Association of Body mass index (BMI) with Critical COVID-19 and in-hospital Mortality: a dose-response meta-analysis
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented health crisis to the entire world. As reported, the body mass index (BMI) may play an important role in COVID-19; however, this still remains unclear. The aim of this study was to explore the association between BMI and COVID-19 severity and mortality. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 16, 2020 Category: Biomedical Science Authors: Yanbin Du, Yuan Lv, Wenting Zha, Nan Zhou, Xiuqin Hong Source Type: research

M2 macrophage markers in type 2 diabetes
Funding: No funding was received to perform this study. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 16, 2020 Category: Biomedical Science Authors: Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler Source Type: research

Parkin-mediated mitophagy in beige adipose tissue
Recently, Ramakrishnan and colleagues studied the degradation of caloric restriction-induced beige adiposes [1]. CR-induced adipose beiging is rapidly transit into white adipocytes when CR withdrawn. However, during beige-to-white transition of their CR-model, there was no significant difference between wild type and Park2 KO mouse. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 11, 2020 Category: Biomedical Science Authors: Zihang Wang, Xiaofang Zhang, Xiaodan Lu Source Type: research

Use of imaging techniques for non-invasive assessment in the diagnosis and staging of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and represent a common finding in highly prevalent metabolic disorders (i.e. type 2 diabetes, metabolic syndrome, obesity). Non-alcoholic steatohepatitis (NASH) requires liver biopsy for grading and staging the liver damage by the assessment of steatosis, inflammation and fibrosis.In parallel with the development of numerous ‘liquid’ biomarkers and algorithms that combine anthropometric and laboratory parameters, innovative hepatic imaging techniques have increasingly been developed to attempt to overcome the need for biopsy, b...
Source: Metabolism - Clinical and Experimental - September 8, 2020 Category: Biomedical Science Authors: Luca Miele, Maria A. Zocco, Fabrizio Pizzolante, Nicoletta De Matthaeis, Maria E. Ainora, Antonio Liguori, Antonio Gasbarrini, Antonio Grieco, Gianludovico Rapaccini Tags: Review Source Type: research

Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults
Fructose consumption increases risk factors for cardiometabolic disease. It is assumed that the effects of free sugars on risk factors are less potent because they contain less fructose. We compared the effects of consuming fructose, glucose or their combination, high fructose corn syrup (HFCS), on cardiometabolic risk factors. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 8, 2020 Category: Biomedical Science Authors: Bettina Hieronimus, Valentina Medici, Andrew A. Bremer, Vivien Lee, Marinelle V. Nunez, Desiree M. Sigala, Nancy L. Keim, Peter J. Havel, Kimber L. Stanhope Source Type: research

Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased risk for T2DM. In mice, hepatic Ide ablation causes glucose intolerance and insulin resistance when mice are fed a regular diet. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 8, 2020 Category: Biomedical Science Authors: Beatriz Merino, Cristina M. Fern ández-Díaz, Cristina Parrado-Fernández, Carlos M. González-Casimiro, Tamara Postigo-Casado, Carmen D. Lobatón, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo Source Type: research

YY1 deficiency in β-cells leads to mitochondrial dysfunction and diabetes in mice
The transcription factor YY1 is an important regulator for metabolic homeostasis. Activating mutations in YY1 lead to tumorigenesis of pancreatic β-cells, however, the physiological functions of YY1 in β-cells are still unknown. Here, we investigated the effects of YY1 ablation on insulin secretion and glucose metabolism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 8, 2020 Category: Biomedical Science Authors: Dalong Song, Qi Yang, Xiuli Jiang, Aijing Shan, Jingminjie Nan, Ying Lei, He Ji, Wei Di, Tianxiao Yang, Tiange Wang, Weiqing Wang, Guang Ning, Yanan Cao Source Type: research

Urinary GC –MS Steroid Metabotyping in treated Children with Congenital Adrenal Hyperplasia.
Treatment of children with classic congenital adrenal hyperplasia (CAH) is a difficult balance between hypercortisolism and hyperandrogenism. Biochemical monitoring of treatment is not well defined. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 8, 2020 Category: Biomedical Science Authors: Clemens Kamrath, Michaela F. Hartmann, J örn Pons-Kühnemann, Stefan A. Wudy Source Type: research

