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Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 29, 2023 Category: Biomedical Science Source Type: research

Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Sarcopenic obesity is becoming a global health concern, owing to the rising older population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding normal age-related changes has been revealed to be associated with obesity, aggravating each other through complex interactions. Physiological regeneration and proliferation of muscle tissue are achieved through harmonious processes of regulated inflammation, autophagy, muscle satellite cell proliferation, and signaling molecule function. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 29, 2023 Category: Biomedical Science Authors: Min Jeong Park, Kyung Mook Choi Tags: Review Source Type: research

DR region of NKA α1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice
Na+/K+-ATPase (NKA), an ion pumping enzyme ubiquitously expressed in various cells, is critically involved in cellular ion homeostasis and signal transduction. However, the role of NKA in hepatic lipid homeostasis has yet to be fully characterized. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 29, 2023 Category: Biomedical Science Authors: Hai-Jian Sun, Jian-Xin Tan, Xiao-Dong Shan, Zi-Chao Wang, Zhi-Yuan Wu, Jin-Song Bian, Xiao-Wei Nie Source Type: research

Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility
Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co-express neurokinin B (NKB; encoded by Tac2). Yet, NKB- and Kiss1-only neurons are also found in the ARC, while a second major Kiss1-neuronal population is present in the rostral hypothalamus. The specific contribution of different Kiss1 neuron sub-sets and kisspeptins originating from them to the control of reproduction and eventually other bodily functions remains to be fully determined. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 28, 2023 Category: Biomedical Science Authors: Inmaculada Velasco, Delphine Franssen, Silvia Daza-Due ñas, Katalin Skrapits, Szabolcs Takács, Encarnación Torres, Elvira Rodríguez-Vazquez, Miguel Ruiz-Cruz, Silvia León, Krisztina Kukoricza, Fu-Ping Zhang, Suvi Ruohonen, Diego Luque-Cordoba, Felici Source Type: research

Neutrophil aging exacerbates high fat diet induced metabolic alterations
High fat diet (HFD) chronically hyper-activate the myeloid cell precursors, but whether it affects the neutrophil aging is unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 25, 2023 Category: Biomedical Science Authors: Andrea Baragetti, Lorenzo Da Dalt, Annalisa Moregola, Monika Svecla, Ottavia Terenghi, Elisa Mattavelli, Lucia Nicolini De Gaetano, Patrizia Uboldi, Alberico Luigi Catapano, Giuseppe Danilo Norata Source Type: research

Association between diabetes and thiamine status - A systematic review and meta-analysis
Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 22, 2023 Category: Biomedical Science Authors: Dan Ziegler, Karlheinz Reiners, Alexander Strom, Rima Obeid Source Type: research

Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPAR α-mediated functional interplay between mitochondria and peroxisomes
This study aimed to characterize the physiological consequences of APOO deficiency in vivo. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 21, 2023 Category: Biomedical Science Authors: Xin Guo, Jiarui Hu, Guangxu He, Jin Chen, Yang Yang, Donglu Qin, Chenyu Li, Zhijie Huang, Die Hu, Cheng Wei, Fengjiao Wang, Bilian Yu Source Type: research

Loss of CEACAM1 in endothelial cells causes hepatic fibrosis
Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered by the development of insulin resistance, visceral obesity, steatohepatitis and fibrosis in mice with global Ceacam1 (Cc1) deletion. In contrast, VECadCre+Cc1fl/fl mice with endothelial loss of Cc1 manifested insulin sensitivity with no visceral obesity despite elevated NF- κB signaling and increased systemic inflammation. We herein investigated whether VECadCre+Cc1fl/fl male mice develop hepatic fibrosis and whether this is mediated by increased production of endothelin1 (ET1), a transcriptional NF-κB target. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 20, 2023 Category: Biomedical Science Authors: Harrison T. Muturi, Hilda E. Ghadieh, Raziyeh Abdolahipour, Hannah L. Stankus, Getachew Debas Belew, James K. Liu, Marziyeh Salehi Jahromi, Abraham D. Lee, Bernhard B. Singer, Isabella Angeli-Pahim, Tejasav S. Sehrawat, Harmeet Malhi, Stefaan Verhulst, Le Source Type: research

MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies
Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein factor X (MLX) acts as a heterodimer binding partner for glucose sensing transcription factors and inhibition of MLX or downstream targets has been shown to alleviate intrahepatic triglyceride (IHTG) accumulation in mice. However, its effect on insulin sensitivity remains unclear. As human data is lacking, the aim of the present work was to investigate the role of MLX in regulating lipid and glucose metabolism in primary human hepatocytes (PHH) and in healthy particip...
Source: Metabolism - Clinical and Experimental - April 20, 2023 Category: Biomedical Science Authors: Shilpa R. Nagarajan, Eilidh J. Livingstone, Thomas Monfeuga, Lara C. Lewis, Shahul Hameed Liyakath Ali, Anandhakumar Chandran, David J. Dearlove, Matt J. Neville, Lingyan Chen, Cyrielle Maroteau, Maxwell A. Ruby, Leanne Hodson Source Type: research

Sarcopenia in youth
Recent research has revealed causes other than aging that may induce sarcopenia in young people, contrary to the long-studied age-dependent reduction in muscular mass and function. The risk of sarcopenia begins in early adulthood, resulting in exaggerated muscle dysfunction in later life. Despite its clinical significance, research on youth-onset sarcopenia is still in its infancy. Due to a paucity of epidemiologic data and standardized criteria for sarcopenia in youth, determining the prevalence of sarcopenia in the young population remains challenging. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 18, 2023 Category: Biomedical Science Authors: Han Na Jung, Chang Hee Jung, You-Cheol Hwang Tags: Review Source Type: research

Letter to the Editor: Clarity and quality assessment of epidemiology of sarcopenia: Prevalence, risk factors, and consequences
This study proposes a novel hybrid joining process, called bonded-hole hemming, for joining dissimilar materials. The process combines the hole hemming process, a newly developed joining process by plastic deformation, and adhesive bonding. The suitability of this process for joining AZ31 magnesium and AA6082-T4 aluminium sheets is evaluated through finite element simulations and experimental tests, where single-lap shear testing is carried out to assess mechanical performance. The experimental and numerical analyses of the single lap joint (SLJ) tests are also performed to validate the cohesive zone model (CZM) employed i...
Source: Metabolism - Clinical and Experimental - April 16, 2023 Category: Biomedical Science Authors: Kiranmayee Muralidhar, Purnima Madhivanan Source Type: research

Response to letter by Muralidhar and Madhivanan: Clarity and quality assessment of epidemiology of sarcopenia: Prevalence, risk factors, and consequences
We thank Muralidhar and Madhivanan for paying attention to our paper and raising some insightful concerns. We have replied to these comments as below. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 15, 2023 Category: Biomedical Science Authors: Shuai Yuan, Susanna C. Larsson Source Type: research

Hepatic IDH2 regulates glycolysis and gluconeogenesis
This study intends to investigate the impact of hepatic IDH2 expression on overnutrition-regulated glucose and lipid metabolism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 10, 2023 Category: Biomedical Science Authors: Huawei Wang, Qing Xiong, Guangzhen He, Jun Tang, Li Sun, Siyuan Cheng, Mengting Ke, Shangyu Chen, Yong Hu, Jieyuan Feng, Linyang Song, Beier Tong, Zhengwei Zhang, Zhe Dai, Yancheng Xu Tags: Brief Report Source Type: research

Defining and diagnosing sarcopenia: Is the glass now half full?
Low muscle mass and function exert a substantial negative impact on quality of life, health and ultimately survival, but their definition, identification and combination to define sarcopenia have suffered from lack of universal consensus. Methodological issues have also contributed to incomplete agreement, as different approaches, techniques and potential surrogate measures inevitably lead to partly different conclusions. As a consequence: 1) awareness of sarcopenia and implementation of diagnostic procedures in clinical practice have been limited; 2) patient identification and evaluation of therapeutic strategies is large...
Source: Metabolism - Clinical and Experimental - April 6, 2023 Category: Biomedical Science Authors: Rocco Barazzoni, Tommy Cederholm, Michela Zanetti, Gianluca Gortan Cappellari Tags: Review Source Type: research

Corrigendum to “Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH” [Metab Volume 137, December 2022, 155329]
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 5, 2023 Category: Biomedical Science Authors: Susanna C. Larsson, Karl Micha ëlsson, Marina Mola-Caminal, Jonas Höijer, Christos S. Mantzoros Tags: Corrigendum Source Type: research