Increased meal-induced neurotensin response predicts successful maintenance of weight loss – Data from a randomized controlled trial

The gut derived anorexigenic hormone neurotensin (NT) is upregulated after bariatric surgery which may contribute to the sustained weight loss. In contrast, diet-induced weight loss is most often followed by weight regain. We therefore investigated whether diet-induced weight loss impacts levels of circulating NT in mice and humans and whether NT levels predicts body weight change after weight loss in humans.

Source: Metabolism - Clinical and Experimental - March 15, 2023 Category: Biomedical Science Authors: Annemette Overgaard Brethvad, Hannah Louise Zakariassen, Joachim Holt, Julie Rehn é Lundgren, Alexander Jakobsen, Bolette Hartmann, Eva Winning Lehmann, Hannelouise Kissow, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov, Birgitte Holst Source Type: research