Interesterified palm oil impairs glucose homeostasis and induces deleterious effects in liver of Swiss mice
Interesterified fats have largely replaced the partially hydrogenated oils which are the main dietary source of trans fat in industrialized food. This process promotes a random rearrangement of the native fatty acids and the results are different triacylglycerol (TAGs) molecules without generating trans isomers. The role of interesterified fats in metabolism remains unclear. We evaluated metabolic parameters, glucose homeostasis and inflammatory markers in mice fed with normocaloric and normolipidic diets or hypercaloric and high-fat diet enriched with interesterified palm oil. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 7, 2020 Category: Biomedical Science Authors: Josiane Érica Miyamoto, Andressa Reginato, Mariana Portovedo, Raísa Magno dos Santos, Marcella Aparecida Stahl, Hervé Le Stunff, Marcia Queiroz Latorraca, Marise Auxiliadora de Barros Reis, Vanessa Cristina Arantes, Diego Luiz Doneda, Leticia Martins I Source Type: research

Association of class number, cumulative exposure, and earlier initiation of antibiotics during the first two-years of life with subsequent childhood obesity
This study aimed to determine whether there is an association between the number, duration of antibiotic exposure, timing of antibiotics initiation and childhood obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 3, 2020 Category: Biomedical Science Authors: Young Jun Park, Jooyoung Chang, Gyeongsil Lee, Joung Sik Son, Sang Min Park Source Type: research

High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study
To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 3, 2020 Category: Biomedical Science Authors: Albert Prats-Uribe, Sergi Sayols-Baixeras, Alba Fern ández-Sanlés, Isaac Subirana, Robert Carreras-Torres, Gemma Vilahur, Fernando Civeira, Jaume Marrugat, Montserrat Fitó, Álvaro Hernáez, Roberto Elosua Source Type: research

Hrd1-mediated ACLY Ubiquitination alleviate NAFLD in db/db mice
The functions of Acly in regulating nonalcoholic fatty liver disease (NAFLD) have been identified; however, the dynamic control of Acly expression under the pathological state of metabolic disorders has not been fully elucidated. Previous studies reported an ubiquitin-proteasome –mediated degradation of Acly, but the mechanism is still largely unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 1, 2020 Category: Biomedical Science Authors: Kai Li, Kaini Zhang, Hai Wang, Yangyang Wu, Nuoqi Chen, Jinfeng Chen, Chen Qiu, Pengpeng Cai, Min Li, Xiubin Liang, Dongming Su Source Type: research

Effect of long-term testosterone therapy on molecular regulators of skeletal muscle mass and fibre-type distribution in aging men with subnormal testosterone
Long-term testosterone replacement therapy (TRT) increases muscle mass in elderly men with subnormal testosterone levels. However, the molecular mechanisms underlying this effect of TRT on protein balance in human skeletal muscle in vivo remain to be established. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 24, 2020 Category: Biomedical Science Authors: Rikke Kruse, Stine J. Petersson, Louise L. Christensen, Jonas M. Kristensen, Rugivan Sabaratnam, Niels Ørtenblad, Marianne Andersen, Kurt Højlund Source Type: research

Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: population-based, prospective cohort study
We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study.Methods and Study Design.Participants (N  = 337,802, aged 56.4 ± 8.1 yr; 55.1% women) underwent biomedical assessments at baseline as part of the UK Biobank prospective cohort study. The outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 21, 2020 Category: Biomedical Science Authors: Mark Hamer, Catharine R. Gale, G. David Batty Source Type: research

Obesity & genetic predisposition with COVID-19
We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data.Research Design and Methods.We analyzed data from 489,769 adults enrolled in the UK Biobank —a population-based cohort study. The exposures of interest are BMI categories and central obesity (e.g., larger waist circumference). Using genome-wide genotyping data, we also computed polygenic risk scores (PRSs) that represent an individual's overall genetic risk for each obesity trait. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 21, 2020 Category: Biomedical Science Authors: Zhaozhong Zhu, Kohei Hasegawa, Baoshan Ma, Michimasa Fujiogi, Carlos A. Camargo, Liming Liang Source Type: research

