Cancers, Vol. 15, Pages 4015: Deciphering Machine Learning Decisions to Distinguish between Posterior Fossa Tumor Types Using MRI Features: What Do the Data Tell Us?
Keserci
Machine learning (ML) models have become capable of making critical decisions on our behalf. Nevertheless, due to complexity of these models, interpreting their decisions can be challenging, and humans cannot always control them. This paper provides explanations of decisions made by ML models in diagnosing four types of posterior fossa tumors: medulloblastoma, ependymoma, pilocytic astrocytoma, and brainstem glioma. The proposed methodology involves data analysis using kernel density estimations with Gaussian distributions to examine individual MRI features, conducting an analysis on the relationships between t...
Source: Cancers - August 8, 2023 Category: Cancer & Oncology Authors: Toygar Tanyel Chandran Nadarajan Nguyen Minh Duc Bilgin Keserci Tags: Article Source Type: research
Postoperative neurological complications in intradural extramedullary tumors: a 10-year experience of a single center
CONCLUSIONS: Neurological complications after surgical resection for IDEM occurred in 5.8% of patients. Meningiomas with postoperative neurological complications located anteriorly or laterally in the thoracic spine.PMID:37543192 | DOI:10.1016/j.neuchi.2023.101476 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - August 5, 2023 Category: Neurosurgery Authors: Hideyuki Arima Tomohiko Hasegawa Yu Yamato Go Yoshida Tomohiro Banno Shin Oe Yuki Mihara Koichiro Ide Yuh Watanabe Keiichi Nakai Kenta Kurosu Yukihiro Matsuyama Source Type: research
Postoperative neurological complications in intradural extramedullary tumors: a 10-year experience of a single center
CONCLUSIONS: Neurological complications after surgical resection for IDEM occurred in 5.8% of patients. Meningiomas with postoperative neurological complications located anteriorly or laterally in the thoracic spine.PMID:37543192 | DOI:10.1016/j.neuchi.2023.101476 (Source: Neurochirurgie)
Source: Neurochirurgie - August 5, 2023 Category: Neurosurgery Authors: Hideyuki Arima Tomohiko Hasegawa Yu Yamato Go Yoshida Tomohiro Banno Shin Oe Yuki Mihara Koichiro Ide Yuh Watanabe Keiichi Nakai Kenta Kurosu Yukihiro Matsuyama Source Type: research
Postoperative neurological complications in intradural extramedullary tumors: a 10-year experience of a single center
CONCLUSIONS: Neurological complications after surgical resection for IDEM occurred in 5.8% of patients. Meningiomas with postoperative neurological complications located anteriorly or laterally in the thoracic spine.PMID:37543192 | DOI:10.1016/j.neuchi.2023.101476 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - August 5, 2023 Category: Neurosurgery Authors: Hideyuki Arima Tomohiko Hasegawa Yu Yamato Go Yoshida Tomohiro Banno Shin Oe Yuki Mihara Koichiro Ide Yuh Watanabe Keiichi Nakai Kenta Kurosu Yukihiro Matsuyama Source Type: research
Postoperative neurological complications in intradural extramedullary tumors: a 10-year experience of a single center
CONCLUSIONS: Neurological complications after surgical resection for IDEM occurred in 5.8% of patients. Meningiomas with postoperative neurological complications located anteriorly or laterally in the thoracic spine.PMID:37543192 | DOI:10.1016/j.neuchi.2023.101476 (Source: Neurochirurgie)
Source: Neurochirurgie - August 5, 2023 Category: Neurosurgery Authors: Hideyuki Arima Tomohiko Hasegawa Yu Yamato Go Yoshida Tomohiro Banno Shin Oe Yuki Mihara Koichiro Ide Yuh Watanabe Keiichi Nakai Kenta Kurosu Yukihiro Matsuyama Source Type: research
Reuse of Nasoseptal Flaps for Endoscopic Endonasal Skull Base Reconstruction
Conclusions NSF reuse is effective at preventing postoperative CSF leak. The primary predictors of leak are high-flow intraoperative leak and inadequate defect coverage with NSF, regardless of the operation number. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - August 4, 2023 Category: Neurosurgery Authors: Bobeff, Ernest J. Mathios, Dimitrios Longo, Davide Estin, Joshua Joshua, Shejoy Tabaee, Abtin Kacker, Ashutosh Anand, Vijay K. Schwartz, Theodore H. Tags: Original Article Source Type: research
Cancers, Vol. 15, Pages 3674: Long-Term Outcomes after Incomplete Resection of Intramedullary Grade II Ependymomas: Is Adjuvant Radiotherapy Justified?
