Clinical presentation and extent of resection impacts progression-free survival in spinal ependymomas
ConclusionsIn this large, contemporary series of adult spinal ependymoma patients, we demonstrated improvements in PFS when GTR was achieved. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2024 Category: Cancer & Oncology Source Type: research
Adult supratentorial extraventricular anaplastic ependymoma with cerebrospinal fluid dissemination metastases: a case report
ConclusionAdult SEAE is a rare tumor with high malignancy and have a tendency to disseminate into the CSF, resulting in drop metastases. Immunohistochemistry is very important for the diagnosis of SEAE. It is recommended to administer adjuvant chemotherapy or radiation therapy appropriately after surgery, based on the tumor being completely resected as much as possible. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Primary central nervous system tumors survival in children in ten Colombian cities: a VIGICANCER report
ConclusionWe found that half of Colombia’s children and adolescents with primary CNS tumors survive five years, compared to 70% to 80% in high-income countries. In addition to tumor biology and location, gross total resection was crucial for improved survival in this cohort. Systematic monitoring of survival and its determinants provides empirical data for guiding cancer control policies. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 27, 2024 Category: Cancer & Oncology Source Type: research
MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
AbstractMYCN (master regulator of cell cycle entry and proliferative metabolism) gene amplification defines a molecular subgroup of spinal cord ependymomas that show high-grade morphology and aggressive behavior. Demonstration ofMYCN amplification by DNA methylation or fluorescence-in situ hybridization (FISH) is required for diagnosis. We aimed to (i) assess prevalence and clinicopathological features ofMYCN-amplified spinal ependymomas and (ii) evaluate utility of immunohistochemistry (IHC) for MYCN protein as a surrogate for molecular testing. A combined retrospective –prospective study spanning 8 years was designed ...
Source: Human Cell - February 27, 2024 Category: Cytology Source Type: research
In vitro and in vivo modeling systems of supratentorial ependymomas
Ependymomas are rare brain tumors that can occur in both children and adults. Subdivided by the tumors’ initial location, ependymomas develop in the central nervous system in the supratentorial or infratentorial/posterior fossa region, or the spinal cord. Supratentorial ependymomas (ST-EPNs) are predominantly characterized by common driver gene fusions such as ZFTA and YAP1 fusions. Some variants of ST-EPNs carry a high overall survival rate. In poorly responding ST-EPN variants, high levels of inter- and intratumoral heterogeneity, limited therapeutic strategies, and tumor recurrence are among the reasons for poor patie...
Source: Frontiers in Oncology - February 26, 2024 Category: Cancer & Oncology Source Type: research
Ependymoma in pineal region: A case report
Asian J Surg. 2024 Feb 21:S1015-9584(24)00285-9. doi: 10.1016/j.asjsur.2024.02.027. Online ahead of print.NO ABSTRACTPMID:38388272 | DOI:10.1016/j.asjsur.2024.02.027 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 22, 2024 Category: Surgery Authors: Xiao Wang Xiaoran Ren Jianfeng Bao Source Type: research
Ependymoma in pineal region: A case report
Asian J Surg. 2024 Feb 21:S1015-9584(24)00285-9. doi: 10.1016/j.asjsur.2024.02.027. Online ahead of print.NO ABSTRACTPMID:38388272 | DOI:10.1016/j.asjsur.2024.02.027 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 22, 2024 Category: Surgery Authors: Xiao Wang Xiaoran Ren Jianfeng Bao Source Type: research
Ependymoma in pineal region: A case report
Asian J Surg. 2024 Feb 21:S1015-9584(24)00285-9. doi: 10.1016/j.asjsur.2024.02.027. Online ahead of print.NO ABSTRACTPMID:38388272 | DOI:10.1016/j.asjsur.2024.02.027 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 22, 2024 Category: Surgery Authors: Xiao Wang Xiaoran Ren Jianfeng Bao Source Type: research
Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma
Anaplastic ependymoma and H3K27M-mutant diffuse midline glioma are two common subtypes of brain tumors with poor long-term prognosis. The present study analyzed and compared the differences in cell types betwe... (Source: BMC Neurology)
Source: BMC Neurology - February 21, 2024 Category: Neurology Authors: Dongdong Zang, Zilong Dong, Yuecheng Liu and Qian Chen Tags: Research Source Type: research
PM2.5, vegetation density, and childhood cancer: a case-control registry-based study from Texas 1995-2011
DISCUSSION: Increasing early life exposure to PM2.5 increased the risk of childhood cancers. NDVI decreased risk of two cancers yet increased risk of others. These findings highlight the complexity between PM2.5 and NDVI in cancer etiology.PMID:38366656 | DOI:10.1093/jnci/djae035 (Source: Cancer Control)
Source: Cancer Control - February 17, 2024 Category: Cancer & Oncology Authors: Lindsay A Williams David Haynes Jeannette M Sample Zhanni Lu Ali Hossaini Laura A McGuinn Thanh T Hoang Philip J Lupo Michael E Scheurer Source Type: research
Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
CONCLUSION: Asymptomatic radiographic changes occurred in 4.8% of patients with ependymoma in a large national series. There was no correlation with dose or technique. No symptomatic brainstem injury was identified.PMID:38367939 | DOI:10.1016/j.radonc.2024.110157 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2024 Category: Radiology Authors: C éline Dalmasso Claire Alapetite St éphanie Bolle Farid Goudjil Am élie Lusque Jacques Desrousseaux Line Claude J érome Doyen Val érie Bernier-Chastagner Anne Ducassou Annick Sevely Margaux Roques Fatima Tensaouti Anne Laprie Source Type: research
Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
CONCLUSION: Asymptomatic radiographic changes occurred in 4.8% of patients with ependymoma in a large national series. There was no correlation with dose or technique. No symptomatic brainstem injury was identified.PMID:38367939 | DOI:10.1016/j.radonc.2024.110157 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 17, 2024 Category: Radiology Authors: C éline Dalmasso Claire Alapetite St éphanie Bolle Farid Goudjil Am élie Lusque Jacques Desrousseaux Line Claude J érome Doyen Val érie Bernier-Chastagner Anne Ducassou Annick Sevely Margaux Roques Fatima Tensaouti Anne Laprie Source Type: research
Brainstem toxicity after proton or photon therapy in children and young adults with localized intracranial ependymoma: a French retrospective study
Ependymoma is the third most common brain tumor in childhood, representing 6 –12% of all pediatric brain cancers [1,2], whose two-third grow in the posterior fossa at the expense of the fourth ventricle and close to the brainstem (BS). (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - February 15, 2024 Category: Radiology Authors: C éline Dalmasso, Claire Alapetite, Stéphanie Bolle, Farid Goudjil, Amélie Lusque, Jacques Desrousseaux, Line Claude, Jérome Doyen, Valérie Bernier-Chastagner, Anne Ducassou, Annick Sevely, Margaux Roques, Fatima Tensaouti, Anne Laprie Tags: Original Article Source Type: research
Pediatric spinal ependymoma with chromothripsis of chromosome 6: a case report and review of the literature
ConclusionThis case adds to the existing literature of pediatric patients with spinal ependymomas and expands the cytogenetic findings that may be seen in patients with this tumor type. This case also highlights the value of cytogenetics and microarray analysis in solid tumors to provide a more accurate molecular diagnosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 14, 2024 Category: General Medicine Source Type: research
Superficial siderosis of the central nervous system caused by myxopapillary ependymoma of cauda equine: a case report
(Source: Neurological Sciences)
Source: Neurological Sciences - February 10, 2024 Category: Neurology Source Type: research