β-Cell impairment and clinically meaningful alterations in Glycemia in obese youth across the glucose tolerance Spectrum
Background/aims.In obese youth, it is not clear what degree of β-cell impairment translates to glucose dysregulation commensurate with shifts from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to type 2 diabetes. We aimed to investigate the quantitative relationship between β-cell (clamp-measured disposition index [DI]) and OGTT glucose a rea under the curve (G-AUC) in obese youth across the spectrum of glucose tolerance. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 21, 2020 Category: Biomedical Science Authors: Joon Young Kim, Hala Tfayli, Fida Bacha, SoJung Lee, Nour Gebara, Silva Arslanian Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 20, 2020 Category: Biomedical Science Source Type: research

Cardiovascular outcomes trials with incretin-based medications: a critical review of data available on GLP-1 receptor agonists and DPP-4 inhibitors
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors are so called “incretin-based therapies” (IBTs) that represent innovative therapeutic approaches and are commonly used in clinical practice for the treatment of type 2 diabetes mellitus (T2DM). The cardiovascular outcome trials (CVOTs) have provided useful information that has helped to shape changes in clini cal practice guidelines for the management of T2DM. At the same time, the mechanisms that may explain the nonglycemic and cardiovascular (CV) benefits of these medications are still being explored. (Source: M...
Source: Metabolism - Clinical and Experimental - August 15, 2020 Category: Biomedical Science Authors: Alexandros Sachinidis, Dragana Nikolic, Anca Pantea Stoian, Nikolaos Papanas, Omer Tarar, Ali A. Rizvi, Manfredi Rizzo Source Type: research

Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology
The objective of the present study was to characterize the effects of AGPAT2 deficiency in brown adipocyte differentiation. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 15, 2020 Category: Biomedical Science Authors: Pablo J. Tapia, Ana-Mar ía Figueroa, Verónica Eisner, Lila González-Hódar, Fermín Robledo, Anil K. Agarwal, Abhimanyu Garg, Víctor Cortés Source Type: research

Revealing the role of Peroxisome Proliferator-Activated Receptor β/δ in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD), a form of chronic liver disease that occurs in individuals with no significant alcohol abuse, has become an increasing concern for global health. NAFLD is defined as the presence of lipid deposits in hepatocytes and it ranges from hepatic steatosis (fatty liver) to steatohepatitis. Emerging data from both preclinical studies and clinical trials suggest that the peroxisome proliferator-activated receptor (PPAR) β/δ plays an important role in the control of carbohydrate and lipid metabolism in liver, and its activation might hinder the progression of NAFLD. (Source: Metabo...
Source: Metabolism - Clinical and Experimental - August 15, 2020 Category: Biomedical Science Authors: Mohammad Zarei, David Aguilar-Recarte, Xavier Palomer, Manuel V ázquez-Carrera Source Type: research

Inhibition of miR-153, an IL-1 β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes
Systemic levels of up-regulated IL-1 β and IL-1 receptors promote the pathogenesis of inflammation-associated diabetes. IL-1 receptor antagonist (IL-Ra) has shown slightly elevated beta cell function in patients with type 2 diabetes without significant improvement of hyperglycaemia. We investigated whether miR-153, an IL-1β responsiv e miRNA, could mimic IL-1β effects and whether its interruption would improve blood glucose control then offer an assistant curative approach to inflammation-associated diabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 11, 2020 Category: Biomedical Science Authors: Yi Sun, Shixiang Zhou, Ying Shi, Yuncai Zhou, Yan Zhang, Kerong Liu, Yunxia Zhu, Xiao Han Source Type: research

Perturbation of the circadian clock and pathogenesis of NAFLD
All living organisms including humans, experience changes in the light exposure generated by the Earth's rotation. In anticipation of this unavoidable geo-physical variability, and to generate an appropriate biochemical response, species of many phyla, including mammals have evolved a nearly 24-h endogenous timing device known as the circadian clock (CC), which is self-sustained, cell autonomous and is present in every cell type. At the heart of the ‘clock’ functioning resides the CC-oscillator, an elegantly designed transcriptional-translational feedback system. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 10, 2020 Category: Biomedical Science Authors: Atish Mukherji, Mayssa Dachraoui, Thomas F. Baumert Source Type: research

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPAR α, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidative tissues and regulate genes involved in substrate delivery and oxidative phosphorylation (OXPHOS) and regulation of energy homeostasis. In contrast, PPARγ is more important in lipogenesis and lipid synthesis, with highest expression levels in white adipose tissue (WAT). (Source: Metabol...
Source: Metabolism - Clinical and Experimental - August 10, 2020 Category: Biomedical Science Authors: Anthos Christofides, Eirini Konstantinidou, Chinmay Jani, Vassiliki A. Boussiotis Source Type: research

