Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 22, 2019 Category: Biomedical Science Source Type: research

Angiotensin-(1 –7), Adipokines and Inflammation
Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the Renin-Angiotensin System (RAS) components that are especially activated in some diseases with increased production of Angiotensin II and several pro-inflammatory hormones. On the other hand, RAS also expresses Angiotensin-(1 –7), which is now recognized as the main peptide on counteracting Ang II effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 21, 2019 Category: Biomedical Science Authors: Deborah Farias Lelis, Daniela Fernandes Freitas, Amanda Souto Machado, Tha ísa Soares Crespo, Sérgio Henrique Sousa Santos Source Type: research

SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
Background and Purpose.In addition to the central nervous system-mediated action, leptin also directly induces fatty acid oxidation in skeletal muscle. Rapid induction of FAO by leptin is mediated by the AMP-activated protein kinase (AMPK) pathway, but the mechanism of prolonged FAO by leptin was previously unknown. In an earlier study, we showed that free fatty acids increase transcription of small ubiquitin-like modifier (SUMO) specific protease 2 (SENP2) in skeletal muscle, and that SENP2 stimulates expression of FAO-associated enzymes by deSUMOylating peroxisome proliferator-activated receptors, PPAR δ and PPAR&g...
Source: Metabolism - Clinical and Experimental - March 19, 2019 Category: Biomedical Science Authors: Young Do Koo, Ji Seon Lee, Seung-Ah Lee, Paula G.F. Quaresma, Ratan Bhat, William G. Haynes, Young Joo Park, Young-Bum Kim, Sung Soo Chung, Kyong Soo Park Source Type: research

Effects of Liraglutide Plus Phentermine in Adults with Obesity Following 1 Year of Treatment by Liraglutide Alone: A Randomized Placebo-Controlled Pilot Trial
This pilot study evaluated whether adding phentermine to liraglutide would induce further weight loss in participants who had previously lost weight with liraglutide alone.Subjects/MethodsParticipants were 45 adults with obesity (75.6% female, 55.6% white, body mass index = 34.3 ±4.7 kg/m2) who had lost an average of 12.6±6.8% of initial weight during a prior 1-year randomized trial with liraglutide and intensive behavioral treatment. Participants were re-randomized, in a double-blinded fashion, to liraglutide 3.0mg plus phentermine 15.0mg (liraglutide-phentermine) or lir aglutide plus placebo (liraglutide-pl...
Source: Metabolism - Clinical and Experimental - March 19, 2019 Category: Biomedical Science Authors: Jena Shaw Tronieri, Thomas A. Wadden, Olivia A. Wals, Robert I. Berkowitz, Naji Alamuddin, Kathryn Gruber, Sharon Leonard, Ariana M. Chao Source Type: research

Epicardial fat: the role of testosterone and lipid metabolism in a cohort of patients with Klinefelter syndrome
Klinefelter syndrome (KS), in which subjects have additional copies of X chromosomes, is the most common male sex chromosome abnormality, with a prevalence of 1 in 660 and an incidence of about 1 in 500-700 newborns. Its sign and symptoms include infertility, generally low testosterone levels, and an increased prevalence of obesity and metabolic syndrome. Epicardial fat thickness (EFT) reflects visceral adiposity rather than general obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 13, 2019 Category: Biomedical Science Authors: S. Granato, G. Barbaro, M.R. Di Giorgio, F.M. Rossi, C. Marzano, F. Impronta, M. Spaziani, A. Anzuini, A. Lenzi, A.F. Radicioni Source Type: research

Systemic PPAR γ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility
The peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response and development. Numerous studies relying on tissue-specific invalidation of the Pparg gene have shown distinct facets of its activity, whereas the effects of its systemic inactivation rema in unexplored due to embryonic lethality. By maintaining PPARγ expression in the placenta, we recently generated a mouse model carrying Pparg full body deletion (PpargΔ/Δ), which in contrast to a previously published model is totally deprived of any form...
Source: Metabolism - Clinical and Experimental - March 13, 2019 Category: Biomedical Science Authors: Federica Gilardi, Carine Winkler, Laure Quignodon, Jean-Gael Diserens, Barbara Toffoli, Mariano Schiffrin, Chiara Sardella, Fr édéric Preitner, Béatrice Desvergne Source Type: research

