Summary of the Major Changes in the 2016 WHO Classification of CNS Tumors

Major restructuring of medulloblastomas, with incorporation of genetically defined entitiesAddition of brain invasion as a criterion for atypical meningiomaRestructuring of solitary fibrous tumor and hemangiopericytoma (SFT/HPC) as one entity and adapting a grading system to accommodate this changeExpansion and clarification of entities included in nerve sheath tumors, with addition of hybrid nerve sheath tumors and separation of melanotic schwannoma from other schwannomasExpansion of entities included in hematopoietic/lymphoid tumors of the CNS (lymphomas and histiocytic tumors)Addition of the following newly recognized entities, variants and patterns:- IDH-wildtype and IDH-mutant glioblastoma (entities)- Diffuse midline glioma, H3 K27M–mutant (entity)- Embryonal tumour with multilayered rosettes, C19MC-altered (entity)- Ependymoma, RELA fusion–positive (entity)- Diffuse leptomeningeal glioneuronal tumor (entity)- Anaplastic PXA (entity)- Epithelioid glioblastoma (variant)- Glioblastoma with primitive neuronal component (pattern)- Multinodular and vacuolated pattern of ganglion cell tumor (pattern)Deletion of the following entities, variants and terms:- Gliomatosis cerebri- Protoplasmic and fibrillary astrocytoma variants- Cellular ependymoma variant- “Primitive neuroectodermal tumour” terminology(Adapted from table 2 in Louis DN et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol (2016) 1...

Source: neuropathology blog - May 27, 2016 Category: Radiology Tags: neoplasms Source Type: blogs