Disrupted Endothelial Cell Heterogeneity and Network Organization Impair Vascular Function in Prediabetic Obesity
Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vascular alterations that give rise to cardiovascular disease. However, the mechanisms that link weight gain to endothelial dysfunction are ill-defined. Increasing evidence suggests that endothelial cells are not a population of uniform cells but are highly heterogeneous and are organized as a communicating multicellular network that controls vascular function. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 10, 2020 Category: Biomedical Science Authors: Calum Wilson, Xun Zhang, Matthew D. Lee, Margaret MacDonald, Helen R. Heathcote, Nasser M.N. Alorfi, Charlotte Buckley, Sharron Dolan, John G. McCarron Source Type: research

Empagliflozin alleviated mitochondrial fission via decreasing PGAM5.
Background and Purpose.Excessive mitochondrial fission was observed in diabetic kidney disease (DKD). Phosphoglycerate mutase family member 5 (PGAM5) plays an important role in mitochondrial fission by dephosphorylating the dynamin-related protein 1 at Ser637 (DRP1S637). Whether PGAM5 participates in the mitochondrial fission in diabetic renal tubular injury is unknown. Clinical trials have observed encouraging effect of Sodium-glucose cotransporter 2 (SGLT2) inhibitors on DKD though the underling mechanisms remain unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 7, 2020 Category: Biomedical Science Authors: Xiangyang Liu, Chaofei Xu, Linxin Xu, Xiaoyu Li, Hongxi Sun, Mei Xue, Ting Li, Xiaochen Yu, Bei Sun, Liming Chen Source Type: research

Alternate-day fasting, obesity, and metabolic syndrome
Background& aims.Alternate-day fasting (ADF) is related to weight reduction, lowered risks of weight regain, and relative lean body mass preservation compared to continuous energy restriction. This meta-analysis aimed to assess the effects of ADF on obesity-related factors and cardiometabolic risk factors in adults. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 7, 2020 Category: Biomedical Science Authors: Jihyun Park, Young-Gyun Seo, Yu-Jin Paek, Hong Ji Song, Kyung Hee Park, Hye-Mi Noh Source Type: research

Generation and characterisation of C-terminally stabilised PYY molecules with potential in vivo NPYR2 activity.
Activation of neuropeptide Y2 receptors (NPYR2) by the N-terminally truncated, dipeptidyl peptidase-4 (DPP-4) generated, Peptide YY (PYY) metabolite, namely PYY(3-36), results in satiating actions. However, PYY(3-36) is also subject to C-terminal enzymatic cleavage, which annuls anorectic effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 7, 2020 Category: Biomedical Science Authors: Ryan A. Lafferty, Neil Tanday, Peter R. Flatt, Nigel Irwin Source Type: research

Making progress towards a better pathophysiological understanding and more promising therapeutic options for treating non-alcoholic steatohepatitis (NASH) / DASH (dysmetabolism associated steatohepatitis)
The prevalence of non-alcoholic fatty liver disease (NAFLD) and its advanced form, i.e. non-alcoholic steatohepatitis (NASH), in the general population are increasing worldwide, reaching 45 and 6.5%, respectively [1,2]. NAFLD, and especially NASH, have been associated with increased cardiovascular (CV) morbidity and mortality, as well as all-cause death and cancer development [3 –12]. Furthermore, there is a bidirectional relationship between NAFLD/NASH and type 2 diabetes mellitus (T2DM). Indeed, in T2DM patients, the prevalence of NAFLD may exceed 70%, whereas for NASH it can reach 50% [13]. (Source: Metabolism - C...
Source: Metabolism - Clinical and Experimental - August 6, 2020 Category: Biomedical Science Authors: Niki Katsiki, Christos Mantzoros Tags: Editorial Source Type: research

Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction
Proprotein convertase subtilisin/kexin (PCSK) family member 3 (FURIN) has been suggested to be involved in the development of atherosclerosis. The aim of this study was to investigate the prognostic implication of FURIN in patients after acute myocardial infarction (AMI). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 27, 2020 Category: Biomedical Science Authors: Yun Kai Wang, Jia Ni Tang, Lu Han, Xian Dong Liu, Yun Li Shen, Chun Yu Zhang, Xue Bo Liu Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Source Type: research

Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19
Obesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitant presence of other comorbidities. However, all reports only focus on BMI, an indirect marker of body fat.AimTo explore the impact on COVID-19 severity of abdominal fat as a marker of body composition easily collected in patients undergoing a chest CT scan. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Authors: Mikiko Watanabe, Damiano Caruso, Dario Tuccinardi, Renata Risi, Marta Zerunian, Michela Polici, Francesco Pucciarelli, Mariarita Tarallo, Lidia Strigari, Silvia Manfrini, Stefania Mariani, Sabrina Basciani, Carla Lubrano, Andrea Laghi, Lucio Gnessi Source Type: research

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose spectrum covers clinical, histological and pathophysiological developments ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and liver fibrosis, potentially evolving into cirrhosis, hepatocellular carcinoma and liver failure. Liver biopsy remains the gold standard for diagnosing NAFLD, while there are no specific treatments. An ever-increasing number of high-throughput Omics investigations on the molecular pathobiology of NAFLD at the cellular, tissue and system levels produce comprehensive biochemical patient snapshot...
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Authors: Nikolaos Perakakis, Konstantinos Stefanakis, Christos S. Mantzoros Source Type: research

Muscle area and density and risk of all-cause mortality: the multi-ethnic study of atherosclerosis
Lean muscle plays critical roles in physical functioning and metabolism. However, little is known regarding associations between muscle and mortality in adults. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Authors: Britta Larsen, John Bellettiere, Matthew Allison, Robyn L. McClelland, Iva Miljkovic, Chantal Vella, Pamela Ouyang, Kimberly R. De-guzman, Michael Criqui, Jonathan Unkart Source Type: research

Commentary. Eliminating Vitamin D Deficiency During the COVID-19 Pandemic: A Call to Action
Long known as critical for bone health, and increasingly recognized as important for cardiometabolic and other non-skeletal outcomes, vitamin D has most recently attracted interest for its possible protective role against COVID-19. If vitamin D is beneficial in this regard —and accumulating evidence suggests that it may be—then the high prevalence of vitamin D deficiency in the United States and globally, especially among nonwhite racial/ethnic groups, is cause for heightened concern and should be rectified expeditiously. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Authors: JoAnn E. Manson, Shari S. Bassuk Source Type: research

Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice
Clinical trials and animal studies have shown that sodium-glucose co-transporter type 2 (SGLT2) inhibitors improve pancreatic beta cell function. Our study aimed to investigate the effect of dapagliflozin on islet morphology and cell phenotype, and explore the origin and possible reason of the regenerated beta cells. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 23, 2020 Category: Biomedical Science Authors: Rui Wei, Xiaona Cui, Jin Feng, Liangbiao Gu, Shan Lang, Tianjiao Wei, Jin Yang, Junling Liu, Yunyi Le, Haining Wang, Kun Yang, Tianpei Hong Source Type: research

Making progress in nonalcoholic fatty liver disease (NAFLD) as we are transitioning from the era of NAFLD to dys-metabolism associated fatty liver disease (DAFLD)
This special issue of “Metabolism, Clinical and Experimental” is dedicated to nonalcoholic fatty liver disease (NAFLD), a disease closely linked with the insulin resistance (IR) syndrome or metabolic syndrome (MetS) [1] and its related comorbidities, including obesity [2], type 2 diabetes mellitus (T2DM) [3], dyslipi demia [4] and cardiovascular disease [5]. The prevalence of NAFLD has been estimated to be about 25%, being higher in selected populations with genetic predisposition (e.g. Hispanics), or certain metabolic traits (e.g. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 20, 2020 Category: Biomedical Science Authors: Stergios A. Polyzos, Christos S. Mantzoros Source Type: research

Commentary: COVID-19 and Obesity: Exploring Biologic Vulnerabilities, Structural Disparities, and Weight Stigma
Obesity has emerged as a risk factor for hospitalization, intensive care, and mortality among patients with COVID-19 [1-9]. These risk signals persist after adjusting for age, sex, and major comorbidities including diabetes and chronic cardiac, pulmonary, and kidney disease [1, 2]. Given this evidence, the United States Centers for Disease Control and Prevention has highlighted obesity (BMI ≥30 kg/m2) as a risk factor for severe COVID-19 [10]. We explore multiple causative pathways by which obesity may worsen risk. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 13, 2020 Category: Biomedical Science Authors: Matthew J. Townsend, Theodore K. Kyle, Fatima C. Stanford Tags: COVID-19, obesity, and weight stigma Source Type: research