GAD65 antibodies and incident type 2 Diabetes mellitus
Context.Antibodies to the 65kD isoform of glutamic acid decarboxylase (GAD65) have been associated with incident Type 2 Diabetes Mellitus, however results are inconsistent. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 7, 2019 Category: Biomedical Science Authors: Anitra D.M. Koopman, Joline W. Beulens, Ellis Voerman, Simone P. Rauh, Amber A. van der Heijden, Timothy J. McDonald, Marlous Gort, Femke Rutters Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 4, 2019 Category: Biomedical Science Source Type: research

Acknolwedgement to Reviewers 2018
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 4, 2019 Category: Biomedical Science Source Type: research

PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9
Low-density lipoprotein cholesterol (LDL-C) is the hallmark of atherosclerotic cardiovascular diseases. The hepatic LDL receptor (LDLR) plays an important role in clearance of circulating LDL-C. PCSK9 facilitates degradation of LDLR in the lysosome and antagonizing PCSK9 has been successfully used in the clinic to reduce blood LDL-C level. Here we identify a new player that modulates LDLR interaction with PCSK9, thus controlling LDLR degradation and cholesterol homeostasis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 1, 2019 Category: Biomedical Science Authors: Meiqin Huang, Zilong Zhao, Qianqian Cao, Xue You, Siying Wei, Jingyu Zhao, Meijuan Bai, Yan Chen Source Type: research

Extracellular vesicles: squeezing every drop of regenerative potential of umbilical cord blood
Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which include a heterogeneous pool of membranous structures secreted by the vast majority of cells, can serve as powerful tools for cell-free therapy due to precise multifunctional molecular cargoes. In this issue, Hu et al. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 1, 2019 Category: Biomedical Science Authors: Santiago Roura, Joaquim Vives Source Type: research

Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study
To investigate the association between biomarkers of inflammation and metabolic dysregulation and cancer mortality by obesity status. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 22, 2019 Category: Biomedical Science Authors: Daniel T. Dibaba, Suzanne E. Judd, Susan C. Gilchrist, Mary Cushman, Maria Pisu, Monika Safford, Tomi Akinyemiju Source Type: research

Combination of exercise and calorie restriction exerts greater efficacy on Cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation
Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and cardiac mitochondrial function. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of LV function. Although either caloric restriction (CR) or exercise (Ex) are shown to strongly affect metabolic status and LV function, the combined effects of exercise and calorie restriction on cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca2+]i transient hom...
Source: Metabolism - Clinical and Experimental - February 21, 2019 Category: Biomedical Science Authors: Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn Source Type: research

Beyond glycemic control: new guidance on cardio-renal protection
Commentary. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 21, 2019 Category: Biomedical Science Authors: Athanasios D. Anastasilakis, Elliot Sternthal, Christos S. Mantzoros Source Type: research

Role of PCSK9 in PCOS
Proprotein convertase subtilisin / kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 12, 2019 Category: Biomedical Science Authors: Meijiao Wang, Dan Zhao, Liangzhi Xu, Wenjing Guo, Li Nie, Yi Lei, Yun Long, Min Liu, Yichen Wang, Xueqin Zhang, Li Zhang, Hanna Li, Jinhu Zhang, Dongzhi Yuan, Limin Yue Source Type: research

Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in the cholesterol metabolism by negatively regulating the low-density lipoprotein receptor (LDLR). Lipid metabolic and ovarian disorders are the common clinical manifestation of polycystic ovary syndrome (PCOS). Here, we intended to elucidate the role of PCSK9 in the pathogenesis of PCOS conducted on a human population in case-control design and animal part in an interventional study. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 12, 2019 Category: Biomedical Science Authors: Meijiao Wang, Dan Zhao, Liangzhi Xu, Wenjing Guo, Li Nie, Yi Lei, Yun Long, Min Liu, Yichen Wang, Xueqin Zhang, Li Zhang, Hanna Li, Jinhu Zhang, Dongzhi Yuan, Limin Yue Tags: Basic Science Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 9, 2019 Category: Biomedical Science Source Type: research

