Ependymomas in Children and Adults
Adv Exp Med Biol. 2023;1405:99-116. doi: 10.1007/978-3-031-23705-8_4.ABSTRACTEpendymomas account for approximately 5% of all CNS tumors in adults and around 10% in the pediatric population. Contrary to traditional theories supporting that ependymomas arise from ependymal cells, recent studies propose radial glial cells as the cells of origin. In adults, half of the ependymomas arise in the spinal cord, whereas in the pediatric population, almost 90% of ependymomas are located intracranially. Most of the ependymomas are usually low-grade tumors except anaplastic variants and some cases of RELA-fusion-positive ependymomas, a...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Marios Lampros Nikolaos Vlachos George A Alexiou Source Type: research
Benign Glioma
Adv Exp Med Biol. 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2.ABSTRACTBenign glioma broadly refers to a heterogeneous group of slow-growing glial tumors with low proliferative rates and a more indolent clinical course. These tumors may also be described as "low-grade" glioma (LGG) and are classified as WHO grade I or II lesions according to the Classification of Tumors of the Central Nervous System (CNS) (Louis et al. in Acta Neuropathol 114:97-109, 2007). Advances in molecular genetics have improved understanding of glioma tumorigenesis, leading to the identification of common mutation profiles with significant trea...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Peter B Wu Anna C Filley Michael L Miller Jeffrey N Bruce Source Type: research
Challenges in treating childhood infratentorial ependymoma: a LMIC experience
We report our experience in treating posterior fossa ependymoma (PFE) at MAHAK, a charity organization in Iran. The radiation oncology department is the only one exclusively dedicated to childhood cancer in the whole country. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 14, 2023 Category: Radiology Authors: Mithra Ghalibafian, Sajad Mirzaei, Theodore Girinsky, Yasaman Sadeghi, Azam Saffar, Neda Ghodsinezhad, Sara Elmi, Eric Bouffet Tags: Clinical Investigation Source Type: research
Challenges in Treating Childhood Infratentorial Ependymoma: A Low- and Middle-Income Country Experience
We report our experience in treating posterior fossa ependymoma (PFE) at MAHAK, a charity organization in Iran whose radiation oncology department is the only one exclusively dedicated to childhood cancer in the whole country. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 14, 2023 Category: Radiology Authors: Mithra Ghalibafian, Sajad Mirzaei, Theodore Girinsky, Yasaman Sadeghi, Azam Saffar, Neda Ghodsinezhad, Sara Elmi, Eric Bouffet Tags: CLINICAL INVESTIGATION Source Type: research
Look (Biopsy) Before You Leap
We would strongly consider tissue confirmation before proceeding with treatment.1 Studies have shown a high rate of inconsistency between preoperative magnetic resonance imaging and pathologic diagnosis.2,3 In one study of 20 intramedullary lesions, only 6 (30%) cases had concordant diagnoses between imaging and pathology.2 The differential diagnosis for an intramedullary spinal lesion is broad and includes inflammatory, infectious, and neoplastic processes. Within neoplastic etiology, the histologic possibilities include ependymoma, astrocytoma, central nervous system lymphoma, melanoma, and metastasis. (Source: Internati...
Source: International Journal of Radiation Oncology * Biology * Physics - July 13, 2023 Category: Radiology Authors: Kaleb R. Darrow, Leo Luo Tags: Gray Zone Source Type: research
Low-Grade Glioma of the Spinal Cord: If Surgery is a No, Radiation is a Go
Although rare,1 intramedullary spinal cord gliomas account for 30% of intramedullary spinal cord tumors.2 The differential for intramedullary disease remains broad, including demyelinating disease, myelitis, sarcoidosis, low- and high-grade glioma, and ependymoma (although these are often characterized by a centrally located, well-defined enhancing mass), which supports the need for the imaging completed in this case and an evaluation of the cerebrospinal fluid. Based on the lack of contrast enhancement for this patient, the lesion was thought to represent a low-grade glioma (LGG). (Source: International Journal of Radiati...
Source: International Journal of Radiation Oncology * Biology * Physics - July 13, 2023 Category: Radiology Authors: Zachary S. Mayo, Erin S. Murphy Tags: Gray Zone Source Type: research
Multi-institutional characterization of outcomes for pediatric and young adult patients with high risk myxopapillary ependymoma after radiotherapy
CONCLUSIONS: While the risk of recurrence within the radiation field is low, pediatric and YA patients with high-risk MPE remain at risk for recurrences in the spine above the radiation field and intracranially after radiotherapy. Future prospective studies are needed to investigate the appropriate radiation field and dose based on the extent of metastases.PMID:37437812 | DOI:10.1016/j.ijrobp.2023.06.2293 (Source: Health Physics)
Source: Health Physics - July 12, 2023 Category: Physics Authors: Kevin X Liu Daniel J Indelicato Arnold C Paulino Wen S Looi Paul J Catalano Murali M Chintagumpala Sara L Gallotto Karen J Marcus Daphne A Haas-Kogan Nancy J Tarbell Shannon M MacDonald Anita Mahajan Torunn I Yock Source Type: research
Multi-institutional characterization of outcomes for pediatric and young adult patients with high risk myxopapillary ependymoma after radiotherapy
CONCLUSIONS: While the risk of recurrence within the radiation field is low, pediatric and YA patients with high-risk MPE remain at risk for recurrences in the spine above the radiation field and intracranially after radiotherapy. Future prospective studies are needed to investigate the appropriate radiation field and dose based on the extent of metastases.PMID:37437812 | DOI:10.1016/j.ijrobp.2023.06.2293 (Source: Health Physics)
Source: Health Physics - July 12, 2023 Category: Physics Authors: Kevin X Liu Daniel J Indelicato Arnold C Paulino Wen S Looi Paul J Catalano Murali M Chintagumpala Sara L Gallotto Karen J Marcus Daphne A Haas-Kogan Nancy J Tarbell Shannon M MacDonald Anita Mahajan Torunn I Yock Source Type: research
Multi-institutional characterization of outcomes for pediatric and young adult patients with high risk myxopapillary ependymoma after radiotherapy
Myxopapillary ependymoma (MPE) is a rare, typically slow-growing subtype of spinal ependymomas. There are no standard guidelines for radiotherapy and long-term outcomes after radiation, particularly patterns of relapse, for pediatric and young adult (YA) patients with MPE remain under-characterized. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 10, 2023 Category: Radiology Authors: Kevin X. Liu, Daniel J. Indelicato, Arnold C. Paulino, Wen S. Looi, Paul J. Catalano, Murali M. Chintagumpala, Sara L. Gallotto, Karen J. Marcus, Daphne A. Haas-Kogan, Nancy J. Tarbell, Shannon M. MacDonald, Anita Mahajan, Torunn I. Yock Tags: Brief Report Source Type: research
Respective roles of surgery, chemotherapy and radiotherapy for recurrent pediatric and adolescent ependymoma: a national multicentric study.
