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Response to letter by Muralidhar and Madhivanan: Clarity and quality assessment of epidemiology of sarcopenia: Prevalence, risk factors, and consequences
We thank Muralidhar and Madhivanan for paying attention to our paper and raising some insightful concerns. We have replied to these comments as below. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 15, 2023 Category: Biomedical Science Authors: Shuai Yuan, Susanna C. Larsson Source Type: research

Hepatic IDH2 regulates glycolysis and gluconeogenesis
This study intends to investigate the impact of hepatic IDH2 expression on overnutrition-regulated glucose and lipid metabolism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 10, 2023 Category: Biomedical Science Authors: Huawei Wang, Qing Xiong, Guangzhen He, Jun Tang, Li Sun, Siyuan Cheng, Mengting Ke, Shangyu Chen, Yong Hu, Jieyuan Feng, Linyang Song, Beier Tong, Zhengwei Zhang, Zhe Dai, Yancheng Xu Tags: Brief Report Source Type: research

Defining and diagnosing sarcopenia: Is the glass now half full?
Low muscle mass and function exert a substantial negative impact on quality of life, health and ultimately survival, but their definition, identification and combination to define sarcopenia have suffered from lack of universal consensus. Methodological issues have also contributed to incomplete agreement, as different approaches, techniques and potential surrogate measures inevitably lead to partly different conclusions. As a consequence: 1) awareness of sarcopenia and implementation of diagnostic procedures in clinical practice have been limited; 2) patient identification and evaluation of therapeutic strategies is large...
Source: Metabolism - Clinical and Experimental - April 6, 2023 Category: Biomedical Science Authors: Rocco Barazzoni, Tommy Cederholm, Michela Zanetti, Gianluca Gortan Cappellari Tags: Review Source Type: research

Corrigendum to “Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH” [Metab Volume 137, December 2022, 155329]
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 5, 2023 Category: Biomedical Science Authors: Susanna C. Larsson, Karl Micha ëlsson, Marina Mola-Caminal, Jonas Höijer, Christos S. Mantzoros Tags: Corrigendum Source Type: research

Commentary on the endocrine society clinical practice guideline on the “treatment of hypercalcemia of malignancy in adults”
The Endocrine Society Guideline Writing Panel identified 8 questions that reflect common clinical scenarios encountered in treating HCM, for which the evidence was systematically assessed and recommendations derived [1]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - April 4, 2023 Category: Biomedical Science Authors: Ghada El-Hajj Fuleihan, Matthew T. Drake Tags: Editorial Source Type: research

Integrated omics analysis for characterization of the contribution of high fructose corn syrup to non-alcoholic fatty liver disease in obesity
High-Fructose Corn Syrup (HFCS), a sweetener rich in glucose and fructose, is nowadays widely used in beverages and processed foods; its consumption has been correlated to the emergence and progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Nevertheless, the molecular mechanisms by which HFCS impacts hepatic metabolism remain scarce, especially in the context of obesity. Besides, the majority of current studies focuses either on the detrimental role of fructose in hepatic steatosis or compare separately the additive impact of fructose versus glucose in high fat diet-induced NAFLD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 27, 2023 Category: Biomedical Science Authors: Grigorios Papadopoulos, Aigli-Ioanna Legaki, Konstantina Georgila, Panagiotis Vorkas, Eirini Giannousi, George Stamatakis, Ioannis I. Moustakas, Maria Petrocheilou, Iryna Pyrina, Bettina Gercken, Eva Kassi, Triantafyllos Chavakis, Ioannis S. Pateras, Geor Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 22, 2023 Category: Biomedical Science Source Type: research

Efficacy and safety of the ghrelin-O-acyltransferase inhibitor BI 1356225 in overweight/obesity: Data from two Phase I, randomised, placebo-controlled studies
Obesity is a complex disease associated with multiple concurrent complications, and the coordinated targeting of multiple pathways in pharmacological treatment may improve weight loss outcomes. During synthesis, ghrelin is converted from the ‘inactive’ unacylated ghrelin (UAG) to the active acylated ghrelin (AG) by the enzyme ghrelin-O-acyltransferase (GOAT), stimulating appetite and food intake. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 21, 2023 Category: Biomedical Science Authors: Susanna Bianzano, Andrea Henrich, Lena Herich, Brigitte Kalsch, Donald Sarubbi, Friedeborg Seitz, Thomas Forst Source Type: research

Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca2+ overload in a Parkin-MCUb-dependent manner
Uncorrected obesity is accompanied by unfavorable structural and functional changes in the heart, known as obesity cardiomyopathy. Recent evidence has revealed a crucial role for mitochondria-associated endoplasmic reticulum membranes (MAMs) in obesity-induced cardiac complication. Syntaxin 17 (STX17) serves as a scaffolding molecule localized on MAMs although its role in obesity heart complication remains elusive. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 20, 2023 Category: Biomedical Science Authors: Haixia Xu, Wenjun Yu, Mingming Sun, Yaguang Bi, Ne N. Wu, Yuan Zhou, Qi Yang, Mengjiao Zhang, Junbo Ge, Yingmei Zhang, Jun Ren Source Type: research

Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice
The monocarboxylate transporter 1 (MCT1) is a member of the MCT family and is implicated in the transport of lactate and a few other monocarboxylates across the cell membrane. How hepatic MCT1 regulates the metabolic functions of the body is currently unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 16, 2023 Category: Biomedical Science Authors: Xuemei Luo, Zixuan Li, Lingling Chen, Xinhui Zhang, Xinyu Zhu, Zinan Wang, Yan Chen Tags: Brief Report Source Type: research

Increased meal-induced neurotensin response predicts successful maintenance of weight loss – Data from a randomized controlled trial
The gut derived anorexigenic hormone neurotensin (NT) is upregulated after bariatric surgery which may contribute to the sustained weight loss. In contrast, diet-induced weight loss is most often followed by weight regain. We therefore investigated whether diet-induced weight loss impacts levels of circulating NT in mice and humans and whether NT levels predicts body weight change after weight loss in humans. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 15, 2023 Category: Biomedical Science Authors: Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Julie Rehn é Lundgren, Alexander Jakobsen, Bolette Hartmann, Eva Winning Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov, Birgitte Holst Source Type: research

Involvement of a novel cAMP signaling mediator for beige adipogenesis
Exposure to cold temperature stimulates the sympathetic nervous system that activates β-adrenergic receptor signals in brown and beige adipocytes, leading to the induction of adaptive thermogenesis in mammals. Prominin-1 (PROM1) is a pentaspan transmembrane protein that is widely identified as a marker for stem cells, although the role of this protein as a regulator of many intracel lular signaling cascades has been recently delineated. The main focus of the current study is to identify the previously unknown role of PROM1 in beige adipogenesis and adaptive thermogenesis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 15, 2023 Category: Biomedical Science Authors: Jun Seok Kim, Hye-Sook Han, Je Kyung Sung, Young-Gyu Ko, Seung-Hoi Koo Source Type: research

The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis
Fibroblast growth factor 21 (FGF21) levels are often elevated in heart failure (HF), although this has not been assessed using a longitudinal study design. Therefore, we investigated the association between baseline plasma FGF21 levels and incident HF in the Multi-Ethnic Study of Atherosclerosis (MESA). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 15, 2023 Category: Biomedical Science Authors: William Tucker, Robyn L. McClelland, Matthew A. Allison, Moyses Szklo, Kerry-Anne Rye, Kwok Leung Ong Source Type: research

Epidemiology of sarcopenia: Prevalence, risk factors, and consequences
Sarcopenia is a geriatric condition featured by a progressive loss of muscle mass and function and associated with various adverse health outcomes. In this review, we aimed to summarize the epidemiological features of sarcopenia as well as consequences and risk factors of the disease. We performed a systematic review of meta-analysis on sarcopenia to collect data. The prevalence of sarcopenia varied between studies and depending on definition used. Sarcopenia was estimated to influence 10  %–16 % of the elderly worldwide. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 10, 2023 Category: Biomedical Science Authors: Shuai Yuan, Susanna C. Larsson Tags: Review Source Type: research

The role of histone deacetylases in cardiac energy metabolism in heart diseases
Heart diseases are associated with substantial morbidity and mortality worldwide. The underlying mechanisms and pathological changes associated with cardiac diseases are exceptionally complex. Highly active cardiomyocytes require sufficient energy metabolism to maintain their function. Under physiological conditions, the choice of fuel is a delicate process that depends on the whole body and organs to support the normal function of heart tissues. However, disordered cardiac metabolism has been discovered to play a key role in many forms of heart diseases, including ischemic heart disease, cardiac hypertrophy, heart failure...
Source: Metabolism - Clinical and Experimental - March 6, 2023 Category: Biomedical Science Authors: Qingwen Yu, Guangyuan Zhao, Jingjing Liu, Yajie Peng, Xueli Xu, Fei Zhao, Yangyang Shi, Chengyun Jin, Ji Zhang, Bo Wei Tags: Review Source Type: research