Metabolism - Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase
This study determined the roles of mitochondrial protein FAM3A in regulating the activity and assembly of ATPS's in hepatocytes. FAM3A is localized in mitochondrial matrix, where it interacts with F1-ATPS to initially activate ATP synthesis and release, and released ATP further activates P2 receptor-Akt-CREB pathway to induce FOXD3 expression. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 2, 2022 Category: Biomedical Science Authors: Han Yan, Yuhong Meng, Xin Li, Rui Xiang, Song Hou, Junpei Wang, Lin Wang, Xiaoxing Yu, Ming Xu, Yujing Chi, Jichun Yang Source Type: research

Hepatic fat as a novel marker for high-risk coronary atherosclerotic plaque features in familial hypercholesterolaemia
Hepatic steatosis has been associated with increased risk of coronary artery disease. Individuals with familial hypercholesterolaemia have accelerated but variable progression of coronary artery disease. We investigated whether hepatic steatosis is associated with novel coronary atherosclerosis biomarkers in adults with heterozygous familial hypercholesterolaemia, using comprehensive coronary computed tomographic angiography. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 30, 2022 Category: Biomedical Science Authors: Gavin Huangfu, Biyanka Jaltotage, Jing Pang, Nick S.R. Lan, Arun Abraham, Jacobus Otto, Abdul R. Ihdayhid, Jamie M. Rankin, Benjamin J.W. Chow, Gerald F. Watts, Oyekoya T. Ayonrinde, Girish Dwivedi Source Type: research

Impaired hepatic glucose metabolism and liver- α-cell axis in mice with liver-specific ablation of the hepatocyte nuclear factor 4α (Hnf4a) gene
Hnf4a gene ablation in mouse liver causes hepatic steatosis, perturbs HDL structure and function and affects many pathways and genes related to glucose metabolism. Our aim here was to investigate the role of liver HNF4A in glucose homeostasis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 30, 2022 Category: Biomedical Science Authors: Efstathia Thymiakou, Maria Tzardi, Dimitris Kardassis Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 22, 2022 Category: Biomedical Science Source Type: research

SUMOylation of ERp44 enhances Ero1 α ER retention contributing to the pathogenesis of obesity and insulin resistance
As the only E2 conjugating enzyme for the SUMO system, Ubc9-mediated SUMOylation has been recognized to regulate diverse biological processes, but its impact on adipocytes relevant to obesity and insulin resistance is yet to be elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 21, 2022 Category: Biomedical Science Authors: Hao Xie, Yu-han Wang, Xin Liu, Jia Gao, Chunliang Yang, Teng Huang, Lu Zhang, Xi Luo, Zhichao Gao, Ting Wang, Tong Yan, Yanjun Liu, Ping Yang, Qilin Yu, Shiwei Liu, Yi Wang, Fei Xiong, Shu Zhang, Qing Zhou, Cong-Yi Wang Source Type: research

Small extracellular vesicle targeting of hypothalamic AMPK α1 promotes weight loss in leptin receptor deficient mice
Leptin receptor (LEPR) deficiency promotes severe obesity and metabolic disorder. However, the current therapeutic options against this syndrome are scarce. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 21, 2022 Category: Biomedical Science Authors: Edward Milbank, Nathalia Dragano, Xavi Vidal-Gomez, Ver ónica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, María P. Pata, José Luis Labandeira-Garcia, Carlos Diéguez, Rubén Nogueiras, M. Carmen Martínez, Ramaroson Andr Source Type: research

Corrigendum to “The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans” [Metab. 97 (2019) 40–49]
The authors regret the originally published manuscript contained an error in Table 1. Specifically, the Glucose Disposal Rates (GDR) were not within the correct columns. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 18, 2022 Category: Biomedical Science Authors: Randall L. Mynatt, Robert C. Noland, Carrie M. Elks, Bolormaa Vandanmagsar, David S. Bayless, Allison C. Stone, Sujoy Ghosh, Eric Ravussin, Jaycob D. Warfel Tags: Corrigendum Source Type: research

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines
Exercise intolerance remains a major unmet medical need in patients with heart failure (HF). Skeletal myopathy is currently considered as the major limiting factor for exercise capacity in HF patients. On the other hand, emerging evidence suggest that physical exercise can decrease morbidity and mortality in HF patients. Therefore, mechanistic insights into skeletal myopathy may uncover critical aspects for therapeutic interventions to improve exercise performance in HF. Emerging data reviewed in this article suggest that the assessment of circulating myokines (molecules synthesized and secreted by skeletal muscle in respo...
Source: Metabolism - Clinical and Experimental - November 17, 2022 Category: Biomedical Science Authors: Robinson Ram írez-Vélez, Arantxa González, Antonio García-Hermoso, Iñigo Latasa Amézqueta, Mikel Izquierdo, Javier Díez Tags: Review Source Type: research

