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Hepatocyte TIPE2 is a fasting-induced Raf-1 inactivator that drives hepatic gluconeogenesis to maintain glucose homeostasis
The liver regulates metabolic balance during fasting-feeding cycle. Hepatic adaptation to fasting is precisely modulated on multiple levels. Tumor necrosis factor- α-induced protein 8-like 2 (TIPE2) is a negative regulator of immunity that reduces several liver pathologies, but its physiological roles in hepatic metabolism are largely unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 15, 2023 Category: Biomedical Science Authors: Yan Tao, Jingyuan Zhao, Jilong Yin, Zixin Zhou, Huijie Li, Jinhao Zang, Tianci Wang, Yalin Wang, Chun Guo, Faliang Zhu, Shen Dai, Fuwu Wang, Hui Zhao, Haiting Mao, Fengming Liu, Lining Zhang, Qun Wang Source Type: research

Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery
The 21st century is characterized by an increasing incidence and prevalence of obesity and the burden of its associated comorbidities, especially cardiometabolic diseases, which are reaching pandemic proportions. In the late '90s, the “black box” of adipose tissue and energy homeostasis was opened with the discovery of leptin, transforming the adipose tissue from an “inert fat-storage organ” to the largest human endocrine organ and creating the basis on which more intensified research efforts to elucidate the pathogenesis of obesity and develop novel treatments were based upon. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 7, 2023 Category: Biomedical Science Authors: Michail Kokkorakis, Angeliki Katsarou, Niki Katsiki, Christos S. Mantzoros Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 2, 2023 Category: Biomedical Science Source Type: research

Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study
Diabetes mellitus (DM) and sarcopenia (SP) are growing public health concerns in an aging society, which share common pathophysiological mechanisms and are associated with serious health consequences. We investigated the impact of DM and SP on all-cause and cardiovascular mortalities in a longitudinal nationwide population-based study. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 21, 2023 Category: Biomedical Science Authors: Eyun Song, Soon Young Hwang, Min Jeong Park, Ahreum Jang, Kyeong Jin Kim, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi Source Type: research

Olfactomedin 4 deletion exacerbates nonalcoholic fatty liver disease through P62-dependent mitophagy in mice
This study aims to investigate the role and mechanisms of OLFM4 in nonalcoholic fatty liver disease (NAFLD). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 20, 2023 Category: Biomedical Science Authors: Shenghui Chen, Xinyu Wang, Zhening Liu, Jinghua Wang, Yanjun Guo, Qinqiu Wang, Hangkai Huang, Youming Li, Chaohui Yu, Chengfu Xu Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 4, 2023 Category: Biomedical Science Source Type: research

Sarcopenia, sarcopenic obesity and nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD), sarcopenia and sarcopenic obesity (SO) are highly prevalent conditions that may coexist, especially in the aging population, without any approved pharmacologic treatment for all of them. There are multiple pathophysiologic mechanisms suggested to explain an association between NAFLD and sarcopenia or SO, including alterations in the adipokines, cytokines, hepatokines and myokines, which may interplay with other factors, such as aging, diet and physical inactivity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 3, 2023 Category: Biomedical Science Authors: Stergios A. Polyzos, Ilias D. Vachliotis, Christos S. Mantzoros Source Type: research

Perinatal metabolic inflammation in the hypothalamus impairs the development of homeostatic feeding circuitry
Over the past few decades, there has been a global increase in childhood obesity. This rise in childhood obesity contributes to the susceptibility of impaired metabolism during both childhood and adulthood. The hypothalamus, specifically the arcuate nucleus (ARC), houses crucial neurons involved in regulating homeostatic feeding. These neurons include proopiomelanocortin (POMC) and agouti-related peptide (AGRP) secreting neurons. They play a vital role in sensing nutrients and metabolic hormones like insulin, leptin, and ghrelin. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 3, 2023 Category: Biomedical Science Authors: Rahim Ullah, Yi Shen, Yu-Dong Zhou, Junfen Fu Tags: Review Source Type: research

Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive non-alcoholic fatty liver disease indexes: Results from a large multi-center study
Non-invasive tools (NIT) for non-alcoholic fatty liver disease (NAFLD) screening or diagnosis need to be thoroughly validated using liver biopsies. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 30, 2023 Category: Biomedical Science Authors: Matina Kouvari, Laura Valenzuela-Vallejo, Valentina Guatibonza-Garcia, Stergios A. Polyzos, Yixiang Deng, Michail Kokkorakis, Melih Agraz, Sophia C. Mylonakis, Angeliki Katsarou, Ornella Verrastro, Georgios Markakis, Mohammed Eslam, Georgios Papatheodorid Source Type: research

