Association of Vancomycin AUC/MIC and Trough Concentration With Early Clinical Response in Enterococcus or Coagulase-Negative Staphylococcus Infection: A Prospective Study
This study was condcuted to examine the association of area under the curve (AUC)/minimum inhibitory concentration (MIC) and trough concentration (Ctrough) of vancomycin with treatment outcome and nephrotoxicity in infections caused by Enterococcus spp. and coagulase-negative Staphylococci (CoNS). Peak and trough concentrations were used to calculate AUC in 89 patients receiving vancomycin for infections with Enterococcus spp. (n = 65) or CoNS (n = 24). Correlations between Ctrough, AUC/MIC, early clinical response (ECR), and nephrotoxicity were assessed and cutoff values were determined. Sixty-three (70.8%) patients showe...
Source: The Journal of Clinical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Chuleephorn Pitayakittiwong Pakawadee Sermsappasuk Atibordee Meesing Siriluk Jaisue Source Type: research

Interaction of selected alkoxy naringenin oximes with model and bacterial membranes
Biomed Pharmacother. 2024 Apr 16;174:116581. doi: 10.1016/j.biopha.2024.116581. Online ahead of print.ABSTRACTNaringenin is a flavonoid found in many fruits and herbs, most notably in grapefruits. In recent years, this compound and its derivatives have been of great interest due to their high biological activity, including fungicidal and bactericidal effects, also in relation to multidrug-resistant bacteria. Membrane interactions of naringenin oxime (NO) and its 7-O-alkyl (7-alkoxy) derivatives, such as methyl (7MENO), ethyl (7ETNO), isopropyl (7IPNO), n-butyl (7BUNO) and n-pentyl (7PENO) were studied. Thermotropic propert...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 18, 2024 Category: Drugs & Pharmacology Authors: Olga Weso łowska Anna Duda-Madej Maria B łaszczyk Kamila Środa-Pomianek Joanna Koz łowska Miros ław Anioł Source Type: research

CCR2-dependent CX3CR1+ colonic macrophages promote Enterococcus faecalis dissemination
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - April 17, 2024 Category: Infectious Diseases Authors: Kevin C. JenningsKaitlin E. JohnsonMichael A. HaywardChristopher J. KristichNita H. Salzman1Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA2Department of Microbiology and Immunology, Medical Source Type: research

Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
CONCLUSION: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.PMID:38619029 | DOI:10.34172/aim.2024.11 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Bahareh Vakili Parisa Shoaei Kiana Shahzamani Seyed Davar Siadat Hasan Shojaei Zahra Esfandiari Elahe Nasri Shiva Shabani Ali Zamani Moghadam Behrooz Ataei Source Type: research

Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
CONCLUSION: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.PMID:38619029 | PMC:PMC11017262 | DOI:10.34172/aim.2024.11 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - April 15, 2024 Category: Middle East Health Authors: Bahareh Vakili Parisa Shoaei Kiana Shahzamani Seyed Davar Siadat Hasan Shojaei Zahra Esfandiari Elahe Nasri Shiva Shabani Ali Zamani Moghadam Behrooz Ataei Source Type: research

Biosynthesis of Ag-Doped CuO Nanoparticles Using Heracleum persicum Extract for Enhanced Antibacterial and Photocatalytic Dye Degradation Properties
This study presents the synthesis of copper oxide nanoparticles doped with silver nanoparticles utilizingHeracleum persicum (H. persicum) extract (CuO-Ag@H. persicum). Characterization techniques including XRD, FT-IR, SEM, and TEM confirmed the successful synthesis of homogeneous CuO-Ag@H. persicum nanoparticles without impurities, exhibiting a spherical morphology with sizes ranging from 35 to 65 nm. The incorporation of silver nanoparticles on the surface of the copper oxide introduces unique optical properties, notably the surface plasmon resonance (SPR) phenomenon, enhancing photocatalytic activity. Under UV and sunlig...
Source: Plasmonics - April 12, 2024 Category: Biomedical Science Source Type: research

