Sleep health among US Navy afloat versus ashore personnel in the Millennium Cohort Study
This study examined sleep metrics (e.g. fatigue, short sleep duration) and mental (e.g. posttraumatic stress disorder, depression) and physical health (e.g. type 2 diabetes, bodily pain) outcomes among naval personnel with recent sea duty (i.e. afloat) compared with naval personnel with recent shore duty (i.e. ashore). Prevalence ratios and mean differences for all outcomes were estimated and adjusted for demographic and military variables, and subsequently stratified by obesity. Sleep metrics were similar between afloat and ashore sailors except for short sleep duration, while sailors with recent shore duty had poorer phy...
Source: Journal of Sleep Research - May 19, 2024 Category: Sleep Medicine Authors: Isabel G Jacobson Judith Harbertson Neika Sharifian Rudolph P Rull Christopher T Steele Dale W Russell Source Type: research
Recent advances in the effect of adipose tissue inflammation on insulin resistance
Cell Signal. 2024 May 17:111229. doi: 10.1016/j.cellsig.2024.111229. Online ahead of print.ABSTRACTObesity is one of the major risk factors for diabetes. Excessive accumulation of fat leads to inflammation of adipose tissue, which can increase the risk of developing diabetes.. Obesity-related chronic inflammation can result in anomalies in glucose-lipid metabolism and insulin resistance, and it is a major cause of β-cell dysfunction in diabetes mellitus. Thus, a long-term tissue inflammatory response is crucial for metabolic diseases, particularly type 2 diabetes. Chronic inflammation associated with obesity increases oxi...
Source: Cellular Signalling - May 19, 2024 Category: Cytology Authors: Kaiyi Yan Source Type: research
Comparison of single- and double-dose methotrexate protocols for treatment of pregnancy of unknown location
CONCLUSION: Single- and double-dose MTX protocols have comparable efficacy and safety, and should be equally considered in women with PUL with initial β-hCG < 2000 mIU/ml.PMID:38762953 | DOI:10.1016/j.ejogrb.2024.05.016 (Source: Reproductive Biology)
Source: Reproductive Biology - May 19, 2024 Category: Reproduction Medicine Authors: Magdalena M Pir óg Anna Pulka Przemys ław Urbaniec Robert Jach Source Type: research
Electroporation enhances cell death in 3D scaffold-based MDA-MB-231 cells treated with metformin
Bioelectrochemistry. 2024 May 16;159:108734. doi: 10.1016/j.bioelechem.2024.108734. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer lacks estrogen, progesterone, and HER2 receptors and hence, is therapeutically challenging. Towards this, we studied an alternate therapy by repurposing metformin (FDA-approved type-2 diabetic drug with anticancer properties) in a 3D-scaffold culture, with electrical pulses. 3D cell culture was used to simulate the tumor microenvironment more closely and MDA-MB-231, human TNBC cells, treated with both 5 mM metformin (Met) and 8 e...
Source: Bioelectrochemistry - May 19, 2024 Category: Biochemistry Authors: Praveen Sahu Ignacio G Camarillo Monica Dettin Annj Zamuner Maria Teresa Conconi Marco Barozzi Pragatheiswar Giri Raji Sundararajan Elisabetta Sieni Source Type: research
Endoplasmic reticulum-resident selenoproteins and their roles in glucose and lipid metabolic disorders
Biochim Biophys Acta Mol Basis Dis. 2024 May 17:167246. doi: 10.1016/j.bbadis.2024.167246. Online ahead of print.ABSTRACTGlucose and lipid metabolic disorders (GLMDs), such as diabetes, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, and obesity, are significant public health issues that negatively impact human health. The endoplasmic reticulum (ER) plays a crucial role at the cellular level for lipid and sterol biosynthesis, intracellular calcium storage, and protein post-translational modifications. Imbalance and dysfunction of the ER can affect glucose and lipid metabolism. As an essential trace elem...
Source: Biochimica et Biophysica Acta - May 19, 2024 Category: Biochemistry Authors: Zhan Shi Ziyu Han Jingyi Chen Ji-Chang Zhou Source Type: research
Antidiabetic properties of Caffeoylmalic acid, a bioactive natural compound isolated from Urtica dioica
Fitoterapia. 2024 May 17:106024. doi: 10.1016/j.fitote.2024.106024. Online ahead of print.ABSTRACTThe uncontrolled hyperglycemia that characterizes diabetes mellitus (DM) causes several complications in the organism. DM is among the major causes of deaths, and the limited efficacy of current treatments push the search for novel drug candidates, also among natural compounds. We focused our attention on caffeoylmalic acid, a phenolic derivative extracted from Urtica dioica, a plant investigated for its potential against type 2 DM. This compound was tested for its antidiabetic activity in vitro through a glucose uptake assay,...
