Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis

Alcohol consumption has been shown to disrupt hepatic lipid homeostasis. Long-chain acyl-CoA synthetase 1 (ACSL1) critically regulates hepatic fatty acid metabolism and lipid homeostasis by channeling fatty acids to lipid metabolic pathways. However, it remains unclear how ACSL1 contributes to the development of alcohol-associated liver disease (ALD).

Source: Metabolism - Clinical and Experimental - October 27, 2022 Category: Biomedical Science Authors: Haibo Dong, Wei Zhong, Wenliang Zhang, Liuyi Hao, Wei Guo, Ruichao Yue, Xinguo Sun, Zhaoli Sun, Ramon Bataller, Zhanxiang Zhou Source Type: research