Metabolism - Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Intermittent fasting protects β-cell identity and function in a type-2 diabetes model
Type 2 diabetes (T2DM) is caused by the interaction of multiple genes and environmental factors. T2DM is characterized by hyperglycemia, insulin secretion deficiency and insulin resistance. Chronic hyperglycemia induces β-cell dysfunction, loss of β-cell mass/identity and β-cell dedifferentiation. Intermittent fasting (IF) a commonly used dietary regimen for weight-loss, also induces metabolic benefits including reduced blood glucose, improved insulin sensitivity, reduced adiposity, inflammation, oxidative-stres s and increased fatty-acid oxidation; however, the mechanisms underlying these effects in pancreatic β-cells...
Source: Metabolism - Clinical and Experimental - January 30, 2024 Category: Biomedical Science Authors: Sumit Patel, Zihan Yan, Maria S. Remedi Source Type: research

Identification of MGMT promoter methylation as a specific lipid metabolism biomarker, reveals the feasibility of atorvastatin application in glioblastoma
Glioblastoma is one of the deadliest tumors, and limited improvement in managing glioblastoma has been achieved in the past decades. The unmethylated promoter area of 6-O-Methylguanine-DNA Methyltransferase (MGMT) is a significant biomarker for recognizing a subset of glioblastoma that is resistant to chemotherapy. Here we identified MGMT methylation can also work as a specific biomarker to classify the lipid metabolism patterns between methylated and unmethylated glioblastoma and verify the potential novel therapeutic strategy for unmethylated MGMT glioblastoma. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2024 Category: Biomedical Science Authors: Zhaonian Hao, Jiejun Wang, Yifan Lv, Weiqi Wu, Shaodong Zhang, Shuyu Hao, Junsheng Chu, Hong Wan, Jie Feng, Nan Ji Source Type: research

LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease
The Developmental Origins of Health and Disease hypothesis sustains that exposure to different stressors during prenatal development prepares the offspring for the challenges to be encountered after birth. We studied the gestational period as a particularly vulnerable window where different stressors can have strong implications for fetal programming of the offspring's life-long metabolic status via alterations of specific placentally expressed nutrient transporters. To study this mechanism, we used a murine prenatal stress model, human preeclampsia, early miscarriage, and healthy placental tissue samples, in addition to i...
Source: Metabolism - Clinical and Experimental - January 28, 2024 Category: Biomedical Science Authors: Mariana Schroeder, Barbara Fuenzalida, Nan Yi, Saira Shahnawaz, J ürg Gertsch, Daniele Pellegata, Edgar Ontsouka, Andrea Leiva, Jaime Gutiérrez, Martin Müller, Marcela A. Brocco, Christiane Albrecht Source Type: research

The risk and benefit of revisional vs. primary metabolic- bariatric surgery and drug therapy - A narrative review
Metabolic and bariatric surgery (MBS) leads to long-term weight loss, reduced risk of cardiovascular events and cancer, and reduced mortality. Sleeve gastrectomy and Roux-en-Y gastric bypass are currently the most common surgical techniques.Weight loss after MBS was previously believed to work through restriction and malabsorption, however, mechanistic studies show that MBS techniques with long term efficacy instead alter physiological signaling between the gut and the brain.In revisional MBS, the initial surgical technique is corrected, modified, or converted to a new one. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 26, 2024 Category: Biomedical Science Authors: Sebastian Nedelcut, Stephan Axer, Torsten Olbers Source Type: research

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Source: Metabolism - Clinical and Experimental - January 23, 2024 Category: Biomedical Science Source Type: research

Steatotic liver disease predicts cardiovascular disease and advanced liver fibrosis: A community-dwelling cohort study with 20-year follow-up
Our study provides new insight into hepatic and cardiovascular outcomes related to SLD subtypes. The risk of CVD increased in the order of no SLD, MASLD, and MetALD. The SLD subcategories, considering CMRFs and alcohol intake, outperformed traditional fatty liver categorizations in predicting CVD risk. The proposed SLD terminology could impact clinical practice, warranting further exploration of the heterogeneity of clinical outcomes among SLD subtypes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 22, 2024 Category: Biomedical Science Authors: Hun Jee Choe, Joon Ho Moon, Won Kim, Bo Kyung Koo, Nam H. Cho Source Type: research

Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice
Imeglimin is a recently developed anti-diabetic drug that could concurrently promote insulin secretion and insulin sensitivity, while its mechanisms of action are not fully understood. Here we show that imeglimin administration could protect mice from high fat diet-induced weight gain with enhanced energy expenditure and attenuated whitening of brown adipose tissue. Imeglimin administration led to significant alteration of gut microbiota, which included an increase of Akkermansia genus, with attenuation of obesity-associated gut pathologies. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 21, 2024 Category: Biomedical Science Authors: Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano, Yuriko Sorimachi, Keiyo Takubo, Kohjiro Ueki Tags: Brief Report Source Type: research

