APOE ε4 carrier status modifies plasma p-tau181 concentrations in cognitively healthy super-seniors
This study investigates the effect of apolipoprotein E (APOE) genotype on neurology plasma biomarkers in cognitively healthy Super-Seniors.METHODS: Three hundred seventy plasma specimens from Super-Senior participants ≥ 85 years old, who have never been diagnosed with dementia, cancer, diabetes, cardiovascular, or major pulmonary disease, were analyzed on the Quanterix Simoa HD-X analyzer using commercial Neurology 4-plex E and phosphorylated tau (p-tau)181 assays.RESULTS: Eighty (22%) participants were APOE ε4 carriers and 290 (73%) were non-carriers. No significant differences were found between APOE ε4 carriers and ...
Source: The Journal of Alzheimers Association - May 16, 2024 Category: Psychiatry Authors: Jennifer G Cooper Mohammad Ghodsi Sophie Stukas Stephen Leach Angela Brooks-Wilson Cheryl L Wellington Source Type: research
Modifiable Risk Factors Associated With Cognitive Decline in Late Life Depression: Findings From the Canadian Longitudinal Study on Aging: Facteurs de risque modifiables associ és au déclin cognitif dans la dépression en fin de vie : constatations de l'Étude longitudinale canadienne sur le vieillissement
CONCLUSIONS: In this large sample of Canadian older adults incorporating several objective health measures, older adults with depression were at increased risk of cognitive decline and had an excess of potentially modifiable risk factors. Clinicians should pay particular attention to control of diabetes, physical inactivity and risk factors for cerebrovascular disease in older adults presenting with depression as they can contribute to accelerated cognitive decline and may be addressed during routine clinical care.PMID:38751067 | DOI:10.1177/07067437241255095 (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - May 16, 2024 Category: Psychiatry Authors: Melissa Wong Alex Kiss Nathan Herrmann Krista L Lanct ôt Damien Gallagher Source Type: research
Transcutaneous vagus nerve stimulation modulates depression-like phenotype induced by high-fat diet via P2X7R/NLRP3/IL-1 β in the prefrontal cortex
CONCLUSION: The P2X7R/NLRP3/IL-1β signaling pathway may play an important role in the antidepressant-like behavior of taVNS, which provides a promising mechanism for taVNS clinical treatment of diabetes combined with depression.PMID:38752512 | PMC:PMC11097256 | DOI:10.1111/cns.14755 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 16, 2024 Category: Neuroscience Authors: Shaoyuan Li Yuzhengheng Zhang Yu Wang Zixuan Zhang Chen Xin Yifei Wang Peijing Rong Source Type: research
Preserved seasonal variation in glycemic control in patients with type 2 diabetes mellitus during COVID-19: a 3-year-long retrospective cohort study in older adults in Japan
CONCLUSIONS: Seasonal variations in glycemic control in patients with DM were not influenced by lifestyle modifications associated with COVID-19. Maintenance of physical activity is necessary to prevent the development of sarcopenia. Moreover, seasonal variations in glycemic metabolism should be considered an independent factor for DM management. Additional extensive multifacility investigations are necessary to corroborate our findings.PMID:38755559 | DOI:10.1186/s12902-024-01602-8 (Source: Molecular Medicine)
Source: Molecular Medicine - May 16, 2024 Category: Molecular Biology Authors: Shimpei Iwata Kenji Ashida Mutsuyuki Demiya Ayako Nagayama Nao Hasuzawa Satoko Yoshinobu Aya Sonezaki Junichi Yasuda Seiichi Motomura Yoshio Katsuki Kenzo Sugi Masatoshi Nomura Source Type: research
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
J Mol Med (Berl). 2024 May 16. doi: 10.1007/s00109-024-02448-2. Online ahead of print.ABSTRACTLiver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world-wide. Although its symptoms are unspecific, it can lead to decompensation events such as ascites, hepatic encephalopathy, variceal hemorrhage, and hepatocellular carcinoma (HCC). In addition, an increased risk for cardiovascular events has been demonstrated in patients with NASH. Pharmacological treatments for NASH cirrhosis are not yet available, one of the reasons being the lack in surrogate endpoints availa...
