Association of Aortic Stiffness and Pressure Pulsatility With Noninvasive Estimates of Hepatic Steatosis and Fibrosis: The Framingham Heart Study
CONCLUSIONS: Elevated aortic stiffness and pressure pulsatility may contribute to hepatic steatosis and fibrosis.PMID:38752348 | DOI:10.1161/ATVBAHA.123.320553 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 16, 2024 Category: Cardiology Authors: Leroy L Cooper Brenton R Prescott Vanessa Xanthakis Emelia J Benjamin Ramachandran S Vasan Naomi M Hamburg Michelle T Long Gary F Mitchell Source Type: research
Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants
CONCLUSION: Diabetes was associated with an increased gastric cancer incidence regardless of sex, anatomical subsite, or subtypes of gastric cancer. The risk of gastric cancer was particularly high during the first decade following diabetes diagnosis.PMID:38751364 | DOI:10.1111/1753-0407.13561 (Source: Cancer Control)
Source: Cancer Control - May 16, 2024 Category: Cancer & Oncology Authors: Katherine De la Torre Minkyo Song Sarah Krull Abe Md Shafiur Rahman Md Rashedul Islam Eiko Saito Sukhong Min Dan Huang Yu Chen Prakash C Gupta Norie Sawada Akiko Tamakoshi Xiao-Ou Shu Wanqing Wen Ritsu Sakata Jeongseon Kim Chisato Nagata Hidemi Ito Sue K Source Type: research
Short-term glycemic variability and intracranial atherosclerotic plaque stability assessed by high-resolution MR vessel wall imaging in type 2 diabetes mellitus
CONCLUSION: 1,5-AG, HbA1c and male sex are independent predictors of intracranial plaques with T1WI hyperintensity, the greater short-term glycemic variability, the higher incidence of vulnerable plaques.PMID:38750835 | DOI:10.1016/j.jstrokecerebrovasdis.2024.107769 (Source: Atherosclerosis)
Source: Atherosclerosis - May 16, 2024 Category: Cardiology Authors: Tiantian Li Chengqun Qian Zhuo Chen Tianle Wang Qingjie Chi Li Zhu Source Type: research
Polychlorinated Biphenyls and Incident Coronary Heart Disease-related Outcomes in Great Lakes Fish Consumers
CONCLUSIONS: This study presents evidence that exposure to PCBs increases the risk of developing coronary heart disease. Given the large number of risk factors and causal pathways for CHD, future research is required to better understand biological mechanisms of action for PCBs on CHD.PMID:38751005 | DOI:10.1016/j.envres.2024.119071 (Source: Atherosclerosis)
Source: Atherosclerosis - May 16, 2024 Category: Cardiology Authors: Michael J Blackowicz Victoria W Persky Robert M Sargis Sally Freels Henry A Anderson Mary E Turyk Source Type: research
Role of Quercetin in DNA Repair: Possible Target to Combat Drug Resistance in Diabetes
Curr Drug Targets. 2024 May 14. doi: 10.2174/0113894501302098240430164446. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) is referred to as hyperglycemia in either fasting or postprandial phases. Oxidative stress, which is defined by an excessive amount of reactive oxygen species (ROS) production, increased exposure to external stress, and an excessive amount of the cellular defense system against them, results in cellular damage. Increased DNA damage is one of the main causes of genomic instability, and genetic changes are an underlying factor in the emergence of cancer. Through covalent connections with DNA and pro...
