Metformin-induced changes of the gut microbiota in patients with type 2 diabetes mellitus: results from a prospective cohort study
ConclusionsMetformin ’s role in glucose metabolism regulation may primarily involve specific alterations in certain gut microbial species rather than an overall increase in microbial species diversity. This may suggest gut microbiota targets in future studies on metabolic abnormalities caused by metformin. (Source: Endocrine)
Source: Endocrine - May 18, 2024 Category: Endocrinology Source Type: research
The effects of policosanol supplementation on blood glucose: A systematic review and dose-response meta-analysis of randomized controlled trials
Previous studies have assessed how supplementing with policosanol affects blood sugar levels. The outcomes, nevertheless, were not constant. Multiple electronic databases were searched including ISI Web of Science, Cochrane Library, PubMed, Google Scholar, and Scopus until February 9, 2023. To assess the effects of policosanol on glucose, we employed a random-effects or fixed-effects meta-analysis approach to examine the weighted mean differences (WMDs) and associated 95 % confidence intervals (CI) before and after policosanol and placebo administration. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - May 18, 2024 Category: Endocrinology Authors: Mohammad Reza Amini, Shervin Kazeminejad, Moharam Jalalzadeh, Sara Sadeghi Majd, Zeynab Kavyani, Gholamreza Askari, Azita Hekmatdoost Tags: Review Source Type: research
Clinical and functional characterization of a novel KCNJ11 (c.101G & gt; A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13
ConclusionFor the first time, we revealed the pathogenic mechanism of KCNJ11 (c.101G > A, p.R34H) associated with MODY13. This mutant can cause alterations in KATP channel activity, reduce sensitivity to glucose stimulation, and impair pancreatic β-cell secretory function by downregulating insulin secretion-associated exocytosis proteins. Therefore, oral sulfonylurea drugs can low er blood glucose levels through pro-insulinotropic effects and are more favorable for patients with this mutation. (Source: Endocrine)
Source: Endocrine - May 18, 2024 Category: Endocrinology Source Type: research
Expecting factors for inadequate glycemic control in children and adolescents with type 1 diabetes mellitus: a single center experience
ConclusionsIn the current study, inadequate glycemic control was induced by many factors, Strategies should be applied to control these factors to minimize the prospective risks of macro-vascular complications linked to T1DM in children& adolescents. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - May 18, 2024 Category: Endocrinology Source Type: research
Insights from the potential impact of pasteurized Akkermansia muciniphila in zebrafish models of obesity and diabetes
AbstractObesity, diabetes, and related metabolic and health conditions are significant concerns in societies worldwide, necessitating the development of effective treatment and prevention strategies. Gut microbiota, particularlyAkkermansia muciniphila (A. muciniphila), have emerged as key players in the onset of obesity and diabetes due to their impact on metabolic pathways related to food absorption, low-grade inflammation, and insulin signaling. UsingA. muciniphila have been identified as a promising approach in obesity and diabetes management. However, the complex culture conditions and animal-based culture medium limit...
Source: Journal of Diabetes and Metabolic Disorders - May 18, 2024 Category: Endocrinology Source Type: research
Mediation effect of metabolic factors and inflammation on the association of serum uric acid with serum proprotein convertase subtilisin/kexin type 9 levels
Serum uric acid (SUA), the end product of purine nucleotide metabolism, has been recognized as an important risk factor for cardiovascular disease (CVD).1, 2 Moreover, emerging evidence in several studies has indicated that high levels of SUA increase risks of type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), and chronic kidney diseases.3, 4 Women usually have lower SUA levels than men, and the gender differences in the association of SUA levels with some diseases, especially CVD, have been widely studied. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - May 18, 2024 Category: Lipidology Authors: Wen Guo, Qin Cui, Zhenzhen Fu, Qun Zhang, Jue Jia Tags: Original Research Source Type: research
An activated near-infrared mitochondrion-targetable fluorescent probe for rapid detection of NADH
Chem. Commun., 2024, Advance Article DOI: 10.1039/D4CC01378F, CommunicationYaxin Sun, Yanyun Mao, Tianwen Bai, Tianqing Ye, Yanfei Lin, Fang Wang, Lei Li, Longhua Guo, Haiying Liu, Jianbo Wang A novel near-infrared fluorescent probe with rapid response for detecting NADH was developed, providing an imaging method for the detection of endogenous and exogenous NADH in cells, and NADH fluctuations in type II diabetic and AD model cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - May 17, 2024 Category: Chemistry Authors: Yaxin Sun Source Type: research
