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Upstream and downstream regulators of Klotho expression in chronic kidney disease
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and progression of CKD. Conversely, an increase in Klotho levels results in improved kidney function and delays CKD progression, supporting the notion that modulating Klotho levels could represent a possible therapeutic strategy for CKD treatment. Nevertheless, the regulatory mechanisms responsible for the loss of Klotho remain elusive. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 28, 2023 Category: Biomedical Science Authors: Sha-Sha Li, Ming-jie Sheng, Zhuo-Yi Sun, Yang Liang, Li-Xia Yu, Qi-Feng Liu Tags: Review Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 25, 2023 Category: Biomedical Science Source Type: research

Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders
Aging is characterized by progressive metabolic dyshomeostasis that increases morbidity and mortality. Solutions for optimizing healthy aging are challenged by lacking appropriate biomarkers. Moreover, druggable targets to rejuvenate the aging-associated metabolic phenotypes remain unavailable. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 24, 2023 Category: Biomedical Science Authors: Jian Lv, Yimeng Hu, Lili Li, Yuan He, Jingjing Wang, Ningning Guo, Yu Fang, Qin Chen, Cheguo Cai, Jingjing Tong, Lixu Tang, Zhihua Wang Source Type: research

Folate metabolism negatively regulates OAS-mediated antiviral innate immunity via ADAR3/endogenous dsRNA pathway
Folate (FA) is an essential cofactor in the one-carbon (1C) metabolic pathway and participates in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. FA metabolism has been reported to play an important role in viral replications; however, the roles of FA metabolism in the antiviral innate immune response are unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 21, 2023 Category: Biomedical Science Authors: Jing Wu, Qiao You, Ruining Lyu, Yajie Qian, Hongji Tao, Fang Zhang, Yurong Cai, Na Jiang, Nan Zheng, Deyan Chen, Zhiwei Wu Source Type: research

Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis
Emerging evidence suggests that crosstalk between Kupffer cells (KCs) and hepatocytes protects against non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms that lead to the reduction of steatosis in NAFLD remain obscure. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 9, 2023 Category: Biomedical Science Authors: Jeongmin Park, So-Young Rah, Hyeong Seok An, Jong Youl Lee, Gu Seob Roh, Stefan W. Ryter, Jeong Woo Park, Chae Ha Yang, Young-Joon Surh, Uh-Hyun Kim, Hun Taeg Chung, Yeonsoo Joe Source Type: research

Chronic physiologic hyperglycemia impairs insulin-mediated suppression of plasma glucagon concentration in healthy humans
We examined the effect of chronic (48 –72 h) physiologic increase (+50 mg/dl) in plasma glucose concentration on suppression of plasma glucagon concentration by insulin and by hyperglycemia in normal glucose tolerant (NGT) individuals. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 4, 2023 Category: Biomedical Science Authors: Xi Chen, Aurora Merovci, Ralph A. DeFronzo, Devjit Tripathy Source Type: research

Subtypes of type 2 diabetes and their association with outcomes in Korean adults - A cluster analysis of community-based prospective cohort
Little is known about the subtypes of type 2 diabetes (T2D) and their association with clinical outcomes in Asians. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 4, 2023 Category: Biomedical Science Authors: You-Cheol Hwang, Hong-Yup Ahn, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung Source Type: research

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(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - February 3, 2023 Category: Biomedical Science Source Type: research

Early humoral response to COVID-19 vaccination in patients living with obesity and diabetes in France. The COVPOP OBEDIAB study with results from the ANRS0001S COV-POPART cohort
Patients with diabetes and obesity are populations at high-risk for severe COVID-19 outcomes and have shown blunted immune responses when administered different vaccines. Here we used the ‘ANRS0001S COV-POPART’ French nationwide multicenter prospective cohort to investigate early humoral response to COVID-19 vaccination in the sub-cohort (‘COVPOP OBEDIAB’) of patients with obesity and diabetes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2023 Category: Biomedical Science Authors: Gaborit B énédicte, Fernandes Sara, Loubet Paul, Ninove Laetitia, Dutour Anne, Cariou Bertrand, Coupaye Muriel, Clement Karine, Czernichow Sébastien, Carette Claire, Resseguier Noémie, Esterle Laure, Sabrina Kali, Marie Houssays, de Lamballerie Xavier Source Type: research