Circulating lipoprotein(a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses
Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic and valvular diseases, but its possible role in other diseases has not yet been established. We conducted phenome-wide Mendelian randomization and disease-trajectory analyses to assess any associations of circulating Lp(a) levels with a broad range of diseases. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 14, 2022 Category: Biomedical Science Authors: Susanna C. Larsson, Lijuan Wang, Xue Li, Fangyuan Jiang, Xiangjun Chen, Christos S. Mantzoros Tags: Brief Report Source Type: research

Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity
Glucagon-like peptide-1 receptor agonists (GLP-1RA) and bariatric surgery have proven to be effective treatments for obesity and cardiometabolic conditions. We aimed to explore the early metabolomic changes in response to GLP-1RA (liraglutide) therapy vs. placebo and in comparison to bariatric surgery. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 11, 2022 Category: Biomedical Science Authors: Angeliki M. Angelidi, Alexander Kokkinos, Despina Sanoudou, Margery A. Connelly, Andreas Alexandrou, Geltrude Mingrone, Christos S. Mantzoros Source Type: research

Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts
Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in the phospholamban (PLN) gene has been implicated in the pathogenesis of ACM. PLN is a key regulator of sarcoplasmic reticulum (SR) Ca2+ cycling and cardiac contractility. Despite global gene and protein expression studies, the molecular mechanisms of PLN-R14del ACM pathogenesis remain unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 11, 2022 Category: Biomedical Science Authors: Malgorzata E. Rogalska, Elizabeth Vafiadaki, Zoi Erpapazoglou, Kobra Haghighi, Lisa Green, Christos S. Mantzoros, Roger J. Hajjar, Michael Tranter, Ioannis Karakikes, Evangelia G. Kranias, Francesca Stillitano, Panagiota Kafasla, Despina Sanoudou Source Type: research

Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases
One of the suggested mechanisms of obesity-induced insulin resistance is mitochondrial dysfunction in target tissues such as skeletal muscle. In our study, we examined whether resistin, an adipokine associated with obesity-mediated insulin resistance, induced metabolic disorders by impairing mitochondrial homeostasis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 7, 2022 Category: Biomedical Science Authors: Han-Mo Yang, Joonoh Kim, Dasom Shin, Ju-Young Kim, Jihye You, Hyun-Chae Lee, Hyun-Duk Jang, Hyo-Soo Kim Source Type: research

Metabolic profile predicts incident cancer: A large-scale population study in the UK Biobank
Analyses to predict the risk of cancer typically focus on single biomarkers, which do not capture their complex interrelations. We hypothesized that the use of metabolic profiles may provide new insights into cancer prediction. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 29, 2022 Category: Biomedical Science Authors: Muktar Ahmed, Ville-Petteri M äkinen, Amanda Lumsden, Terry Boyle, Anwar Mulugeta, Sang Hong Lee, Ian Olver, Elina Hyppönen Source Type: research

Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis
Alcohol consumption has been shown to disrupt hepatic lipid homeostasis. Long-chain acyl-CoA synthetase 1 (ACSL1) critically regulates hepatic fatty acid metabolism and lipid homeostasis by channeling fatty acids to lipid metabolic pathways. However, it remains unclear how ACSL1 contributes to the development of alcohol-associated liver disease (ALD). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 27, 2022 Category: Biomedical Science Authors: Haibo Dong, Wei Zhong, Wenliang Zhang, Liuyi Hao, Wei Guo, Ruichao Yue, Xinguo Sun, Zhaoli Sun, Ramon Bataller, Zhanxiang Zhou Source Type: research

Hypothalamic integrity is necessary for sustained weight loss after bariatric surgery: A prospective, cross-sectional study
The hypothalamus is the main integrator of peripheral and central signals in the control of energy homeostasis. Its functional relevance for the effectivity of bariatric surgery is not entirely elucidated. Studying the effects of bariatric surgery in patients with hypothalamic damage might provide insight. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 27, 2022 Category: Biomedical Science Authors: Ulrich Dischinger, Laura K ötzner, Petia Kovatcheva-Datchary, Helena Kleinschmidt, Christina Haas, Jose Perez, Cornelius Presek, Ann-Cathrin Koschker, Alexander D. Miras, Mohammed K. Hankir, Jörg Vogel, Christoph-Thomas Germer, Martin Fassnacht, Martin Source Type: research