A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments
GTP cyclohydrolase I (GTPCH) deficiency could impair the synthesis of tetrahydrobiopterin and causes metabolic diseases involving phenylalanine catabolism, neurotransmitter synthesis, nitric oxide production and so on. Though improvements could be achieved by tetrahydrobiopterin and neurotransmitter precursor levodopa supplementation, residual motor and mental deficits remain in some patients. An appropriate GTPCH deficiency animal model with clinical symptoms, especially the motor impairments, is still not available for mechanism and therapy studies yet. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 8, 2019 Category: Biomedical Science Authors: Xiaoling Jiang, Huazhen Liu, Yongxian Shao, Mingzhi Peng, Wen Zhang, Duan Li, Xiuzhen Li, Yanna Cai, Ting Tan, Xinshuo Lu, Jianan Xu, Xueying Su, Yunting Lin, Zongcai Liu, Yonglan Huang, Chunhua Zeng, Ya-ping Tang, Li Liu Source Type: research

Effects of isolated soy protein and strength exercise training on exercise performance and biochemical profile in postpartum mice
Postpartum women are at an increased risk for obesity and metabolic diseases because of excessive weight gain during pregnancy and weight retention after delivery. Maintenance of good nutrition and regular physical activity is used as a therapeutic approach for promotion of health and well-being in postpartum women. The aim of this study is to assess the independent and additive effects of isolated soy protein (ISP) and strength exercise training (ET) on weight management, exercise performance and health maintenance in postpartum mice. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 4, 2019 Category: Biomedical Science Authors: Li Wei, Ya-Ting Wen, Mon-Chien Lee, Hua-Ming Ho, Chi-Chang Huang, Yi-Ju Hsu Source Type: research

LncRNA MEG3 functions as a ceRNA in regulating hepatic lipogenesis by competitively binding to miR-21 with LRP6
Hepatic lipogenesis dysregulation is essential for the development of non-alcoholic fatty liver disease (NAFLD). Emerging evidence indicates the importance of the involvement of long non-coding RNAs (LncRNAs) in lipogenesis. However, the specific mechanism underlying this process is not clear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 1, 2019 Category: Biomedical Science Authors: Peng Huang, Fei-zhou Huang, Huai-zheng Liu, Tian-yi Zhang, Ming-shi Yang, Chuan-zheng Sun Source Type: research

The tRNA-associated dysregulation in diabetes mellitus
Diabetes mellitus (DM) is a complex endocrine and metabolic disorder for human health and well-being. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease. Transfer RNAs (tRNAs) are considered to mainly participate in protein translation and may contribute to complex human pathologies. Although the molecular mechanisms remain, for the most part, unknown, accumulating evidence indicates that tRNAs play a vital role in the pathogenesis of DM. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 31, 2019 Category: Biomedical Science Authors: Zheng Zhou, Bao Sun, Shiqiong Huang, Wenrui Jia, Dongsheng Yu Source Type: research

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity
Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways have also shown to predict accelerated aging. Using information from the Long Life Family Study (LLFS), a multi-center study of two-generation families selected for exceptional longevity, we developed an indicator of healthy metabolism to determine whether metabolic health was more prevalent in a subset of LLFS families and whether it was heritable and associated with other metrics of heal...
Source: Metabolism - Clinical and Experimental - January 30, 2019 Category: Biomedical Science Authors: Megan M. Marron, Iva Miljkovic, Robert M. Boudreau, Kaare Christensen, Mary F. Feitosa, Joseph H. Lee, Paola Sebastiani, Bharat Thyagarajan, Mary K. Wojczynski, Joseph M. Zmuda, Anne B. Newman, KatherineM. Detre Source Type: research

Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes
Chronic ER stress and dysfunction is a hallmark of obesity and a critical contributor to metaflammation, abnormal hormone action and altered substrate metabolism in metabolic tissues, such as liver and adipocytes. Lack of STAMP2 in lean mice induces inflammation and insulin resistance on a regular diet, and it is dysregulated in the adipose tissue of obese mice and humans. We hypothesized that the regulation of STAMP2 is disrupted by ER stress. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2019 Category: Biomedical Science Authors: J ørgen Sikkeland, Torstein Lindstad, Hatice Zeynep Nenseth, Xavier Dezitter, Su Qu, Ridhwan M. Muhumed, Meric Erikci Ertunc, Margaret F. Gregor, Fahri Saatcioglu Source Type: research

Diagnosis of disorders of glucose tolerance in women with polycystic ovary syndrome (PCOS) at a tertiary care center: fasting plasma glucose or oral glucose tolerance test?
The risk of developing prediabetes and type 2 diabetes (dysglycemia) may be increased in women with PCOS. Whether an oral glucose tolerance test (OGTT) should be performed routinely in all PCOS women at presentation or should be recommended only to a selected subset of patients is still controversial. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2019 Category: Biomedical Science Authors: A.E. Ortiz-Flores, M. Luque-Ram írez, E. Fernández-Durán, F. Alvarez-Blasco, H.F. Escobar-Morreale Source Type: research

Core body temperature, energy expenditure, and epinephrine during fasting, eucaloric feeding, and overfeeding in healthy adult men: evidence for a ceiling effect for human thermogenic response to diet
In homeothermic animals, approximately 50% of daily energy expenditure (EE) is spent to maintain a consistent core body temperature (CBT). In humans, little is known about CBT responses to feeding and overfeeding and their relationship to diet-related changes in EE. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2019 Category: Biomedical Science Authors: Karyne L. Vinales, Brittany Begaye, Marie S. Thearle, Jonathan Krakoff, Paolo Piaggi Source Type: research

Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study
Muscle weakness is followed by insulin resistance which is associated with metabolic disorders leading to metabolic syndrome (MetS). Therefore, muscle strength decline may be associated with MetS. The aim of this study was to investigate the relationships between muscle strength and MetS and its separate components. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 25, 2019 Category: Biomedical Science Authors: Hongmei Wu, Mingyue Liu, Vu Thi Quynh Chi, Jing Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Xue Bao, Yeqing Gu, Shunming Zhang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu Source Type: research

Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor?
Irisin is a protein derived from C-terminal cleavage of the fibronectin type III domain containing (FNDC)5 transmembrane protein, a process induced by the peroxisome proliferator-activated receptor (PPAR)- γ coactivator (PGC)-1a [1]. Irisin is mainly produced by the skeletal muscle in response to exercise in mice [2] and possibly in humans [3], and it may be beneficial in several metabolic disorders [4], especially those known to improve with exercise [5]. Exercise is a potent stimulus of bone format ion, improving bone mineral density (BMD) mainly through loading on the skeleton, thus reducing fracture risk [6]. (So...
Source: Metabolism - Clinical and Experimental - January 25, 2019 Category: Biomedical Science Authors: Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras, Eleni Douni, Christos S. Mantzoros Source Type: research

Physiology of FGF23 and overview of genetic diseases associated with renal phosphate wasting
Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal absorption: parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1 –25-dihydroxyvitamin D (1,25(OH)2D). FGF23 is mainly synthesized by osteocytes; it is a direct phosphaturic factor that also inhibits 1,25(OH)2D and PTH. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 19, 2019 Category: Biomedical Science Authors: Justine Bacchetta, Claire Bardet, Dominique Pri é Source Type: research

FGF23, hypophosphatemia and genetic disorders
Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal absorption: parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1 –25-dihydroxyvitamin D (1,25(OH)2D). FGF23 is mainly synthesized by osteocytes; it is a direct phosphaturic factor that also inhibits 1,25(OH)2D and PTH. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 19, 2019 Category: Biomedical Science Authors: Justine Bacchetta, Claire Bardet, Dominique Pri é Source Type: research

Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice
Senile osteoporosis is one of the most common age-related diseases worldwide. Accumulating evidences have indicated that young blood can reverse age-related impairments. Extracellular vesicles (EVs) exert therapeutic effects in a variety of diseases by delivering bioactive molecules such as microRNAs (miRNAs). The aim of the study is to evaluate the therapeutic potential of EVs from human umbilical cord blood plasma (UCB-EVs) on senile osteoporosis and to preliminarily clarify the underlying mechanism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 19, 2019 Category: Biomedical Science Authors: Yin Hu, Ran Xu, Chun-Yuan Chen, Shan-Shan Rao, Kun Xia, Jie Huang, Hao Yin, Zhen-Xing Wang, Jia Cao, Zheng-Zhao Liu, Yi-Juan Tan, Juan Luo, Hui Xie Source Type: research

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1 −/− null mice display hyperinsulinemia due to impaired insulin clearance at 2 months of age, followed by insulin resistance, steatohepatitis, visceral obesity and leptin resistance at 6 months. The study aimed at investigating the primary role of hepatic CEACAM1 in insulin and lipid homeosta sis independently of its metabolic effect in extra-hepatic tissues. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 18, 2019 Category: Biomedical Science Authors: Hilda E. Ghadieh, Lucia Russo, Harrison T. Muturi, Simona S. Ghanem, Iyad H. Manaserh, Hye Lim Noh, Sujin Suk, Jason K. Kim, Jennifer W. Hill, Sonia M. Najjar Source Type: research

Fibroblast growth factor 21: a role in cardiometabolic disorders and cardiovascular risk prediction?
In this issue of Metabolism, Ong et al [1] report that fibroblast growth factor 21 (FGF21) levels could predict major cardiovascular (CV) events (MCVE) in statin-treated patients with stable coronary heart disease (CHD) using data from the Treating to New Targets (TNT) trial (n  = 10,001; median follow-up = 4.9 years) [2]; MCVE were defined as a composite of CHD death, cardiac arrest, fatal or non-fatal stroke and non-fatal myocardial infarction (MI). In the Ong et al study [1], 1996 patients with plasma FGF21 concentrations available at baseline were analyzed; 1 835 of them had also FGF21 measurements at the 1-y...
Source: Metabolism - Clinical and Experimental - January 16, 2019 Category: Biomedical Science Authors: Niki Katsiki, Christos Mantzoros Source Type: research

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans
Background and aims.Placement of the duodenal-jejunal bypass liner (DJBL) leads to rapid weight loss and restoration of insulin sensitivity in a similar fashion to bariatric surgery. Increased systemic bile acid levels are candidate effectors for these effects through postprandial activation of their receptors TGR5 and FXR. We aimed to quantify postprandial bile acid, GLP-1 and FGF19 responses and assess their temporal relation to the weight loss and metabolic and hormonal changes seen after DJBL placement. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 15, 2019 Category: Biomedical Science Authors: F. Samuel van Nierop, C. de Jonge, W. Kulik, Nicole Bouvy, Frank G. Schaap, Steven W. Olde Damink, Sander Rensen, Johannes A. Romijn, Jan Willem M. Greve, Maarten R. Soeters Source Type: research

Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the look AHEAD trial
Metformin and lifestyle intervention are frequently prescribed together as first-line treatments for type 2 diabetes. However, little is known about their interplay. We investigated if the effects of a lifestyle intervention on glycemia, body mass and cardiorespiratory fitness (CRF) were influenced by metformin therapy. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 14, 2019 Category: Biomedical Science Authors: Tasuku Terada, Normand G. Boul é Source Type: research

Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: the ATTICA cohort study
Metabolically benign obesity remains a scientific field of considerable debate.The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 10, 2019 Category: Biomedical Science Authors: Matina Kouvari, Demosthenes B. Panagiotakos, Mary Yannakoulia, Ekavi Georgousopoulou, Elena Critselis, Christina Chrysohoou, Dimitrios Tousoulis, Christos Pitsavos, the ATTICA study Investigators Source Type: research

