Hyperglycemia-simulating environment attenuated experimentally induced calcification in cultured human aortic valve interstitial cells
Conclusions: In vitro hyperglycemia-like conditions attenuated calcification in VICs. High glucose levels may trigger a series of events that secondarily stimulate calcification of VICs in vivo.PMID:38757904 | DOI:10.1080/14017431.2024.2353070 (Source: Scandinavian Cardiovascular Journal)
Source: Scandinavian Cardiovascular Journal - May 17, 2024 Category: Cardiology Authors: Arsenii Zabirnyk Daria Evensen John-Peder Escobar Kvitting Mari-Liis Kaljusto K åre-Olav Stensløkken Jarle Vaage Source Type: research
Diagnosis and Management of Periprosthetic Joint Infections After Total Ankle Arthroplasty
J Am Acad Orthop Surg. 2024 May 16. doi: 10.5435/JAAOS-D-23-01266. Online ahead of print.ABSTRACTPeriprosthetic joint infection (PJI) after total ankle arthroplasty (TAA) is a dreaded complication that may lead to catastrophic outcomes. Risk factors include a history of surgery on the operated ankle, low preoperative function scores, diabetes, extended surgical time, and postoperative wound-healing problems. Clinical presentation varies and may include increasing ankle pain and swelling, high temperature, local erythema, wound drainage, and dehiscence. The initial diagnostic evaluation should include plain radiographs, ery...
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 17, 2024 Category: Orthopaedics Authors: Kivanc Atesok Daniel J Scott Shepard Hurwitz Christopher E Gross Source Type: research
The causal relationship between sarcopenia-related traits and ischemic stroke: Insights from univariable and multivariable Mendelian randomization analyses
CONCLUSION: Our study revealed a causal protective effect of higher ALM on IS, independent of physical activity and adiposity-related indices. Moreover, we found that higher ALM could reduce susceptibility to IS partially by lowering the risk of vascular risk factors, including CHD, hypertension, T2DM, and hyperlipidemia. In brief, we elucidated another modifiable factor for IS and implied that maintaining sufficient muscle mass may reduce the risk of such disease.PMID:38757378 | PMC:PMC11099748 | DOI:10.1111/cns.14759 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 17, 2024 Category: Neuroscience Authors: Jiahao Song Da Zhou Jingrun Li Mengqi Wang Lina Jia Duo Lan Haiqing Song Xunming Ji Ran Meng Source Type: research
Harmine exhibits anti-apoptotic properties and reduces diabetes-induced testicular damage caused by streptozotocin in rats
CONCLUSION: Harmine protects testicular tissue and sperm against diabetes-induced damage. This effect of harmine is associated with a rebalancing of the antioxidant capacity that subsequently decreases apoptosis in the testes.PMID:38757277 | DOI:10.5653/cerm.2023.06254 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - May 17, 2024 Category: Reproduction Medicine Authors: Ali Ghanbari Cyrus Jalili Kaveh Shahveisi Nasim Akhshi Source Type: research
Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population
CONCLUSION: In elderly individuals, Streptococcus emerges as a potential biomarker linked to diabetes, exhibiting elevated abundance in diabetic patients influenced by disease exposure and limited bacterial interactions.PMID:38756148 | PMC:PMC11097700 | DOI:10.1080/20002297.2024.2345942 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - May 17, 2024 Category: Microbiology Authors: Xin Zeng Shuqi Huang Xin Ye Siping Song Jing He Liwei Hu Sicheng Deng Fan Liu Source Type: research