The role of visceral adiposity in the severity of COVID-19: highlights from a unicenter cross-sectional pilot study in Germany
Overall obesity has recently been established as an independent risk factor for critical illness in patients with coronavirus disease 2019 (COVID-19). The role of fat distribution and especially that of visceral fat, which is often associated with metabolic syndrome, remains unclear. Therefore, this study aims at investigating the association between fat distribution and COVID-19 severity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 13, 2020 Category: Biomedical Science Authors: Antonia Petersen, Keno Bressem, Jakob Albrecht, Hans-Martin Thie ß, Janis Vahldiek, Bernd Hamm, Marcus R. Makowski, Alexandra Niehues, Stefan Niehues, Lisa C. Adams Source Type: research

Legacy effect of intensive glucose control on major adverse cardiovascular outcome: systematic review and meta-analyses of trials according to different scenarios
Early and intensive glycaemic control provides long-term protection against the development of microvascular complications, a phenomenon defined legacy effect. Whether a legacy effect of high glucose exists also on macrovascular endpoints is uncertain. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 3, 2020 Category: Biomedical Science Authors: Francesco Prattichizzo, Paola de Candia, Valeria De Nigris, Antonio Nicolucci, Antonio Ceriello Source Type: research

Defects in high density lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of hepatocyte nuclear factor 4 α
Aberrant concentration, structure and functionality of High Density Lipoprotein (HDL) is associated with many prevalent diseases, including cardiovascular disease and non-alcoholic fatty liver disease (NAFLD). Mice with liver-specific ablation of Hnf4 α (H4LivKO) present steatosis and dyslipidemia by mechanisms that are not completely understood. The aim of this study was to explore the role of liver Hnf4α in HDL metabolism and the development of steatosis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 2, 2020 Category: Biomedical Science Authors: Efstathia Thymiakou, Alaa Othman, Thorsten Hornemann, Dimitris Kardassis Source Type: research

SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes
Iron is finely regulated due to its vital roles in organisms and the peroxidase reactivity if excess. Solute Carrier Family 46 Member 1 (SLC46A1), also named PCFT/HCP1, is the main importer of heme ‑iron in the intestine, but has a high abundance in the liver. Since the liver has a central role in iron homeostasis, whether SLC46A1 regulates hepatic iron metabolism is of interest to be identified. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 1, 2020 Category: Biomedical Science Authors: Hongxia Li, Dongyao Wang, Huiwen Wu, Hui Shen, Diya Lv, Yinyin Zhang, Hongtao Lu, Jianxin Yang, Yuxiao Tang, Min Li Source Type: research

Early Adaptive Thermogenesis Is a Determinant of Weight Loss after Six Weeks of Caloric Restriction in Overweight Subjects
Adaptive thermogenesis during prolonged energy deficit refers to the greater than expected reduction in energy expenditure (EE) independent of concomitant loss of metabolically active body mass. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2020 Category: Biomedical Science Authors: Sascha Heinitz, Tim Hollstein, Takafumi Ando, Mary Walter, Alessio Basolo, Jonathan Krakoff, Susanne B. Votruba, Paolo Piaggi Source Type: research

Functional loss of pancreatic islets in type 2 diabetes: how can we halt it?
The loss of beta-cell functional mass is a necessary and early condition in the development of type 2 diabetes (T2D). In T2D patients, beta-cell function is already reduced by about 50% at diagnosis and further declines thereafter. Beta-cell mass is also reduced in subjects with T2D, and islets from diabetic donors are smaller compared to non-diabetic donors. Thus, beta-cell regeneration and/or preservation of the functional islet integrity should be highly considered for T2D treatment and possibly cure. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2020 Category: Biomedical Science Authors: Nicola Marrano, Giuseppina Biondi, Angelo Cignarelli, Sebastio Perrini, Luigi Laviola, Francesco Giorgino, Annalisa Natalicchio Source Type: research

Commentary: From mice to men: in search for dietary interventions to form the background on which pharmacotherapy for non-alcoholic fatty liver disease should be based
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2020 Category: Biomedical Science Authors: Emir Muzurovi ć, Dimitri P. Mikhailidis, Christos Mantzoros Source Type: research

