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Plasma proteome profiling reveals metabolic and immunologic differences between Anorexia Nervosa subtypes
Anorexia Nervosa (AN) is a severe psychiatric disorder of an unknown etiology with a crude mortality rate of about 5  % per decade, making it one of the deadliest of all psychiatric illnesses. AN is broadly classified into two main subtypes, restricting and binge/purging disorder. Despite extensive research efforts during several decades, the underlying pathophysiology of AN remains poorly understood. In this st udy, we aimed to identify novel protein biomarkers for AN by performing a proteomics analysis of fasting plasma samples from 78 females with AN (57 restrictive and 21 binge/purge type) and 70 healthy controls. (S...
Source: Metabolism - Clinical and Experimental - December 14, 2023 Category: Biomedical Science Authors: Diana Samodova, August Hoel, Tue Haldor Hansen, Loa Clausen, Gry Kjaersdam Tell éus, Hans-Peter Marti, Oluf Pedersen, Rene Klinkby Støving, Atul Shahaji Deshmukh Source Type: research

Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming
Mitochondrial dysfunction and metabolic reprogramming are key features of hepatocellular carcinoma (HCC). Despite its significance, the precise underlying mechanism behind these processes has not been fully elucidated. The latest investigations, along with our previous discoveries, have substantiated the significant role of mitochondrial ribosomal protein L12 (MRPL12), a newly identified gene involved in mitochondrial transcription regulation, in the modulation of mitochondrial metabolism. Nevertheless, the role of MRPL12 in tumorigenesis has yet to be investigated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 14, 2023 Category: Biomedical Science Authors: Xingzhao Ji, Zhen Yang, Chensheng Li, Suwei Zhu, Yu Zhang, Fuyuan Xue, Shengnan Sun, Tingting Fu, Can Ding, Yi Liu, Qiang Wan Source Type: research

Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD
Subcutaneous adipose tissue (SAT) dysfunction contributes to NAFLD pathogenesis and may be influenced by the gut microbiota. Whether transcript profiles of SAT are associated with liver fibrosis and are influenced by synbiotic treatment (that changes the gut microbiome) is unknown. We investigated: (a) whether the presence of clinically significant, ≥F2 liver fibrosis associated with adipose tissue (AT) dysfunction, differential gene expression in SAT, and/or a marker of tissue fibrosis (Composite collagen gene expression (CCGE)); and (b) whether synbiotic treatment modified markers of AT dysfunction and the SAT transcri...
Source: Metabolism - Clinical and Experimental - December 12, 2023 Category: Biomedical Science Authors: Josh Bilson, Carolina J. Oquendo, James Read, Eleonora Scorletti, Paul R. Afolabi, Jenny Lord, Laure B. Bindels, Giovanni Targher, Sumeet Mahajan, Diana Baralle, Philip C. Calder, Christopher D. Byrne, Jaswinder K. Sethi Source Type: research

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(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 9, 2023 Category: Biomedical Science Source Type: research

Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis
Chemokine (CC motif) receptor 1 (CCR1) promotes liver fibrosis in mice. However, its effects on nonalcoholic steatohepatitis (NASH) remain unclear. Therefore, the present study aimed to investigate the role of CCR1 in the progression of NASH. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - December 7, 2023 Category: Biomedical Science Authors: Haoran Li, Tongtong Pan, Lingjia Gao, Rongxiu Ding, Yanwen Yu, Mengchen Ma, Yajiao Wang, Shengnan Jin, Yongping Chen, Chunming Ding, Liang Xu Source Type: research

The role of ROS in tumor infiltrating immune cells and cancer immunotherapy
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and epigenetic programs and have an indispensable role in cellular function. In immune cells, ROS are mediators of specialized functions such as phagocytosis, antigen presentation, activation, cytolysis, and differentiation. ROS have a fundamental role in the tumor microenvironment (TME) where they are produced by immune cell-intrinsic and -extrinsic mechanisms. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 29, 2023 Category: Biomedical Science Authors: Rushil Shah, Betul Ibis, Monisha Kashyap, Vassiliki A. Boussiotis Tags: Review Source Type: research

Bariatric Surgery in Women with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2023 Category: Biomedical Science Authors: Suhaniya N.S. Samarasinghe, Casper Woods, Alexander Dimitri Miras Tags: Review Source Type: research

The impact of bariatric surgery on women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 27, 2023 Category: Biomedical Science Authors: Suhaniya N.S. Samarasinghe, Casper Woods, Alexander Dimitri Miras Tags: Review Source Type: research

