Metabolism - Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mitochondrial quality control mechanisms as molecular targets in diabetic heart
Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In addition to their canonical metabolic actions, mitochondria influence various other aspects of cardiomyocyte function, including oxidative stress, iron regulation, metabolic reprogramming, intracellular signaling transduction and cell death. These effects depend on the mitochondrial quality control (MQC) system, which includes mitochondrial dynamics, mitophagy and mitochondrial biogenesis. Mitochondria are not static entities, but dynamic units that undergo fission and fusion cycles to maintain their structural integrity. (Source: Meta...
Source: Metabolism - Clinical and Experimental - September 16, 2022 Category: Biomedical Science Authors: Xing Chang, Yukun Li, Chen Cai, Feng Wu, Jing He, Yaoyuan Zhang, Jiankai Zhong, Ying Tan, Ruxiu Liu, Hang Zhu, Hao Zhou Tags: Review Source Type: research

Increased risk of incident diabetes after therapy with immune checkpoint inhibitor compared with conventional chemotherapy: A longitudinal trajectory analysis using a tertiary care hospital database
Immune checkpoint inhibitor (ICI) has been emerged as a promising cancer treatment. However, ICI use induces immune-related adverse events, including diabetes mellitus. We compared the risk of new-onset diabetes between patients receiving an ICI and those receiving conventional chemotherapy (CC). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 16, 2022 Category: Biomedical Science Authors: Minyoung Lee, Kyeongseob Jeong, Yu Rang Park, Yumie Rhee Source Type: research

Changes in circulating bile acid subtypes in response to weight-loss diets are associated with improvements in glycemic status and insulin resistance: The POUNDS Lost trial
Various primary and secondary bile acids (BAs) may play pivotal roles in glucose/insulin metabolism. We investigated whether changes in specific BA subtypes were associated with long-term changes in glucose and insulin sensitivity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 15, 2022 Category: Biomedical Science Authors: Yoriko Heianza, Xuan Wang, Jennifer Rood, Clary B. Clish, George A. Bray, Frank M. Sacks, Lu Qi Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 2, 2022 Category: Biomedical Science Source Type: research

Sodium-glucose cotransporter-2 inhibitors: A treatment option for recurrent vasovagal syndrome?
The increasing prevalence of metabolic disease, along with cardiometabolic multimorbidity remains a leading healthcare challenge, despite advances in biomarker discovery and a broad pharmacological armamentarium [1 –4]. Sodium-glucose cotransporter-2 (SGLT2) inhibitors introduced a paradigm shift in the management of diabetes. They have been shown to lower glycated hemoglobin, fasting and postprandial plasma glucose levels, body weight, and blood pressure, while also offering cardio- and nephroprotection (Fi g. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 2, 2022 Category: Biomedical Science Authors: Despina Sanoudou, Christos S. Mantzoros, Michael A. Hill Source Type: research

Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat
Recurrent hypoglycemia (RH) impairs secretion of counterregulatory hormones. Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory hormones are poorly understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 2, 2022 Category: Biomedical Science Authors: Zejian Liu, Lingyu Zhang, Chen Qian, Ying Zhou, Qiuyu Yu, Jiaqi Yuan, Yunfan Lv, Leheng Zhang, Xiaoai Chang, Yangyang Li, Yu Liu Source Type: research

Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification
Genetically determined fat mass is causally and linearly associated with mortality. The J-shape association between anthropometric FMI and mortality is caused by high-risk lifestyle factors. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 1, 2022 Category: Biomedical Science Authors: Jinbo Hu, Xiangjun Chen, Jun Yang, Edward Giovannucci, Dong Hoon Lee, Wenjin Luo, Qingfeng Cheng, Lilin Gong, Zhihong Wang, Qifu Li, Shumin Yang Source Type: research

Joint effect of blood pressure and glycemic variation on the risk of cardiovascular morbidity and mortality in persons with type 2 diabetes
This study aimed to examine the independent and joint effect of visit-to-visit BP and glycemic variation on CVD morbidity and mortality in persons with T2DM. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 1, 2022 Category: Biomedical Science Authors: Cheng-Chieh Lin, Chia-Ing Li, Ya-Ling Juan, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li Source Type: research

Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset
Prader-Willi syndrome (PWS) is a rare genetic imprinting disorder resulting from the expression loss of genes on the paternally inherited chromosome 15q11 –13. Early-onset life-thriving obesity and hyperphagia represent the clinical hallmarks of PWS. The noncoding RNA gene SNORD116 within the minimal PWS genetic lesion plays a critical role in the pathogenesis of the syndrome. Despite advancements in understanding the genetic basis for PWS, the path ophysiology of obesity development in PWS remains largely uncharacterized. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 21, 2022 Category: Biomedical Science Authors: Yunqi Chao, Lei Gao, Xiangzhi Wang, Yuqing Cai, Yingying Shu, Xinyi Zou, Yifang Qin, Chenxi Hu, Yangli Dai, Mingqiang Zhu, Zheng Shen, Chaochun Zou Source Type: research

Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis
Mitochondrial FAM3A has been revealed to be a viable target for treating diabetes and nonalcoholic fatty liver disease (NAFLD). However, its distinct mechanism in ameliorating hepatic steatosis remained unrevealed. High-throughput RNA sequencing revealed that carnitine palmityl transferase 2 (CPT2), one of the key enzymes for lipid oxidation, is the downstream molecule of FAM3A signaling pathway in hepatocytes. Intensive study demonstrated that FAM3A-induced ATP release activated P2 receptor to promote the translocation of calmodulin (CaM) from cytoplasm into nucleus, where it functioned as a co-activator of forkhead box p...
Source: Metabolism - Clinical and Experimental - August 19, 2022 Category: Biomedical Science Authors: Xiangyang Liu, Song Hou, Rui Xiang, Chengqing Hu, Zhenzhen Chen, Na Li, Han Yan, Xiaoxing Yu, Xin Li, Yujing Chi, Jichun Yang Source Type: research

Novel metabolic classification for extrahepatic complication of metabolic associated fatty liver disease: A data-driven cluster analysis with international validation
Traditional classification systems of metabolic-associated fatty liver disease (MAFLD) do not account for the high rate of extrahepatic complications. To create a new classification of MAFLD using metabolic parameters to identify risks of complications more accurately. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 19, 2022 Category: Biomedical Science Authors: Junzhao Ye, Xiaodong Zhuang, Xin Li, Xiaorong Gong, Yanhong Sun, Wei Wang, Shiting Feng, Tingfeng Wu, Bihui Zhong Source Type: research

Kdm6a deficiency in microglia/macrophages epigenetically silences Lcn2 expression and reduces photoreceptor dysfunction in diabetic retinopathy
Diabetic retinopathy (DR) is one of the leading causes of severe visual impairment worldwide. However, the role of adaptive immune inflammation driven by microglia/macrophages in DR is not yet well elucidated. Kdm6a is a histone demethylase that removes the trimethyl groups of histones H3K27 and plays important biological roles in activating target genes. To elucidate the role of Kdm6a in microglia/macrophages in diabetic retinas, we established diabetic animal models with conditional knockout mice to investigate the impacts of Kdm6a deficiency. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 19, 2022 Category: Biomedical Science Authors: Yanjun Wen, Xin Chen, Huazhang Feng, Xu Wang, Xiaoli Kang, Peiquan Zhao, Chen Zhao, Yan Wei Source Type: research

Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial
Men with obesity tend to be insulin resistant and often have low-normal testosterone concentrations. We conducted a clinical trial aimed to evaluate potential therapeutic strategies for low testosterone in men with obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 17, 2022 Category: Biomedical Science Authors: Jos é Carlos Fernández-García, Rocío Barrios-Rodríguez, Maite Asenjo-Plaza, Bruno Ramos-Molina, María Molina-Vega, Antonio Guzmán-Guzmán, Luis Moreno-León, Elena M. Yubero-Serrano, Francisca Rius-Díaz, Sergio Valdés, Miguel Ángel Martínez-Gon Source Type: research

Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis
Cholesterol is central to pancreatic β-cell physiology and alterations of its homeostasis contribute to β-cell dysfunction and diabetes. Proper intracellular cholesterol levels are maintained by different mechanisms including uptake via the low-density lipoprotein receptor (LDLR). In the liver, the proprotein convertase subtilisin/ke xin type 9 (PCSK9) routes the LDLR to lysosomes for degradation, thus limiting its recycling to the membrane. PCSK9 is also expressed in the pancreas and loss of function mutations of PCSK9 result in higher plasma glucose levels and increased risk of Type 2 diabetes mellitus. (Source: Metabo...
Source: Metabolism - Clinical and Experimental - August 15, 2022 Category: Biomedical Science Authors: Algerta Marku, Lorenzo Da Dalt, Alessandra Galli, Nevia Dule, Paola Corsetto, Angela Maria Rizzo, Annalisa Moregola, Patrizia Uboldi, Fabrizia Bonacina, Paola Marciani, Michela Castagna, Alberico Luigi Catapano, Giuseppe Danilo Norata, Carla Perego Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - August 9, 2022 Category: Biomedical Science Source Type: research