Transcription factor EB: A potential integrated network regulator in metabolic-associated cardiac injury
With the worldwide pandemic of metabolic diseases, such as obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), cardiometabolic disease (CMD) has become a significant cause of death in humans. However, the pathophysiology of metabolic-associated cardiac injury is complex and not completely clear, and it is important to explore new strategies and targets for the treatment of CMD. A series of pathophysiological disturbances caused by metabolic disorders, such as insulin resistance (IR), hyperglycemia, hyperlipidemia, mitochondrial dysfunction, oxidative stress, inflammation, endoplasmic reticulum stress (ERS), a...
Source: Metabolism - Clinical and Experimental - July 28, 2023 Category: Biomedical Science Authors: Weixing Wen, Haoxiao Zheng, Weiwen Li, Guolin Huang, Peng Chen, Xiaolin Zhu, Yue Cao, Jiahuan Li, Xiaohui Huang, Yuli Huang Tags: Review Source Type: research

Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD
The biological mediators supporting the resolution of liver steatosis, inflammation and fibrosis after bariatric surgery in patients with obesity and NAFLD remain unclear. We sought to analyze whether uroguanylin and guanylin, two gut hormones involved in the regulation of satiety, food preference and adiposity, are involved in the amelioration of obesity-associated NAFLD after bariatric surgery. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 28, 2023 Category: Biomedical Science Authors: Eva M. Fern ández-Sáez, Maite Losarcos, Sara Becerril, Víctor Valentí, Rafael Moncada, Marina Martín, María A. Burrell, Victoria Catalán, Javier Gómez-Ambrosi, Carmen Mugueta, Inmaculada Colina, Camilo Silva, Javier Escalada, Gema Frühbeck, Amaia Source Type: research

Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma
Protein kinases (PKs), one of the largest protein families, can be further divided into different groups based on their substrate or structure and function. PKs are important signaling messengers in numerous life activities, including cell metabolism, proliferation, division, differentiation, senescence, death, and disease. Among PK-related diseases, nonalcoholic fatty liver disease (NAFLD) has been recognized as a major contributor to hepatocellular carcinoma (HCC) and liver transplantation. Unfortunately, NAFLD-derived HCC (NAFLD-HCC) has poor prognosis because it is typically accompanied by older age, multiple metabolic...
Source: Metabolism - Clinical and Experimental - July 28, 2023 Category: Biomedical Science Authors: Rong Liu, Mingping Qian, Ying-Yu Cui Tags: Review Source Type: research

From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic condition and unmet clinical need
“Ἀρχὴ Σοφίας ἡ τῶν Ὀνομάτων Ἐπίσκεψις” [(Αντισθένης ο Αθηναίος, 445–360 π.Χ.)] “The beginning of the journey to wisdom is the appropriate definition of terminology” [(Antisthenes the Athenean; 445–360 BCE)]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 28, 2023 Category: Biomedical Science Authors: Michail Kokkorakis, Chrysoula Boutari, Niki Katsiki, Christos S. Mantzoros Tags: Editorial Source Type: research

Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide; however, the underlying mechanisms remain poorly understood. FAM3D is a member of the FAM3 family; however, its role in hepatic glycolipid metabolism remains unknown. Serum FAM3D levels are positively correlated with fasting blood glucose levels in patients with diabetes. Hepatocytes express and secrete FAM3D, and its expression is increased in steatotic human and mouse livers. Hepatic FAM3D overexpression ameliorated hyperglycemia and steatosis in obese mice, whereas FAM3D-deficient mice exhibited exaggerated hyperglycemia and ste...
Source: Metabolism - Clinical and Experimental - July 14, 2023 Category: Biomedical Science Authors: Yuntao Hu, Jing Li, Xin Li, Di Wang, Rui Xiang, Wenjun Liu, Song Hou, Qinghe Zhao, Xiaoxing Yu, Ming Xu, Dong Zhao, Tao Li, Yujing Chi, Jichun Yang Source Type: research

miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis
MicroRNA-dependent regulation of hepatic lipid metabolism has been recognized recently as a key pathological mechanism contributing to the development of NAFLD. However, whether miR-32-5p (miR-32) plays a role in lipid metabolism or contributes to NAFLD remains unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 11, 2023 Category: Biomedical Science Authors: Ya-Di Wang, Liang-Liang Wu, Yun-Ni Mai, Kai Wang, Yi Tang, Qi-Yu Wang, Jiao-Yang Li, Li-Yan Jiang, Zhe-Zhen Liao, Can Hu, Yuan-Yuan Wang, Jing-Jing Liu, Jiang-Hua Liu, Xin-Hua Xiao Source Type: research