Cauda equina mass: An Approach

-    CLINICAL PRESENTATION&FINDINGS    57 yr male with h/o low back pain with no h/o trauma presents for MRI lumbar spine which shows – Large relatively well defined , regular, intradural, subtly&heterogeneously enhancing SOL, seen from lower L3 border to middle of body of L5 with compression of cauda equina fibers, displaying mostly soft tissue signals on all sequences / normal meningeal  enhancement, with no significant hemorrhage / fat / cystic / necrosis/ MR demonstrable calcification  components / sugarcoating / scalloping or enlargement of the posterior neural elements/ dumbbell shaped extension across the neural foramina / marrow signal abnormality / soft tissue collections  -intradural neoplastic etiology is possible like astrocytoma (though no significant enhancement) / gangliogloma (though no calcification) / unusual epidermoid (though no cyst ) etc. may need consideration. Other etiology like myxopapillary ependymoma or neuroenic etiologies less likely, in view of enhancement pattern.Case Submitted by Dr MGK Murthy, Dr GA Prasad.Tumors of cauda equina&filum terminal region -Myxopapillary ependymomas arethe most common tumor of the conus medullaris and filum terminale, representing more than 90% of tumors in this region seen in young adults and usually showmarked homogeneous enhancement&may have hemorrhagic areas ( cap sign) &calcifications.Cord edema& nontumoral cysts&n...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs

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Authors: Harrington P, Radia D, de Lavallade H Abstract INTRODUCTION: The outlook for patients with chronic myeloid leukaemia (CML) has changed dramatically with the development of tyrosine kinase inhibitors (TKIs) with the current treatment goal for many patients being to obtain a durable deep molecular remission, discontinue TKI therapy and remain treatment-free.Areas covered: In this article the authors review the data from the major TKI discontinuation studies, explore potential predictors of discontinuation outcome and look at possible mechanisms to explain the variable outcomes following TKI discontinuation i...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Jeffrey A. SingerOn January 20th, theCincinnati Enquirer ran a story on the recentreport from the Centers for Disease Control and Prevention that showed a 30.1 percent drop in prescription opioid volume from 2010  – 2011 to 2016 – 2017. While the CDC report was non‐​judgmental, it was greeted by hospital administrators and emergency physicians in the Cincinnati area as good news.The article quotes one physician/ ​hospital spokesperson as saying:“The patient can know, ‘My encounter with the ED will … lead to a good outcome. I will not be ex...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
ConclusionBM-MSCs delivered miR-222-3p via exosomes to inhibit cell proliferation and promote cell apoptosis by targeting IRF2 and negatively regulating IRF2/INPP4B signaling in THP-1 cells.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
RESUMO Objetivo: Avaliar o impacto de um protocolo de manejo da dor e redu ção do consumo de opioides no consumo geral de opioides e nos desfechos clínicos. Métodos: Estudo em centro único, quasi-experimental, retrospectivo, de coortes antes e depois. Utilizamos uma série temporal interrompida para analisar as alterações no nível e na tendência de utilização d e diferentes analgésicos. Foram usadas comparações bivariadas nas coortes antes e depois, regressão logística e regressão quantílica pa...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
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Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
In this study we evaluated the influence of pain as a risk factor for recurrent falls (two or more in 1  year) in the older (65-79 years) and oldest-old (80 or more years) non-insti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
BACKGROUND: Childhood trauma is considered to be a risk factor for developing anxiety as well as chronic pain. The aim of this study was to assess the association between childhood trauma and reporting anxiety and long-term pain conditions in the general a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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