Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2

Hepatosteatosis is one of the early features of alcoholic liver disease (ALD) and pharmaceutical or genetic interfering of the development of hepatosteatosis will efficiently alleviate the progression of ALD. Currently, the role of histone methyltransferase Setdb1 in ALD is not yet well understood.

Source: Metabolism - Clinical and Experimental - July 5, 2023 Category: Biomedical Science Authors: Yi Zhang, Yanhui Li, Yang Liu, Hongzhi Wang, Yingli Chen, Bing Zhang, Meiqi Song, Lei Song, Qinchao Ding, Jiannan Qiu, Mingjian Fan, Lihui Qu, Zhigang Wang Source Type: research