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Glucocorticoids and intrauterine programming of nonalcoholic fatty liver disease
Accumulating epidemiological and experimental evidence indicates that nonalcoholic fatty liver disease (NAFLD) has an intrauterine origin. Fetuses exposed to adverse prenatal environments (e.g., maternal malnutrition and xenobiotic exposure) are more susceptible to developing NAFLD after birth. Glucocorticoids are crucial triggers of the developmental programming of fetal-origin diseases. Adverse intrauterine environments often lead to fetal overexposure to maternally derived glucocorticoids, which can program fetal hepatic lipid metabolism through epigenetic modifications. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 30, 2023 Category: Biomedical Science Authors: Ze Chen, Li-Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang Tags: Review Source Type: research

Metabolically unhealthy obesity, sarcopenia and their interactions in obesity pathophysiology and therapeutics: Room for improvement in pharmacotherapy
Obesity is the fastest-growing medical condition, globally, with the current prevalence being approximately 30  %. This metabolic disorder is magnified by the prevalence of overweight being observed in a further 30 % of the population. Such numbers stand in stark contrast to what characterized the population several decades ago [1]. In the United States (US), obesity affects around 40 % of adults [2], accounting for $172.74 billion in annual expenditures [3] with the medical costs for adults with obesity being $1861 higher than those with healthy weight [4]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 27, 2023 Category: Biomedical Science Authors: Angeliki Katsarou, Matina Kouvari, Michael A. Hill, Christos S. Mantzoros Tags: Editorial Source Type: research

Upper small intestine microbiome in obesity and related metabolic disorders: A new field of investigation
The study of the gut microbiome holds great promise for understanding and treating metabolic diseases, as its functions and derived metabolites can influence the metabolic status of the host. While research on the fecal microbiome has provided valuable insights, it tells us only part of the story. This limitation arises from the substantial variations in microorganism distribution throughout the gastrointestinal tract due to changes in physicochemical conditions. Thus, relying solely on the fecal microbiome may not be sufficient to draw comprehensive conclusions about metabolic diseases. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 23, 2023 Category: Biomedical Science Authors: Emilie Steinbach, Davide Masi, Agn ès Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clément Source Type: research

Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass and function. This disorder has been associated with a range of adverse health outcomes, including fractures, functional deterioration, and increased mortality. The pathophysiology of sarcopenia is highly complex and multifactorial, involving both genetic and environmental factors as key contributors. This review consolidates current knowledge on the genetic factors influencing the pathogenesis of sarcopenia, particularly focusing on the altered gene expression of structural and metabolic proteins, growth factors, hormones, and inflamm...
Source: Metabolism - Clinical and Experimental - October 21, 2023 Category: Biomedical Science Authors: Arif Muhammad Aslam, Eun Bi Ma, Joo Young Huh Source Type: research

Brown adipose tissue-derived metabolites and their role in regulating metabolism
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult humans have offered a new approach to treating obesity and metabolic diseases. Beyond an accomplished role in adaptive thermogenesis, BAT secretes signaling molecules known as “batokines”, which are instrumental in regulating whole-body metabolism via autocrine, paracrine, and endocrine action. In addition to the intrinsic BAT metabolite-oxidizing activity, the endocrine functions of these molecules may help to explain the association between BAT activity and a health y systemic metabolic profile. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 19, 2023 Category: Biomedical Science Authors: Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje Tags: Review Source Type: research

Safety and efficacy of the new, oral, small-molecule, GLP-1 receptor agonists orforglipron and danuglipron for the treatment of type 2 diabetes and obesity: systematic review and meta-analysis of randomized controlled trials
The present systematic review aimed to synthesize available data from recently published randomized trials (RCTs) investigating the efficacy and safety of the novel, orally administered, small-molecule glucagon-like peptide 1 receptor agonists (GLP-1RAs) orforglipron and danuglipron for the treatment of type 2 diabetes mellitus (T2DM), obesity or both. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 16, 2023 Category: Biomedical Science Authors: Paschalis Karakasis, Dimitrios Patoulias, Konstantinos Pamporis, Panagiotis Stachteas, Konstantinos I. Bougioukas, Aleksandra Klisic, Nikolaos Fragakis, Manfredi Rizzo Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 15, 2023 Category: Biomedical Science Source Type: research

Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity
Dysregulation of angiotensin II type 1 receptor-associated protein (ATRAP) expression in cardiovascular, kidney, and adipose tissues is involved in the pathology of hypertension, cardiac hypertrophy, atherosclerosis, kidney injury, and metabolic disorders. Furthermore, ATRAP is highly expressed in bone marrow-derived immune cells; however, the functional role of immune cell ATRAP in obesity-related pathology remains unclear. Thus, we sought to identify the pathophysiological significance of immune cell ATRAP in the development of visceral obesity and obesity-related metabolic disorders using a mouse model of diet-induced o...
Source: Metabolism - Clinical and Experimental - October 13, 2023 Category: Biomedical Science Authors: Shunichiro Tsukamoto, Toru Suzuki, Hiromichi Wakui, Tatsuki Uehara, Juri Ichikawa, Hiroshi Okuda, Kotaro Haruhara, Kengo Azushima, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Keigo Hirota, Sho Kinguchi, Akio Yamashita, Tomohiko Tamura, Kouichi Tamura Source Type: research

Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents
Growing evidence demonstrates the role of the striatal dopamine system in the regulation of glucose metabolism. Treatment with dopamine antagonists is associated with insulin resistance and hyperglycemia, while dopamine agonists are used in treatment of diabetes mellitus type 2. The mechanism underlying striatal dopamine effects in glucose metabolism, however is not fully understood. Here, we provide mechanistic insights into the role of nucleus accumbens shell (sNAc) dopaminergic signaling in systemic glucose metabolism. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 5, 2023 Category: Biomedical Science Authors: Charlene Diepenbroek, Merel Rijnsburger, Astrid A.S. van Irsen, Leslie Eggels, Alexandre Kisner, Ewout Foppen, Unga A. Unmehopa, Chlo é Berland, Sophie Dólleman, Marene Hardonk, Céline Cruciani-Guglielmacci, Rudi Faust, Rick Wenning, Clarissa M. Maya-M Source Type: research

Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study
Gestational diabetes (GDM) is a distinctive form of diabetes that first presents in pregnancy. While most women return to normoglycemia after delivery, they are nearly ten times more likely to develop type 2 diabetes than women with uncomplicated pregnancies. Current prevention strategies remain limited due to our incomplete understanding of the early underpinnings of progression. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 4, 2023 Category: Biomedical Science Authors: Julie A.D. Van, Yihan Luo, Jayne S. Danska, Feihan Dai, Stacey E. Alexeeff, Erica P. Gunderson, Hannes Rost, Michael B. Wheeler Source Type: research

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study
The role of metabolic/inflammatory hormonal systems in metabolic dysfunction associated steatotic liver disease (MASLD) remains to be fully elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 25, 2023 Category: Biomedical Science Authors: Laura Valenzuela-Vallejo, Pavlina Chrysafi, Matina Kouvari, Valentina Guatibonza-Garcia, Sophia C. Mylonakis, Angeliki Katsarou, Ornella Verrastro, Georgios Markakis, Mohammed Eslam, Georgios Papatheodoridis, Geltrude Mingrone, Jacob George, Christos S. M Source Type: research

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis
The role of metabolic/inflammatory hormonal systems in metabolic dysfunction associated steatotic liver disease (MASLD) remains to be fully elucidated. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 25, 2023 Category: Biomedical Science Authors: Laura Valenzuela-Vallejo, Pavlina Chrysafi, Matina Kouvari, Valentina Guatibonza-Garcia, Sophia C. Mylonakis, Angeliki Katsarou, Ornella Verrastro, Georgios Markakis, Mohammed Eslam, Georgios Papatheodoridis, Geltrude Mingrone, Jacob George, Christos S. M Source Type: research

The global burden of metabolic disease in children and adolescents: Data from the Global Burden of Disease 2000 –2019
We read with great interest the study by Chong et al. [1], which reported the worrisome growing global burden of metabolic diseases, increasing obesity-related mortality trends, and significant sex-regional-socioeconomic differences among young adults and provided constructive advice for the prevention and treatment of these diseases. A heavy metabolic disease burden is also observed among children and adolescents owing to cultural changes, unhealthy eating habits, and decreased physical activity caused by rapid socioeconomic development [2 –5]. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 23, 2023 Category: Biomedical Science Authors: Jieyu Peng, Muhan L ü, Ping Wang, Yan Peng, Xiaowei Tang Source Type: research

ATG14 plays a critical role in hepatic lipid droplet homeostasis
In this study, we aimed to elucidate the role of ATG14 in lipid droplet homeostasis. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 21, 2023 Category: Biomedical Science Authors: Menghao Huang, Yang Zhang, Jimin Park, Kushan Chowdhury, Jiazhi Xu, Alex Lu, Lu Wang, Wenjun Zhang, Burcin Ekser, Liqing Yu, X. Charlie Dong Source Type: research

Pharmacotherapy before and after bariatric surgery
Diabetes is a chronic disease that affects a vast number of individuals globally, and without optimal treatment, can lead to significant health complications. Moreover, obesity is another chronic disease with several complications, which includes type 2 diabetes. Bariatric surgery is a viable long-term choice for managing diseases such as obesity and type 2 diabetes. However, the impact of pharmacotherapy before and after surgery remains unclear. In this review, we assessed the use of pharmacotherapy in patients with obesity with or without diabetes before and after bariatric surgery, focusing on weight loss, glycemic cont...
Source: Metabolism - Clinical and Experimental - September 17, 2023 Category: Biomedical Science Authors: Khaled Alabduljabbar, Carel W. le Roux Source Type: research