Rising global burden of cancer attributable to high BMI from 2010 to 2019
High body mass index (BMI) is a major risk factor for cancer development, but its impact on the global burden of cancer remains unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 26, 2023 Category: Biomedical Science Authors: Darren Jun Hao Tan, Cheng Han Ng, Mark Muthiah, Jie Ning Yong, Douglas Chee, Margaret Teng, Zhen Yu Wong, Rebecca Wenling Zeng, Yip Han Chin, Jiong-Wei Wang, Pojsakorn Danpanichkul, Ruveena Bhavani Rajaram, Ramanuj DasGupta, Hiroyuki Suzuki, Hirokazu Taka Source Type: research

Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss
In this study, we identified Tm4sf19, a member of the tetraspanin family, as a regulator of osteoclast function. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 26, 2023 Category: Biomedical Science Authors: Sujin Park, Jin Sun Heo, Seiya Mizuno, Min Woo Kim, Haein An, Eunji Hong, Min Gi Kang, Junil Kim, Rebecca Yun, Hyeyeon Park, Eun-Hye Noh, Min-Jung Lee, Kwiyeom Yoon, Pyunggang Kim, Minjung Son, Kyoungwha Pang, Jihee Lee, Jinah Park, Akira Ooshima, Tae-Jin Source Type: research

Plasma metabolite predictors of metabolic syndrome incidence and reversion
Metabolic Syndrome (MetS) is a progressive pathophysiological state defined by a cluster of cardiometabolic traits. However, little is known about metabolites that may be predictors of MetS incidence or reversion. Our objective was to identify plasma metabolites associated with MetS incidence or MetS reversion. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 23, 2023 Category: Biomedical Science Authors: Zhila Semnani-Azad, Estefan ía Toledo, Nancy Babio, Miguel Ruiz-Canela, Clemens Wittenbecher, Cristina Razquin, Fenglei Wang, Courtney Dennis, Amy Deik, Clary B. Clish, Dolores Corella, Montserrat Fitó, Ramon Estruch, Fernando Arós, Emilio Ros, Jesús Source Type: research

Intestinal glucose excretion: A potential mechanism for glycemic control
The gut has been increasingly recognized in recent years as a pivotal organ in the maintenance of glucose homeostasis. Specifically, the profound and enduring improvement in glucose metabolism achieved through metabolic surgery to modify the anatomy of the gut has prompted scholars to acknowledge that the most effective strategy for treating type 2 diabetes mellitus (T2DM) involves the gut. The mechanisms underlying the regulation of glucose metabolism by the gut encompass gut hormones, bile acids, intestinal gluconeogenesis, gut microbiota, and signaling interactions between the gut and other organs (liver, brain, adipose...
Source: Metabolism - Clinical and Experimental - November 23, 2023 Category: Biomedical Science Authors: Zhigang Ke, Zongshi Lu, Qing Li, Weidong Tong Tags: Mini-Review Source Type: research

Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond
Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related comorbidities. Accumulating evidence on the mechanisms through which MS exerts its actions has highlighted the altered secretion of hormonally active peptides of intestinal origin with biological actions crucial to energy metabolism as key drivers of MS clinical effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 21, 2023 Category: Biomedical Science Authors: Dimitrios Tsilingiris, Alexander Kokkinos Source Type: research

Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation
Dysbiosis contributes to alcohol-associated liver disease (ALD); however, the precise mechanisms remain elusive. Given the critical role of the gut microbiota in ammonia production, we herein aim to investigate whether and how gut-derived ammonia contributes to ALD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 21, 2023 Category: Biomedical Science Authors: Qing Song, Chueh-Lung Hwang, Yanhui Li, Jun Wang, Jooman Park, Samuel M. Lee, Zhaoli Sun, Jun Sun, Yinglin Xia, Natalia Nieto, Jose Cordoba-Chacon, Yuwei Jiang, Xiaobing Dou, Zhenyuan Song Source Type: research

How can we pharmacologically mimic the mechanisms that make gastric bypass so effective? Are we close to a “medical bypass”?
Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related comorbidities. Accumulating evidence on the mechanisms through which MS exerts its actions has highlighted the altered secretion of hormonally active peptides of intestinal origin with biological actions crucial to energy metabolism as key drivers of MS clinical effects. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 21, 2023 Category: Biomedical Science Authors: Dimitrios Tsilingiris, Alexander Kokkinos Source Type: research