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Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation
Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great potential for the treatment of diabetic ulceration; however, the underlying mechanism as well as its compatibility with the first-line anti-diabetic drug, metformin (MTF), has not been well elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 7, 2023 Category: Biomedical Science Authors: Fangzhou Du, Mengmeng Liu, Jingwen Wang, Lvzhong Hu, Dongao Zeng, Shaocong Zhou, Lixing Zhang, Meijia Wang, Xi Xu, Chenglong Li, Jingzhong Zhang, Shuang Yu Source Type: research

TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury
The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized. Transmembrane BAX inhibitor motif containing 6 (TMBIM6) is an endoplasmic reticulum protein with Ca2+ leak activity that modulates cellular responses to various cellular stressors. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 2, 2023 Category: Biomedical Science Authors: Hao Zhou, Zhe Dai, Jialei Li, Jin Wang, Hang Zhu, Xing Chang, Yijin Wang Source Type: research

Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment in type 2 diabetes mellitus patients results in glucosuria, causing an energy loss, and triggers beneficial metabolic adaptations. It is so far unknown if SGLT2i exerts beneficial metabolic effects in prediabetic insulin resistant individuals, yet this is of interest since SGLT2is also reduce the risk for progression of heart failure and chronic kidney disease in patients without diabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 30, 2022 Category: Biomedical Science Authors: Anna Veelen, Charlotte Andriessen, Yvo Op den Kamp, Edmundo Erazo-Tapia, Marlies de Ligt, Julian Mevenkamp, Johanna A. J örgensen, Esther Moonen-Kornips, Gert Schaart, Russell Esterline, Bas Havekes, Jan Oscarsson, Vera B. Schrauwen-Hinderling, Esther Ph Source Type: research

Activins, follistatins and inhibins in postmenopausal osteoporosis: A proof of concept, case-control study
Bone metabolism has been proposed to be affected by the activins-follistatins-inhibins (AFI) hormonal system. We aimed to evaluate AFI in patients with osteoporosis and osteopenia compared with postmenopausal and premenopausal controls. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 29, 2022 Category: Biomedical Science Authors: Athanasios D. Anastasilakis, Stergios A. Polyzos, Nikolaos E. Rodopaios, Polyzois Makras, Ajay Kumar, Bhanu Kalra, Christos S. Mantzoros Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 27, 2022 Category: Biomedical Science Source Type: research

Relationship between circulating adipokines and cholesterol efflux in subjects with severe carotid atherosclerosis
Cholesterol efflux capacity (CEC) as a measure of high-density lipoprotein functionality is independently and inversely associated with increased risk of cardiovascular events and mortality, and advanced plaque morphology. Adipokines, adipose tissue-derived factors, can influence systemic lipoprotein metabolism, and participate in the regulation of vascular function and inflammation. We aimed to investigate the association between CEC and circulating adipokine levels (anti-inflammatory adiponectin, and pro-inflammatory chemerin and resistin) in subjects with severe carotid atherosclerotic disease and evaluate its impact on...
Source: Metabolism - Clinical and Experimental - December 21, 2022 Category: Biomedical Science Authors: Karina Gasbarrino, Anouar Hafiane, Ioanna Gianopoulos, Huaien Zheng, Christos S. Mantzoros, Stella S. Daskalopoulou Source Type: research

Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes
Studying renal glucose metabolism non-invasively in humans is an unmet need. Positron emission tomography (PET) is the current gold standard for measuring regional tissue glucose uptake rates, but the most widely used glucose analog ([18F]FDG) is not a good substrate for sodium-glucose cotransporters (SGLTs). As a consequence, [18F]FDG spills over into the urine and [18F]FDG-PET considerably underestimates published rates of whole renal glucose uptake obtained using the arterial-venous difference technique. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 21, 2022 Category: Biomedical Science Authors: Eleni Rebelos, Andrea Mari, Vesa Oikonen, Hidehiro Iida, Pirjo Nuutila, Ele Ferrannini Source Type: research

Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway
Liver fibrogenesis is orchestrated by the paracrine signaling interaction between several resident cell types regulating the activation of hepatic stellate cells (HSCs). However, the molecular mechanisms underlying paracrine regulation are largely unknown. The aim of this study is to elucidate the role of Ninjurin2 in the crosstalk between hepatocytes and HSCs and better understand the implications of Ninjurin2 in liver fibrosis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 19, 2022 Category: Biomedical Science Authors: Yifan Wang, Pengyun Wang, Yubing Yu, Erwen Huang, Yufeng Yao, Di Guo, Huixin Peng, Beijia Tian, Qian Zheng, Mengru Jia, Jing Wang, Xinna Wu, Jianding Cheng, Huiying Liu, Qing K. Wang, Chengqi Xu Source Type: research

Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis
Oxidative stress (OS) is the main cause leading to diabetic renal fibrosis. Recently, Fyn was paid much attention on OS and emerged as a pivotal player in acute kidney injury, while whether Fyn regulates oxidative stress in chronic diabetes nephropathy (DN) has not been clarified yet. The purpose of this study was to identify the role of Fyn in DN and elucidated its regulatory mechanism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 17, 2022 Category: Biomedical Science Authors: Shanshan Li, Zhanchi Xu, Zeyuan Lin, Haiming Xiao, Chuting Li, Jingran Zeng, Xi Xie, Li Deng, Heqing Huang Source Type: research

Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis
Skeletal muscle plays important roles in normal biological activities and whole-body energy homeostasis in humans. The growth and development of skeletal muscle also directly influence meat production and meat quality in animal production. Therefore, regulating the development and homeostasis of skeletal muscle is crucial for human health and animal production. Adipose tissue, which includes white adipose tissue (WAT) and brown adipose tissue (BAT), not only functions as an energy reserve but also has attracted substantial attention because of its role as an endocrine organ. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 16, 2022 Category: Biomedical Science Authors: Xin Gu, Liyi Wang, Shiqi Liu, Tizhong Shan Tags: Review Source Type: research

ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease
In this study, the effects of glomerular cholesterol accumulation primarily due to ABCA1 deficiency on glomerular endothelial injury in diabetic kidney disease (DKD) and the possible mechanisms were investigated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 12, 2022 Category: Biomedical Science Authors: Junlin Zhang, Yucheng Wu, Jie Zhang, Rui Zhang, Yiting Wang, Fang Liu Source Type: research

Inhibition of S100A8/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy
Renal interstitial fibrosis (RIF) is one of the main features of diabetic nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully understood. S100A8 and S100A9 are the proteins associated with immune and inflammation response. Here we reported the expression of S100A8 and S100A9 were significantly increased on tubular epithelial cells in diabetic kidneys through a proteomic analysis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 11, 2022 Category: Biomedical Science Authors: Lei Du, Yibing Chen, Jiasen Shi, Xiujuan Yu, Jieling Zhou, Xue Wang, Liu Xu, Junjie Liu, Jian Gao, Xiaoke Gu, Tao Wang, Zeyuan Yin, Chenglin Li, Meng Yan, Jianyun Wang, Xiaoxing Yin, Qian Lu Source Type: research

Glucagon-like peptide-1 secretion in people with versus without type 2 diabetes: a systematic review and meta-analysis of cross-sectional studies
The aim of this systematic review was to synthesise the study findings on whether GLP-1 secretion in response to a meal tolerance test is affected by the presence of type 2 diabetes (T2D). The influence of putative moderators such as age, sex, meal type, meal form, and assay type were also explored. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 7, 2022 Category: Biomedical Science Authors: J.D. Watkins, S. Carter, G. Atkinson, F. Koumanov, J.A. Betts, J.J. Holst, J.T. Gonzalez Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 3, 2022 Category: Biomedical Science Source Type: research

FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase
This study determined the roles of mitochondrial protein FAM3A in regulating the activity and assembly of ATPS's in hepatocytes. FAM3A is localized in mitochondrial matrix, where it interacts with F1-ATPS to initially activate ATP synthesis and release, and released ATP further activates P2 receptor-Akt-CREB pathway to induce FOXD3 expression. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 2, 2022 Category: Biomedical Science Authors: Han Yan, Yuhong Meng, Xin Li, Rui Xiang, Song Hou, Junpei Wang, Lin Wang, Xiaoxing Yu, Ming Xu, Yujing Chi, Jichun Yang Source Type: research