Cancers, Vol. 16, Pages 404: Intramedullary Spinal Cord Tumors: Whole-Genome Sequencing to Assist Management and Prognosis
eill
Kimberly Hoang
Intramedullary spinal cord tumors (IMSCTs) harbor unique genetic mutations which may play a role in prognostication and management. To this end, we present the largest cohort of IMSCTs with genetic characterization in the literature from our multi-site institutional registry. A total of 93 IMSCT patient records were reviewed from the years 1999 to 2020. Out of these, 61 complied with all inclusion criteria, 14 of these patients had undergone genetic studies with 8 undergoing whole-genomic sequencing. Univariate analyses were used to assess any factors associated with progression-free survival (PFS...
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Miguel Mayol del Valle Bryan Morales Brandon Philbrick Segun Adeagbo Subir Goyal Sarah Newman Natasha L. Frontera Edjah Nduom Jeffrey Olson Stewart Neill Kimberly Hoang Tags: Article Source Type: research
Prognostic Factors of Pediatric Ependymomas at a National Cancer Reference Hospital in Peru
Conclusions: The survival of patients with ependymoma is below that reported in high-income countries. Incomplete treatment and treatment abandonment are factors that negatively impact the prognosis. Further studies are needed to identify barriers in the referral and treatment process for patients with ependymoma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 17, 2024 Category: Cancer & Oncology Source Type: research
Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru
ConclusionsThe survival of patients with ependymoma is below that reported in high-income countries. Incomplete treatment and treatment abandonment are factors that negatively impact the prognosis. Further studies are needed to identify barriers in the referral and treatment process for patients with ependymoma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 17, 2024 Category: Cancer & Oncology Source Type: research
Case report: meningeal lymphangiogenesis around ependymoma forming along the dura matter
We report a unique case of recurrent ependymoma in the dura mater, showing histopathological signs of lymphatic proliferation at the tumor attachment site. The patient initially presented with a headache, and was diagnosed with ZFTA fusion-positive supratentorial ependymoma, central nervous system WHO Grade 3. Following multiple dura mater recurrences and surgery, the fifth procedure revealed numerous tumors contralateral to the original site, with genetic testing confirming ZFTA fusion positivity, indicating recurrent ependymoma. Immunohistochemical analysis showed D2-40+ lymphatic vessel proliferation around tumor attach...
Source: Frontiers in Oncology - January 12, 2024 Category: Cancer & Oncology Source Type: research
Ependymoma with metastases to the gallbladder: A case report and literature review
Oncol Lett. 2023 Dec 21;27(2):72. doi: 10.3892/ol.2023.14205. eCollection 2024 Feb.ABSTRACTMetastatic ependymoma of the gallbladder is an exceptionally rare condition that remains relatively unreported in the scientific literature. The present study described a case involving a 42-year-old female patient who underwent right frontal lobe surgery for ependymoma in 2017 and subsequently received adjuvant chemotherapy. The histological examination of the surgical specimen confirmed the presence of ependymoma metastasis in the gallbladder. The presentation and outcome of this patient with regard to metastatic ependymoma in the ...
Source: Oncology Letters - January 9, 2024 Category: Cancer & Oncology Authors: Xinying Han Qingming Shu Shuai Shi Hongzheng Liu Songlin Han Zhigang Zhang Source Type: research
GSE241396 Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq
Contributors : Min K Lee ; Brock C ChristensenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCentral nervous system (CNS) tumors are the leading cause of pediatric cancer death, and these patients have an increased risk for developing secondary neoplasms. Due to the low prevalence of pediatric CNS tumors, major advances in targeted therapies have been lagging compared to other adult tumors. We collected single nuclei RNA-seq data from 35 pediatric CNS tumors and three non-tumoral pediatric brain tissues (84,700 nuclei) and characterized tumor heterogeneity and transcriptomic alterati...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Distinct MRI characteristics of spinal cord diffuse midline glioma, H3 K27-altered in comparison to spinal cord glioma without H3 K27-alteration and demyelination disorder
CONCLUSION: Based on cMRI, we developed a model with good performance for differentiating among DMGs, H3 K27-altered, wild-type glioma, and demyelinating lesions in the spinal cord.PMID:38115811 | DOI:10.1177/02841851231215803 (Source: Acta Radiologica)
Source: Acta Radiologica - December 20, 2023 Category: Radiology Authors: Yinwei Ying Xiujuan Liu Xuanxuan Li Nan Mei Zhuoying Ruan Yiping Lu Bo Yin Source Type: research
Distinct MRI characteristics of spinal cord diffuse midline glioma, H3 K27-altered in comparison to spinal cord glioma without H3 K27-alteration and demyelination disorder
CONCLUSION: Based on cMRI, we developed a model with good performance for differentiating among DMGs, H3 K27-altered, wild-type glioma, and demyelinating lesions in the spinal cord.PMID:38115811 | DOI:10.1177/02841851231215803 (Source: Acta Radiologica)
Source: Acta Radiologica - December 20, 2023 Category: Radiology Authors: Yinwei Ying Xiujuan Liu Xuanxuan Li Nan Mei Zhuoying Ruan Yiping Lu Bo Yin Source Type: research
Recurrent intracranial anaplastic ependymoma with late ‐onset giant scalp metastasis
Brain CT images with three-dimensional reconstruction of a large left temporo-parietal scalp metastasis from ependymoma. Key Clinical MessageEpendymomas are primary brain tumors that predominantly affect individuals between 0 and 4 years of age. Although ependymomas have a propensity for recurrence and the potential to spread within the central nervous system through cerebrospinal fluid (resulting in drop metastases), reports of extra-neural metastatic localizations are exceedingly rare in the existing literature. This case report presents a unique and rare instance of recurrent intracranial anaplastic ependymoma with a...
