source: Metabolism...
Source: Metabolism - Clinical and Experimental - November 13, 2020 Category: Biomedical Science Authors: Yanyang Zhang, Tao Zhou, Shiyu Feng, Wenxin Wang, Hailong Liu, Peng Wang, Zhiqiang Sha, Xinguang Yu Source Type: research

Type VI collagen and its cleavage product, endotrophin, cooperatively regulate the adipogenic and lipolytic capacity of adipocytes
Obesity-induced adipose tissue remodeling is closely associated with systemic insulin resistance. However, the mechanistic involvement of adipocyte-derived extracellular matrix proteins under pathophysiological conditions remains unclear. Our aim was to investigate the distinctive contributions of each chain of type VI collagens (Col6) and its cleavage protein endotrophin to adipocyte functions and insulin sensitivity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 11, 2020 Category: Biomedical Science Authors: Jiyoung Oh, Chu-Sook Kim, Min Kim, Woobeen Jo, Young Hoon Sung, Jiyoung Park Source Type: research

A requirement for pak1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis
p21 (Cdc42/Rac1) activated Kinase 1 (PAK1) is a candidate susceptibility factor for type 2 diabetes (T2D). PAK1 is depleted in the islets from T2D donors, compared to control individuals. In addition, whole-body PAK1 knock out (PAK1-KO) in mice worsens the T2D-like effects of high-fat diet. The current study tested the effects of modulating PAK1 levels only in β-cells. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 9, 2020 Category: Biomedical Science Authors: Miwon Ahn, Eunjin Oh, Erika M. McCown, Xin Wang, Rajakrishnan Veluthakal, Debbie C. Thurmond Source Type: research

Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity.
The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we investigated whether CETP expression modulate adiposity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 6, 2020 Category: Biomedical Science Authors: Helena F. Raposo, Patricia Forsythe, Bruno Chausse, J úlia Z. Castelli, Pedro M. Moraes-Vieira, Valéria S. Nunes, Helena C.F. Oliveira Source Type: research

Effect of 2-deoxyglucose-mediated inhibition of glycolysis on the regulation of mTOR signaling and protein synthesis before and after high-intensity muscle contraction
Glycolysis controls mTORC1 signaling and protein synthesis. In skeletal muscle, glucose metabolism increases with both exercise/contraction intensity and volume, and therefore, high-intensity muscle contraction (HiMC) such as resistance exercise facilitates glycolysis including glucose uptake and glycogen breakdown. However, it is unknown whether glycolysis regulates HiMC-induced mTORC1 activation and increase in protein synthesis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 4, 2020 Category: Biomedical Science Authors: Takeshi Suginohara, Koki Wakabayashi, Satoru Ato, Riki Ogasawara Source Type: research

Letter to the Editor: Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: Biomarker response to hypoglycemia
Type 2 diabetes (T2D) is associated with high risk for acquiring SARS-Cov-2 infection, severe disease, acute respiratory distress syndrome and increased mortality [1,2] A recent publication reported five predictive COVID-19 severity markers that included CCL17 which was expressed in low levels in severe/critical patients at an early phase of infection; IFN λ, IL6, IP10, and CXCL9 values surged and then dropped suddenly before the development of severe disease requiring oxygen support [3]. This suggested that CCL17 may be a useful first triage marker and the other reported proteins may help to predict severe disease ...
Source: Metabolism - Clinical and Experimental - November 3, 2020 Category: Biomedical Science Authors: Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler Tags: Correspondence Source Type: research

Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: biomarker response to hypoglycemia
Type 2 diabetes (T2D) is associated with high risk for acquiring SARS-Cov-2 infection, severe disease, acute respiratory distress syndrome and increased mortality [1,2] A recent publication reported five predictive COVID-19 severity markers that included CCL17 which was expressed in low levels in severe/critical patients at an early phase of infection; IFN λ, IL6, IP10, and CXCL9 values surged and then dropped suddenly before the development of severe disease requiring oxygen support [3]. This suggested that CCL17 may be a useful first triage marker and the other reported proteins may help to predict severe disease ...
Source: Metabolism - Clinical and Experimental - November 3, 2020 Category: Biomedical Science Authors: Abu Saleh Md Moin, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler Source Type: research

Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score
This study identified T1D cases with low polygenic risk score (PRS) to better represent T1D cases with less prominent autoimmune response (T1bD), and performed a gene-based association study to identify novel susceptibility loci in two independent cohorts, characterized by low PRS. The Notch ligand Delta-like 1 gene (DLL1) was identified with genome-wide significance in both cohorts, highlighting the roles of DLL1 genetic variants in T1D patients with low PRS, supported by functional evidence from a recent study by Rubey et al. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 3, 2020 Category: Biomedical Science Authors: Jingchun Qu, Hui-Qi Qu, Jonathan Bradfield, Joseph Glessner, Xiao Chang, Lifeng Tian, Michael March, Jeffrey D. Roizen, Patrick Sleiman, Hakon Hakonarson Tags: Brief Report Source Type: research

Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
Background and aims.The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of pharmacological GIP doses remain unexplained. We aimed to characterize incretin action in vivo in subjects with normal glucose tolerance (NGT) or T2D and provide an explanation for the different insulinotropic activity of GIP and GLP-1 in T2D subjects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 30, 2020 Category: Biomedical Science Authors: Eleonora Grespan, Toni Giorgino, Andrea Natali, Ele Ferrannini, Andrea Mari Source Type: research