Dysregulation of autophagy activation induced by atorvastatin contributes to new-onset diabetes mellitus in western diet-fed mice
The incidence of statin-induced new-onset diabetes (NOD) is increasing but its underlying mechanisms remain unclear. We aimed to investigate the effects of various doses of atorvastatin (ATO)-induced autophagy on the development of NOD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 19, 2024 Category: Biomedical Science Authors: Juhee Kim, Minjune Kim, Minjeong Kim, Young-Hye You, Youngmi Song, Byung-Wan Lee Source Type: research

Effect of sodium-glucose cotransporter-2 inhibitors on continuous glucose monitoring metrics, as adjunctive to insulin in adults with type 1 diabetes mellitus: a meta-analysis of randomized controlled trials
This meta-analysis of randomized trials (RCTs) aimed to evaluate the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on continuous glucose monitoring metrics as adjunctive to insulin in adults with type 1 diabetes mellitus (T1D). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 14, 2024 Category: Biomedical Science Authors: Djordje S. Popovic, Paschalis Karakasis, Theocharis Koufakis, Nikolaos Fragakis, Nikolaos Papanas, Milena Mitrovic, Evanthia Gouveri, Dimitrios Patoulias Source Type: research

A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation
Macrophage migration inhibitory factor (MIF) is an innate cytokine that regulates both inflammatory and homeostatic responses. MIF is expressed by cardiomyocytes, where it exerts a protective action against ischemia-reperfusion (I/R) injury by activating AMP-activated protein kinase (AMPK). This effect is attenuated in the senescent heart due to an intrinsic, age-related reduction in MIF expression. We hypothesized that treating the aged heart with the small molecule MIF agonist (MIF20) can reinforce protective MIF signaling in cardiomyocytes, leading to a beneficial effect against I/R stress. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 14, 2024 Category: Biomedical Science Authors: Hao Wang, Lily Slotabec, Steven Didik, Zehui Li, Lin Leng, Bi Zhao, Richard Bucala, Ji Li Source Type: research

Performance of non-invasive tests for liver fibrosis resolution after bariatric surgery
The value of non-invasive tests for monitoring the resolution of significant liver fibrosis after treatment is poorly investigated. We compared the performances of six non-invasive tests to predict the resolution of significant fibrosis after bariatric surgery. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 12, 2024 Category: Biomedical Science Authors: Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Robert Caiazzo, Chiara Saponaro, Guillaume Lassailly, Helene Verkindt, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Viviane Gnemmi, Emmanuelle Leteurtre, Alain Duhamel, Ma Source Type: research

Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study
A new fatty liver disease nomenclature, steatotic liver disease (SLD) has been proposed; however, there are no data on clinical outcomes. We investigated the impact of SLD with metabolic dysfunction (MD; SLD-MD) on all-cause mortality. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 12, 2024 Category: Biomedical Science Authors: Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim Source Type: research

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction
Adipose tissue dysfunction is more related to insulin resistance than body mass index itself and an alteration in adipose tissue function is thought to underlie the shift from metabolically healthy to unhealthy obesity. Herein, we performed a clustering analysis that revealed distinct visceral adipose tissue gene expression patterns in patients with obesity at distinct stages of metabolic dysregulation. We have built a cross-sectional cohort that aims at reflecting the evolution of the metabolic sequelae of obesity with the main objective to map the sequential events that play a role in adipose tissue dysfunction from the ...
Source: Metabolism - Clinical and Experimental - January 12, 2024 Category: Biomedical Science Authors: Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr é Nogueira da Costa, Philipp E. Scherer, Flávio Reis, Francisco Pereira, Raquel Seiça, Paulo Matafome Source Type: research

Performance of non-invasive tests for liver fibrosis and resolution after bariatric surgery
The value of non-invasive tests for monitoring the resolution of significant liver fibrosis after treatment is poorly investigated. We compared the performances of six non-invasive tests to predict the resolution of significant fibrosis after bariatric surgery. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 12, 2024 Category: Biomedical Science Authors: Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Robert Caiazzo, Chiara Saponaro, Guillaume Lassailly, Helene Verkindt, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Viviane Gnemmi, Emmanuelle Leteurtre, Alain Duhamel, Ma Source Type: research

Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes
The coexistence of cardiovascular disease (CVD) and diabetic kidney disease (DKD) is common in people with type 1 diabetes (T1D) and is strongly associated with an increased risk of morbidity and mortality. Hence, it is imperative to explore robust tools that can accurately reflect the development and progression of cardiorenal complications. Several cardiovascular and kidney biomarkers have been identified to detect at-risk individuals with T1D. The primary aim of this review is to highlight biomarkers of injury, inflammation, or renal hemodynamic changes that may influence T1D susceptibility to CVD and DKD. (Source: Meta...
Source: Metabolism - Clinical and Experimental - January 10, 2024 Category: Biomedical Science Authors: Luxcia Kugathasan, Vikas S. Sridhar, Kalie L. Tommerdahl, Cheng Xu, Petter Bjornstad, Andrew Advani, David Z.I. Cherney Tags: Mini-Review Source Type: research