Source: Clinical Case Reports - December 13, 2023 Category: General Medicine Authors: Gianluca Scalia,
Gianluca Ferini,
Bipin Chaurasia,
Francesca Graziano,
Stefano Priola,
Paolo Amico,
Giuseppe Emmanuele Umana Tags: CASE REPORT Source Type: research
Fluorescence-guided resection of intradural spinal tumors: a systematic review and meta-analysis
AbstractIntradural spinal tumors present significant challenges due to involvement of critical motor and sensory tracts. Achieving maximal resection while preserving functional tissue is therefore crucial. Fluorescence-guided surgery aims to improve resection accuracy and is well studied for brain tumors, but its efficacy has not been fully assessed for spinal tumors. This meta-analysis aims to delineate the efficacy of fluorescence guidance in intradural spinal tumor resection. The authors performed a systematic review in four databases. We included studies that have utilized fluorescence agents, 5-aminolevulinic acid (...
Source: Neurosurgical Review - December 12, 2023 Category: Neurosurgery Source Type: research
Imaging of supratentorial intraventricular masses in children: a pictorial review —part 2
ConclusionThe WHO CNS5 introduces notable changes, emphasizing the vital importance of molecular diagnostics in classifying pediatric central nervous system tumors. These foundational shifts have significant potential to impact management strategies and, as a result, the outcomes of intraventricular masses in children. (Source: Neuroradiology)
Source: Neuroradiology - December 12, 2023 Category: Radiology Source Type: research
Spinal Cord Tumors: A Review of Demographic Characteristics and Treatment Follow-Up of Patients in Isfahan City, Iran
CONCLUSION: The results may contribute to improve the pre-operative planning, optimization, and monitoring of the patient's recovery after the operation.PMID:38073727 | PMC:PMC10699237 | DOI:10.4103/abr.abr_168_23 (Source: Adv Data)
Source: Adv Data - December 11, 2023 Category: Epidemiology Authors: Mehdi Mahmoodkhani Majid Rezvani Majid Aliyari Mehdi Shafiei Donya S Tehrani Source Type: research
RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma
ConclusionsRFX2 activates PAF1 transcription, which promotes tumor stemness of SE cells and leads to the malignant progression of SE. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 6, 2023 Category: Cancer & Oncology Source Type: research
Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments
We present a protocol that enables efficient generation, expansion, and biobanking of pediatric brain cancer organoids. Utilizing our protocol, we have established patient-derived organoids (PDOs) from ependymomas, medulloblastomas, low-grade glial tumors, and patient-derived xenograft organoids (PDXOs) from medulloblastoma xenografts. PDOs and PDXOs recapitulate histological features, DNA methylation profiles, and intratumor heterogeneity of the tumors from which they were derived. We also showed that PDOs can be xenografted. Most interestingly, when subjected to the same routinely applied therapeutic regimens, PDOs respo...
Source: Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Chiara Lago Aniello Federico Gloria Leva Norman L Mack Benjamin Schwalm Claudio Ballabio Matteo Gianesello Luana Abballe Isabella Giovannoni Sofia Reddel Sabrina Rossi Nicolas Leone Andrea Carai Angela Mastronuzzi Alessandra Bisio Alessia Soldano Concetta Source Type: research
Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments
We present a protocol that enables efficient generation, expansion, and biobanking of pediatric brain cancer organoids. Utilizing our protocol, we have established patient-derived organoids (PDOs) from ependymomas, medulloblastomas, low-grade glial tumors, and patient-derived xenograft organoids (PDXOs) from medulloblastoma xenografts. PDOs and PDXOs recapitulate histological features, DNA methylation profiles, and intratumor heterogeneity of the tumors from which they were derived. We also showed that PDOs can be xenografted. Most interestingly, when subjected to the same routinely applied therapeutic regimens, PDOs respo...
Source: Molecular Medicine - December 1, 2023 Category: Molecular Biology Authors: Chiara Lago Aniello Federico Gloria Leva Norman L Mack Benjamin Schwalm Claudio Ballabio Matteo Gianesello Luana Abballe Isabella Giovannoni Sofia Reddel Sabrina Rossi Nicolas Leone Andrea Carai Angela Mastronuzzi Alessandra Bisio Alessia Soldano Concetta Source Type: research