Source: Molecular Medicine - May 16, 2024 Category: Molecular Biology Authors: Mattia Amoroso Salvador Augustin Sven Moosmang Isabella Gashaw Source Type: research
Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats
CONCLUSION: This study indicates that supplementation of menhaden FO inhibits the LPS signaling pathway and protects against neuroinflammation, consequently maintaining cognitive performance in diabetic animals. Thus, the current study suggested that fish oil may be effective as a supporting therapy option for diabetes to avoid diabetes-cognitive impairment.PMID:38753370 | DOI:10.1080/13880209.2024.2351933 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 16, 2024 Category: Drugs & Pharmacology Authors: Nurina Titisari Ahmad Fauzi Intan Shameha Abdul Razak Mohd Hezmee Mohd Noor Nurdiana Samsulrizal Hafandi Ahmad Source Type: research
How pregnant women with diabetes experience telemonitoring of the fetal heart rate - An interview study
CONCLUSIONS: Pregnant women with type 1 diabetes or Gestational Diabetes Mellitus benefit from the use of telemonitoring. To further improve the implementation and use of telemonitoring clinical implications, consider how timing and coordination of care, technical equipment, and feedback mechanisms could be improved.PMID:38754278 | DOI:10.1016/j.ejogrb.2024.04.039 (Source: Reproductive Biology)
Source: Reproductive Biology - May 16, 2024 Category: Reproduction Medicine Authors: Ingrid Jepsen Jane H Nielsen Stine A Eriksen Rikke D Maimburg Source Type: research
Oral glucagon-like peptide-1 receptor agonists and combinations of entero-pancreatic hormones as treatments for adults with type 2 diabetes: where are we now?
Expert Opin Pharmacother. 2024 May 16. doi: 10.1080/14656566.2024.2356254. Online ahead of print.ABSTRACTINTRODUCTION: Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have changed the landscape of type 2 diabetes (T2D) management due to their cardio-renal benefits, their glucose-lowering efficacy and weight loss (WL) maintenance. However, the response to GLP-1 RA monotherapy is heterogeneous. Additionally, the majority of GLP-1 RAs are injectable treatments. Oral GLP-1 RAs and injectable combinations of GLP-1 with other entero-pancreatic hormones [glucose-dependent insulinotropic polypeptide (GIP), glucagon and amy...
Source: Expert Opinion on Pharmacotherapy - May 16, 2024 Category: Drugs & Pharmacology Authors: Prathima Gogineni Eka Melson Dimitris Papamargaritis Melanie Davies Source Type: research
A multifunctional silk-hyaluronic acid self-healing hydrogel laden with alternatively activated macrophage-derived exosomes reshape microenvironment of diabetic wound and accelerate healing
Int J Biol Macromol. 2024 May 14:132384. doi: 10.1016/j.ijbiomac.2024.132384. Online ahead of print.ABSTRACTThe impairment of phenotype switching of pro-inflammatory M1 to pro-healing M2 macrophage induced by hyperglycemic microenvironment often elevates oxidative stress, impairs angiogenesis, and leads to chronic non-healing wounds in diabetic patients. Administration of M2Exo at wound site is known to polarize M1 to M2 macrophage and can accelerate wound healing by enhancing collagen deposition, angiogenesis, and re-epithelialization. In the present study, M2 macrophage-derived exosomes (M2Exo) were conjugated with oxidi...
Source: International Journal of Biological Macromolecules - May 16, 2024 Category: Biochemistry Authors: Ahana Banerjee Prerna Singh Parvaiz A Sheikh Ashok Kumar Veena Koul Jayanta Bhattacharyya Source Type: research
3D printed VEGF-CPO biomaterial scaffold to promote subcutaneous vascularization and survival of transplanted islets for the treatment of diabetes
In this study, we utilize biocompatible copolymers l-lactide and D,l-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells. The scaffold maintains the sustained release of vascular endothelial growth factor (VEGF) and a slow release of oxygen from calcium peroxide (CPO), thereby regulating the microenvironment for islet survival. This helps to improve insufficient subcutaneous vascularization and reduce islet death due to hypoxia post-transplantation. By pre-implanting VEGF-CPO scaffolds subcutaneously in...
