Assessing mortality risk in Type 2 Diabetes patients with prolonged ASCVD risk factors: the inclusive Poh-Ai predictive scoring system with CAC Score integration
To enhance the predictive risk model for all-cause mortality in individuals with Type 2 Diabetes (T2DM) and prolonged Atherosclerotic Cardiovascular Disease (ASCVD) risk factors. Despite the utility of the Cor... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 19, 2024 Category: Endocrinology Authors: Meng-Huan Lei, Yu-Chen Hsu, Sheng-Liang Chung, Chao-Chin Chen, Wei-Cheng Chen, Wan-Ming Chen, An-Tzu Jao, Ju-Feng Hsiao, Jen-Te Hsu and Szu-Yuan Wu Tags: Research Source Type: research
Adipose stem cells-derived small extracellular vesicles transport Thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a highly prevalent disease and poses a significant risk to the health of pregnant women. Abdominal adipose tissue (AT) contributes to insulin resistance (IR) associated w... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 19, 2024 Category: Endocrinology Authors: Huaping Li, Hao Yang, Jingyan Liu, Hedi Yang, Xinyu Gao, Xiaoying Yang, Zhou Liu and Qiaohui Qian Tags: Research Source Type: research
Evaluation of the Effectiveness of In-Hospital Exercise Rehabilitation in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus Combined with Sarcopenia Effect of Lifestyle Management on Disease Status in Patients with Type 2 Diabetes Mellitus
. (Source: Endocrine Research)
Source: Endocrine Research - May 19, 2024 Category: Endocrinology Authors: Jianhua ShiGaojun YinZhiyun ShiShengjun ZhangJing WeiTao XueXiaoqian Sua Health Management Center, General Hospital of Ningxia Medical University, Yinchuan, Chinab Inspection Center, General Hospital of Ningxia Medical University, Yinchuan, Chinac Departm Source Type: research
Epidemiology, microbiology, and diagnosis of infection in diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: A multicenter retrospective observational study
Infection is a leading trigger of hyperglycemic emergencies. The prevalence of infectious disease is as high as 40 to 60 % among patients with diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS) [1,2]. Infection worsens hyperglycemia by decreasing insulin secretion and glucose uptake, further impairing immune response [3]. It is thereby known as a significant risk factor for mortality [4]. Pro mpt diagnosis and management of infection are crucial for these patients as early treatment reduces mortality [5]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - May 19, 2024 Category: Endocrinology Authors: Kyosuke Takahashi, Norimichi Uenishi, Masamitsu Sanui, Shigehiko Uchino, Naoki Yonezawa, Tetsuhiro Takei, Norihiro Nishioka, Hirotada Kobayashi, Shunichi Otaka, Kotaro Yamamoto, Hideto Yasuda, Shintaro Kosaka, Hidehiko Tokunaga, Naoki Fujiwara, Takashiro Source Type: research
Molecules, Vol. 29, Pages 2386: An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging
ng Wang
Monitoring hydrogen sulfide (H2S) in living organisms is very important because H2S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H2S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 μM) for H2S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism betw...
Source: Molecules - May 19, 2024 Category: Chemistry Authors: Xin-Hui Tang Hao-Na Zhang Wen-Ling Wang Qing-Ming Wang Tags: Article Source Type: research
Association of Aldosterone, Renin, and Aldosterone to Renin Ratio with Metabolic Profile in Primary Aldosteronism
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 18, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research
Type 2 diabetes mellitus/obesity drugs: a neurodegenerative disorders savior or a bridge too far?
Ageing Res Rev. 2024 May 16:102343. doi: 10.1016/j.arr.2024.102343. Online ahead of print.ABSTRACTGlucagon-like peptide-1 (GLP-1) receptor agonist-based drugs (incretin mimetics) have meaningfully impacted current treatment of type 2 diabetes mellitus (T2DM), and their actions on satiety and weight loss have led to their use as an obesity medication. With multiple pleotropic actions beyond their insulinotropic and weight loss ones, including anti-inflammatory and anti-insulin-resistant effects selectively mediated by their receptors present within numerous organs, this drug class offers potential efficacy for an increasing...
Source: Ageing Research Reviews - May 18, 2024 Category: Genetics & Stem Cells Authors: Katherine O Kopp Elliot J Glotfelty Yazhou Li Debomoy K Lahiri Nigel H Greig Source Type: research
Novel therapeutics to treat chronic pancreatitis: targeting pancreatic stellate cells and macrophages
Expert Rev Gastroenterol Hepatol. 2024 May 18:1-13. doi: 10.1080/17474124.2024.2355969. Online ahead of print.ABSTRACTINTRODUCTION: Chronic pancreatitis (CP) is a persistent, recurrent, and progressive disorder that is characterized by chronic inflammation and irreversible fibrosis of the pancreas. It is associated with severe morbidity, resulting in intense abdominal pain, diabetes, exocrine and endocrine dysfunction, and an increased risk of pancreatic cancer. The etiological factors are diverse and the major risk factors include smoking, chronic alcoholism, as well as other environmental and genetic factors. The treatme...