Analysis of the Cadmium Removal Mechanism of Human Gut Bacteria Enterococcus faecalis Strain ATCC19433 from a Genomic Perspective
This study evaluated the Cd removal capability and mechanism of Enterococcus faecalis strain ATCC19433 while annotating the genetic functions related to Cd removal, which may facilitate the development of potential human gut strains for the removal of Cd.PMID:38602649 | DOI:10.1007/s12011-024-04169-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 11, 2024 Category: Biology Authors: Yu Zheng Zhibin Duan Yonggui Wu Yang Luo Xiaoyu Peng Jianye Wu Source Type: research

Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research

Analysis of the Cadmium Removal Mechanism of Human Gut Bacteria Enterococcus faecalis Strain ATCC19433 from a Genomic Perspective
This study evaluated the Cd removal capability and mechanism of Enterococcus faecalis strain ATCC19433 while annotating the genetic functions related to Cd removal, which may facilitate the development of potential human gut strains for the removal of Cd.PMID:38602649 | DOI:10.1007/s12011-024-04169-6 (Source: Cell Research)
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Yu Zheng Zhibin Duan Yonggui Wu Yang Luo Xiaoyu Peng Jianye Wu Source Type: research

Analysis of the Cadmium Removal Mechanism of Human Gut Bacteria Enterococcus faecalis Strain ATCC19433 from a Genomic Perspective
This study evaluated the Cd removal capability and mechanism of Enterococcus faecalis strain ATCC19433 while annotating the genetic functions related to Cd removal, which may facilitate the development of potential human gut strains for the removal of Cd.PMID:38602649 | DOI:10.1007/s12011-024-04169-6 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 11, 2024 Category: Biology Authors: Yu Zheng Zhibin Duan Yonggui Wu Yang Luo Xiaoyu Peng Jianye Wu Source Type: research

Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research

Antimicrobial and Probiotic Potential of Lactobacilli Associated with Traditional Fermented Beverages
In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity. These isolates also showed characteristics associated with probiotic properties, such as tolerance to low pH and bile salts, survival in the gastric tract,...
Source: Current Microbiology - April 10, 2024 Category: Microbiology Authors: Surmani Huidrom Pulok K Mukherjee Sarangthem Indira Devi Source Type: research

Antimicrobial and Probiotic Potential of Lactobacilli Associated with Traditional Fermented Beverages
In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity. These isolates also showed characteristics associated with probiotic properties, such as tolerance to low pH and bile salts, survival in the gastric tract,...
Source: Current Microbiology - April 10, 2024 Category: Microbiology Authors: Surmani Huidrom Pulok K Mukherjee Sarangthem Indira Devi Source Type: research

Antimicrobial and Probiotic Potential of Lactobacilli Associated with Traditional Fermented Beverages
In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity. These isolates also showed characteristics associated with probiotic properties, such as tolerance to low pH and bile salts, survival in the gastric tract,...
Source: Current Microbiology - April 10, 2024 Category: Microbiology Authors: Surmani Huidrom Pulok K Mukherjee Sarangthem Indira Devi Source Type: research

The virtue of training: extending phage host spectra against vancomycin-resistant < em > Enterococcus faecium < /em > strains using the Appelmans method
Antimicrob Agents Chemother. 2024 Apr 9:e0143923. doi: 10.1128/aac.01439-23. Online ahead of print.ABSTRACTPhage therapy has (re)emerged as a serious possibility for combating multidrug-resistant bacterial infections, including those caused by vancomycin-resistant Enterococcus faecium strains. These opportunistic pathogens belong to a specific clonal complex 17, against which relatively few phages have been screened. We isolated a collection of 21 virulent phages growing on these vancomycin-resistant isolates. Each of these phages harbored a typical narrow plaquing host range, lysing at most 5 strains and covering together...
Source: Antimicrobial Agents and Chemotherapy - April 9, 2024 Category: Microbiology Authors: Julien Lossouarn Elsa Beurrier Astrid Bouteau Elisabeth Moncaut Maria Sir Silmane He ïdi Portalier Asma Zouari Vincent Cattoir Pascale Serror Marie-Agn ès Petit Source Type: research