A low resting metabolic rate in late childhood is associated with weight gain in adolescence
Background and Objectives.Lower total energy expenditure (TEE) and resting metabolic rate (RMR) are associated with greater weight gain in Native American adults. Whether these effects exist in childhood is unclear. We hypothesized that lower energy expenditure measured in childhood would predict greater relative change in body mass index (BMI) during adolescence. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 9, 2019 Category: Biomedical Science Authors: Maximilian G. Hohenadel, Tim Hollstein, Marie Thearle, Martin Reinhardt, Paolo Piaggi, Arline D. Salbe, Jonathan Krakoff Source Type: research

The pathogenesis of obesity
Body fat mass increases when energy intake exceeds energy expenditure. In the long term, a positive energy balance will result in obesity. The worldwide prevalence of obesity has increased dramatically, posing a serious threat to human health. Therefore, insight in the pathogenesis of obesity is important to identify novel prevention and treatment strategies. This review describes the physiology of energy expenditure and energy intake in the context of body weight gain in humans. We focus on the components of energy expenditure and the regulation of energy intake. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 9, 2019 Category: Biomedical Science Authors: Sabrina M. Oussaada, Katy A. van Galen, Mellody I. Cooiman, Lotte Kleinendorst, Eric J. Hazebroek, Mieke M. van Haelst, Kasper W. ter Horst, Mireille J. Serlie Source Type: research

Obesity: seize the day, fight the fat
Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [1]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [2]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [2]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (N...
Source: Metabolism - Clinical and Experimental - January 6, 2019 Category: Biomedical Science Authors: Stergios A. Polyzos, Christos S. Mantzoros Source Type: research

Dietary modifications for weight loss and weight loss maintenance
Worldwide obesity rates remain at a rise, and to treat obesity is at the top of the global public health agenda. In 2013, the AHA/ACC/TOS obesity management guidelines were published, in essence suggesting that any dietary scheme seems to be effective for weight loss, as long as it can induce a sustainable energy deficit. In the present review, we update and critically discuss available information regarding dietary modifications for weight loss and weight loss maintenance, published after the 2013 guidelines. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 6, 2019 Category: Biomedical Science Authors: Mary Yannakoulia, Dimitrios Poulimeneas, Eirini Mamalaki, Costas A. Anastasiou Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 5, 2019 Category: Biomedical Science Source Type: research

Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes
We have reported that partial PERK attenuation using PERK inhibitors (PI) enhanced glucose-stimulated insulin secretion (GSIS) from pancreatic islets and mice through induction of ER chaperone BIP. Therefore, we investigated if PI would have the same effects in a diabetic condition as well. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 4, 2019 Category: Biomedical Science Authors: Min Joo Kim, Mi Na Kim, Se Hee Min, Dong-Sik Ham, Ji-Won Kim, Kun-Ho Yoon, Kyong Soo Park, Hye Seung Jung Tags: Brief Report Source Type: research

Vitamin D supplementation in obesity and during weight loss: a review of randomized controlled trials
Vitamin D deficiency is common in obese individuals and during weight loss. The recommended vitamin D doses in this specific population are higher than for healthy adults. We reviewed vitamin D supplementation trials in obesity, and during medical or surgical weight loss, and report the effects on 25-hydroxyvitamin D [25(OH)D] concentrations and other relevant outcomes.We conducted a systematic search in PubMed, Medline, Embase and the Cochrane library for relevant randomized controlled trials (RCTs) of oral vitamin D supplementation for at least 3  months in obese individuals without weight loss (OB), and those on medic...
Source: Metabolism - Clinical and Experimental - January 4, 2019 Category: Biomedical Science Authors: Aya Bassatne, Marlene Chakhtoura, Randa Saad, Ghada El-Hajj Fuleihan Source Type: research

Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: a pilot randomized controlled trial
The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 4, 2019 Category: Biomedical Science Authors: A-Ra Cho, Ju-Yeon Moon, Sue Kim, Ki-Yong An, Minsuk Oh, Justin Y. Jeon, Dong-Hyuk Jung, Man Ho Choi, Ji-Won Lee Source Type: research

