Ependymoma: Radiopath correlation
Presenting DAMS Medicine Teaching unplugged video on Radiological and pathological aspects of ependymoma.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - November 11, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
3D Microenvironments to Grow Brain Tumors in Lab
Clinical researchers are constantly thwarted by the inability to quickly and easily try new therapies in tumors and other disease targets. Tumors within the brain are particularly hard to study because of the difficulty with access and the incredible fragility of nearby tissues. Researchers at Tufts University have just developed a way to create an environment that closely mimics that of the brain and were able to grow pediatric and adult tumors within it. The microenvironment allows for non-invasive imaging of the tumors and for easy manipulation of the cells growing within.
The model tumors were grown in the presence ...
Source: Medgadget - October 8, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Neurosurgery Oncology Source Type: blogs
Cauda equina mass: An Approach
- CLINICAL PRESENTATION&FINDINGS 57 yr male with h/o low back pain with no h/o trauma presents for MRI lumbar spine which shows – Large relatively well defined , regular, intradural, subtly& heterogeneously enhancing SOL, seen from lower L3 border to middle of body of L5 with compression of cauda equina fibers, displaying mostly soft tissue signals on all sequences / normal meningeal enhancement, with no significant hemorrhage / fat / cystic / necrosis/ MR demonstrable calcification components / sugarcoating / scalloping or enlargement of the posterior neural e...
Source: Sumer's Radiology Site - January 12, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
A gaggle of Rosenthal fibers forming at the pushing border of an ependymoma
Ependymoma (left) pushing on adjacent brain induces numerous Rosenthal fibers,particularly around a blood vessel (Source: neuropathology blog)
Source: neuropathology blog - August 18, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Best Post of June 2018: Who was Rosenthal?
Of the ten posts from June 2018, my favorite was " Who was Rosenthal? " from June 22. So, here ' s the next in our " Best of the Month " series:A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at the University of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supp...
Source: neuropathology blog - August 10, 2018 Category: Radiology Tags: Best of the Month series history Source Type: blogs
Who was Rosenthal?
A Rosenthal fiber in pilocytic astrocytoma" In 1898, the German pathologist Werner Rosenthal noted elongated inclusions within the gliotic edge of a syringeal cavity of an ependymoma. Assigned to write the case report by a senior mentor while serving as a “first assistant” at theUniversity of Erlangen, Rosenthal colorfully described these inclusions as a “glossy formation of little bulbs or wavy sausages with one thick and one pointed end.”…. His supposition that they were related to glial fibers would prove surprisingly insightful. Not until some 20 years later did Bielschowsky and Unger use the t...
Source: neuropathology blog - June 22, 2018 Category: Radiology Tags: neoplasms Source Type: blogs
Neuropathology Maintenance of Certification Topics
For those taking the maintenance of certification (MOC) examination at some point in the next few years, the American Board of Pathology (ABP) has published topics that may be covered in the examination. The examination consists of 150 multiple-choice questions, 50 of which are required to be in the a category designated " general neuropathology I " . The remaining 100 questions can be from various categories which the examinee chooses (general neuropathology II, degenerative I& II, developmental/pediatric/congenital I& II, neoplastic I& II, and neuromuscular I& II). The ABP provides an MOC examination...
Source: neuropathology blog - November 2, 2016 Category: Radiology Tags: MOC Source Type: blogs
Best Post of May 2016 -- MYB-QKI fusion: A novel alteration that may define and drive pediatric angiocentric glioma
The next in our "Best of the Month" series comes from May 12, 2016Angiiocentric gliomaAngiocentric glioma is a rare form of pediatric low-grade gliomas (PLGG), first described in 2005, that arises in the cerebral cortex and shares histological features of astrocytomas and ependymomas. Until now, nothing was known of the genetic events underlying this tumor type. In a recent study published in Nature Genetics, Bhandopadhayay et al (see reference below) used whole genome sequencing and/or RNAseq to show that all seven angiocentric gliomas in their sample set harbored rearrangements in MYB, the most common bein...
Source: neuropathology blog - June 28, 2016 Category: Radiology Tags: Best of the Month series neoplasms Source Type: blogs
2016 WHO Classification Brain Tumours
WHO brain tumour classification has been updated in 2016. The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both hist...
Source: Sumer's Radiology Site - June 25, 2016 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Toward an integrated histomolecular diagnosis of supratentorial ependymoma
In an editorial in the July 2016 issue of Neuro-Oncology, Dr. Kristian W. Pajtler -- from the Department of Pediatric Oncology at the University Hospital, Heidelberg, Germany -- reflects on the fact that ependymomas are no longer considered a single disease entity regardless of location or molecular profile. Three ependymoma subgroups have now been identified in the supratentorial (ST) compartment. Pajtler writes: "One subgroup was enriched for World Health Organization (WHO) grade I tumors, and termed “molecular” subependymoma (ST-SE), while the other 2 were characterized by mutually exclusive prototypic fusion genes ...
Source: neuropathology blog - June 8, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
Choroid plexus hemorrhage mimicking an intraventricular neoplasm in a newborn
Imaging yielded a differential diagnosis of embryonal tumor, ependymoma, and hemorrhagic choroid plexus papilloma. Histomorphology shows acute hemorrhage and hemosiderin-stained choroid plexus with a rounded, hobnail-shaped epithelial surface. The rounded surface distinguishes this normal choroid plexus from the epithelium of a choroid plexus papilloma, which has a flat surface. (Source: neuropathology blog)
Source: neuropathology blog - May 31, 2016 Category: Radiology Tags: vascular disease Source Type: blogs
Summary of the Major Changes in the 2016 WHO Classification of CNS Tumors
Major restructuring of medulloblastomas, with incorporation of genetically defined entitiesAddition of brain invasion as a criterion for atypical meningiomaRestructuring of solitary fibrous tumor and hemangiopericytoma (SFT/HPC) as one entity and adapting a grading system to accommodate this changeExpansion and clarification of entities included in nerve sheath tumors, with addition of hybrid nerve sheath tumors and separation of melanotic schwannoma from other schwannomasExpansion of entities included in hematopoietic/lymphoid tumors of the CNS (lymphomas and histiocytic tumors)Addition of the following newly recognized e...
Source: neuropathology blog - May 27, 2016 Category: Radiology Tags: neoplasms Source Type: blogs
Relationship between Hamartoma and Cancer
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. The book has an extensive glossary, that explains the meaning and relevance of medical terms appearing throughout the chapters. The glossary can be read as a stand-along document. Here is an example of one term, "hamartoma", excerpted from the glossary.Hamartoma - Hamartomas are benign tumors that occupy a peculiar zone lying between neoplasi...
Source: Specified Life - July 15, 2014 Category: Pathologists Tags: cancer types carcinogenesis common cancers disease genes genetic disease hyperplasia orphan disease orphan drugs rare cancers rare disease tissue overgrowth tumor biology tumor types Source Type: blogs
