Association of early surgery and absence of ataxia with full recovery after spinal intramedullary ependymoma resection
CONCLUSIONS: The data presented solidify the role of early surgery in the management of spinal IEs, especially in patients with mild neurological deficits. Furthermore, the presence of gait disturbance or ataxia confers a higher risk of incomplete long-term recovery after spinal ependymoma resection. Because a distinct subgroup of patients had nonresolving deterioration, even when presenting with an uneventful history, further analyses into this subgroup of patients are required.PMID:37922542 | DOI:10.3171/2023.8.SPINE23606 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - November 3, 2023 Category: Neurosurgery Authors: Obada T Alhalabi Stefan Heene Vincent Landr é Jan-Oliver Neumann Daniel Haux Klaus Zweckberger Andreas W Unterberg Alexander Younsi Source Type: research
Association of early surgery and absence of ataxia with full recovery after spinal intramedullary ependymoma resection
CONCLUSIONS: The data presented solidify the role of early surgery in the management of spinal IEs, especially in patients with mild neurological deficits. Furthermore, the presence of gait disturbance or ataxia confers a higher risk of incomplete long-term recovery after spinal ependymoma resection. Because a distinct subgroup of patients had nonresolving deterioration, even when presenting with an uneventful history, further analyses into this subgroup of patients are required.PMID:37922542 | DOI:10.3171/2023.8.SPINE23606 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - November 3, 2023 Category: Neurosurgery Authors: Obada T Alhalabi Stefan Heene Vincent Landr é Jan-Oliver Neumann Daniel Haux Klaus Zweckberger Andreas W Unterberg Alexander Younsi Source Type: research
A fully automated deep-learning model for predicting the molecular subtypes of posterior fossa ependymomas using T2-weighted images
CONCLUSIONS: A fully automated DL model was developed and validated to accurately segment PF-EPNs and predict molecular subtypes using only T2w MR images, which could help in clinical decision-making.PMID:37916978 | DOI:10.1158/1078-0432.CCR-23-1461 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 2, 2023 Category: Cancer & Oncology Authors: Dan Cheng Zhizheng Zhuo Jiang Du Jinyuan Weng Chengzhou Zhang Yunyun Duan Ting Sun Minghao Wu Min Guo Tiantian Hua Ying Jin Boyang Peng Zhaohui Li Mingwang Zhu Maliha Imami Chetan Bettegowda Haris Sair Harrison X Bai Frederik Barkhof Xing Liu Yaou Liu Source Type: research
A fully automated deep-learning model for predicting the molecular subtypes of posterior fossa ependymomas using T2-weighted images
CONCLUSIONS: A fully automated DL model was developed and validated to accurately segment PF-EPNs and predict molecular subtypes using only T2w MR images, which could help in clinical decision-making.PMID:37916978 | DOI:10.1158/1078-0432.CCR-23-1461 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 2, 2023 Category: Cancer & Oncology Authors: Dan Cheng Zhizheng Zhuo Jiang Du Jinyuan Weng Chengzhou Zhang Yunyun Duan Ting Sun Minghao Wu Min Guo Tiantian Hua Ying Jin Boyang Peng Zhaohui Li Mingwang Zhu Maliha Imami Chetan Bettegowda Haris Sair Harrison X Bai Frederik Barkhof Xing Liu Yaou Liu Source Type: research
96. A unique case presentation of pediatric spinal ependymoma with chromothripsis of chromosome 6: case report
We present the case of a 16-year-old female with a history of neurofibromatosis type 2 with multiple schwannomas, meningioma, and spinal ependymoma. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Keela Scott, Melissa Gener, Elena Repnikova Source Type: research
23. Optical genome mapping reveals new insights into ZFTA fusion in supratentorial ependymomas
Supratentorial ependymoma, ZFTA fusion positive, is a subtype of ependyoma with a ZFTA (C11orf95) fusion, most often involving RELA as the partner. ZFTA rearrangements were initially reported to result from intrachromosomal deletions or chromothripsis in chromosome 11 which are typically detected by chromosomal microarray analysis (CMA). We use CMA, our OncoKids NGS panel, and whole transcriptome RNA-seq to identify ZFTA fusions in pediatric brain tumors. For several tumors with ZFTA fusions detected by RNA-seq, complex copy number alterations involving chromosome 11 were not detected by CMA. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Jianling Ji, Jennifer Cotter, Ben Clifford, Jennifer Han, Cindy Fong, Dharmadhikari V. Avinash, Debra Hawes, Gordana Raca, Jaclyn Biegel Source Type: research
Blood-based biomarkers: diagnostic value in brain tumors (focus on gliomas)
ConclusionNLR, PIV, and their combinations show high sensitivity and specificity in the diagnosis of brain tumors, especially gliomas. Overall, our results provide evidence for these convenient and reliable peripheral blood markers. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 23, 2023 Category: Neurology Source Type: research
Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO)
AbstractThe Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group includes neuroradiologists, neuro-oncologists, neurosurgeons, radiation oncologists, and clinicians in various additional specialties. This review paper will summarize the imaging recommendations from RAPNO for the six RAPNO publications to date covering pediatric low-grade glioma, pediatric high-grade glioma, medulloblastoma and other leptomeningeal seeding tumors, diffuse intrinsic pontine glioma, ependymoma, and craniopharyngioma. (Source: Pediatric Radiology)
Source: Pediatric Radiology - October 21, 2023 Category: Radiology Source Type: research
C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B Fusion Negative Anaplastic Ependymoma with Lipogenic Differentiation
Shilpy Jha, Prit Benny Mulgulwar, Mehar Chand Sharma, Suvendu Purkait, Ashis Pattnaik, Mukund Namdev SableNeurology India 2023 71(5):1011-1014Lipogenic differentiation in ependymoma is an infrequent occurrence with very few reported cases. The grading was done solely based on the histomorphology and molecular subtyping was not described in such ependymomas. New molecular classification divided ependymomas in nine different subgroups, of which supratentorial location tumor usually exhibits C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B fusion proteins. A 46-year-old female presented with headache and right-sided parapresis. R...
