Metabolism - Clinical and Experimental This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis
MicroRNA-dependent regulation of hepatic lipid metabolism has been recognized recently as a key pathological mechanism contributing to the development of NAFLD. However, whether miR-32-5p (miR-32) plays a role in lipid metabolism or contributes to NAFLD remains unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 11, 2023 Category: Biomedical Science Authors: Ya-Di Wang, Liang-Liang Wu, Yun-Ni Mai, Kai Wang, Yi Tang, Qi-Yu Wang, Jiao-Yang Li, Li-Yan Jiang, Zhe-Zhen Liao, Can Hu, Yuan-Yuan Wang, Jing-Jing Liu, Jiang-Hua Liu, Xin-Hua Xiao Source Type: research

Ferroptosis, a new pathogenetic mechanism in cardiometabolic diseases and cancer: Is there a role for statin therapy?
One of the newly recognized types of cell death is ferroptosis which is related to the accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a programmed cell death with a different mechanism from apoptosis, necrosis, and autophagy. Emerging evidence suggests that ferroptosis may occur in the context of cardiovascular disease (CVD), cancer, neurodegenerative diseases, and non-alcoholic fatty liver disease (NAFLD). Statins are the first-line therapy for dyslipidemia. The suppression of the HMG-CoA reductase by statins leads to decreased expression of glutathione peroxidase 4 (GPX4), a key regulat...
Source: Metabolism - Clinical and Experimental - July 11, 2023 Category: Biomedical Science Authors: Amirhossein Sahebkar, Zahra Foroutan, Niki Katsiki, Tannaz Jamialahmadi, Christos S. Mantzoros Tags: Mini-Review Source Type: research

PRDM16 exerts critical role in myocardial metabolism and energetics in type 2 diabetes induced cardiomyopathy
The prevalence of type 2 diabetes mellitus (T2DM) has increased over the past decades. Diabetic cardiomyopathy (DCM) is the leading cause of death in T2DM patients, however, the mechanism underlying DCM remains largely unknown. Here, we aimed to investigate the role of cardiac PR-domain containing 16 (PRDM16) in T2DM. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 8, 2023 Category: Biomedical Science Authors: Tongtong Hu, Qingqing Wu, Qi Yao, Jiabin Yu, Kebing Jiang, Ying Wan, Qizhu Tang Source Type: research

SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis
Activation of hepatic stellate cells (HSCs), the central event of fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) participate in this process. Treatment with a sodium-glucose cotransporter 2 inhibitor (SGLT2i) alleviates liver fibrosis in patients with type 2 diabetes and NAFLD; however, the role of SGLT2i in ameliorating liver fibrosis in NAFLD by regulating miRNAs remains unclear. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 6, 2023 Category: Biomedical Science Authors: Yunfeng Shen, Lidan Cheng, Minxuan Xu, Wei Wang, Zhiping Wan, Haixia Xiong, Wanrong Guo, Mengyin Cai, Fen Xu Source Type: research

Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2
Hepatosteatosis is one of the early features of alcoholic liver disease (ALD) and pharmaceutical or genetic interfering of the development of hepatosteatosis will efficiently alleviate the progression of ALD. Currently, the role of histone methyltransferase Setdb1 in ALD is not yet well understood. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 5, 2023 Category: Biomedical Science Authors: Yi Zhang, Yanhui Li, Yang Liu, Hongzhi Wang, Yingli Chen, Bing Zhang, Meiqi Song, Lei Song, Qinchao Ding, Jiannan Qiu, Mingjian Fan, Lihui Qu, Zhigang Wang Source Type: research

Editorial Board
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - July 2, 2023 Category: Biomedical Science Source Type: research

Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: A randomized controlled trial
Randomized evidence comparing the cardiovascular effects of surgical and conservative weight management is lacking. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 30, 2023 Category: Biomedical Science Authors: Ann-Cathrin Koschker, Bodo Warrings, Caroline Morbach, Florian Seyfried, Pius Jung, Ulrich Dischinger, Frank Edelmann, Martin J. Herrmann, Christine Stier, Stefan Frantz, Uwe Malzahn, Stefan St örk, Martin Fassnacht, WAS study group Source Type: research

The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD
Central to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is the accumulation of lipids in the liver and various fat tissues. We aimed to elucidate the mechanisms by which lipid droplets (LDs) in the liver and adipocytes are degraded by the autophagy-lysosome system and develop therapeutic means to modulate lipophagy, i.e., autophagic degradation of LDs. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 27, 2023 Category: Biomedical Science Authors: Eui Jung Jung, Ki Woon Sung, Tae Hyun Bae, Hee-Yeon Kim, Ha Rim Choi, Sung Hyun Kim, Chan Hoon Jung, Su Ran Mun, Yeon Sung Son, Shin Kim, Young Ho Suh, Anna Kashina, Joo-Won Park, Yong Tae Kwon Source Type: research

