FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase

This study determined the roles of mitochondrial protein FAM3A in regulating the activity and assembly of ATPS's in hepatocytes. FAM3A is localized in mitochondrial matrix, where it interacts with F1-ATPS to initially activate ATP synthesis and release, and released ATP further activates P2 receptor-Akt-CREB pathway to induce FOXD3 expression.

Source: Metabolism - Clinical and Experimental - December 2, 2022 Category: Biomedical Science Authors: Han Yan, Yuhong Meng, Xin Li, Rui Xiang, Song Hou, Junpei Wang, Lin Wang, Xiaoxing Yu, Ming Xu, Yujing Chi, Jichun Yang Source Type: research