Source: Neurology India - October 18, 2023 Category: Neurology Authors: Shilpy Jha Prit Benny Mulgulwar Mehar Chand Sharma Suvendu Purkait Ashis Pattnaik Mukund Namdev Sable Source Type: research
“Soap bubble” sign as an imaging marker for posterior fossa ependymoma Group B
ConclusionThe “soap bubble” sign represents a highly specific imaging marker for the PFB molecular subtype of PF-EPNs. (Source: Neuroradiology)
Source: Neuroradiology - October 14, 2023 Category: Radiology Source Type: research
GSE190798 Retrospective DNA Methylation profiles collated from Nottingham, UK
Contributors : Timothy A Ritzmann ; Rebecca J Chapman ; Andrea Griesinger ; Andrew Donson ; Simon M Paine ; Richard Grundy ; Nicholas ForemanSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensDNA Methylation profiles were generated for retrospective cases to support work into investigation of the immune environment in pediatric ependymoma. Samples were analyzed using the Illumina 450k beadchip and processed using the Heidelberg classifier (v11.2b and subsequently v12.3 for subgrouping/subtyping).The aim of the study was to better understand the immune-tumor microenvironment in pediatric ep...
Source: GEO: Gene Expression Omnibus - October 2, 2023 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Neurologic outcomes for adult spinal cord ependymomas stratified by tumor location: a retrospective cohort study and 2-year outlook
AbstractDetermine whether craniocaudal spinal cord tumor location affects long-term neurologic outcomes in adults diagnosed with spinal ependymomas (SE). A retrospective cohort analysis of patients aged ≥ 18 years who underwent surgical resection for SE over a ten-year period was conducted. Tumor location was classified as cervical, thoracic, or lumbar/conus. Primary endpoints were post-operative McCormick Neurologic Scale (MNS) scores at< 3 days, 6 weeks, 1 year, and 2 years. One-way ANOVA was performed to detect significant differences in MNS scores between tumor locations. Twenty-eight patients were identified. The...
Source: Neurosurgical Review - September 29, 2023 Category: Neurosurgery Source Type: research
Influence of beam pruning techniques on LET and RBE in proton arc therapy
IntroductionProton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed to investigate if pruning the highest energy layers in each beam direction could increase the LET in the target and reduce LET in tissue and organs at risk (OAR) surrounding the target volume, thus reducing the relative biological effectiveness (RBE)-weighted dose and sparing healthy tissue.MethodsPAT plans for a germinoma, an ependymoma and a rhabdomyosarcoma patient were created in the Eclipse treatment planning system with a prescr...
Source: Frontiers in Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Molecular neuropathology: an essential and evolving toolbox for the diagnosis and clinical management of central nervous system tumors
AbstractMolecular profiling has transformed the diagnostic workflow of CNS tumors during the last years. The latest WHO classification of CNS tumors (5th edition), published in 2021, pushed forward the integration between histopathological features and molecular hallmarks to achieve reproducible and clinically relevant diagnoses. To address these demands, pathologists have to appropriately deal with multiple molecular assays mainly including DNA methylation profiling and DNA/RNA next generation sequencing. Tumor classification by DNA methylation profiling is now a critical tool for many diagnostic tasks in neuropathology i...
Source: Virchows Archiv - September 2, 2023 Category: Pathology Source Type: research
Imaging features to distinguish posterior fossa ependymoma subgroups
ConclusionMorphological characteristics from imaging differ between posterior fossa ependymoma subtypes and may help to distinguish them preoperatively.Clinical relevance statementThis study provides a tool to differentiate between group A and group B ependymomas, which will ultimately allow the therapeutic strategy to be adapted in the early stages of patient management.Key Points•Posterior fossa ependymoma subtypes often have different imaging characteristics.•Posterior fossa ependymomas group A are commonly median or lateral tissular calcified masses, with incomplete enhancement, affecting young children and respons...
Source: European Radiology - September 2, 2023 Category: Radiology Source Type: research