In this study, the rate of symptomatic progression and retreatment after incomplete resection of IME-II without adjuvant radiotherapy was low, suggesting a conservative approach in such cases. (Source: Cancers)
Source: Cancers - July 19, 2023 Category: Cancer & Oncology Authors: Elly Chaskis Mohamed Bouchaala Philippe David Fabrice Parker Nozar Aghakhani Steven Knafo Tags: Article Source Type: research
Benign Spinal Tumors
Adv Exp Med Biol. 2023;1405:583-606. doi: 10.1007/978-3-031-23705-8_23.ABSTRACTBenign spinal intradural tumors are relatively rare and include intramedullary tumors with a favorable histology such as low-grade astrocytomas and ependymomas, as well as intradural extramedullary tumors such as meningiomas and schwannomas. The effect on the neural tissue is usually a combination of mass effect and neuronal involvement in cases of infiltrative tumors. The new understanding of molecular profiling of different tumors allowed us to better define central nervous system tumors and tailor treatment accordingly. The mainstay of manage...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Mohammad Hassan A Noureldine Nir Shimony George I Jallo Source Type: research
Tumors of Choroid Plexus and Other Ventricular Tumors
Adv Exp Med Biol. 2023;1405:175-223. doi: 10.1007/978-3-031-23705-8_7.ABSTRACTTumors arising inside the ventricular system are rare but represent a difficult diagnostic and therapeutic challenge. They usually are diagnosed when reaching a big volume and tend to affect young children. There is a wide broad of differential diagnoses with significant variability in anatomical aspects and tumor type. Differential diagnosis in tumor type includes choroid plexus tumors (papillomas and carcinomas), ependymomas, subependymomas, subependymal giant cell astrocytomas (SEGAs), central neurocytomas, meningiomas, and metastases. Choroid...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Pietro Spennato Lucia De Martino Carmela Russo Maria Elena Errico Alessia Imperato Federica Mazio Giovanni Miccoli Lucia Quaglietta Massimo Abate Eugenio Covelli Vittoria Donofrio Giuseppe Cinalli Source Type: research
Ependymomas in Children and Adults
Adv Exp Med Biol. 2023;1405:99-116. doi: 10.1007/978-3-031-23705-8_4.ABSTRACTEpendymomas account for approximately 5% of all CNS tumors in adults and around 10% in the pediatric population. Contrary to traditional theories supporting that ependymomas arise from ependymal cells, recent studies propose radial glial cells as the cells of origin. In adults, half of the ependymomas arise in the spinal cord, whereas in the pediatric population, almost 90% of ependymomas are located intracranially. Most of the ependymomas are usually low-grade tumors except anaplastic variants and some cases of RELA-fusion-positive ependymomas, a...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Marios Lampros Nikolaos Vlachos George A Alexiou Source Type: research
Benign Glioma
Adv Exp Med Biol. 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2.ABSTRACTBenign glioma broadly refers to a heterogeneous group of slow-growing glial tumors with low proliferative rates and a more indolent clinical course. These tumors may also be described as "low-grade" glioma (LGG) and are classified as WHO grade I or II lesions according to the Classification of Tumors of the Central Nervous System (CNS) (Louis et al. in Acta Neuropathol 114:97-109, 2007). Advances in molecular genetics have improved understanding of glioma tumorigenesis, leading to the identification of common mutation profiles with significant trea...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Peter B Wu Anna C Filley Michael L Miller Jeffrey N Bruce Source Type: research
Benign Spinal Tumors
Adv Exp Med Biol. 2023;1405:583-606. doi: 10.1007/978-3-031-23705-8_23.ABSTRACTBenign spinal intradural tumors are relatively rare and include intramedullary tumors with a favorable histology such as low-grade astrocytomas and ependymomas, as well as intradural extramedullary tumors such as meningiomas and schwannomas. The effect on the neural tissue is usually a combination of mass effect and neuronal involvement in cases of infiltrative tumors. The new understanding of molecular profiling of different tumors allowed us to better define central nervous system tumors and tailor treatment accordingly. The mainstay of manage...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Mohammad Hassan A Noureldine Nir Shimony George I Jallo Source Type: research
Tumors of Choroid Plexus and Other Ventricular Tumors
Adv Exp Med Biol. 2023;1405:175-223. doi: 10.1007/978-3-031-23705-8_7.ABSTRACTTumors arising inside the ventricular system are rare but represent a difficult diagnostic and therapeutic challenge. They usually are diagnosed when reaching a big volume and tend to affect young children. There is a wide broad of differential diagnoses with significant variability in anatomical aspects and tumor type. Differential diagnosis in tumor type includes choroid plexus tumors (papillomas and carcinomas), ependymomas, subependymomas, subependymal giant cell astrocytomas (SEGAs), central neurocytomas, meningiomas, and metastases. Choroid...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Pietro Spennato Lucia De Martino Carmela Russo Maria Elena Errico Alessia Imperato Federica Mazio Giovanni Miccoli Lucia Quaglietta Massimo Abate Eugenio Covelli Vittoria Donofrio Giuseppe Cinalli Source Type: research
Ependymomas in Children and Adults
Adv Exp Med Biol. 2023;1405:99-116. doi: 10.1007/978-3-031-23705-8_4.ABSTRACTEpendymomas account for approximately 5% of all CNS tumors in adults and around 10% in the pediatric population. Contrary to traditional theories supporting that ependymomas arise from ependymal cells, recent studies propose radial glial cells as the cells of origin. In adults, half of the ependymomas arise in the spinal cord, whereas in the pediatric population, almost 90% of ependymomas are located intracranially. Most of the ependymomas are usually low-grade tumors except anaplastic variants and some cases of RELA-fusion-positive ependymomas, a...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Marios Lampros Nikolaos Vlachos George A Alexiou Source Type: research
Benign Glioma
Adv Exp Med Biol. 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2.ABSTRACTBenign glioma broadly refers to a heterogeneous group of slow-growing glial tumors with low proliferative rates and a more indolent clinical course. These tumors may also be described as "low-grade" glioma (LGG) and are classified as WHO grade I or II lesions according to the Classification of Tumors of the Central Nervous System (CNS) (Louis et al. in Acta Neuropathol 114:97-109, 2007). Advances in molecular genetics have improved understanding of glioma tumorigenesis, leading to the identification of common mutation profiles with significant trea...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Peter B Wu Anna C Filley Michael L Miller Jeffrey N Bruce Source Type: research
