Perceived Hospital Preparedness Is Negatively Associated With Pandemic-Induced Psychological Vulnerability in Primary Care Employees: A Multicentre Cross-Sectional Observational Study
CONCLUSIONS: Difficult working conditions during the pandemic had a major impact on the psychological wellbeing of emergency department HPs, but this effect might have been lessened if they had been informed about adequate measures for minimizing the risk of exposure.PMID:38600791 | DOI:10.1002/cpp.2969 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 11, 2024 Category: Psychiatry Authors: Corrado Corradi-Dell'Acqua Garance Horisberger David Caillet-Bois Alessio Toraldo Michael Christ Vincent Della Santa Vincent Frochaux Pierre Mols Andrea Penaloza Sara Rezzonico Luca Tagliabue Olivier Hugli Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Perceived Hospital Preparedness Is Negatively Associated With Pandemic-Induced Psychological Vulnerability in Primary Care Employees: A Multicentre Cross-Sectional Observational Study
CONCLUSIONS: Difficult working conditions during the pandemic had a major impact on the psychological wellbeing of emergency department HPs, but this effect might have been lessened if they had been informed about adequate measures for minimizing the risk of exposure.PMID:38600791 | DOI:10.1002/cpp.2969 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 11, 2024 Category: Psychiatry Authors: Corrado Corradi-Dell'Acqua Garance Horisberger David Caillet-Bois Alessio Toraldo Michael Christ Vincent Della Santa Vincent Frochaux Pierre Mols Andrea Penaloza Sara Rezzonico Luca Tagliabue Olivier Hugli Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Trends and predictors of unmet need for family planning among women living with HIV in Zambia: implications for elimination of vertical transmission of HIV
Prevention of vertical (mother to child) transmission of HIV is one of the key strategies towards HIV epidemic control. Despite considerable progress over the past decade in Zambia, the country is yet to reach... (Source: BMC Public Health)
Source: BMC Public Health - April 11, 2024 Category: Consumer Health News Authors: Edgar Arnold Lungu and Mwimba Chewe Tags: Research Source Type: research
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340420. Online ahead of print.ABSTRACTNon-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PEDV), causes high mortality in neonatal piglets worldwide. To determine the biological role of nsp2, we generated a PEDV mutant containing a complete nsp2 deletion (rPEDV-Δnsp2) from a highly pathogenic strain by reverse genetics, showing that nsp2 was dispensable for PEDV infection, while its deficiency reduced viral replication in vitro. In...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yajuan Jiao Pengwei Zhao Ling-Dong Xu Jia-Qi Yu Hou-Li Cai Chong Zhang Chao Tong Yong-Le Yang Pinglong Xu Qiming Sun Ning Chen Bin Wang Yao-Wei Huang Source Type: research
Wolbachia-carrying Aedes mosquitoes for preventing dengue infection
CONCLUSIONS: The included trial demonstrates the potential significant impact of wMel-Wolbachia-carrying Ae aegypti mosquitoes on preventing dengue infection in an endemic setting, and supports evidence reported in non-randomized and uncontrolled studies. Further trials across a greater diversity of settings are required to confirm whether these findings apply to other locations and country settings, and greater reporting of acceptability and cost are important.PMID:38597256 | DOI:10.1002/14651858.CD015636.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Tilly Fox Yanina Sguassero Marty Chaplin Winsley Rose Dyna Doum Ingrid Arevalo-Rodriguez Gemma Villanueva Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
Effectiveness of nirmatrelvir-ritonavir versus azvudine for adult inpatients with severe or critical COVID-19
CONCLUSION: Paxlovid and azvudine had similar effectiveness on in-hospital all-cause mortality and hospital length of stay. Compared with the azvudine group, after 7 days of therapy, the degree of decline in SOFA score was significantly higher in the Paxlovid group. These findings need to be verified in larger prospective studies or randomised controlled trials.PMID:38599779 | DOI:10.1136/bmjresp-2023-001944 (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2024 Category: Respiratory Medicine Authors: Huan Zhang Tan Xiaojiao Junjun Chen Zheng Zhang Chenxi Wang Haiqing Shi Yao Li Jianbo Li Yan Kang Xiaodong Jin Xuelian Liao Source Type: research
Assessing the Time Evolution of COVID-19 Effective Reproduction Number in Brazil
An Acad Bras Cienc. 2024 Apr 5;96(1):e20221050. doi: 10.1590/0001-3765202420221050. eCollection 2024.ABSTRACTIn this paper, we use a Bayesian method to estimate the effective reproduction number ( R ( t ) ), in the context of monitoring the time evolution of the COVID-19 pandemic in Brazil at different geographic levels. The focus of this study is to investigate the similarities between the trends in the evolution of such indicators at different subnational levels with the trends observed nationally. The underlying question addressed is whether national surveillance of such variables is enough to provide a picture of the e...
Source: An Acad Bras Cienc - April 10, 2024 Category: Science Authors: Edson Porto DA Silva Antonio M N Lima Source Type: research
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340420. Online ahead of print.ABSTRACTNon-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PEDV), causes high mortality in neonatal piglets worldwide. To determine the biological role of nsp2, we generated a PEDV mutant containing a complete nsp2 deletion (rPEDV-Δnsp2) from a highly pathogenic strain by reverse genetics, showing that nsp2 was dispensable for PEDV infection, while its deficiency reduced viral replication in vitro. In...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yajuan Jiao Pengwei Zhao Ling-Dong Xu Jia-Qi Yu Hou-Li Cai Chong Zhang Chao Tong Yong-Le Yang Pinglong Xu Qiming Sun Ning Chen Bin Wang Yao-Wei Huang Source Type: research
Wolbachia-carrying Aedes mosquitoes for preventing dengue infection
CONCLUSIONS: The included trial demonstrates the potential significant impact of wMel-Wolbachia-carrying Ae aegypti mosquitoes on preventing dengue infection in an endemic setting, and supports evidence reported in non-randomized and uncontrolled studies. Further trials across a greater diversity of settings are required to confirm whether these findings apply to other locations and country settings, and greater reporting of acceptability and cost are important.PMID:38597256 | PMC:PMC11005084 | DOI:10.1002/14651858.CD015636.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 10, 2024 Category: General Medicine Authors: Tilly Fox Yanina Sguassero Marty Chaplin Winsley Rose Dyna Doum Ingrid Arevalo-Rodriguez Gemma Villanueva Source Type: research
Anti-CD20 therapy for older patients with B-cell non-Hodgkin lymphoma in the context of epidemic normalization
Asian J Surg. 2024 Apr 10:S1015-9584(24)00581-5. doi: 10.1016/j.asjsur.2024.03.154. Online ahead of print.NO ABSTRACTPMID:38599972 | DOI:10.1016/j.asjsur.2024.03.154 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Dongdong Zhang Shuangnian Xu Source Type: research