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000 –2019
We examined the global trends and mortality of metabolic diseases in individuals aged below 40  years using data from the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 27, 2023 Category: Biomedical Science Authors: Bryan Chong, Gwyneth Kong, Kannan Shankar, H.S. Jocelyn Chew, Chaoxing Lin, Rachel Goh, Yip Han Chin, Darren Jun Hao Tan, Kai En Chan, Wen Hui Lim, Nicholas Syn, Siew Pang Chan, Jiong-Wei Wang, Chin Meng Khoo, Georgios K. Dimitriadis, Karn Wijarnpreecha, Source Type: research

Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis
The trajectory from healthy to critical illness is influenced by numerous factors, including metabolism, which differs substantially between males and females. Whole body protein breakdown is substantially increased in critically ill patients, but it remains unclear whether there are sex differences that could explain the different health outcomes. Hence, we performed a secondary analysis of a study, where we used a novel pulse isotope method in critically ill and matched healthy males and females. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 26, 2023 Category: Biomedical Science Authors: Nicolaas E.P. Deutz, Pierre Singer, Raven A. Wierzchowska-McNew, Marina V. Viana, Itai A. Ben-David, Olivier Pantet, John J. Thaden, Gabriella A.M. Ten Have, Mari ëlle P.K.J. Engelen, Mette M. Berger Source Type: research

Adherence to the EAT-Lancet diet, genetic susceptibility, and risk of type 2 diabetes in Swedish adults
In 2019, the EAT-Lancet Commission proposed a mainly plant-based diet that nurtures human health and supports environmental sustainability. However, its association with type 2 diabetes (T2D) has not been widely studied, and it remains unclear whether genetic susceptibility for T2D can modify this association. The aim was therefore to investigate the association between the EAT-Lancet diet and risk of T2D and assess whether the association differs by the genetic predisposition to T2D. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 19, 2023 Category: Biomedical Science Authors: Shunming Zhang, Anna Stubbendorff, Kjell Olsson, Ulrika Ericson, Kaijun Niu, Lu Qi, Yan Born é, Emily Sonestedt Source Type: research

Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures
Mitochondria regulate immune and organ function. It is unknown whether higher intracellular drug levels observed in peripheral blood mononuclear cells (PBMCs) treated with tenofovir alafenamide (TAF) compared to tenofovir disoproxil fumarate (TDF) may alter mitochondrial function and energy production in immune cells in HIV(+) patients. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 13, 2023 Category: Biomedical Science Authors: Eleni Ritou, Sandro Satta, Anton Petcherski, Maria Daskou, Madhav Sharma, Hariclea Vasilopoulos, Eisuke Murakami, Orian S. Shirihai, Theodoros Kelesidis Source Type: research

Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD
Production rates of the short-chain fatty acids (SCFA) acetate, propionate, and butyrate, which are beneficial metabolites of the intestinal microbiota, are difficult to measure in humans due to inaccessibility of the intestine to perform measurements, and the high first-pass metabolism of SCFAs in colonocytes and liver. We developed a stable tracer pulse approach to estimate SCFA whole-body production (WBP) in the accessible pool representing the systemic circulation and interstitial fluid. Compartmental modeling of plasma enrichment data allowed us to additionally calculate SCFA kinetics and pool sizes in the inaccessibl...
Source: Metabolism - Clinical and Experimental - January 12, 2023 Category: Biomedical Science Authors: Sarah K. Kirschner, Parisa Ghane, Jaekwan K. Park, Sunday Y. Simbo, Ivan Ivanov, Ulisses M. Braga-Neto, Gabri ëlla A.M. Ten Have, John J. Thaden, Mariëlle P.K.J. Engelen, Nicolaas E.P. Deutz Source Type: research

Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation
Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great potential for the treatment of diabetic ulceration; however, the underlying mechanism as well as its compatibility with the first-line anti-diabetic drug, metformin (MTF), has not been well elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 7, 2023 Category: Biomedical Science Authors: Fangzhou Du, Mengmeng Liu, Jingwen Wang, Lvzhong Hu, Dongao Zeng, Shaocong Zhou, Lixing Zhang, Meijia Wang, Xi Xu, Chenglong Li, Jingzhong Zhang, Shuang Yu Source Type: research