Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
This study aimed to evaluate the safety and activity of two adenoviral vectors expressing HSV1-TK (Ad-hCMV-TK) and Flt3L (Ad-hCMV-Flt3L) in patients with high-grade glioma.METHODS: In this dose-finding, first-in-human trial, treatment-naive adults aged 18-75 years with newly identified high-grade glioma that was evaluated per immunotherapy response assessment in neuro-oncology criteria, and a Karnofsky Performance Status score of 70 or more, underwent maximal safe resection followed by injections of adenoviral vectors expressing HSV1-TK and Flt3L into the tumour bed. The study was conducted at the University of Michigan Me...
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: Yoshie Umemura Daniel Orringer Larry Junck Maria L Varela Molly E J West Syed M Faisal Andrea Comba Jason Heth Oren Sagher Denise Leung Aaron Mammoser Shawn Hervey-Jumper Daniel Zamler Viveka N Yadav Patrick Dunn Wajd Al-Holou Todd Hollon Michelle M Kim D Source Type: research
The evolving role of reirradiation in the management of recurrent brain tumors
AbstractDespite aggressive management consisting of surgery, radiation therapy (RT), and systemic therapy given alone or in combination, a significant proportion of patients with brain tumors will experience tumor recurrence. For these patients, no standard of care exists and management of either primary or metastatic recurrent tumors remains challenging.Advances in imaging and RT technology have enabled more precise tumor localization and dose delivery, leading to a reduction in the volume of health brain tissue exposed to high radiation doses. Radiation techniques have evolved from three-dimensional (3-D) conformal RT to...
Source: Journal of Neuro-Oncology - August 25, 2023 Category: Cancer & Oncology Source Type: research
Aggressive fibromatosis near the incision after cervical spinal cord ependymoma: A case report
Exp Ther Med. 2023 Aug 4;26(3):456. doi: 10.3892/etm.2023.12155. eCollection 2023 Sep.ABSTRACTAggressive fibromatosis (AF), also known as ligamentoid fibromatosis and desmoid tumor, is a fibroblast clonoproliferative lesion located in the deep soft tissue. The present study reports the case of a 36-year-old female with AF who underwent cervical spinal cord ependymoma surgery. AF developed in the soft tissue of the neck adjacent to the incision site. The size of the neck AF increased rapidly over 2 years, and due to discomfort, the patient underwent initial surgical resection without any other combined treatment methods. Wh...
Source: Experimental and Therapeutic Medicine - August 24, 2023 Category: General Medicine Authors: Xuewei Zheng Guiqiu Chen Shuo Liu Tong Li Yuyao Guan Baoting Yu Jun Ding Source Type: research
A nomogram for predicting survival in children with ependymoma based on the SEER database
Asian J Surg. 2023 Aug 16:S1015-9584(23)01202-2. doi: 10.1016/j.asjsur.2023.08.032. Online ahead of print.NO ABSTRACTPMID:37591759 | DOI:10.1016/j.asjsur.2023.08.032 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - August 17, 2023 Category: Surgery Authors: Shishi Ming Dianlong Zhang Source Type: research
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
AbstractTo explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometry (FCM), immunohistochemical (IHC), bulk RNA expression and single cell RNA sequencing (scRNA-seq), we collected the intraoperative specimens of MB, ependymoma (EPN), high-grade glioma (HGG), and low-grade glioma (LGG) to make a cross-cancer comparison. The specimens were subjected to FCM and IHC respectively, and deconvolution from bulk RNA expression data and scRNA-seq analysis were performed in MB from the GEO database. FCM and IHC analysis found that the proportion of lymphocytes (LC) and T ...
Source: Brain Tumor Pathology - August 9, 2023 Category: Neurology Source Type: research
Cancers, Vol. 15, Pages 4015: Deciphering Machine Learning Decisions to Distinguish between Posterior Fossa Tumor Types Using MRI Features: What Do the Data Tell Us?
Keserci
Machine learning (ML) models have become capable of making critical decisions on our behalf. Nevertheless, due to complexity of these models, interpreting their decisions can be challenging, and humans cannot always control them. This paper provides explanations of decisions made by ML models in diagnosing four types of posterior fossa tumors: medulloblastoma, ependymoma, pilocytic astrocytoma, and brainstem glioma. The proposed methodology involves data analysis using kernel density estimations with Gaussian distributions to examine individual MRI features, conducting an analysis on the relationships between t...
Source: Cancers - August 8, 2023 Category: Cancer & Oncology Authors: Toygar Tanyel Chandran Nadarajan Nguyen Minh Duc Bilgin Keserci Tags: Article Source Type: research
Postoperative neurological complications in intradural extramedullary tumors: a 10-year experience of a single center
CONCLUSIONS: Neurological complications after surgical resection for IDEM occurred in 5.8% of patients. Meningiomas with postoperative neurological complications located anteriorly or laterally in the thoracic spine.PMID:37543192 | DOI:10.1016/j.neuchi.2023.101476 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - August 5, 2023 Category: Neurosurgery Authors: Hideyuki Arima Tomohiko Hasegawa Yu Yamato Go Yoshida Tomohiro Banno Shin Oe Yuki Mihara Koichiro Ide Yuh Watanabe Keiichi Nakai Kenta Kurosu Yukihiro Matsuyama Source Type: research
