Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice
Exercise is an effective non-pharmacological strategy for the treatment of nonalcoholic steatohepatitis (NASH), but the underlying mechanism needs further investigation. Kruppel-like factor 10 (Klf10) is a transcriptional factor that is expressed in multiple tissues including liver, whose role in NASH is not well defined. In our study, exercise induces hepatic Klf10 expression through the cAMP/PKA/CREB pathway. Hepatocyte-specific knockout of Klf10 (Klf10LKO) increases lipid accumulation, cell death, inflammation and fibrosis in NASH diet-fed mice and reduces the protective effects of treadmill exercise against NASH, while hepatocyte-specific overexpression of Klf10 (Klf10LTG) works in concert with exercise to reduce NASH in mice.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Hong-Yang Luo, Wang-Jing Mu, Min Chen, Jie-Ying Zhu, Yang Li, Shan Li, Lin-Jing Yan, Ruo-Ying Li, Meng-Ting Yin, Xin Li, Hu-Min Chen, Liang Guo Source Type: research
More News: Biomedical Science | Diets | Liver | Men | Nutrition | Sports Medicine | Study | Urology & Nephrology