A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
AbstractEPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is currently available. Therefore, this study investigated its clinicopathological features, evaluated the utility of MTAP and p16 IHC as surrogate markers ofCDKN2A alterations, and characterized the immune microenvironment of EPN-ZFTA. Thirty surgically removed brain tumors, including 10 EPN-ZFTA, were subjected to IHC. MLPA was performed forCDKN2A HD in 20 ependymal tumors, including EPN-ZFTA. The 5-years OS and PFS of EPN-ZFTA were 90% and 60%, respectively.CDKN2A HD was detected in two cases of ...
Source: Brain Tumor Pathology - June 16, 2023 Category: Neurology Source Type: research
The World Health Organization Classification of Tumors of the Central Nervous System, Fifth Edition, 2021: A Critical Analysis
Adv Tech Stand Neurosurg. 2023;46:1-21. doi: 10.1007/978-3-031-28202-7_1.ABSTRACTIn 2021 the World Health Organization issued the fifth edition of its classification of the tumors of the central nervous system. This revision made many significant changes in the overall structure of the tumor taxonomy, as well as utilizing to a greatly increased reliance on molecular genetic data to specify the various diagnoses described in the classification, and to add some new tumor types. This represents a trend following the pioneering introduction of certain required genetic alterations for particular diagnoses encoded in the 2016 re...
Source: Adv Data - June 15, 2023 Category: Epidemiology Authors: Douglas C Miller Source Type: research