Analyzing Immune Cell Infiltration and Copper Metabolism in Diabetic Foot Ulcers
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - May 17, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa
In conclusion, the three lncRNAs isolated in the present study may be useful for improving the prognostic prediction of HS, as well as contributing towards an improved understanding of the underlying pathogenic mechanisms, thereby potentially providing new therapeutic targets.PMID:38757342 | PMC:PMC11094584 | DOI:10.3892/mmr.2024.13236 (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - May 17, 2024 Category: Molecular Biology Authors: Bruna De Felice Pasquale De Luca Concetta Montanino Marta Mallardo Graziella Babino Edi Mattera Raffaele Sorbo Giovanni Ragozzino Giuseppe Argenziano Aurora Daniele Ersilia Nigro Source Type: research
Development and validation of a novel nomogram for predicting good neoangiogenesis after encephaloduroarteriosynangiosis in patients with moyamoya disease and type 2 diabetes mellitus: a case-control study
CONCLUSIONS: The nomogram developed in this study accurately predicted neoangiogenesis in patients with MMD and T2DM after EDAS and may assist neurosurgeons in identifying suitable candidates for indirect revascularization surgery.PMID:38759234 | DOI:10.3171/2024.2.JNS24208 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - May 17, 2024 Category: Neurosurgery Authors: Jing-Jie Li Bin Ren Xiao-Peng Wang Qian-Nan Wang Xiang-Yang Bao Qing-Bao Guo Zi-Qing Kong Jia-Qi Liu Gan Gao Min-Jie Wang Si-Meng Liu He-Guan Fu Huai-Yu Tong Lian Duan Source Type: research
The use of sodium-glucose cotransporter 2 inhibitors and the incidence of uveitis in type 2 diabetes: a population-based cohort study
CONCLUSIONS: The use of SGLT2 inhibitors could be an independent protective factor for uveitis development in T2DM population.PMID:38757017 | PMC:PMC11094819 | DOI:10.5114/aoms/174228 (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2024 Category: Biomedical Science Authors: Jui-Fu Chung Po-Jen Yang Chao-Kai Chang Chia-Yi Lee Jing-Yang Huang Kai Wang Shun-Fa Yang Source Type: research
Cost-effectiveness of empagliflozin as add-on to standard of care for chronic kidney disease management in the United Kingdom
CONCLUSIONS: Empagliflozin as an add-on to SoC for treatment of adults with CKD represents cost-effective use of UK National Health Service (NHS) resources.PMID:38758099 | DOI:10.1080/13696998.2024.2357041 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - May 17, 2024 Category: Health Management Authors: Mafalda Ramos Laetitia Gerlier Anastasia Uster Louise Muttram Andrew H Frankel Mark Lamotte Source Type: research
The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses
CONCLUSION: Our study revealed a causal protective effect of higher ALM on IS, independent of physical activity and adiposity-related indices. Moreover, we found that higher ALM could reduce susceptibility to IS partially by lowering the risk of vascular risk factors, including CHD, hypertension, T2DM, and hyperlipidemia. In brief, we elucidated another modifiable factor for IS and implied that maintaining sufficient muscle mass may reduce the risk of such disease.PMID:38757378 | PMC:PMC11099748 | DOI:10.1111/cns.14759 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2024 Category: Neuroscience Authors: Jiahao Song Da Zhou Jingrun Li Mengqi Wang Lina Jia Duo Lan Haiqing Song Xunming Ji Ran Meng Source Type: research
Harmine exhibits anti-apoptotic properties and reduces diabetes-induced testicular damage caused by streptozotocin in rats
CONCLUSION: Harmine protects testicular tissue and sperm against diabetes-induced damage. This effect of harmine is associated with a rebalancing of the antioxidant capacity that subsequently decreases apoptosis in the testes.PMID:38757277 | DOI:10.5653/cerm.2023.06254 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - May 17, 2024 Category: Reproduction Medicine Authors: Ali Ghanbari Cyrus Jalili Kaveh Shahveisi Nasim Akhshi Source Type: research
Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota
CONCLUSION: This review highlights the importance of targeting the gut-kidney axis to regulate microbial disorders, their metabolites, and associated signaling pathways in DKD. The Qing-Re-Xiao-Zheng formula, the Shenyan Kangfu tablet, the Huangkui capsule, and the Bekhogainsam decoction are potential candidates to address the gut-kidney axis. TCM interventions offer a significant therapeutic approach by targeting microbial dysregulation in patients with DKD.PMID:38757785 | PMC:PMC11104709 | DOI:10.1080/13880209.2024.2351946 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 17, 2024 Category: Drugs & Pharmacology Authors: Xia-Qing Wu Lei Zhao Yan-Long Zhao Xin-Yao He Liang Zou Ying-Yong Zhao Xia Li Source Type: research