Source: Expert Review of Gastroenterology and Hepatology - May 18, 2024 Category: Gastroenterology Authors: Srikanth Iyer Macie Enman Preeti Sahay Vikas Dudeja Source Type: research
Genetically predicted type 2 diabetes mellitus mediates the causal association between plasma uric acid and ischemic stroke
CONCLUSIONS: The study suggests that genetic predisposition to uric acid is linked to a greater risk of IS, especially LAS and SVS. T2DM might mediate a significant proportion of the associations between uric acid and LAS as well as SVS.PMID:38761781 | DOI:10.1016/j.intimp.2024.112267 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 18, 2024 Category: Allergy & Immunology Authors: Chaoqun Wang Yikun Gao Daniel Smerin Xiaoxing Xiong Zhibiao Chen Lijuan Gu Source Type: research
Risk factors of periprosthetic joint infection after hemiarthroplasty for displaced femoral neck fracture in the elderly: Analysis of 1619 cases in the multicenter database
CONCLUSION: This multicenter retrospective study demonstrates a low incidence (1.4%) of PJI in elderly patients undergoing hemiarthroplasty for FNF, primarily due to Staphylococcus aureus. Increased usage of antiplatelets and anticoagulants, as well as comorbidities related to atherosclerosis, like peripheral vascular disease and diabetes mellitus, were observed in patients with PJI. Additionally, these patients experienced higher rates of blood transfusion and postoperative hematomas, highlighting the need for careful management. It should be noted, however, that this finding is a conclusion limited by study design issues...
Source: Atherosclerosis - May 18, 2024 Category: Cardiology Authors: Satoshi Sumi Yasuhiko Takegami Katsuhiro Tokutake Hiroaki Nakashima Kenichi Mishima Tetsuro Takatsu Shiro Imagama Source Type: research
Metabolic profiling reveals the nutraceutical effect of Gongolaria abies-marina and Rosmarinus officinalis extracts in a type 1 diabetes animal model
In conclusion, our findings suggest that environmentally clean extracts from R. officinalis and G. abies-marina possess nutraceutical potential, as they were able to modulate the metabolic profile in streptozotocin-induced diabetic rats. G. abies-marina extract exhibited a more substantial effect on metabolic alterations induced by diabetes compared to R. officinalis. These results warrant further exploration of these plant extracts for their potential in managing diabetes-related metabolic disturbances.PMID:38761421 | DOI:10.1016/j.biopha.2024.116731 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 18, 2024 Category: Drugs & Pharmacology Authors: Joanna Godzien Kacper Jablonowski Francisco J Ruperez Adam Kretowski Michal Ciborowski Bartlomiej Kalaska Source Type: research
Development and Validation of a Nomogram for Predicting Nutritional Risk Based on Frailty Scores in Older Stroke Patients
CONCLUSIONS: Elderly individuals recovering from stroke often experience significant nutritional deficiencies. The nomogram we devised accurately assesses this risk by combining physiological, psychological, and biochemical metrics. It equips healthcare providers with the means to actively screen for and manage the nutritional care of these patients. This tool is instrumental in swiftly identifying those in urgent need of targeted nutritional support, which is essential for optimizing their recovery and managing their nutrition more effectively.PMID:38761298 | PMC:PMC11102373 | DOI:10.1007/s40520-023-02689-0 (Source: Aging...
Source: Aging Clinical and Experimental Research - May 18, 2024 Category: Geriatrics Authors: Lei Liu Chunyu He Jiaxin Yang Wenbo Chen Yan Xie Xiaofang Chen Source Type: research
Effects of molting on the expression of ecdysteroid responsive genes in the crustacean molting gland (Y-organ)
Gen Comp Endocrinol. 2024 May 16:114548. doi: 10.1016/j.ygcen.2024.114548. Online ahead of print.ABSTRACTEcdysteroid molting hormones coordinate arthropod growth and development. Binding of 20-hydroxyecdysone (20E) to ecdysteroid receptor EcR/RXR activates a cascade of nuclear receptor transcription factors that mediate tissue responses to hormone. Insect ecdysteroid responsive and Forkhead box class O (FOXO) transcription factor gene sequences were used to extract orthologs from blackback land crab (Gecarcinus lateralis) Y-organ (YO) transcriptome: Gl-Ecdysone Receptor (EcR), Gl-Broad Complex (Br-C), Gl-E74, Gl-Hormone Re...
Source: General and Comparative Endocrinology - May 18, 2024 Category: Endocrinology Authors: Samiha A M Benrabaa Sharon A Chang Ernest S Chang Donald L Mykles Source Type: research
Longitudinal evaluation of fetal and infant AGD in healthy children: association with penile size, testosterone and DHT
CONCLUSIONS: AGD is sexual dimorphic already in the 3rd trimester. Fetal and infant AGD correlates. AGD is associated with body size but not circulating androgen levels at minipuberty. These findings suggest that fetal and infant AGD, reflect androgen action during early fetal development.PMID:38761403 | DOI:10.1210/clinem/dgae342 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 18, 2024 Category: Endocrinology Authors: Margit Bistrup Fischer Gylli Mola L ærke Priskorn Lone Scheel Hanne Kristine Hegaard Karin Sundberg Hanne Frederiksen Anna-Maria Andersson Anders Juul Casper P Hagen Source Type: research
Understanding the link between different types of maternal diabetes and the onset of autism spectrum disorders
Diabetes Metab. 2024 May 16:101543. doi: 10.1016/j.diabet.2024.101543. Online ahead of print.ABSTRACTAutism spectrum disorders (ASD) encompass a collection of neurodevelopmental disorders that exhibit impaired social interactions and repetitive stereotypic behaviors. Although the exact cause of these disorders remains unknown, it is widely accepted that both genetic and environmental factors contribute to their onset and progression. Recent studies have highlighted the potential negative impact of maternal diabetes on embryonic neurodevelopment, suggesting that intrauterine hyperglycemia could pose an additional risk to ea...
Source: Diabetes and Metabolism - May 18, 2024 Category: Endocrinology Authors: Wenyu Shao Yichun Su Jiayin Liu Yu Long Liu Jinghui Zhao Xiaotang Fan Source Type: research