Half of the children and adolescents treated for intracranial ependymoma experience recurrences that are not managed in a standardized manner. Our study aimed at retrospectively evaluating recurrence treatments. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 10, 2023 Category: Radiology Authors: Jacques DESROUSSEAUX, Line CLAUDE, Leonor CHALTIEL, Fatima TENSAOUTI, Laetitia PADOVANI, Stephanie BOLLE, Alexandre ESCANDE, Claire ALAPETITE, St éphane SUPIOT, Valérie BERNIER-CHASTAGNER, Aymeri HUCHET, Julie LESEUR, Gilles TRUC, Pierre LEBLOND, Anne-I Source Type: research
Multi-institutional Characterization of Outcomes for Pediatric and Young Adult Patients With High-Risk Myxopapillary Ependymoma After Radiation Therapy
A rare subtype of spinal ependymoma, myxopapillary ependymoma (MPE) is typically slow-growing and is now classified as grade 2 (instead of grade 1) in the 2021 World Health Organization Classification of Tumors of the Central Nervous System.1-3 MPE in children and young adults (YAs) is poorly characterized. Case series suggest that while pediatric patients with MPE have excellent survival, they have higher rates of local and disseminated recurrences compared with adult patients with MPE (Table E1). (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 10, 2023 Category: Radiology Authors: Kevin X. Liu, Daniel J. Indelicato, Arnold C. Paulino, Wen S. Looi, Paul J. Catalano, Murali M. Chintagumpala, Sara L. Gallotto, Karen J. Marcus, Daphne A. Haas-Kogan, Nancy J. Tarbell, Shannon M. MacDonald, Anita Mahajan, Torunn I. Yock Tags: Brief Report Source Type: research
Respective Roles of Surgery, Chemotherapy, and Radiation Therapy for Recurrent Pediatric and Adolescent Ependymoma: A National Multicentric Study
This study aimed to retrospectively evaluate recurrence treatments. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 10, 2023 Category: Radiology Authors: Jacques Desrousseaux, Line Claude, Leonor Chaltiel, Fatima Tensaouti, Laetitia Padovani, Stephanie Bolle, Alexandre Escande, Claire Alapetite, St éphane Supiot, Valérie Bernier-Chastagner, Aymeri Huchet, Julie Leseur, Gilles Truc, Pierre Leblond, Anne-I Tags: CLINICAL INVESTIGATION Source Type: research
Breastfeeding and risk of childhood brain tumors: a report from the Childhood Cancer and Leukemia International Consortium
CONCLUSION: Our data suggest that breastfeeding does not protect against CBT.PMID:37421504 | DOI:10.1007/s10552-023-01746-3 (Source: Cancer Control)
Source: Cancer Control - July 8, 2023 Category: Cancer & Oncology Authors: Jeremy M Schraw Eleni Th Petridou Audrey Bonaventure John D Dockerty Maria Karalexi Evangelia Ntzani Claire Infante-Rivard Jacqueline Clavel Paige M Bracci Roberta McKean-Cowdin Eve Roman Eleanor Kane Friederike Erdmann Joachim Sch üz Beth A Mueller Mich Source Type: research
Breastfeeding and risk of childhood brain tumors: a report from the Childhood Cancer and Leukemia International Consortium
ConclusionOur data suggest that breastfeeding does not protect against CBT. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - July 8, 2023 Category: Cancer & Oncology Source Type: research
Surgical outcomes and risk factors for recurrence of myxopapillary ependymoma: a single-center experience
CONCLUSIONS: Findings of this study emphasize the importance of tumor size and location-particularly involvement of the sacral canal-in determining resectability. Reoperation for recurrence was necessary in 78% of patients with subtotally resected tumors; none of the patients who underwent GTR required reoperation. Most patients had stable neurological status postoperatively.PMID:37410596 | DOI:10.3171/2023.5.SPINE23433 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - July 6, 2023 Category: Neurosurgery Authors: Mark C Dougherty Mani Ratnesh S Sandhu Nahom Teferi Jennifer L Noeller Clayton L Rosinski Brian J Park Arnold H Menezes Kirill V Nourski Patrick W Hitchon Source Type: research
