Snakebite-Associated Infections: A Systematic Review and Meta-Analysis
The objective of this systematic review was to determine the prevalence of snakebite infections and characterize the bacteria isolated from these infections. A systematic literature review in five databases was carried out to assess the prevalence of snakebite infection. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% CIs. Cochran's Q test and the I2 statistic were used to assess between-study heterogeneity. The pooled prevalence of infection due to snakebite was 27.0% (95% CI: 22.0-32.0%), with high heterogeneity among studies (I2 = 99.7%). The prevalence was higher in...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: D Katterine Bonilla-Aldana Jorge Luis Bonilla-Aldana Juan R Ulloque-Badaracco Ali Al-Kassab-C órdova Enrique A Hernandez-Bustamante Esteban A Alarcon-Braga Abdelmonem Siddiq Vicente A Benites-Zapata Alfonso J Rodriguez-Morales Camila Luna Jose A Suarez Source Type: research
Snakebite-Associated Infections: A Systematic Review and Meta-Analysis
The objective of this systematic review was to determine the prevalence of snakebite infections and characterize the bacteria isolated from these infections. A systematic literature review in five databases was carried out to assess the prevalence of snakebite infection. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% CIs. Cochran's Q test and the I2 statistic were used to assess between-study heterogeneity. The pooled prevalence of infection due to snakebite was 27.0% (95% CI: 22.0-32.0%), with high heterogeneity among studies (I2 = 99.7%). The prevalence was higher in...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: D Katterine Bonilla-Aldana Jorge Luis Bonilla-Aldana Juan R Ulloque-Badaracco Ali Al-Kassab-C órdova Enrique A Hernandez-Bustamante Esteban A Alarcon-Braga Abdelmonem Siddiq Vicente A Benites-Zapata Alfonso J Rodriguez-Morales Camila Luna Jose A Suarez Source Type: research
Snakebite-Associated Infections: A Systematic Review and Meta-Analysis
The objective of this systematic review was to determine the prevalence of snakebite infections and characterize the bacteria isolated from these infections. A systematic literature review in five databases was carried out to assess the prevalence of snakebite infection. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% CIs. Cochran's Q test and the I2 statistic were used to assess between-study heterogeneity. The pooled prevalence of infection due to snakebite was 27.0% (95% CI: 22.0-32.0%), with high heterogeneity among studies (I2 = 99.7%). The prevalence was higher in...
Source: The American Journal of Tropical Medicine and Hygiene - March 20, 2024 Category: Tropical Medicine Authors: D Katterine Bonilla-Aldana Jorge Luis Bonilla-Aldana Juan R Ulloque-Badaracco Ali Al-Kassab-C órdova Enrique A Hernandez-Bustamante Esteban A Alarcon-Braga Abdelmonem Siddiq Vicente A Benites-Zapata Alfonso J Rodriguez-Morales Camila Luna Jose A Suarez Source Type: research
Snakebite-Associated Infections: A Systematic Review and Meta-Analysis
The objective of this systematic review was to determine the prevalence of snakebite infections and characterize the bacteria isolated from these infections. A systematic literature review in five databases was carried out to assess the prevalence of snakebite infection. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% CIs. Cochran's Q test and the I2 statistic were used to assess between-study heterogeneity. The pooled prevalence of infection due to snakebite was 27.0% (95% CI: 22.0-32.0%), with high heterogeneity among studies (I2 = 99.7%). The prevalence was higher in...
Source: Am J Trop Med Hyg - March 20, 2024 Category: Infectious Diseases Authors: D Katterine Bonilla-Aldana Jorge Luis Bonilla-Aldana Juan R Ulloque-Badaracco Ali Al-Kassab-C órdova Enrique A Hernandez-Bustamante Esteban A Alarcon-Braga Abdelmonem Siddiq Vicente A Benites-Zapata Alfonso J Rodriguez-Morales Camila Luna Jose A Suarez Source Type: research
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Angew Chem Int Ed Engl. 2024 Mar 19:e202319765. doi: 10.1002/anie.202319765. Online ahead of print.ABSTRACTThe natural product chlorotonil displays high potency against multidrug-resistant Gram-positive bacteria and Plasmodium falciparum. Yet, its scaffold is characterized by low solubility and oral bioavailability but progress was recently made to enhance these properties. Applying late-stage functionalization, we aimed to further optimize the molecule. Previously unknown reactions including a sulfur-mediated dehalogenation were revealed. Dehalogenil, the product of this reaction, was identified as the most promising comp...