Source: Current Drug Targets - May 16, 2024 Category: Drugs & Pharmacology Authors: Yaseen Hussain - Abdullah Fazlullah Khan Waqas Alam Haseeba Sardar Muhammad Ajmal Khan Xiaoyan Shen Haroon Khan Source Type: research
T-cell immunity against Severe Acute Respiratory Syndrome Coronavirus 2 proteins in patients with type 1 diabetes
CONCLUSIONS: The increased frequency of SAR-CoV-2- reactive T cells in T1D patients might protect against severe COVID-19 and overt infections. These results emphasise the long-standing association between viral infections and T1D.PMID:38751148 | DOI:10.1002/dmrr.3811 (Source: Cell Research)
Source: Cell Research - May 16, 2024 Category: Cytology Authors: Camillo Palmieri Gianluca Santamaria Costanza Maria Cristiani Cinzia Garofalo Christine Y L Tham Antonio Abatino Antonio Cutruzzol à Martina Parise Ilenia Aversa Donatella Malanga Raffaella Gallo Giovanni Cuda Giuseppe Viglietto Francesco Costanzo Antoni Source Type: research
Modifiable Risk Factors Associated With Cognitive Decline in Late Life Depression: Findings From the Canadian Longitudinal Study on Aging: Facteurs de risque modifiables associ és au déclin cognitif dans la dépression en fin de vie : constatations de l'Étude longitudinale canadienne sur le vieillissement
CONCLUSIONS: In this large sample of Canadian older adults incorporating several objective health measures, older adults with depression were at increased risk of cognitive decline and had an excess of potentially modifiable risk factors. Clinicians should pay particular attention to control of diabetes, physical inactivity and risk factors for cerebrovascular disease in older adults presenting with depression as they can contribute to accelerated cognitive decline and may be addressed during routine clinical care.PMID:38751067 | DOI:10.1177/07067437241255095 (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - May 16, 2024 Category: Psychiatry Authors: Melissa Wong Alex Kiss Nathan Herrmann Krista L Lanct ôt Damien Gallagher Source Type: research
Predictive value of Systematic Coronary Risk Evaluation 2 ‐Diabetes risk model and arterial stiffness for cardiovascular events in the Asian population with type 2 diabetes mellitus
ConclusionsAdding the CAVI to the SCORE2-Diabetes risk algorithm did not improve individual risk stratification in patients with diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 16, 2024 Category: Endocrinology Authors: Pannipa Suwannasom,
Tasalak Thonghong,
Krit Leemasawat,
Teerapat Nantsupawat,
Narawudt Prasertwitayakij,
Chutamas Pairoj,
Wanwarang Wongcharoen,
Arintaya Phrommintikul,
CORE ‐Thailand Investigators Tags: Original Article Source Type: research
Dietary Intakes of Women with Gestational Diabetes Mellitus and Pregnancy Outcomes: A Prospective Observational Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 16, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
ROF ‐2 as an Aggregation‐Induced Emission (AIE) Probe for Multi‐Target Amyloid Detection and Screening of Amyloid Inhibitors
Here, an aggregation-induced emission (AIE) molecule of ROF2 with its multifaceted functionalities as i) an amyloid probe to distinguish amyloid aggregates of different sequences (A β, hIAPP, or hCT) and sizes (monomers, oligomers, or fibrils) and ii) a screening tool for amyloid inhibitors to identify and repurpose several cardiovascular drugs as amyloid inhibitors by using different biophysical, cellular, and worm assays, is reported. AbstractMisfolding and aggregation of amyloid peptides into β-structure-rich fibrils represent pivotal pathological features in various neurodegenerative diseases, including Alzheimer's d...
Source: Small - May 16, 2024 Category: Nanotechnology Authors: Yijing Tang,
Dong Zhang,
Jie Zheng Tags: Research Article Source Type: research
Targeted next-generation sequencing for maturity onset diabetes of the young (MODY) in a South Indian cohort of type 1 diabetes mellitus patients with preserved C-peptide
ConclusionIn a South Indian cohort of T1DM with preserved C-peptide, we could not find any case of MODY through targeted NGS. UCPCR can be used as a screening tool to identify cases needing genetic testing for MODY. Larger studies utilizing whole exome sequencing should be conducted to know the actual prevalence of MODY among T1DM. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 16, 2024 Category: Endocrinology Source Type: research
The effect of atorvastatin on the concentrations of methylglyoxal, glyoxalase 1, and aldo –keto reductase family 1 member B10 in patients with type 2 diabetes mellitus and prediabetes
ConclusionAtorvastatin can improve the level of GLO-1 activity and thereby prevent diabetic complications. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 16, 2024 Category: Endocrinology Source Type: research
Family-based association of 4q27chromosomal region covering IL2-IL21 genes with type 1 diabetes (T1D) —a study of genetic risk factors
ConclusionSeveral autoimmune disorders (ADs) have been linked to the IL2/IL21 genes, suggesting that there is a shared genetic background that confers a common genetic predisposition across ADs. More research into the genetic and functional aspects of the 4q27 region is needed to better explain the role it plays in the risk of ADs. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - May 16, 2024 Category: Endocrinology Source Type: research
GSE267285 Preweaning β-hydroxybutyrate elevation attenuates predisposition to metabolic dysregulation and impairs beige fat biogenesis in offspring of parents with high-fat diet-induced obesity
Contributor : Fu-Jung LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusParental obesity (PO) predisposes offspring to an increased risk of obesity and type 2 diabetes in adulthood. We demonstrated that exogenous ketosis enhances blood ketone body β-hydroxybutyrate (βHB) concentration, regulating the adipogenic activity of parental obesity (PO) offspring and promoting beige adipogenesis to counteract obesity. Bulk RNA-seq analysis was performed on inguinal white adipose tissue-derived stromal vascular cells (iWAT-SVCs) obtained from offspri ng of control mice (Ln-F1) and obese mic...
Source: GEO: Gene Expression Omnibus - May 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
DNA methylation and type 2 diabetes: a systematic review
DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid early detection and/or therapeutic treatm... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - May 16, 2024 Category: Research Authors: Nikhil Nadiger, Jyothisha Kana Veed, Priyanka Chinya Nataraj and Arpita Mukhopadhyay Tags: Review Source Type: research