Source: Fitoterapia - May 19, 2024 Category: Biochemistry Authors: Gauhar Rehman Ilman Khan Abdur Rauf Umer Rashid Arshma Siddique Syed Muhammad Mukarram Shah Zuneera Akram Najla AlMasoud Taghrid S Alomar Zafar Ali Shah Giovanni Ribaudo Source Type: research
Association between long-term exposure to air pollution and diabetic retinopathy: Evidence from the Fujian Eye Study
CONCLUSIONS: These findings showed that long-term exposure to ambient particulate matter and NO2 was associated with a high DR risk in Fujian province, where ambient air pollution is relatively low.PMID:38763052 | DOI:10.1016/j.ecoenv.2024.116459 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - May 19, 2024 Category: Environmental Health Authors: Bo Zuo Qinrui Hu Yixue Wu Xiaoxin Li Bin Wang Meilin Yan Yang Li Source Type: research
Impact of High Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial
CONCLUSIONS: In this secondary analysis of the TEAM trial, in patients with diabetes, a high dose early mobilization strategy did not significantly decrease the number of days alive and out of hospital at day 180 but it increased 180-day mortality.PMID:38763167 | DOI:10.1164/rccm.202312-2289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - May 19, 2024 Category: Intensive Care Authors: Ary Serpa Neto Michael Bailey Daniel Seller Alicia Agli Rinaldo Bellomo Kathy Brickell Tessa Broadley Heidi Buhr Belinda J Gabbe Doug W Gould Meg Harrold Alisa M Higgins Sally Hurford Theodore J Iwashyna Alistair D Nichol Jeffrey J Presneill Stefan J Scha Source Type: research
Early Mobilization in the ICU and Diabetes: A Bittersweet Concoction?
Am J Respir Crit Care Med. 2024 May 19. doi: 10.1164/rccm.202405-0964ED. Online ahead of print.NO ABSTRACTPMID:38763507 | DOI:10.1164/rccm.202405-0964ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - May 19, 2024 Category: Intensive Care Authors: Matthew F Mart E Wesley Ely Source Type: research
Early Mobilization in the ICU and Diabetes: A Bittersweet Concoction?
Am J Respir Crit Care Med. 2024 May 19. doi: 10.1164/rccm.202405-0964ED. Online ahead of print.NO ABSTRACTPMID:38763507 | DOI:10.1164/rccm.202405-0964ED (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2024 Category: Respiratory Medicine Authors: Matthew F Mart E Wesley Ely Source Type: research
The Risk of Secondary Spontaneous Pneumothorax in Patients with Chronic Obstructive Pulmonary Disease in Taiwan
CONCLUSION: Our study revealed an elevated risk of SSP in patients with COPD. It has also been suggested that COPD patients with comorbidities, such as atrial fibrillation, congestive heart failure, coronary artery disease, diabetes mellitus, hypertension, and cancer, have an increased risk of developing SSP.PMID:38763446 | DOI:10.1016/j.rmed.2024.107672 (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2024 Category: Respiratory Medicine Authors: Kuang-Ming Liao Chong-Chi Chiu Hsueh-Yi Lu Source Type: research
Impact of High Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial
CONCLUSIONS: In this secondary analysis of the TEAM trial, in patients with diabetes, a high dose early mobilization strategy did not significantly decrease the number of days alive and out of hospital at day 180 but it increased 180-day mortality.PMID:38763167 | DOI:10.1164/rccm.202312-2289OC (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2024 Category: Respiratory Medicine Authors: Ary Serpa Neto Michael Bailey Daniel Seller Alicia Agli Rinaldo Bellomo Kathy Brickell Tessa Broadley Heidi Buhr Belinda J Gabbe Doug W Gould Meg Harrold Alisa M Higgins Sally Hurford Theodore J Iwashyna Alistair D Nichol Jeffrey J Presneill Stefan J Scha Source Type: research
Cross ‐Sectional and Prospective Association of Serum 25‐Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes
ConclusionBlood vitamin D status is associated with the diversity and composition of gut mycobiota in women with GDM, which may provide new insights into the mechanistic understanding of the relationship between vitamin D levels and metabolic health. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - May 19, 2024 Category: Food Science Authors: Yuhui Liang,
Zengliang Jiang,
Yuanqing Fu,
Sha Lu,
Zelei Miao,
Menglei Shuai,
Xinxiu Liang,
Wanglong Gou,
Ke Zhang,
Rui ‐Qi Shi,
Chang Gao,
Mei‐Qi Shi,
Xu‐Hong Wang,
Wen‐Sheng Hu,
Ju‐Sheng Zheng Tags: Research Article Source Type: research
Aqueous humor proteomics analyzed by bioinformatics and machine learning in PDR cases versus controls
ConclusionsAH proteomics provides stable and accurate biomarkers for early warning and diagnosis of PDR. This study provides a deep understanding of the molecular mechanisms of PDR and a rich resource for optimizing PDR management. (Source: Clinical Proteomics)
Source: Clinical Proteomics - May 19, 2024 Category: Biochemistry Source Type: research
Assessing mortality risk in Type 2 Diabetes patients with prolonged ASCVD risk factors: the inclusive Poh-Ai predictive scoring system with CAC Score integration
To enhance the predictive risk model for all-cause mortality in individuals with Type 2 Diabetes (T2DM) and prolonged Atherosclerotic Cardiovascular Disease (ASCVD) risk factors. Despite the utility of the Cor... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 19, 2024 Category: Endocrinology Authors: Meng-Huan Lei, Yu-Chen Hsu, Sheng-Liang Chung, Chao-Chin Chen, Wei-Cheng Chen, Wan-Ming Chen, An-Tzu Jao, Ju-Feng Hsiao, Jen-Te Hsu and Szu-Yuan Wu Tags: Research Source Type: research
