Assessing the Time Evolution of COVID-19 Effective Reproduction Number in Brazil
An Acad Bras Cienc. 2024 Apr 5;96(1):e20221050. doi: 10.1590/0001-3765202420221050. eCollection 2024.ABSTRACTIn this paper, we use a Bayesian method to estimate the effective reproduction number ( R ( t ) ), in the context of monitoring the time evolution of the COVID-19 pandemic in Brazil at different geographic levels. The focus of this study is to investigate the similarities between the trends in the evolution of such indicators at different subnational levels with the trends observed nationally. The underlying question addressed is whether national surveillance of such variables is enough to provide a picture of the e...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Edson Porto DA Silva Antonio M N Lima Source Type: research
GSE260739 Characterization of a new selective glucocorticoid receptor modulator with anorexigenic activity
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity, a worldwide epidemic, leads to various metabolic disorders threatening human health. In response to stress or fasting, glucocorticoid (GC) levels are elevated to promote food intake. This involves GC-induced expression of the orexigenic neuropeptides in agouti-related protein (AgRP) neurons of the hypothalamic arcuate nucleus (ARC) via the GC receptor (GR). Here, we report a selective GR modulator (SGRM) that suppresses GR-induced transcription of genes with non-classical glucocorticoid response elements (GREs) such as Agrp-GRE,...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
< i > DeepDynaForecast < /i > : Phylogenetic-informed graph deep learning for epidemic transmission dynamic prediction
by Chaoyue Sun, Ruogu Fang, Marco Salemi, Mattia Prosperi, Brittany Rife Magalis
In the midst of an outbreak or sustained epidemic, reliable prediction of transmission risks and patterns of spread is critical to inform public health programs. Projections of transmission growth or decline among specific risk groups can aid in optimizing interventions, particularly when resources are limited. Phylogenetic trees have been widely used in the detection of transmission chains and high-risk populations. Moreover, tree topology and the incorporation of population parameters (phylodynamics) can be useful in reconstructing the evol...
Source: PLoS Computational Biology - April 10, 2024 Category: Biology Authors: Chaoyue Sun Source Type: research
Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures
In this study, we first generated and characterized several hiPSC lines from health y human donor skin fibroblast cells. hiPSCs were then used for the generation of microglia-containing human cerebral organoids (hCOs). Once fully characterized, hCOs were infected with HIV-1 in the presence and absence of cART regimens and viral infection was studied by cellular, molecular/biochemic al, and virological assays. Our results revealed that hCOs were productively infected with HIV-1 as evident by viral p24-ELISA in culture media, RT-qPCR and RNAscope analysis of viral RNA, as well as ddPCR analysis of proviral HIV-1 in genomic D...
Source: Journal of NeuroVirology - April 10, 2024 Category: Neurology Source Type: research
Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem
J Bras Nefrol. 2024 Apr 5;46(3):e20230123. doi: 10.1590/2175-8239-JBN-2023-0123en. eCollection 2024.ABSTRACTIn the past decades, an epidemic of chronic kidney disease (CKD) has been associated with environmental and occupational factors (heat stress from high workloads in hot temperatures and exposure to chemicals, such as pesticides and metals), which has been termed CKD of non-traditional origin (CKDnt). This descriptive review aims to present recent evidence about heat stress, pesticides, and metals as possible causes of CKDnt and provide an overview of the related Brazilian regulation, enforcement, and health surveilla...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Rafael Junqueira Buralli Polianna L M Moreira Albuquerque Cintia da Espiritu Santo Viviane Calice-Silva Fabiana Baggio Nerbass Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 9, 2024 Category: Infectious Diseases Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem
J Bras Nefrol. 2024 Apr 5;46(3):e20230123. doi: 10.1590/2175-8239-JBN-2023-0123en. eCollection 2024.ABSTRACTIn the past decades, an epidemic of chronic kidney disease (CKD) has been associated with environmental and occupational factors (heat stress from high workloads in hot temperatures and exposure to chemicals, such as pesticides and metals), which has been termed CKD of non-traditional origin (CKDnt). This descriptive review aims to present recent evidence about heat stress, pesticides, and metals as possible causes of CKDnt and provide an overview of the related Brazilian regulation, enforcement, and health surveilla...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Rafael Junqueira Buralli Polianna L M Moreira Albuquerque Cintia da Espiritu Santo Viviane Calice-Silva Fabiana Baggio Nerbass Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 9, 2024 Category: Infectious Diseases Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem
J Bras Nefrol. 2024 Apr 5;46(3):e20230123. doi: 10.1590/2175-8239-JBN-2023-0123en. eCollection 2024.ABSTRACTIn the past decades, an epidemic of chronic kidney disease (CKD) has been associated with environmental and occupational factors (heat stress from high workloads in hot temperatures and exposure to chemicals, such as pesticides and metals), which has been termed CKD of non-traditional origin (CKDnt). This descriptive review aims to present recent evidence about heat stress, pesticides, and metals as possible causes of CKDnt and provide an overview of the related Brazilian regulation, enforcement, and health surveilla...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Rafael Junqueira Buralli Polianna L M Moreira Albuquerque Cintia da Espiritu Santo Viviane Calice-Silva Fabiana Baggio Nerbass Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - April 9, 2024 Category: Infectious Diseases Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem
J Bras Nefrol. 2024 Apr 5;46(3):e20230123. doi: 10.1590/2175-8239-JBN-2023-0123en. eCollection 2024.ABSTRACTIn the past decades, an epidemic of chronic kidney disease (CKD) has been associated with environmental and occupational factors (heat stress from high workloads in hot temperatures and exposure to chemicals, such as pesticides and metals), which has been termed CKD of non-traditional origin (CKDnt). This descriptive review aims to present recent evidence about heat stress, pesticides, and metals as possible causes of CKDnt and provide an overview of the related Brazilian regulation, enforcement, and health surveilla...
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Rafael Junqueira Buralli Polianna L M Moreira Albuquerque Cintia da Espiritu Santo Viviane Calice-Silva Fabiana Baggio Nerbass Source Type: research
The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients
We report that a substantial number of patients developed severe dengue during the epidemic in 2023, and provide detailed clinical-epidemiological profiles of the patients, offering valuable insight into management of dengue cases.PMID:38593789 | DOI:10.4269/ajtmh.23-0806 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - April 9, 2024 Category: Tropical Medicine Authors: Urby Saraf Anika Muna Islam Fatema E Nur Mou Mrinal Saha Aparna Deb Rubaiya Rahman Tui Joarder Rakeen Manzoor Afroza Jesmin Ayesha Martuja Jannatul Fardous Mohiuddin Sharif Md Abdur Rafi Mohammad Jahid Hasan Source Type: research