Letter to the editor: Unexpected high mortality in COVID-19 and diabetic ketoacidosis
Patients with diabetes mellitus (DM) appear to be at a greater risk for severe symptoms and complications, including death from COVID-19 [1,2]. DM is a common comorbidity in patients affected with COVID-19 and may cause ketosis, ketoacidosis, and diabetic ketoacidosis (DKA) [3]. In patients with DM, acute hyperglycemic crises such as DKA and hyperosmolar hyperglycemic state can be precipitated by an acute illness such as COVID-19 and it can result in catastrophic outcomes. At Jacobi Medical Center, an epicenter of the COVID-19 pandemic crisis, we noted that a significant proportion of patients with COVID-19 also presented ...
Source: Metabolism - Clinical and Experimental - June 23, 2020 Category: Biomedical Science Authors: Natalia Chamorro-Pareja, Sahana Parthasarathy, Jayabhargav Annam, Julie Hoffman, Christine Coyle, Preeti Kishore Source Type: research

Unexpected high mortality in COVID-19 and diabetic ketoacidosis
TO THE EDITOR: Patients with diabetes mellitus (DM) appear to be at a greater risk for severe symptoms and complications, including death from COVID-19 [1,2]. DM is a common comorbidity in patients affected with COVID-19 and may cause ketosis, ketoacidosis, and diabetic ketoacidosis (DKA) [3]. In patients with DM, acute hyperglycemic crises such as DKA and hyperosmolar hyperglycemic state can be precipitated by an acute illness such as COVID-19 and it can result in catastrophic outcomes. At Jacobi Medical Center, an epicenter of the COVID-19 pandemic crisis, we noted that a significant proportion of patients with COVID-19 ...
Source: Metabolism - Clinical and Experimental - June 23, 2020 Category: Biomedical Science Authors: Natalia Chamorro-Pareja, Sahana Parthasarathy, Jayabhargav Annam, Julie Hoffman, Christine Coyle, Preeti Kishore Source Type: research

Ubiquitination of PPAR-gamma by pVHL inhibits ACLY expression and lipid metabolism, is implicated in tumor progression
Intracellular lipid accumulation is associated with various diseases, particularly cancer. Mitochondrial dysfunction is considered as a cause of lipid accumulation; however, the related underlying mechanism remains unclear.FindingsWe found that Von Hippel-Lindau (VHL)-deficiency led to lipid accumulation and mitochondrial dysfunction in renal cell carcinoma cells. Moreover, VHL downregulated ATP-citrate lyase (ACLY), a key enzyme in de novo lipid synthesis, at the transcriptional level, which inhibited intracellular lipid accumulation in human renal carcinoma tissues. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 23, 2020 Category: Biomedical Science Authors: Kyung Hee Noh, Hyun Mi Kang, Wonbeak Yoo, Yoohong Min, Daehun Kim, Mijin Kim, Sihyung Wang, Jung Hwa Lim, Cho-Rok Jung Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 22, 2020 Category: Biomedical Science Source Type: research

Letter to the editor: Immunomodulation by phosphodiesterase-4 inhibitor in COVID-19 patients
We read with interest the commentary by Dalamaga and colleagues [1] that brought to the attention of the scientific community the potential role of Phosphodiesterase 4 (PDE4) inhibitors in the treatment of SARS-CoV-2 infection. Coronavirus disease 2019 (COVID-19) is associated with a variable clinical picture, ranging from mild “flu-like” cases to severe interstitial pneumonia leading to fatal respiratory insufficiency. This heterogeneity is attributed to the degree of the host's inflammatory reaction and cytokine production [2]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 20, 2020 Category: Biomedical Science Authors: Alessandro Santaniello, Barbara Vigone, Lorenzo Beretta Source Type: research

Letter to the editor: Immunomodulation by phsphodiesterase-4 inhibitor in COVID-19 patients
we read with interest the commentary by Dalamaga and colleagues [1] that brought to the attention of the scientific community the potential role of Phosphodiesterase 4 (PDE4) inhibitors in the treatment of SARS-CoV-2 infection. Coronavirus disease 2019 (COVID-19) is associated with a variable clinical picture, ranging from mild “flu-like” cases to severe interstitial pneumonia leading to fatal respiratory insufficiency. This heterogeneity is attributed to the degree of the host’s inflammatory reaction and cytokine production [2]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 20, 2020 Category: Biomedical Science Authors: Alessandro Santaniello, Barbara Vigone, Lorenzo Beretta Source Type: research