Sarcopenic obesity: emerging mechanisms and therapeutic potential
Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewhat paradoxical and mechanistically undefined as to why a subset of adults with obesity develop muscular decline, an anabolic stimulus generally associated with retention of lean mass. Here, we review evidence surrounding the definition, etiology, and treatment of sarcopenic obesity with an emphasis on emerging regulatory nodes with therapeutic potential. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2023 Category: Biomedical Science Authors: Christopher L. Axelrod, Wagner S. Dantas, John P. Kirwan Tags: Review Source Type: research

Nonalcoholic fatty liver disease (NAFLD) and associated mortality in individuals with type 2 diabetes, pre-diabetes, metabolically unhealthy, and metabolically healthy individuals in the United States
Metabolic abnormality impacts both prevalence and outcomes of subjects with NAFLD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2023 Category: Biomedical Science Authors: Pegah Golabi, James M. Paik, Ameeta Kumar, Reem Al Shabeeb, Kathrine E. Eberly, Kenneth Cusi, Nagashree GunduRao, Zobair M. Younossi Source Type: research

A healthy lifestyle, Life's Essential 8 scores and new-onset severe NAFLD: A prospective analysis in UK Biobank
The association of a healthy lifestyle and the American Heart Association (AHA) Life's Essential 8 (LE8) score with the risk of new-onset nonalcoholic fatty liver disease (NAFLD) remains uncertain. We aimed to explore the associations between a healthy lifestyle and higher LE8 scores with new-onset severe NAFLD in the general population. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 26, 2023 Category: Biomedical Science Authors: Panpan He, Yanjun Zhang, Ziliang Ye, Huan Li, Mengyi Liu, Chun Zhou, Sisi Yang, Xiaoqin Gan, Yuanyuan Zhang, Xianhui Qin Source Type: research

Blocking IL-6 signaling improves glucose tolerance via SLC39A5-mediated suppression of glucagon secretion
In this study, we investigated the regulatory role of proinflammatory cytokine interleukin-6 (IL-6) on glucagon secretion. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 25, 2023 Category: Biomedical Science Authors: Wenli Chen, Weiyi Cui, Jianhong Wu, Wen Zheng, Xueting Sun, Jie Zhang, Haibao Shang, Ye Yuan, Xue Li, Jue Wang, Xinli Hu, Liangyi Chen, Fanxin Zeng, Rui-Ping Xiao, Xiuqin Zhang Source Type: research

Continuous glucose monitoring in a healthy population: understanding the post-prandial glycemic response in individuals without diabetes mellitus
Continuous glucose monitoring has become a common adjunct in the management of Diabetes Mellitus. However, there has been a recent trend among individuals without diabetes using these devices as a means of monitoring their health. The increased visibility of glucose data has allowed users to study the effect lifestyle has upon post-prandial glucose levels. Although post-prandial hyperglycemia is well understood in the setting of diabetes, its impact in individuals without diabetes is less well defined. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 23, 2023 Category: Biomedical Science Authors: Paul R.E. Jarvis, Jessica L. Cardin, Pamela M. Nisevich-Bede, James P. McCarter Tags: Review Source Type: research

Diet for the prevention and management of sarcopenia
Sarcopenia is a geriatric condition characterized by a progressive loss of skeletal muscle mass and strength, with an increased risk of adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality of life, mortality). Pharmacological remedies are currently unavailable for preventing the development of sarcopenia, halting its progression, or impeding its negative health outcomes. The most effective strategies to contrast sarcopenia rely on the adoption of healthier lifestyle behaviors, including adherence to high-quality diets and regular physical activity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 20, 2023 Category: Biomedical Science Authors: Riccardo Calvani, Anna Picca, H élio José Coelho-Júnior, Matteo Tosato, Emanuele Marzetti, Francesco Landi Source Type: research

“Diet for the prevention and management of sarcopenia”
Sarcopenia is a geriatric condition characterized by a progressive loss of skeletal muscle mass and strength, with an increased risk of adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality of life, mortality). Pharmacological remedies are currently unavailable for preventing the development of sarcopenia, halting its progression, or impeding its negative health outcomes. The most effective strategies to contrast sarcopenia rely on the adoption of healthier lifestyle behaviors, including adherence to high-quality diets and regular physical activity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 20, 2023 Category: Biomedical Science Authors: Riccardo Calvani, Anna Picca, H élio José Coelho-Júnior, Matteo Tosato, Emanuele Marzetti, Francesco Landi Source Type: research