Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells
CONCLUSIONS: In summary, vaspin observably reduces HG-mediated inhibition of PDLSCs OD by modulating the TGF-β1/Smad signaling pathway. Vaspin may be a potential therapeutic for periodontal tissue regeneration in diabetic patients.PMID:38699861 | DOI:10.1111/jre.13254 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Zhihui Jing Xinran Feng Xin Li Xiaoyu Zhang Chunling Pan Source Type: research
Left ventricular systolic dysfunction predicts clinical prognosis in patients with acute ischemic stroke after intravenous thrombolysis
CONCLUSIONS: Our finding indicated that AIS patients with LVSD after IVT had poorer outcomes, suggesting the need to monitor and optimize LVEF in stroke management.PMID:38700495 | DOI:10.18632/aging.205786 (Source: Aging)
Source: Aging - May 3, 2024 Category: Biomedical Science Authors: Chi Zhang Jun-Cang Wu Zheng Tan Xiao-Lu He Fei Li Long Wang Yu Wang Source Type: research
Analysis of chemoresistance characteristics and prognostic relevance of postoperative gemcitabine adjuvant chemotherapy in pancreatic cancer
ConclusionsPatients with pancreatic cancer receiving postoperative gemcitabine adjuvant therapy are more likely to develop chemoresistance when their tumor sizes are larger (diameter>3 cm). Development of chemoresistance exacerbates the prognosis of patients with pancreatic cancer, and larger tumor size is also a risk factor for poor prognosis in these patients. (Source: Cancer Medicine)
Source: Cancer Medicine - May 3, 2024 Category: Cancer & Oncology Authors: Jiaqiang Ren,
Shuai Wu,
Tong Su,
Jiachun Ding,
Fan Chen,
Jie Li,
Zheng Wang,
Liang Han,
Zheng Wu Tags: RESEARCH ARTICLE Source Type: research
GSE265976 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [first cohort, targeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE265980 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [first cohort, untargeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
GSE265981 A set of circulating microRNAs belonging to the 14q32 chromosomic locus identifies two different subgroups of individuals with recent onset Stage 3 type 1 diabetes [second cohort, untargeted]
In this study, we employ a multiplatform sequencing approach to analyze circulating microRNAs in an extended cohort of individuals with T1DM from the INNODIA consortium. Our findings reveal that a set of microRNAs located within the T1DM susceptibility chromosomal locus 14q32 distinguishes two subgroups of individuals. To validate our results, we conduct additional analyses on a second cohort of T1DM individuals, confirming the identification of these subgroups, which we have named Cluster A and Cluster B. Remarkably, Cluster B T1DM individuals, who exhibit increased expression of a set of 14q32 miRNAs, show better glycaem...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Source Type: research
Factors influencing optimal diabetes care and clinical outcomes in Thai patients with type 2 diabetes mellitus: a multilevel modelling analysis
Conclusion
This highlights the necessity for targeted interventions to bridge urban–suburban care gaps, optimise drug prescriptions and implement comprehensive care strategies for improved glycaemic control, DR prevention and CKD progression mitigation among in Thai patients with T2DM. The value of the clinical target aggregate (ABC) and the process of care aggregate (FAACE) was also conclusively demonstrated. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Surawit, A., Pongkunakorn, T., Manosan, T., Mongkolsucharitkul, P., Chamnan, P., Suvarnabhumi, K., Puangpet, T., Suta, S., Pumeiam, S., Pinsawas, B., Ophakas, S., Pisitpornsuk, S., Utchin, C., Mayurasakorn, K. Tags: Open access, Diabetes and Endocrinology Source Type: research
Utilisation of the health belief model to study the behavioural intentions relating to obesity management among university students: a cross-sectional study
Conclusion
This study underscores the need for tailored health promotion strategies that consider the perceptions and beliefs of people about the management of obesity. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Albasheer, O., Hakami, N., Abdelwahab, S. I., Alqassim, A. Y., Alharbi, A., Abdelmola, A. O., Altraifi, A. A. A., Medani, I. E., Hakami, A. M. S., Moafa, M. H., Abuhadi, R. I., Hobani, A. H. Tags: Open access, Public health Source Type: research
Financial protection and equity in the healthcare financing system in Iran: a cross-sectional study among slum dwellers with type 2 diabetes
Conclusions
As a result of insufficient use of insurance, cost-coping strategies used by slum dwellers vis-à-vis T2D expenditures do not protect them from financial risks. Expanding universal health coverage and providing supplemental insurance for those with T2D living in slums are recommended. Iran Health Insurance should adequately cover the costs of T2D care for slum dwellers so that they do not need to use alternative strategies. (Source: BMJ Open)
Source: BMJ Open - May 3, 2024 Category: General Medicine Authors: Ghammari, F., Heidari, K., Jalilian, H. Tags: Open access, Health services research Source Type: research
Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model
British Journal of Cancer, Published online: 03 May 2024; doi:10.1038/s41416-024-02693-9Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Ash Kieran Clift Pui San Tan Martina Patone Weiqi Liao Carol Coupland Rachael Bashford-Rogers Shivan Sivakumar Julia Hippisley-Cox Source Type: research
Deciphering M üller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis
AbstractDiabetic retinopathy (DR), a leading cause of visual impairment, demands a profound comprehension of its cellular mechanisms to formulate effective therapeutic strategies. Our study presentes a comprehensive single-cell analysis elucidating the intricate landscape of M üller cells within DR, emphasizing their nuanced involvement. Utilizing scRNA-seq data from both Sprague–Dawley rat models and human patients, we delineated distinct Müller cell clusters and their corresponding gene expression profiles. These findings were further validated through differential gene expression analysis utilizing human transcripto...
Source: European Journal of Medical Research - May 3, 2024 Category: Research Source Type: research
Optimal Glycated Hemoglobin Cutoff for Diagnosis of Diabetes and Prediabetes in Chinese Breast Cancer Women
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 2, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
The Efficacy of Diabetic Foot Treatment in a “TOSF” Pattern: A Five-Year Retrospective Study
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 2, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Don't hold the metformin: Enhancing inpatient diabetes education to encourage best practices in a public hospital
(Source: Journal of Hospital Medicine)
Source: Journal of Hospital Medicine - May 2, 2024 Category: Hospital Management Authors: Samantha F. Sanders,
Michael S. Shen,
Daniel Alaiev,
Brianna Knoll,
Hyung J. Cho,
Surafel Tsega,
Mona Krouss,
Ian Fagan,
Amanda Klinger Tags: INNOVATIONS CORNER Source Type: research
Dulaglutide restores endothelial progenitor cell levels in diabetic mice and mitigates high glucose-induced endothelial injury through SIRT1-mediated mitochondrial fission
This study investigates dulaglutide's effects on peripheral blood levels of CD34+ and CD133+ cells in a mouse model of lower limb ischemia and its protective mechanisms against high-glucose-induced damage in endothelial cells. Results demonstrated that dulaglutide significantly improves blood flow, reduces tissue damage and inflammation in ischemic limbs, and enhances glycemic control. Furthermore, dulaglutide alleviated high-glucose-induced endothelial cell damage, evident from improved tube formation, reduced reactive oxygen species accumulation, and restored endothelial junction integrity. Mechanistically, dulaglutide m...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Xi Mei Yao Li Jinlin Wu Lumiu Liao Di Lu Ping Qiu Hui-Lan Yang Ming-Wei Tang Xin-Ying Liang Dongfang Liu Source Type: research