Source: International Journal of Biological Macromolecules - May 16, 2024 Category: Biochemistry Authors: Xuchun Chen Kangchun Wang Yang Han Qi Pan Xinrui Jiang Zitong Yu Weichen Zhang Ziqi Wang Haomin Yan Ping Sun Jingjing Liang Heran Li Ying Cheng Source Type: research
Estimation of the relationship between the thermal environment of a house in winter and its occupants' health
This study aims to quantify the relationship between the arbitrary thermal environment of houses in winter and their occupants' health through a comprehensive questionnaire survey, involving approximately 24,000 individuals who moved into insulated dwellings in Japan. A relationship between the degree of the thermal insulation of these houses and corresponding rates of improvement in the following 10 diseases were formulated: heart disease, cerebrovascular disease, hypertension, diabetes mellitus, asthma, dermatitis and eczema, pneumonia, inflammatory polyarthropathies, allergic rhinitis, and conjunctivitis. Following the ...
Source: Environmental Research - May 16, 2024 Category: Environmental Health Authors: Koji Fujita Satoshi Yoshida Risa Ishizaki Eiji Yamamoto Naoko Takahashi Atsushi Iwamae Source Type: research
Polychlorinated Biphenyls and Incident Coronary Heart Disease-related Outcomes in Great Lakes Fish Consumers
CONCLUSIONS: This study presents evidence that exposure to PCBs increases the risk of developing coronary heart disease. Given the large number of risk factors and causal pathways for CHD, future research is required to better understand biological mechanisms of action for PCBs on CHD.PMID:38751005 | DOI:10.1016/j.envres.2024.119071 (Source: Environmental Research)
Source: Environmental Research - May 16, 2024 Category: Environmental Health Authors: Michael J Blackowicz Victoria W Persky Robert M Sargis Sally Freels Henry A Anderson Mary E Turyk Source Type: research
The effect of per and polyfluoroalkyl substance (PFAS) exposure on gestational diabetes mellitus and its subclinical risk factors: A systematic review and meta-analysis protocol
The objective of this study is to assess the effect of higher PFAS exposure (defined by individual compounds or mixtures measured before or during pregnancy) on GDM and subclinical measures of impaired glucose homeostasis (measured during pregnancy) compared to lower PFAS exposure in pregnant.METHODS: We developed our systematic review protocol in accordance with the Navigation Guide. Peer-reviewed journal and grey literature searches were piloted in to identify relevant studies and refine our search terms and strategy. We also piloted the study screening criteria and data extraction form in DistillerSR, and refined our pr...
Source: Environment International - May 16, 2024 Category: Environmental Health Authors: Abigail P Bline Lauren B Ellis Katherine E Pelch Juleen Lam Saunak Sen Marya Zlatnik Julia Varshavsky Source Type: research
Investigation of crucial genes and mitochondrial function impairment in diabetic cardiomyopathy
CONCLUSION: Our research defined four crucial genes, as well as determined that mitochondrial function impairment compromises calcium homeostasis ultimately resulting in contractile dysfunction is a central contributor to DCM progression. Hopefully, this study will offer more effective biomarkers for DCM diagnosis and treatment.PMID:38754569 | DOI:10.1016/j.gene.2024.148563 (Source: Gene)
Source: Gene - May 16, 2024 Category: Genetics & Stem Cells Authors: Maierhaba Tuersuntuoheti Lei Zhou Juexing Li Shangneng Yang Suying Zhou Hui Gong Source Type: research
Clinical and Genetic Characteristics and Outcome in Patients with Neonatal Diabetes Mellitus from a Low Middle-Income Country
J Clin Res Pediatr Endocrinol. 2024 May 16. doi: 10.4274/jcrpe.galenos.2024.2024-2-17. Online ahead of print.ABSTRACTNeonatal Diabetes Mellitus (NDM) is a disorder characterized by persistent, severe hyperglycemia presenting during the first 6 months of life. These disorders are rare and the incidence is approximately 1 in 90,000 live births. To describe the clinical presentation, molecular genetics and outcome of patients with NDM from a single paediatric endocrine center from a low middle income country. A retrospective study was conducted on patients diagnosed with NDM. Medical records were reviewed for demographic data...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - May 16, 2024 Category: Endocrinology Authors: I M Kumarasiri T J Hoole M W A Nimanthi I Jayasundara R Balasubramaniam N Atapattu Source Type: research
