Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
This study builds on our initial data, which showed that panaxynol - a novel, potent, bioavailable compound found in American ginseng - can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p&l...
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Brooke M Bullard Sierra J McDonald Thomas D Cardaci Brandon N VanderVeen Ahmed D Mohammed Jason L Kubinak Joseph F Pierre Ioulia Chatzistamou Daping Fan Lorne J Hofseth E Angela Murphy Source Type: research
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
This study builds on our initial data, which showed that panaxynol - a novel, potent, bioavailable compound found in American ginseng - can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p&l...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - March 12, 2024 Category: Physiology Authors: Brooke M Bullard Sierra J McDonald Thomas D Cardaci Brandon N VanderVeen Ahmed D Mohammed Jason L Kubinak Joseph F Pierre Ioulia Chatzistamou Daping Fan Lorne J Hofseth E Angela Murphy Source Type: research
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
This study builds on our initial data, which showed that panaxynol - a novel, potent, bioavailable compound found in American ginseng - can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p&l...
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Brooke M Bullard Sierra J McDonald Thomas D Cardaci Brandon N VanderVeen Ahmed D Mohammed Jason L Kubinak Joseph F Pierre Ioulia Chatzistamou Daping Fan Lorne J Hofseth E Angela Murphy Source Type: research
Non- < em > faecium < /em > non- < em > faecalis < /em > enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Clin Microbiol Rev. 2024 Mar 11:e0012123. doi: 10.1128/cmr.00121-23. Online ahead of print.ABSTRACTSUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: Enterococcus faecium and Enterococcus faecalis. However, there is an increasing number of clinical infections caused by non-faecium non-faecalis (NFF) enterococci. Although ...
Source: Clinical Microbiology Reviews - March 11, 2024 Category: Microbiology Authors: Christopher A Mullally Marhami Fahriani Shakeel Mowlaboccus Geoffrey W Coombs Source Type: research
Efficient biogenesis of calcium oxide nanoparticles using the extract of Eleusine coracana seeds and their application against multidrug-resistant ocular bacterial pathogens
This study provides a potential therapeutic option for multiple drug-resistant corneal pathogens that cause vision impairment.PMID:38467361 | DOI:10.1016/j.envres.2024.118632 (Source: Environmental Research)
Source: Environmental Research - March 11, 2024 Category: Environmental Health Authors: Sandhanasamy Devanesan Heber A David Amirtham J Ranjitsingh Tariq Alzahim Robert Selvam Mohamad S AlSalhi Source Type: research
Non- < em > faecium < /em > non- < em > faecalis < /em > enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Clin Microbiol Rev. 2024 Mar 11:e0012123. doi: 10.1128/cmr.00121-23. Online ahead of print.ABSTRACTSUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: Enterococcus faecium and Enterococcus faecalis. However, there is an increasing number of clinical infections caused by non-faecium non-faecalis (NFF) enterococci. Although ...
Source: Clinical Microbiology Reviews - March 11, 2024 Category: Microbiology Authors: Christopher A Mullally Marhami Fahriani Shakeel Mowlaboccus Geoffrey W Coombs Source Type: research
Efficient biogenesis of calcium oxide nanoparticles using the extract of Eleusine coracana seeds and their application against multidrug-resistant ocular bacterial pathogens
This study provides a potential therapeutic option for multiple drug-resistant corneal pathogens that cause vision impairment.PMID:38467361 | DOI:10.1016/j.envres.2024.118632 (Source: Environmental Research)
Source: Environmental Research - March 11, 2024 Category: Environmental Health Authors: Sandhanasamy Devanesan Heber A David Amirtham J Ranjitsingh Tariq Alzahim Robert Selvam Mohamad S AlSalhi Source Type: research
Non- < em > faecium < /em > non- < em > faecalis < /em > enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Clin Microbiol Rev. 2024 Mar 11:e0012123. doi: 10.1128/cmr.00121-23. Online ahead of print.ABSTRACTSUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: Enterococcus faecium and Enterococcus faecalis. However, there is an increasing number of clinical infections caused by non-faecium non-faecalis (NFF) enterococci. Although ...
Source: Clinical Microbiology Reviews - March 11, 2024 Category: Microbiology Authors: Christopher A Mullally Marhami Fahriani Shakeel Mowlaboccus Geoffrey W Coombs Source Type: research
Non- < em > faecium < /em > non- < em > faecalis < /em > enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance
Clin Microbiol Rev. 2024 Mar 11:e0012123. doi: 10.1128/cmr.00121-23. Online ahead of print.ABSTRACTSUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: Enterococcus faecium and Enterococcus faecalis. However, there is an increasing number of clinical infections caused by non-faecium non-faecalis (NFF) enterococci. Although ...