The role of metabolism in the pathogenesis of systemic sclerosis
Systemic sclerosis (SSc) is an immune-mediated autoimmune disease characterized by fibrosis and vascular abnormalities. The cellular and molecular mechanisms remain unclear, and current therapies are limited. Cell metabolism has been shown to play an essential role in cancer survival and tumour invasion as well as in rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis. Although little is known about SSc, cell metabolism may provide new clues for understanding its pathogenesis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 23, 2018 Category: Biomedical Science Authors: Honglin Zhu, Weilin Chen, Di Liu, Hui Luo Source Type: research

Contribution of endogenous glucagon-like Peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after roux-en-Y gastric bypass (RYGB)
Glucagon-Like Peptide-1 (GLP-1) is an insulin secretagogue which is elevated after Roux-en-Y Gastric Bypass (RYGB). However, its contribution to glucose metabolism after RYGB remains uncertain. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 23, 2018 Category: Biomedical Science Authors: Meera Shah, Marcello C. Laurenti, Chiara Dalla Man, Jing Ma, Claudio Cobelli, Robert A. Rizza, Adrian Vella Source Type: research

Diagnosis of obesity and use of obesity biomarkers in science and clinical medicine
The global epidemic of obesity is a major public health problem today. Obesity increases the risk of many chronic diseases, such as type 2 diabetes, coronary heart disease, and certain types of cancer, and is associated with lower life expectancy. The body mass index (BMI), which is currently used to classify obesity, is only an imperfect measure of abnormal or excessive body fat accumulation. Studies have shown that waist circumference as a measure of fat distribution may improve disease prediction. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 23, 2018 Category: Biomedical Science Authors: Katharina Nimptsch, Stefan Konigorski, Tobias Pischon Source Type: research

Surgical management of obesity
We describe common surgical procedures as well as emerging and investigational procedures in terms of their capacity to induce weight reduction and their risk profiles. We then discuss the impact of weight loss surgery on important obesity related disorders including diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. The question of operative choice is discussed with respect to benefits and risks of common procedures. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 18, 2018 Category: Biomedical Science Authors: Jacob Nudel, Vivian M. Sanchez Source Type: research

Ectopic lipid deposition mediates insulin resistance in adipose specific 11 β-Hydroxysteroid dehydrogenase type 1 transgenic mice
Excessive adipose glucocorticoid action is associated with insulin resistance, but the mechanisms linking adipose glucocorticoid action to insulin resistance are still debated. We hypothesized that insulin resistance from excess glucocorticoid action may be attributed in part to increased ectopic lipid deposition in liver. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 18, 2018 Category: Biomedical Science Authors: Abudukadier Abulizi, Jo ão-Paulo Camporez, Dongyan Zhang, Varman T. Samuel, Gerald I. Shulman, Daniel F. Vatner Source Type: research

Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood
Prevalence of childhood obesity has worldwide more than doubled since 1980. Underlying factors are complex and are far from completely understood. Strategies to prevent childhood obesity have mainly focused on behavioral intervention; and obesity therapy was mainly based on lifestyle modification to date. However, effects for both have been quite limited so far and no country has succeeded in fighting the obesity epidemy we are facing.Normalization of body weight before onset of puberty is crucial for several reasons: First, obese children and adolescents frequently stay obese until adulthood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 5, 2018 Category: Biomedical Science Authors: Susann Weihrauch-Bl üher, Peter Schwarz, Jan-Henning Klusmann Source Type: research

Central obesity transition increased urinary levels of 8-hydroxydeoxyguanosine in male adults: A 3-year follow up study
Association of oxidative DNA damage with gain in anthropometric indices has not been fully elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 1, 2018 Category: Biomedical Science Authors: Chen Hu, Guiyang Wang, WenjunYin, Yun Zhou, Jian Hou, Xian Wang, Weihong Chen, Jing Yuan Source Type: research