Source: Angewandte Chemie - March 19, 2024 Category: Chemistry Authors: Walter Hofer Felix Deschner Gwena ëlle Jézéquel La ìs Pessanha de Carvalho Noran Abdel-Wadood Linda P ätzold Steffen Bernecker Bernd Morgenstern Andreas Martin Kany Miriam Gro ße Marc Stadler Markus Bischoff Anna Katharina Herta Hirsch Jana Held Jen Source Type: research
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Angew Chem Int Ed Engl. 2024 Mar 19:e202319765. doi: 10.1002/anie.202319765. Online ahead of print.ABSTRACTThe natural product chlorotonil displays high potency against multidrug-resistant Gram-positive bacteria and Plasmodium falciparum. Yet, its scaffold is characterized by low solubility and oral bioavailability but progress was recently made to enhance these properties. Applying late-stage functionalization, we aimed to further optimize the molecule. Previously unknown reactions including a sulfur-mediated dehalogenation were revealed. Dehalogenil, the product of this reaction, was identified as the most promising comp...
Source: Angewandte Chemie - March 19, 2024 Category: Chemistry Authors: Walter Hofer Felix Deschner Gwena ëlle Jézéquel La ìs Pessanha de Carvalho Noran Abdel-Wadood Linda P ätzold Steffen Bernecker Bernd Morgenstern Andreas Martin Kany Miriam Gro ße Marc Stadler Markus Bischoff Anna Katharina Herta Hirsch Jana Held Jen Source Type: research
Perioperative pancreaticoduodenectomy management strategy focusing on postoperative early drain colonization
ConclusionWe observed a strong correlation between POEDC and poor postoperative outcomes. The BMI, age, and PCT and drain amylase level on POD 1 should be considered POEDC risk factors, with the need to propose an antibiotic perioperative strategy. POEDC control may represent the key to improving postoperative outcomes after PD. (Source: Surgery Today)
Source: Surgery Today - March 19, 2024 Category: Surgery Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
Formation/characterization of humin-mediated anaerobic granular sludge and enhanced methanogenic performance
This study presents a novel method for accelerating the granulation of methanogenic anaerobic granular sludge (AnGS) in an upflow anaerobic sludge blanket (UASB) reactor using solid-phase humin (HM). The results demonstrated that HM-mediated AnGS (HM-AnGS) formed rapidly within 50 days. The increase in particle size, settling velocity and mechanical strength was attributed to the rapid granulation of the HM-AnGS. The maximum methane yield of the HM-AnGS was 5-fold higher than that of the control group. This is consistent with the findings, which showed that HM-AnGS had 3.2-3.4 times more methyl-coenzyme M reductase (Mcr) a...
Source: Bioresource Technology - March 18, 2024 Category: Biotechnology Authors: Ningli Zhou Zhixing Xiao Dan Chen Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
Formation/characterization of humin-mediated anaerobic granular sludge and enhanced methanogenic performance
This study presents a novel method for accelerating the granulation of methanogenic anaerobic granular sludge (AnGS) in an upflow anaerobic sludge blanket (UASB) reactor using solid-phase humin (HM). The results demonstrated that HM-mediated AnGS (HM-AnGS) formed rapidly within 50 days. The increase in particle size, settling velocity and mechanical strength was attributed to the rapid granulation of the HM-AnGS. The maximum methane yield of the HM-AnGS was 5-fold higher than that of the control group. This is consistent with the findings, which showed that HM-AnGS had 3.2-3.4 times more methyl-coenzyme M reductase (Mcr) a...
Source: Bioresource Technology - March 18, 2024 Category: Biotechnology Authors: Ningli Zhou Zhixing Xiao Dan Chen Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
Heat-Killed < em > Enterococcus faecium < /em > KU22001 Having Effective Anti-Cancer Effects on HeLa Cell Lines at a Lower Temperature
In conclusion, these results suggest that KU22001 can be beneficial owing to the anti-cancer effects and production of functional materials, such as EPS.PMID:38494869 | DOI:10.4014/jmb.2310.10050 (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - March 18, 2024 Category: Biotechnology Authors: Jun-Su Ha Na-Kyoung Lee Hyun-Dong Paik Source Type: research