Source: Clinical Microbiology Reviews - March 11, 2024 Category: Microbiology Authors: Christopher A Mullally Marhami Fahriani Shakeel Mowlaboccus Geoffrey W Coombs Source Type: research
A Versatile Thioesterase Involved in Dimerizationduring Cinnamoyl Lipid Biosynthesis
This study enhances our understanding of the multifunctionality of the TE protein family.PMID:38462490 | DOI:10.1002/anie.202402010 (Source: Angewandte Chemie)
Source: Angewandte Chemie - March 10, 2024 Category: Chemistry Authors: Zirong Deng Chunni Liu Fang Wang Ni Song Jing Liu Huayue Li Siyu Liu Tong Li Zengzhi Liu Fei Xiao Wenli Li Source Type: research
Polydispersity-mediated high efficacy of an in-situ aqueous nanosuspension of PPEF.3HCl in methicillin resistant Staphylococcus aureus sepsis model
Int J Pharm. 2024 Mar 7:123982. doi: 10.1016/j.ijpharm.2024.123982. Online ahead of print.ABSTRACTRecently, World Health Organization declared antimicrobial resistance as the third greatest threat to human health. Absence of known cross-resistance, new class, new target, and a new mode of action are few major strategies being undertaken by researches to combat multidrug resistant pathogen. PPEF.3HCl, a bisbenzimidazole was developed as highly potent antibacterial agent against ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter specie...
Source: Cell Research - March 9, 2024 Category: Cytology Authors: Amit S Lokhande Vikas Maurya Komal Rani Palak Parashar Rajni Gaind Vibha Tandon Padma V Devarajan Source Type: research
Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria
Eur J Med Chem. 2024 Mar 4;268:116303. doi: 10.1016/j.ejmech.2024.116303. Online ahead of print.ABSTRACTMethionyl-tRNA synthetase (MetRS) catalyzes the attachment of l-methionine (l-Met) to tRNAMet to generate methionyl-tRNAMet, an essential substrate for protein translation within ribosome. Owing to its indispensable biological function and the structural discrepancies with human counterpart, bacterial MetRS is considered an ideal target for developing antibacterials. Herein, chlorhexidine (CHX) was identified as a potent binder of Staphylococcus aureus MetRS (SaMetRS) through an ATP-aided affinity screening. The co-cryst...
Source: European Journal of Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Feihu Lu Kaijiang Xia Jingtian Su Jia Yi Zhiteng Luo Jun Xu Qiong Gu Bingyi Chen Huihao Zhou Source Type: research
Biochemical and structural characterization of chlorhexidine as an ATP-assisted inhibitor against type 1 methionyl-tRNA synthetase from Gram-positive bacteria
Eur J Med Chem. 2024 Mar 4;268:116303. doi: 10.1016/j.ejmech.2024.116303. Online ahead of print.ABSTRACTMethionyl-tRNA synthetase (MetRS) catalyzes the attachment of l-methionine (l-Met) to tRNAMet to generate methionyl-tRNAMet, an essential substrate for protein translation within ribosome. Owing to its indispensable biological function and the structural discrepancies with human counterpart, bacterial MetRS is considered an ideal target for developing antibacterials. Herein, chlorhexidine (CHX) was identified as a potent binder of Staphylococcus aureus MetRS (SaMetRS) through an ATP-aided affinity screening. The co-cryst...
Source: European Journal of Medicinal Chemistry - March 8, 2024 Category: Chemistry Authors: Feihu Lu Kaijiang Xia Jingtian Su Jia Yi Zhiteng Luo Jun Xu Qiong Gu Bingyi Chen Huihao Zhou Source Type: research
GSE234500 YvcL-regulated genes in Enterococcus faecalis
Contributors : Samantha N Atkinson ; Dusanka Djoric ; Christopher J KristichSeries Type : Expression profiling by high throughput sequencingOrganism : Enterococcus faecalisThe goal was to identify genes regulated by YvcL (EF0768) by assessing changes in the yvcL deletion mutant relative to the isogenic wild-type. Wild-type E. faecalis OG1 and the mutant lacking yvcL were cultured in Mueller-Hinton broth to exponential phase. Total RNA was purified, depleted for rRNA, and subjected to preparation of mRNA libraries. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 8, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Enterococcus faecalis Source Type: research
Genome-wide analysis of acid tolerance genes of Enterococcus faecalis with RNA-seq and Tn-seq
Enterococcus faecalis, a formidable nosocomial and community-acquired opportunistic pathogen, can persist a wide range of extreme environments, including low pH and nutrient deficiency. Clarifying the survival me... (Source: BMC Genomics)
Source: BMC Genomics - March 8, 2024 Category: Genetics & Stem Cells Authors: Zhanyi Chen, Chenguang Niu, Lifan Wei, Zhengwei Huang and Shujun Ran Tags: Research Source Type: research
