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Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization
Impairment of regulatory T (Treg) cells function is implicated in the pathogenesis of immune imbalance-mediated cognitive impairment. A complete understanding of whether and how this imbalance affect cognitive function in type 2 diabetes is lacking, and the driver affecting this imbalance remains unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 24, 2022 Category: Biomedical Science Authors: Ya Hui, Zhiqiang Xu, Jiaxiu Li, Liuyu Kuang, Yuanmei Zhong, Yunyun Tang, Junjie Wei, Huimin Zhou, Tianpeng Zheng Source Type: research

Mitochondrial adaptations to calorie restriction and bariatric surgery in human skeletal muscle: a systematic review with meta-analysis
We performed a meta-analysis to determine the changes induced by calorie restriction (CR) and bariatric surgery on human skeletal muscle mitochondria. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 24, 2022 Category: Biomedical Science Authors: Miguel P érez-Rodríguez, Jesús R. Huertas, José M. Villalba, Rafael A. Casuso Source Type: research

Long noncoding TSI attenuates aortic valve calcification by suppressing TGF- β1-induced osteoblastic differentiation of valve interstitial cells
Calcific aortic valve disease (CAVD) is an active and cellular-driven fibrocalcific process characterised by differentiation of valve interstitial cells (VICs) towards an osteogenic-like phenotype. A recently identified lncRNA, lncTSI, has been reported to inhibit fibrogenesis through transforming growth factor (TGF)- β/Smad3 pathway. Here, the present study aimed to investigate the role of lncTSI in CAVD. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 20, 2022 Category: Biomedical Science Authors: Zongtao Liu, Yixuan Wang, Fayuan Liu, Da Zhu, Yuqi Chen, Wei Yen Yim, Ke Hu, Zhenqi Rao, Xiangbin Pan, Fei Li, Nianguo Dong Source Type: research

Acyl-CoA binding protein regulates nutrient-dependent autophagy
Homeostasis of autophagy under normal conditions and nutrient stress is maintained by adaptive activation of regulatory proteins. However, the protein-lipid crosstalk that modulates the switch from suppression to activation of autophagy initiation is largely unknown. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 20, 2022 Category: Biomedical Science Authors: Prajna Udupa, Abhishek Kumar, Rahul Parit, Debasish Kumar Ghosh Source Type: research

Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Second-generation antipsychotics (SGAs) are a mainstay therapy for schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and hyperglycemia. Herein, we evaluated the effects of olanzapine (OLA), widely prescribed SGA, in mice focusing on changes in body weight and energy balance. We further explored OLA effects in protein tyrosine phosphatase-1B deficient (PTP1B-KO) mice, a preclinical model of leptin hypersensitivity protected against obesity. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 18, 2022 Category: Biomedical Science Authors: V ítor Ferreira, Cintia Folgueira, Maria Guillén, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar López Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde Source Type: research

Metabolism, clinical and experimental: seventy years young and growing
Article Influence Score (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 13, 2022 Category: Biomedical Science Authors: Stergios A. Polyzos, Michael A. Hill, Ghada El-Hajj Fuleihan, Luigi Gnudi, Young-Bum Kim, Susanna Larson, Hiroaki Masuzaki, Giuseppe Matarese, Despina Sanoudou, Manuel Tena-Sempere, Christos S. Mantzoros Source Type: research

Pharmacotherapy of type 2 diabetes: An update and future directions
Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and social impact for which multiple conventional and novel pharmacotherapies are currently available; however, the landscape of T2D treatment is constantly changing as new therapies emerge and the understanding of currently available agents deepens. This review aims to provide an updated summary of the pharmacotherapeutic approach to T2D. Each class of agents is presented by mechanism of action, details of administration, side effect profile, cost, and use in certain populations including heart failure, non-alcoholic fatty liver disease, obesity...
Source: Metabolism - Clinical and Experimental - October 11, 2022 Category: Biomedical Science Authors: Antea DeMarsilis, Niyoti Reddy, Chrysoula Boutari, Andreas Filippaios, Elliot Sternthal, Niki Katsiki, Christos Mantzoros Tags: Review Source Type: research

Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity
The triglyceride (TG) transfer activity of microsomal triglyceride transfer protein (MTP) is essential for lipoprotein assembly in the liver and intestine; however, its function in adipose tissue, which does not assemble lipoproteins, is unknown. Here we have elucidated the function of MTP in adipocytes. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 9, 2022 Category: Biomedical Science Authors: Sujith Rajan, Peter Hofer, Amanda Christiano, Matthew Stevenson, Louis Ragolia, Eugenia Villa-Cuesta, Susan K. Fried, Raymond Lau, Collin Braithwaite, Rudolf Zechner, Gary J. Schwartz, M. Mahmood Hussain Source Type: research

Risk of incident diabetes after COVID-19 infection: A systematic review and meta-analysis
COVID-19 might be a risk factor for various chronic diseases. However, the association between COVID-19 and the risk of incident diabetes remains unclear. We aimed to meta-analyze evidence on the relative risk of incident diabetes in patients with COVID-19. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 7, 2022 Category: Biomedical Science Authors: Honghao Lai, Manli Yang, Mingyao Sun, Bei Pan, Quan Wang, Jing Wang, Jinhui Tian, Guowu Ding, Kehu Yang, Xuping Song, Long Ge Source Type: research

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH
Fibroblast growth factor 21 (FGF21) is a hepatokine that produces metabolic benefits, such as improvements of lipid profile. We performed a genome-wide association study (GWAS) to identify genetic variants associated with circulating FGF21 and investigated the causal effects of FGF21 on pertinent outcomes using Mendelian randomization (MR). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 4, 2022 Category: Biomedical Science Authors: Susanna C. Larsson, Karl Micha ëlsson, Marina Mola-Caminal, Jonas Höijer, Christos S. Mantzoros Source Type: research

Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
We investigated the effects of fenofibrate add-on to statin treatment on all-cause death and cardiovascular disease (CVD) in the general population who had high triglyceride (TG). (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 3, 2022 Category: Biomedical Science Authors: Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park Source Type: research

Adipose tissue aging: An update on mechanisms and therapeutic strategies
Aging is a complex biological process characterized by a progressive loss of physiological integrity and increased vulnerability to age-related diseases. Adipose tissue plays central roles in the maintenance of whole-body metabolism homeostasis and has recently attracted significant attention as a biological driver of aging and age-related diseases. Here, we review the most recent advances in our understanding of the molecular and cellular mechanisms underlying age-related decline in adipose tissue function. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 3, 2022 Category: Biomedical Science Authors: Zhaohua Cai, Ben He Tags: Review Source Type: research

Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
This narrative review highlights current evidence linking greater body fatness to risk of various cancers, with focus on evidence from recent large cohort studies and pooled analyses of cohort studies as well as Mendelian randomization studies (which utilized genetic variants associated with body mass index to debrief the causal effect of higher body fatness on cancer risk). This review also provides insights into the biological mechanisms underpinning the associations. Data from both observational and Mendelian randomization studies support the associations of higher body mass index with increased risk of many cancers wit...
Source: Metabolism - Clinical and Experimental - September 30, 2022 Category: Biomedical Science Authors: Susanna C. Larsson, Nikolaos Spyrou, Christos S. Mantzoros Tags: Review Source Type: research

Body fatness associations with cancer from recent epidemiologic studies
This narrative review highlights current evidence linking greater body fatness to risk of various cancers, with focus on evidence from recent large cohort studies and pooled analyses of cohort studies as well as Mendelian randomization studies (which utilized genetic variants associated with body mass index to debrief the causal effect of higher body fatness on cancer risk). This review also provides insights into the biological mechanisms underpinning the associations. Data from both observational and Mendelian randomization studies support the associations of higher body mass index with increased risk of many cancers wit...
Source: Metabolism - Clinical and Experimental - September 30, 2022 Category: Biomedical Science Authors: Susanna C. Larsson, Nikolaos Spyrou, Christos S. Mantzoros Tags: Review Source Type: research

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Source: Metabolism - Clinical and Experimental - September 29, 2022 Category: Biomedical Science Source Type: research