SUMOylation of ERp44 enhances Ero1 α ER retention contributing to the pathogenesis of obesity and insulin resistance

As the only E2 conjugating enzyme for the SUMO system, Ubc9-mediated SUMOylation has been recognized to regulate diverse biological processes, but its impact on adipocytes relevant to obesity and insulin resistance is yet to be elucidated.

Source: Metabolism - Clinical and Experimental - November 21, 2022 Category: Biomedical Science Authors: Hao Xie, Yu-han Wang, Xin Liu, Jia Gao, Chunliang Yang, Teng Huang, Lu Zhang, Xi Luo, Zhichao Gao, Ting Wang, Tong Yan, Yanjun Liu, Ping Yang, Qilin Yu, Shiwei Liu, Yi Wang, Fei Xiong, Shu Zhang, Qing Zhou, Cong-Yi Wang Source Type: research